Module number 2480




Database revision : gnsdb28.10
Date : Tue Feb 25 17:24:11 2003
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Cond292:Glucosamine\n Cond102:mrt4\n Cond541:fus3D+50nMaF,30min/wtlog10(intensity)\n mSKN7:Protein with similarity to DNA-binding region of heat shock \ntranscription factors,,Null mutant is viable\n Cond130:rml2(**13)\n mSEC31:involved in protein transport from endoplasmic reticulum to \nGolgi,COPII coat of secretory pathway vesicles component (p1\n50),Null mutant is inviable\n mESS1:Mitotic regulator; structurally and functionally homologous \nto human PIN1,peptidyl-prolyl cis-trans isomerase (PPIase),N\null mutant is inviable; arrest phenotype of mitotic arrest a\nnd nuclear fragmentation\n mYGL245W:Unknown ,, Unknown\n Cond280:FKS1(tetpromoter)\n Cond185:ubr2\n mLAT1:Dihydrolipoamide acetyltransferase component (E2) of pyruvat\ne dehydrogenase complex,pyruvate dehydrogenase complex dihyd\nrolipoamide acetyltransferase component (E2),Null mutant is \nviable\n mYJR116W:Unknown ,, Unknown\n Cond140:rps24a(**9)\n mSCS2:Likely to be involved in regulating INO1 expression, suppres\nsor of a dominant nuclear mutation that is inositol-dependen\nt in the presence of choline,,Null mutant is viable but is a\nn inositol auxotroph above 34 deg.\n Cond105:nrf1\n mSIM1:(putative) invovled in control of DNA replication,,Null muta\nnt is viable; mutant allows an extra round of DNA replicatio\nn without mitosis\n Cond81:hog1(haploid)\n mECM33:ExtraCellular Mutant,,A Tn3 insertion into this gene causes \nhypersensitivity to the cell surface polymer perturbing agen\nt calcofluor white.\n Cond719:t4-SSD1\n mSHP1:isolated as a suppressor of the lethality caused by overexpr\nession of the phosphoprotein phosphatase 1 catalytic subuniu\nt encoded by GLC7,,Null mutant is viable; sporulation defect\nive, slow growth; is deficient in glycogen accumulation; low\n Glc7p specific activity\n mRHR2:DL-glycerol-3-phosphatase,DL-glycerol-3-phosphatase,\n Cond808:Na15'\n Cond:\n Cond724:t4+SSD1,H44\n mDNF2:Drs2 Neo1 Family,Potential aminophospholipid translocase,via\nble\n mHEM1:First enzyme in heme biosynthetic pathway,5-aminolevulinate \nsynthase,Null mutant is viable; auxotroph for heme and methi\nonine\n mTHR1:homoserine kinase,homoserine kinase,Null mutant is viable, t\nhreonine auxotroph\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Mating.Mating:Signaling and circuitry of multiple MAPK pathways revealed b\ny a matrix of global gene expression profiles. Science. 200\n0 Feb 4;287(5454):873-80\n Cond210:yer002w\n Cond200:yel001c\n mRPA14:14 kDa subunit of RNA polymerase I,RNA polymerase I subunit,\nNull mutant is viable but is temperature sensitive\n mCWP1:cell wall protein, involved in O and N glycosylation, accept\nor of B1-6 glucan.,cell wall mannoprotein,Null mutant is via\nble, has increased sensitivities to calcoflour white and con\ngo red\n Cond718:t4+SSD1wt\n Cond285:RHO1(tetpromoter)\n COMP.CH:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mYPR114W:Unknown ,, Unknown\n Cond709:t0+Vec\n Cond61:fks1(haploid)\n mCDC19:Required for START A in the cell cycle and sporulation,pyruv\nate kinase,Null mutant is inviable. cdc19 mutants are pyruva\nte kinase deficient and show cell division cycle blocked at \n36 degrees C\n Cond287:2-deoxy-D-glucose\n Cond273:yor078w\n mOXA1:Mediates the export of proteins from the mitchondrial matrix\n to the intermembrane space. ,,Null mutant is viable but is \nrespiratory-deficient and lacks cytochrome oxidase activity;\n oxa1 mutant can be complemented by human OXA1; multicopy OX\nA1 suppresses afg3 and rca1 mutants\n mPAB1:Poly(A) binding protein, cytoplasmic and nuclear,poly(A) bin\nding protein,Null mutant is inviable.\n Cond717:t2-SSD1\n mCAM1:Calcium and phospholipid binding protein homologous to trans\nlation elongation factor 1-gamma (EF-1gamma),calcium and pho\nspholipid binding protein homologous to translation elongati\non factor 1-gamma (EF-1gamma),Null mutant is viable under no\nrmal growth conditions\n Cond720:t0+SSD1,H44\n Cond716:t2+SSD1wt\n mPDA1:alpha subunit of pyruvate dehydrogenase (E1 alpha),pyruvate \ndehydrogenase alpha subunit (E1 alpha),Null mutant is viable\n, exhibits reduced growth on glucose and increased formation\n of petites\n Cond725:t4-SSD1,M31\n mPMT1:Transfers mannose residues from dolichyl phosphate-D-mannose\n to specific serine/threonine residues of proteins in the se\ncretory pathway; acts in complex with Pmt2p,dolichyl phospha\nte-D-mannose:protein O-D-mannosyltransferase,Null mutant is \nviable but shows decrease by 40-50% of in vivo protein O-man\nnosylation; pmt1 pmt2 double mutant shows severe growth defe\nct but residual O-mannosylation activity; the pmt1 pmt2 pmt3\n pmt4 quadruple mutant is inviable\n Cond708:t0+SSD1\n mSRV2:70-kDa adenylyl cyclase-associated protein,70 kDa adenylyl c\nyclase-associated protein,Null mutant is inviable.\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mSTT3:Required for protein glycosylation,integral ER membrane prot\nein , oligosaccharyltransferase complex subunit (putative),N\null mutant is inviable. sst3 mutants are defective in protei\nn glycosylation, sensitive to hygromycin B, and resistant to\n sodium orthovanadate. Depletion of the STT3 protein results\n in loss of oligosaccharyl transferase activity in vivo and \na deficiency in the assembly of oligosaccharyl transferase c\nomplex.\n mYIL041W:Unknown ,, Unknown\n mRNQ1:Rich in asparagine (N) and glutamine (Q),transferable epigen\netic modifier,\n Cond134:rpl12a\n Cond256:ymr141c\n Cond62:fpr1\n Cond26:cka2\n mDPM1:dolichol phosphate mannose synthase,dolichol phosphate manno\nse synthase,Null mutant is inviable\n mADE3:Required for the biosynthesis of purines, thymidylate, methi\nonine, histidine, pantothenic acid and formylmethionyl-tRNA,\nC1-tetrahydrofolate synthase,Null mutant is viable, adenine \nauxotroph, histidine auxotroph\n mAHP1:alkyl hydroperoxide reductase,alkyl hydroperoxide reductase,\nhypersensitive to tert-butyl hydroperoxide\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond712:t4+SSD1\n Cond205:yel033w\n Cond284:PMA1(tetpromoter)\n Cond91:kim4\n mNCP1:NADP-cytochrome P450 reductase,NADP-cytochrome P450 reductas\ne,Null mutant is viable\n Cond723:t2-SSD1,M31\n mFAS2:Trifunctional enzyme,fatty acid synthase alpha subunit,Fatty\n acid synthetase deficient\n mSED1:putative cell surface glycoprotein,cell surface glycoprotein\n (putative),Null mutant is viable; during stationary phase, \nnull mutants exhibit increased sensitivity to Zymolyase.\n Cond283:KAR2(tetpromoter)\n Cond714:t0+SSD1wt\n mSPF1:Sensitivity to a killer toxin (SMK toxin) produced by Pichia\n farinosa,P-type ATPase,The null mutant is viable and resist\nant to the SMK toxin, but grows slowly and has glycosylation\n defects.\n mCSR1:chs5 spa2 rescue; isolated as a multicopy suppressor of the \nlethality of chs5 spa2 double mutant at 37 degrees.,,Null mu\ntant is viable\n mGCN20:Positive effector of the EIF-2-alpha kinase activity of GCN2\n; component of a heteromeric complex that includes GCN1 and \nGCN20,ATP-binding cassette (ABC) family,Null mutant is viabl\ne and shows impaired derepression of GCN4 translation and re\nduced levels of eIF-2 alpha phosphorylation\n mTEF4:Translation elongation factor EF-1gamma,translation elongati\non factor EF-1gamma,\n Calcin.Na:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n mWTM1:WD repeat containing transcriptional modulator 1,transcripti\nonal modulator,Null mutant is viable\n mCAR2:ornithine aminotransferase,ornithine aminotransferase,Catabo\nlism of arginine defective\n mGPD2:Involved in glycerol production via conversion of glyerol-3-\nphosphate and NAD+ to glycerol phosphate and NADH,glycerol-3\n-phosphate dehydrogenase (NAD+),Null mutant is viable\n COMP.TE:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mPIN3:[PSI+] induction,,Other phenotypes: overexpression of PIN3 a\nllows for the induction of the [PSI+] prion in strains cured\n of [PIN+].\n mSRL1:Suppressor of rad53 lethality,,\n Cond521:fus3-K42Dą50nMaF,30minlog10(intensity)\n Cond710:t2+SSD1\n mYEL043W:Unknown ,, Unknown\n mKRE22:Killer toxin REsistant,,Null mutant is K1 killer toxin resis\ntent\n mCCT6:cytoplasmic chaperonin of the Cct ring complex (previously c\nalled TCP1 or TRiC), distantly related to Tcp1p and to Hsp60\n,,Null mutant is inviable; overexpression suppresses a TOR2 \ndominant nagative allele\n mCCT6 mWTM1 mESS1 mCAR2
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Computational Genomics Lab, Tel-Aviv uniresity