Module number 2481




Database revision : gnsdb28.10
Date : Tue Feb 25 17:24:26 2003
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Cond626:DY1457_(wild_type)_3_mM_vs._61_nM_zinc_y13-121\n mBUD28:Hypothetical ORF,,Diploid null mutants exhibit random buddin\ng\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n Cond399:Nitrogen_Depletion_8_h\n mTKL1:Transketolase 1,transketolase 1,Null mutant is viable; growt\nh on fermentable carbon sources, but not gluconeogenic carbo\nn sources, is reduced; tkl1 tkl2 mutants are auxotrophic for\n aromatic amino acids\n mSSB2:stress-seventy subfamily B,SSB1 homolog , heat shock protein\n of HSP70 family,Null mutant is viable, ssb1 ssb2 double dis\nruption mutants exhibit poor growth at all temperatures, but\n particularly at low temperatures; as well as hypersensitivi\nty to certain protein synthesis inhibitors, including aminog\nlycosides such as hygromycin B\n Cond432:YPD_stationary_phase_22_d_ypd-1\n Cond410:diauxic_shift_timecourse_18.5_h\n Cond418:YPD_1_d_ypd-2\n Cond675:MHY1_(dun1)_+_heat_20_min\n mURA5:Fifth step in pyrimidine biosynthesis pathway,orotate phosph\noribosyltransferase 1,Null mutant is viable\n GCR1.gcr1:Understanding the growth phenotype of the yeast gcr1 mutant \nin terms of global genomic expression patterns. J Bacteriol\n. 2000 Sep;182(17):4970-8.\n Cond362:dtt_000_min__dtt-2\n Cond913:(99i3)_S150-2B_YPD_NormInt\n Cond400:Nitrogen_Depletion_12_h\n mAAH1:adenine aminohydrolase (adenine deaminase),adenine aminohydr\nolase (adenine deaminase),Null mutant is viable\n mYGL245W:Unknown ,, Unknown\n Cond467:steady_state_21_dec_C_ct-2\n Cond416:YPD_10_h__ypd-2\n Cond425:YPD_stationary_phase_12_h_ypd-1\n Cond674:DES459_(mec1)_+_heat_20_min\n Cond810:Na45'\n Stress.Carbon:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond364:dtt_030_min__dtt-2\n mDYS1:Deoxyhypusine synthase carries out the first step in hypusin\ne biosynthesis, converting lysine and spermidine into deoxyh\nypusine.,deoxyhypusine synthase,Null mutant is inviable\n mRPB8:16-kDa RNA polymerase subunit (common to polymerases I, II a\nnd III),16 kDa RNA polymerase subunit (common to polymerases\n I, II and III),Null mutant is inviable\n Cond445:Msn4_overexpression\n mGAS1:Glycophospholipid-anchored surface protein,cell surface glyc\noprotein 115-120 kDa,Null mutant is slow growing and exhibit\ns cell wall defects.\n mDIM1:Dimethyladenosine transferase, (rRNA(adenine-N6,N6-)-dimethy\nltransferase),reponsible for m6[2]Am6[2]A dimethylation in 3\n'-terminal loop of 18S rRNA,dimethyladenosine transferase,Nu\nll mutant is inviable\n mNOP13:Nucleolar Protein 13,,\n Cond724:t4+SSD1,H44\n mAUR1:involved in phospolipid metabolism,,Null mutant is inviable;\n mutant exhibits dominant resistance to aureobasidin A. Wild\n type (sensitive) is recessive.\n mGAS5:Unknown ,, Unknown\n Cond391:aa_starv_1_h\n mYNR021W:Unknown ,, Unknown\n Cond435:DBYmsn2-4-_37degree_heat_-_20_min\n mRPL6B:Homology to rat and human L6; involved initiation of protein\n synthesis,ribosomal protein L6B (L17B) (rp18) (YL16),Null m\nutant is viable, grows slower than wild-type. rpl6a rpl6b do\nuble mutants are inviable; rpl6 mutants are deficient in 60S\n ribosomal subunits relative to 40S subunits; 43S preinitiat\nion complexes accumulate in half-mer polyribosomes in the ab\nsence of sufficient 60S subunits.\n Cond814:Na+FK45'\n Cond310:Heat_Shock_000_minutes_hs-2\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond873:10min\n mADO1:adenosine kinase,adenosine kinase,\n mRPP2A:Homology to rat P2, human P2, and E.coli L12eIB,60S acidic r\nibosomal protein P2A (L44) (A2) (YP2alpha),Null mutant is vi\nable\n mRPA12:A12.2 subunit of RNA polymerase I,RNA polymerase I A12.2 sub\nunit,Null mutant is viable but is temperature sensitive; syn\nthetically lethal with RPA14\n Stress.aa_starv:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond480:WT+/-100mM3AT(SetA)(R491)\n Cond429:YPD_stationary_phase_5_d_ypd-1\n Cond318:37C_to_25C_shock_-_60_min\n Cond897:STATMMS\n Cond718:t4+SSD1wt\n Cond894:G2\n mRPS1B:Homologous to rat ribosomal protein S3A,ribosomal protein S1\nB (rp10B),\n Cond395:Nitrogen_Depletion_30_min.\n Cond404:Nitrogen_Depletion_5_d\n mADH3:alcohol dehydrogenase isoenzyme III,alcohol dehydrogenase is\noenzyme III,Null mutant is viable\n Cond306:Heat_Shock_60_minutes_hs-1\n Cond430:YPD_stationary_phase_7_d_ypd-1\n mYOL092W:Unknown ,, Unknown\n mMES1:methionyl tRNA synthetase,methionine-tRNA ligase,no growth a\nt 36 degrees C\n mTIF11:Translation initiation factor eIF1A,translation initiation f\nactor eIF1A,Null mutant is inviable\n Cond879:MMC\n mYLR413W:Unknown ,, Unknown\n mGDS1:involved in nuclear control of mitochondria,,Null mutant is \nviable, shows partial impairment of growth on medium contain\ning glycerol as the carbon source. Overexpxression suppresse\ns NAM9-1 glycerol deficient phenotype\n Cond708:t0+SSD1\n Stress.Heat1:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond481:WT+/-100mM3AT(SetB)(491)\n Stress.Heat2:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mIMD1:IMP dehydrogenase homolog,IMP dehydrogenase homolog,\n mIMD3:Hypothetical ORF,IMP dehydrogenase homolog,\n Cond378:1M_sorbitol_-_15_min\n Cond427:YPD_stationary_phase_2_d_ypd-1\n Cond945:W303_YPD\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mSIK1:homology to microtubule binding proteins and to X90565_5.cds\n,similar to microtubule binding proteins and to X90565_5.cds\n,wild-type gene suppresses toxicity of GAL4-I-Kappa-B alpha \nin yeast\n mRPL19A:Homology to rat L19,ribosomal protein L19A (L23A) (rpl5L) (Y\nL14),Null mutant is viable but grows slowly.\n mCYS4:Cystathionine beta-synthase,cystathionine beta-synthase,Null\n mutant is viable, exhibits vacuolar acidification defects; \ncys2 and cys4 mutations are linked together and co-operative\nly confer cysteine dependence\n Cond433:YPD_stationary_phase_28_d_ypd-1\n Cond714:t0+SSD1wt\n Stress.ColdShock:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond942:SK1ume6_YPD\n Cond965:ndt80_delete_mid_g/r_ratio_\n Cond891:G1MMS\n Cond881:4NQO\n Cond303:Heat_Shock_20_minutes_hs-1\n mRPL5:Homology to rat ribosomal protein L5; required for assembly \nof stable 60S ribosomal subunits,ribosomal protein L5 (L1a)(\nYL3),Null mutant is inviable.\n Cond627:DY1457_(wild_type)_3_mM_vs._76_nM_zinc_y12-122\n mTIF6:similar to human translation initiation factor 6 (eIF6); how\never, TIF6 does not act as a true translation initiation fac\ntor.The protein may be involved in the biogenesis and or sta\nbility of the 60S ribosomal subunits,,Null mutant is inviabl\ne; cells are depleted of 60S ribosomal subunits, translation\n initiation is inhibited, and cells arrest in G1\n mGUA1:GMP synthase,GMP synthase,Null mutant is viable but is a gua\nnine auxotroph\n mLCB2:Involved in sphingolipid biosynthesis; may catalyze the firs\nt step in biosynthesis of long-chain sphingolipids,serine pa\nlmitoyltransferase component (putative),Auxotrophic for long\n-chain component of sphingolipids; some mutations can suppre\nss the Ca2+-sensitive mutant csg2\n Cond438:DBYyap1_+_37degree_heat_(repeat)\n Cond710:t2+SSD1\n mSUP45:Recessive omnipotent suppressor. The wild-type gene function\ns in termination of translation.,eRF1 (eukaryotic Release Fa\nctor 1) homolog,The null mutant is inviable. Other mutant al\nleles produce a variety of phenotypes which can include: omn\nipotent nonsense suppression, osmotic sensitivity, benomyl s\nensitivity, paromomycin sensitivity, and novobiocin resistan\nce.\n Stress.dshift:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mNOP1:nucleolar protein, homologous to mammalian fibrillarin,nucle\nolar protein , similar to mammalian fibrillarin,Null mutant \nis inviable. Temperature-sensitive alleles exhibit various d\nefects in rRNA processing.\n Cond390:aa_starv_0.5_h\n Cond320:heat_shock_17_to_37,_20_minutes\n Cond316:37C_to_25C_shock_-_30_min\n Cond305:Heat_Shock_40_minutes_hs-1\n Cond396:Nitrogen_Depletion_1_h\n mNOP7:Required for normal pre-rRNA processing,,Null: lethal.\n Cond887:t-BuOOH\n mTIF34:p39 subunit of translation initiation factor eIF3,translatio\nn initiation factor eIF3 p39 subunit,Null mutant is inviable\n mTUB2:beta subunit of tubulin monomer; involved in chromosome segr\negation and nuclear migration,beta-tubulin,null is inviable;\n conditional mutants show block of mitotic nuclear migration\n and chromosome segregation and defects in spindle and/or cy\ntoplasmic microtubules at non-permissive conditions; some mu\ntants are benomyl-hypersensitive\n Cond363:dtt_015_min_dtt-2\n Cond941:SK1_YPD\n mNEW1:This gene encodes a protein with an Q/N-rich amino terminal \ndomain that acts as a prion, termed [NU]+.,,Null mutant is v\niable\n mRPL25:Homology to E. coli L23 and rat L23a,ribosomal protein L25 (\nrpl6L) (YL25),\n mYVH1:nitrogen starvation-induced protein phosphatase,protein tyro\nsine phosphatase induced by nitrogen starvation,\n mERG2:sterol biosynthesis,C-8 sterol isomerase,Null mutant is viab\nle\n mHIP1:histidine permease,histidine permease,requires supplementati\non with large amounts of histidine for growth\n Stress.YPD:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mPSA1:mannose-1-phosphate guanyltransferase, GDP-mannose pyrophosp\nhorylase,GDP-mannose pyrophosphorylase , mannose-1-phosphate\n guanyltransferase , GDP-mannose pyrophosphorylase , mannose\n-1-phosphate guanyltransferase , GDP-mannose pyrophosphoryla\nse , mannose-1-phosphate guanyltransferase,Null mutant is in\nviable; PSA1 is an extragenic suppressor of alg1 mutants; os\nmotically sensitive--lyses upon transfer to hypertonic condi\ntions\n Cond414:YPD_6_h_ypd-2\n mPRS1:ribose-phosphate pyrophosphokinase,ribose-phosphate pyrophos\nphokinase,\n Cond898:RPN4\n mPRS5:Phosphoribosylpyrophosphate synthetase (ribose-phosphate pyr\nophosphokinase),phosphoribosylpyrophosphate synthetase (ribo\nse-phosphate pyrophosphokinase),Null mutant is viable but re\nduces the cellular 5-phosphoribosyl-1(alpha)-pyrophosphate s\nynthetase activity by 84%. prs5 mutations are synthetically \nlethal with mutations in prs1 or prs3.\n mSIM1:(putative) invovled in control of DNA replication,,Null muta\nnt is viable; mutant allows an extra round of DNA replicatio\nn without mitosis\n mVAS1:mitochondrial and cytoplasmic valyl-tRNA synthetase,valine-t\nRNA ligase,Null mutant is inviable\n Stress.YPDStat:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond323:heat_shock_29_to_37,_20_minutes\n GCN4.gcn4:Transcriptional profiling shows that Gcn4p is a master regul\nator of gene expression during amino acid starvation in yeas\nt. Mol Cell Biol. 2001 Jul;21(13):4347-68.\n mYNL247W:Unknown ,, Unknown\n Cond872:Zero1\n Stress.DTT2:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond889:4NQO_2\n mEMG1:Essential for Mitotic Growth,ribosome biogenesis,Lethal\n Cond426:YPD_stationary_phase_1_d_ypd-1\n mEFT1:translation elongation factor 2 (EF-2),translation elongatio\nn factor 2 (EF-2),Null mutant is viable (eft1 eft2 double mu\ntant is lethal)\n Cond437:DBYyap1-_37degree_heat_-_20_min_(redo)\n mGOT1:Golgi Transport,membrane protein,Null mutant is viable but e\nxhibits ER to Golgi transport defects in vitro. got1 is synt\nhetically lethal with mutations in sft2; the got1 sft2 doubl\ne mutant exhibits defects in transport to the Golgi complex.\n Cond322:heat_shock_25_to_37,_20_minutes\n Cond459:YP_sucrose_vs_reference_pool_car-2\n Cond420:YPD_3_d_ypd-2\n Cond893:SMMS\n mYPR114W:Unknown ,, Unknown\n Cond709:t0+Vec\n Cond379:1M_sorbitol_-_30_min\n mSUI2:Translation initiation factor eIF-2 alpha subunit,,suppressi\non of initiator codon mutations\n mCDC19:Required for START A in the cell cycle and sporulation,pyruv\nate kinase,Null mutant is inviable. cdc19 mutants are pyruva\nte kinase deficient and show cell division cycle blocked at \n36 degrees C\n mCBF5:major low affinity 55 kDa Centromere/microtubule binding pro\ntein,major low affinity 55 kDa centromere/microtubule bindin\ng protein,Null mutant is inviable\n mYEF3:contains two ABC cassettes, and binds and hydrolyses ATP,Tra\nnslation elongation factor 3 (EF-3),Null mutant is inviable\n Stress.NitroDepl:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond317:37C_to_25C_shock_-_45_min\n Cond434:DBY7286_37degree_heat_-_20_min\n UME6.ume6:The Ume6 regulon coordinates metabolic and meiotic gene expr\nession in yeast. Proc Natl Acad Sci U S A. 2002 Oct 15;99(2\n1):13431-6.\n Cond717:t2-SSD1\n Cond419:YPD_2_d_ypd-2\n Cond321:heat_shock_21_to_37,_20_minutes\n Cond431:YPD_stationary_phase_13_d_ypd-1\n Cond878:MNNG\n Cond895:G2MMS\n mTHS1:Threonyl-tRNA synthetase, cytoplasmic,threonine-tRNA ligase,\n mSEC14:Required for vesicle budding from the Golgi,phosphatidylinos\nitol transfer protein,Null mutant is inviable; other mutatio\nns are temperature sensitive\n Cond725:t4-SSD1,M31\n Cond882:zero3\n Cond877:MMS\n Sporulation.Series0:The transcriptional program of sporulation in budding yeast.\n Science. 1998 Oct 23;282(5389):699-705.\n Cond417:YPD_12_h_ypd-2\n Cond946:W303ume6_YPD\n Cond886:g-ray\n mYHM2:Yeast suppressor gene of HM mutant (abf2),DNA binding protei\nn , mtDNA stabilizing protein, mitochondrial inner membrane \nprotein with low homology to RIM2,Null mutant is viable but \nshows slow growth in the presence of non-fermentable carbon \nsources; mutant shows mitochondrial genome unstability\n mDPM1:dolichol phosphate mannose synthase,dolichol phosphate manno\nse synthase,Null mutant is inviable\n Stress.Sorbitol:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond403:Nitrogen_Depletion_3_d\n Cond415:YPD_8_h_ypd-2\n mMVD1:involved in the polyisoprene biosynthesis pathway,mevalonate\n pyrophosphate decarboxylase,Null mutant is inviable; a sing\nle leucine to proline mutation causes temperature sensitivit\ny.\n Cond319:37C_to_25C_shock_-_90_min\n Cond402:Nitrogen_Depletion_2_d\n mSES1:seryl-tRNA synthetase,serine-tRNA ligase,Null mutant is invi\nable.\n Cond723:t2-SSD1,M31\n Cond811:Na60'\n mUTP19:Unknown ,, Unknown\n Cond876:zero2\n Stress.HeatVar:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond401:Nitrogen_Depletion_1_d\n mVMA5:42 kDa subunit of V1 sector,V1 sector hydrophilic subunit C \n, vacuolar ATPase V1 domain subunit C (42 kDa) , vacuolar H-\nATPase , V1 sector hydrophilic subunit C , vacuolar ATPase V\n1 domain subunit C (42 kDa) , vacuolar H-ATPase,Null mutant \nis viable; certain vma5 mutations show allele-specific synth\netic lethality with cdc24-ls mutants\n Cond885:20\n mYLL044W:Unknown ,, Unknown\n Cond411:diauxic_shift_timecourse_20.5_h\n Stress.Various:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mTEF4:Translation elongation factor EF-1gamma,translation elongati\non factor EF-1gamma,\n mEGD1:beta subunit of the nascent-polypeptide-associated complex (\nNAC); homologous to human BTF3b; GAL4 enhancer protein,pol I\nI transcribed genes regulator,Null mutant is viable; reduced\n induction of galactose-regulated genes upon shift from gluc\nose to galactose\n Calcin.Na:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n Cond815:Na+FK60'\n Cond453:YP_ethanol_vs_reference_pool_car-2\n mYAR075W:Unknown ,, Unknown\n mSUR4:Required for conversion of 24-carbon fatty acids to 26-carbo\nn species,,Null mutants is viable, not sensitive to UV or ga\nmma radiation. sur4 mutants suppress rad3, rvs161 delta, and\n rvs167 mutations. sur4 fen1 mutants and sur4 elo2 mutants a\nre inviable.\n zap1.Series0:Genome-wide characterization of the Zap1p zinc-responsive re\ngulon in yeast. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14)\n:7957-62.\n mRPP0:Homology to rat P0, human P0, and E. coli L10e,ribosomal pro\ntein P0 (A0) (L10E),Null mutant is inviable\n Calcin.NaFK:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n mSRL1:Suppressor of rad53 lethality,,\n Cond421:YPD_5_d_ypd-2\n mTOM40:Translocase of Outer Mitochondrial membrane,forms the outer \nmembrane import channel , mitochondrial outer membrane prote\nin , forms the outer membrane import channel , mitochondrial\n outer membrane protein,Null mutant is inviable; cells accum\nulate uncleaved mitochondrial precursor proteins\n Cond428:YPD_stationary_phase_3_d_ypd-1\n Cond304:Heat_Shock_30_minutes_hs-1\n mFAA4:acyl-CoA synthetase (long-chain fatty acid CoA ligase) (fatt\ny acid activator 2), activates imported fatty acids and prov\nides substrates for N-myristoylation,long chain fatty acyl:C\noA synthetase , long-chain fatty acid:CoA ligase,Not essenti\nal for vegetative growth when fatty acid synthase (fas) is a\nctive\n mARC1:associated with tRNA and amino acyl-tRNA synthetases; has af\nfinity for quadruplex nucleic acids,,Null mutant is viable, \nleads to slow growth and reduced MetRS activity; arc1- mutan\nts are synthetic lethals and are complemented by the genes f\nor methionyl-tRNA and glutamyl-tRNA synthetase.\n Stress.tempsteady:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond884:10\n mNOP1 mNOP7 mSIK1 mNOP13 mTIF6 mCBF5 mRPP0 mIMD3 mRPL5 mARC1 mYGL245W mMES1
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Computational Genomics Lab, Tel-Aviv uniresity