Module number 2482




Database revision : gnsdb28.10
Date : Tue Feb 25 17:24:32 2003
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Cond423:YPD_stationary_phase_4_h_ypd-1\n mNOP2:May participate in nucleolar function during the transition \nfrom stationary phase to rapid growth,90 kDa protein homolog\nous to a human proliferation-associated nucleolar protein, p\n120,Null mutant is inviable; overexpression leads to changes\n in nucleolar morphology\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n mSAM1:S-adenosylmethionine synthetase,,Null mutant is viable.\n mSML1:Suppressor of mec lethality,,Null mutant is viable and suppr\nesses mec1 and rad53 lethality; suppresses mip1-1 at 37 C, s\nuppresses dun1 DNA damage sensitivity; increased resistance \nto DNA damage; increased dNTP pools\n Cond711:t2+Vec\n mURA5:Fifth step in pyrimidine biosynthesis pathway,orotate phosph\noribosyltransferase 1,Null mutant is viable\n Cond780:Peroxide_10'\n mTIR3:TIP1-related,cell wall mannoprotein,inviable under unaerobic\n conditions\n Cell Cycle.alpha:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion. Mol Biol Cell. 1998 Dec;9(12):3273-97.\n mTUB2:beta subunit of tubulin monomer; involved in chromosome segr\negation and nuclear migration,beta-tubulin,null is inviable;\n conditional mutants show block of mitotic nuclear migration\n and chromosome segregation and defects in spindle and/or cy\ntoplasmic microtubules at non-permissive conditions; some mu\ntants are benomyl-hypersensitive\n Cond400:Nitrogen_Depletion_12_h\n Cond941:SK1_YPD\n mHIP1:histidine permease,histidine permease,requires supplementati\non with large amounts of histidine for growth\n Cond883:5\n Stress.Carbon:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond244:ymr010w\n Cond898:RPN4\n mPIS1:phosphatidylinositol synthase,phosphatidylinositol synthase,\nNull mutant is inviable\n mSIM1:(putative) invovled in control of DNA replication,,Null muta\nnt is viable; mutant allows an extra round of DNA replicatio\nn without mitosis\n mDYS1:Deoxyhypusine synthase carries out the first step in hypusin\ne biosynthesis, converting lysine and spermidine into deoxyh\nypusine.,deoxyhypusine synthase,Null mutant is inviable\n Stress.YPDStat:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond719:t4-SSD1\n Cond872:Zero1\n mRHR2:DL-glycerol-3-phosphatase,DL-glycerol-3-phosphatase,\n mGAS3:Unknown ,, Unknown\n Cond724:t4+SSD1,H44\n mAUR1:involved in phospolipid metabolism,,Null mutant is inviable;\n mutant exhibits dominant resistance to aureobasidin A. Wild\n type (sensitive) is recessive.\n Cond889:4NQO_2\n mGAS5:Unknown ,, Unknown\n mECM39:ExtraCellular Mutant,,A Tn3 insertion into this gene causes \nhypersensitivity to the cell surface polymer perturbing agen\nt calcofluor white.\n Cond713:t4+Vec\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond873:10min\n mEFT1:translation elongation factor 2 (EF-2),translation elongatio\nn factor 2 (EF-2),Null mutant is viable (eft1 eft2 double mu\ntant is lethal)\n mADO1:adenosine kinase,adenosine kinase,\n mGOT1:Golgi Transport,membrane protein,Null mutant is viable but e\nxhibits ER to Golgi transport defects in vitro. got1 is synt\nhetically lethal with mutations in sft2; the got1 sft2 doubl\ne mutant exhibits defects in transport to the Golgi complex.\n mCWP1:cell wall protein, involved in O and N glycosylation, accept\nor of B1-6 glucan.,cell wall mannoprotein,Null mutant is via\nble, has increased sensitivities to calcoflour white and con\ngo red\n Cond897:STATMMS\n Cond718:t4+SSD1wt\n Cond888:MNNG_2\n Cond894:G2\n mSAC1:integral membrane protein localizing to the ER and Golgi,int\negral membrane protein,suppressor of actin mutations, suppre\nssor of sec14 alleles, inositol auxotrophy\n Cond459:YP_sucrose_vs_reference_pool_car-2\n Cond404:Nitrogen_Depletion_5_d\n Cond588:cdc15_230\n Cond893:SMMS\n mYPR114W:Unknown ,, Unknown\n Cond709:t0+Vec\n mYMR010W:Unknown ,, Unknown\n mFKS1:Required for viability of calcineurin mutants,1,3-beta-D-glu\ncan synthase,Null mutant is viable, demonstrates slow growth\n, hypersensitivity to FK506 and cyclosporin A, sensitivity t\no echinocandin and a reduction in 1,3-beta-D-glucan synthase\n activity in vitro; sensitivity to papulacandin B\n mCDC19:Required for START A in the cell cycle and sporulation,pyruv\nate kinase,Null mutant is inviable. cdc19 mutants are pyruva\nte kinase deficient and show cell division cycle blocked at \n36 degrees C\n Cond557:alpha42\n mPTR2:Functions in transport of small peptides into the cell,pepti\nde transporter,Null mutant is viable\n mCBF5:major low affinity 55 kDa Centromere/microtubule binding pro\ntein,major low affinity 55 kDa centromere/microtubule bindin\ng protein,Null mutant is inviable\n mYEF3:contains two ABC cassettes, and binds and hydrolyses ATP,Tra\nnslation elongation factor 3 (EF-3),Null mutant is inviable\n Stress.NitroDepl:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n UME6.ume6:The Ume6 regulon coordinates metabolic and meiotic gene expr\nession in yeast. Proc Natl Acad Sci U S A. 2002 Oct 15;99(2\n1):13431-6.\n Cond717:t2-SSD1\n mYOL092W:Unknown ,, Unknown\n mCDC91:member of major facilitator superfamily,,\n mEFB1:Translation elongation factor EF-1beta, GDP/GTP exchange fac\ntor for Tef1p/Tef2p,translation elongation factor EF-1beta, \nGDP/GTP exchange factor for Tef1p/Tef2p,Null mutant is invia\nble\n Cond878:MNNG\n Cond716:t2+SSD1wt\n Cond879:MMC\n mGDS1:involved in nuclear control of mitochondria,,Null mutant is \nviable, shows partial impairment of growth on medium contain\ning glycerol as the carbon source. Overexpxression suppresse\ns NAM9-1 glycerol deficient phenotype\n mSEC14:Required for vesicle budding from the Golgi,phosphatidylinos\nitol transfer protein,Null mutant is inviable; other mutatio\nns are temperature sensitive\n Cond708:t0+SSD1\n Cond725:t4-SSD1,M31\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond882:zero3\n mSTT3:Required for protein glycosylation,integral ER membrane prot\nein , oligosaccharyltransferase complex subunit (putative),N\null mutant is inviable. sst3 mutants are defective in protei\nn glycosylation, sensitive to hygromycin B, and resistant to\n sodium orthovanadate. Depletion of the STT3 protein results\n in loss of oligosaccharyl transferase activity in vivo and \na deficiency in the assembly of oligosaccharyl transferase c\nomplex.\n mBOP1:bypass of PAM1,,\n Cond886:g-ray\n mDPM1:dolichol phosphate mannose synthase,dolichol phosphate manno\nse synthase,Null mutant is inviable\n Cond945:W303_YPD\n Cond712:t4+SSD1\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond403:Nitrogen_Depletion_3_d\n mSIK1:homology to microtubule binding proteins and to X90565_5.cds\n,similar to microtubule binding proteins and to X90565_5.cds\n,wild-type gene suppresses toxicity of GAL4-I-Kappa-B alpha \nin yeast\n Cond319:37C_to_25C_shock_-_90_min\n mOST3:Catalyzes the transfer of oligosaccharide from dolichol-olig\nosaccharide donor to consensus glycosylation acceptor sites \n(asparagines) in newly synth. proteins - ER lumen; may enhan\nce oligosacch. transfer to subset of acceptor substrates,oli\ngosaccharyl transferase glycoprotein complex 34 kDa gamma su\nbunit,Null mutant is viable but shows underglycosylation of \nsoluble and membrane-bound glycoproteins and contains less o\nligosaccharyltransferase activity in vitro\n Cond402:Nitrogen_Depletion_2_d\n mCYS4:Cystathionine beta-synthase,cystathionine beta-synthase,Null\n mutant is viable, exhibits vacuolar acidification defects; \ncys2 and cys4 mutations are linked together and co-operative\nly confer cysteine dependence\n mSES1:seryl-tRNA synthetase,serine-tRNA ligase,Null mutant is invi\nable.\n Cond723:t2-SSD1,M31\n mGSF2:Glucose Signaling Factor,,A Tn3 insertion into this gene cau\nses hypersensitivity to the cell surface polymer perturbing \nagent calcofluor white; Defective in glucose repression; mut\nants decrease transcriptional repression by MIG1; alter gluc\nose-regulated subunit interactions within the Snf1 protein k\ninase complex; the effects of eff1 and eff2 on SUC2 repressi\non are strongly synergistic.\n Cond876:zero2\n Cond401:Nitrogen_Depletion_1_d\n Cond714:t0+SSD1wt\n mRPL4B:Highly similar to ribosomal protein L4A,ribosomal protein L4\nB (L2B) (rp2) (YL2),\n Cond885:20\n Cond942:SK1ume6_YPD\n Stress.ColdShock:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mTOS11:Hypothetical ORF,,\n mEXG1:Exo-1,3-beta-glucanase,exo-1,3-beta-glucanase,Null mutant is\n viable, displays modest increase in killer toxin sensitivit\ny and beta 1,6-glucan levels\n Cond891:G1MMS\n Cond206:yel044w\n mSUR4:Required for conversion of 24-carbon fatty acids to 26-carbo\nn species,,Null mutants is viable, not sensitive to UV or ga\nmma radiation. sur4 mutants suppress rad3, rvs161 delta, and\n rvs167 mutations. sur4 fen1 mutants and sur4 elo2 mutants a\nre inviable.\n Cond881:4NQO\n mGPD2:Involved in glycerol production via conversion of glyerol-3-\nphosphate and NAD+ to glycerol phosphate and NADH,glycerol-3\n-phosphate dehydrogenase (NAD+),Null mutant is viable\n Cell Cycle.cdc15:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion. Mol Biol Cell. 1998 Dec;9(12):3273-97.\n mRPP0:Homology to rat P0, human P0, and E. coli L10e,ribosomal pro\ntein P0 (A0) (L10E),Null mutant is inviable\n mSRL1:Suppressor of rad53 lethality,,\n Y-Stre.Peroxide:Remodeling of yeast genome expression in response to environ\nmental changes. Mol Biol Cell. 2001 Feb;12(2):323-37.\n Cond710:t2+SSD1\n Cond884:10\n mCBF5 mSIK1 mNOP2
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Computational Genomics Lab, Tel-Aviv uniresity