Module number 2463




Database revision : gnsdb28.10
Date : Tue Feb 25 17:21:55 2003
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mHSP104:involved in thermal and ethanol tolerance, inheritance of [P\nSI+], and reactivation of mRNA splicing after heat shock,hea\nt shock protein 104,Null mutant is viable and defective in i\nnduced thermotolerance\n mYNL191W:Unknown ,, Unknown\n mSAP30:Hypothetical ORF,,\n mYPL208W:Unknown ,, Unknown\n mCEG1:mRNA guanylyltransferase (mRNA capping enzyme), alpha subuni\nt,mRNA capping enzyme alpha subunit , mRNA guanylyltransfera\nse,Null mutant is inviable\n mOXR1:OXidation Resistance,,Null mutant is sensitive to hydrogen p\neroxide.\n mATE1:arginyl-tRNA-protein transferase,arginyl-tRNA-protein transf\nerase,Null mutant is viable, but unable to degrade substrate\ns of the N-end rule pathway that start with residues recogni\nzed by the Arg-transferase\n mYBL009W:Unknown ,, Unknown\n mSTE11:involved in the mating signalling pathway,,Null mutant is vi\nable but sterile\n mQRI5:Product of gene unknown,,\n mYJR097W:Unknown ,, Unknown\n mSEN15:Trna splicing endonuclease 15kDa subunit,tetrameric tRNA spl\nicing endonuclease 15kDa subunit,Null mutant is inviable\n mCBP3:Protein required for assembly of ubiquinol cytochrome-c redu\nctase complex (cytochrome bc1 complex),,reduced levels of a \nsubset of subunit polypeptides of the coenzyme QH2-cytochrom\ne c reductase complex\n mYDR115W:Unknown ,, Unknown\n mYLR426W:Unknown ,, Unknown\n mCLB4:Involved in mitotic induction,B-type cyclin,Null mutant is v\niable\n mLST8:Required for amino acid permease transport from the Golgi to\n the cell surface,,Reduced activity of a broad set of amino \nacid permeases\n mYLR419W:Unknown ,, Unknown\n mYGL085W:Unknown ,, Unknown\n mYJR141W:Unknown ,, Unknown\n mPEX10:C3HC4 zinc-binding integral peroxisomal membrane protein,C3H\nC4 zinc-binding integral peroxisomal membrane protein,mutant\n lacks morphologically recognizable peroxisomes and shows cy\ntosolic mislocalization of peroxisomal matrix proteins\n mYJL051W:Unknown ,, Unknown\n mDAL82:Positive regulator of allophanate inducible genes,positive t\nranscriptional regulator,loss of induction for allantoin deg\nradation pathways\n mMNN5:mannan synthesis,golgi alpha-1,2-mannosyltransferase (putati\nve),Null mutant is viable but defective in addition of the a\nlpha-1,3-linked mannose branch to the mannan structure found\n on N-linked glycans.\n mUBC1:ubiquitin-conjugating enzyme,ubiquitin-conjugating enzyme,Nu\nll mutant is viable but exhibit moderately slow growth.\n mTOA2:Transcription factor IIA, small chain,small chain , transcri\nption factor IIA subunit,Null mutant is inviable. Overexpres\nsion of TFIIA partially suppresses an spt3 delta mutation.\n mXDJ1:Homolog of E. coli DnaJ, closely related to Ydj1p,,Null muta\nnt is viable, displays no detectable phenotype\n mPEX15:44 kDa phosphorylated integral peroxisomal membrane protein,\n44 kDa phosphorylated integral peroxisomal membrane protein,\nNull mutant lacks morphologically recognizable peroxisomes a\nnd shows cytosolic mislocalization of peroxisomal matrix pro\nteins; overexpression of Pex15p results in proliferation of \nER membranes\n mYPL150W:Unknown ,, Unknown\n Cond724:t4+SSD1,H44\n mRRD2:Resistant to Rapamycin Deletion 2,,Null mutant is viable and\n shows rapamycin resistance; synthetic lethal with RRD1 (YIL\n153w)\n mGPM3:converts 3-phosphoglycerate to 2-phosphoglycerate in glycoly\nsis,phosphoglycerate mutase,Null mutant is viable, gpm3 gpm2\n double deletion mutants exhibit no synthetic phenotypes\n mYIR003W:Unknown ,, Unknown\n mYGR205W:Unknown ,, Unknown\n Cond713:t4+Vec\n mYGR125W:Unknown ,, Unknown\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mSMM1:Suppressor of Mitochondrial Mutation in the tRNAasp gene; Di\nhydrouridine synthase 2,tRNA dihydrouridine synthase,Overexp\nression weakly suppresses a mutation affecting the maturatio\nn of mitochondrial tRNA-Asp.\n mCOX6:subunit VI of cytochrome c oxidase,cytochrome c oxidase subu\nnit,Null mutant is viable, sensitive to H2O2\n mESA1:contains amino-terminal chromodomains; Essential SAS family \nAcetyltransferase sharing homology with acetyltransferases f\nrom many different organisms,acetyltransferase in the SAS ge\nne family,Null mutant is inviable\n mNDT80:Meiosis-specific gene; mRNA is sporulation specific; require\nd for exit from pachytene and for full meiotic recombination\n,DNA binding transcription factor that activates middle spor\nulation genes,Null mutant is viable, arrests in pachytene st\nage of meiosis at the mononucleate stage with duplicated spi\nndle pole bodies and no spindles, is not rescued by spo11 or\n rad50; no mitotic phenotype detected, dispensable for doubl\ne-stranded breaks\n mYER087W:Unknown ,, Unknown\n mROM2:Gdp-GTP Exchange Protein (GEP) for the Rho1p Small GTP-bindi\nng Protein; high copy suppressor of cik1 and kar3 deletion m\nutants.,,Null mutant is viable but shows temperature- and co\nld-sensitive growth defects at 37 and 11 degrees, increased \nsensitivity to benomyl, and elongated buds and abnormal mati\nng projections at the permissive temperature; synthetically \nlethal with rom1\n mMGE1:involved in protein import into mitochondria,GrpE homolog,Nu\nll mutant is inviable\n Cond718:t4+SSD1wt\n mARL3:Similar to ADP-ribosylation factor,,Null mutant is viable, d\nisplays cold-sensitive growth\n mHRB1:an ORF of unknown function located in a centromeric region d\nuplicated between chromosomes III and XIV,hypothetical RNA-b\ninding protein,\n mAPC1:anaphase-promoting complex component,ubiquitin ligase subuni\nt,\n mPRP4:associated with the U4/U6 snRNP,associates with the U4/U6 sn\nRNP,Null mutant is inviable; other alleles are defective in \nRNA synthesis and unable to grow at 36 degrees C.\n mYEL041W:Unknown ,, Unknown\n mRAX1:A rax1 mutation converts the budding pattern of an axl1 null\n mutant from bipolar to axial.,,\n mVPS15:myristoylated protein kinase involved in vacuolar protein so\nrting,serine/threonine protein kinase,defective vacuolar pro\ntein localization\n mIES4:Ino Eighty Subunit 4,,Null: non essential.\n mIES5:Ino Eighty Subunit 5,,Null: non essential.\n mIES6:Ino Eighty Subunit 6,,Null: non essential.\n mPPG1:Serine/threonine protein phosphatase involved in glycogen ac\ncumulation,,Null mutant is viable but accumulates less glyco\ngen\n mCSM1:Hypothetical ORF,,missegregates chromosomes in meiosis\n mUBS1:General positive regulator of CDC34; Suppress some cdc34 mut\nations when over-expressed,,Null mutant is viable but exhibi\nts a synthetic phenotype with temperature-sensitive alleles \nof cdc34.\n mSPC19:Spindle Pole Component of molecular weight 23kDa,spindle pol\ne component,Null mutant is inviable\n mFKS3:Protein with similarity to Gls1p and Gls2p (GB:Z49212),,\n mYKR070W:Unknown ,, Unknown\n mYCR079W:Unknown ,, Unknown\n mYFR045W:Unknown ,, Unknown\n mYNL193W:Unknown ,, Unknown\n mYMR007W:Unknown ,, Unknown\n mSSU72:functionally related to TFIIB, affects start site selection \nin vivo,,Null mutant is inviable\n mBSD2:metal homeostasis protein; putative membrane protein,,Null m\nutant is viable; suppressor of oxygen toxicity in sod1 mutan\nts, increased sensitivity to copper and cadmium toxicity, el\nevation in copper ion accumulation\n mSPT6:may be involved in transcription elongation by mediating int\neractions between RNA polymerase II and chromatin,interacts \nwith histones, primarily histone H3, possesses nucleosome as\nsembly activity , transcriptional regulator , interacts with\n histones, primarily histone H3, possesses nucleosome assemb\nly activity , transcriptional regulator,Null mutant is invia\nble, spt6 mutations exhibit synthetic lethality in combinati\non with spt4 or spt5 mutations\n mYER182W:Unknown ,, Unknown\n mYOR291W:Unknown ,, Unknown\n mODC2:Hypothetical ORF,mitochondrial 2-oxodicarboxylate transport \nprotein,\n mMHR1:Involved in mitochondrial homologous DNA recombination,,Temp\nerature sensitive in the maintenance of mitochondrial DNA\n mYLR057W:Unknown ,, Unknown\n mSEN34:tRNA splicing endonuclease 34kDa subunit; homologous to the \n42-kDa subunit, SEN2; contains active site for 3' splice sit\ne cleavage,tetrameric tRNA splicing endonuclease 34 kDa subu\nnit,Null mutant is inviable and shows H242A impaired 3'splic\ne site cleavage\n mTRX3:mitochondrial thioredoxin,thioredoxin,Null mutant is viable,\n normal sensitivity to hydrogen peroxide\n mTRI1:Topoisomerase 1 and RAD52 epistasis group Interactions,,Null\n mutant is viable.\n mCBC2:cap binding complex,nuclear cap binding complex subunit,muta\nnts exhibit promiscuous 3'-end formation; sae-1 mutation cau\nses temporary cell cycle arrest in meiotic prophase\n mYNL063W:Unknown ,, Unknown\n mAPD1:actin patches distal,,\n mECM10:ExtraCellular Mutant,,A Tn3 insertion into this gene causes \nhypersensitivity to the cell surface polymer perturbing agen\nt calcofluor white.\n mYLR021W:Unknown ,, Unknown\n mVPS24:involved in secretion,,Null mutant missorts vacuolar hydrola\nses and accumulates a late endosomal compartment; Class E vp\ns mutant\n mSSL1:Component of RNA polymerase transcription factor TFIIH,RNA p\nolymerase transcription factor TFIIH component,Null mutant i\ns inviable; temperature-sensitive mutants are UV-sensitive a\nnd deficient in nucleotide excision repair.\n mYHR192W:Unknown ,, Unknown\n mYEL028W:Unknown ,, Unknown\n mVPS29:vacuolar protein sorting,,Defective for sorting of soluble h\nydrolases to the vacuole. Mislocalisation of the vacuolar hy\ndrolase sorting receptor Vps10p.\n mCAF130:Hypothetical ORF,,Null mutant is viable\n mDPB3:C and C' subunits of DNA polymerase II,DNA polymerase II C a\nnd C' subunits,Null mutant is viable, shows increased sponta\nneous mutation rate\n mYML005W:Unknown ,, Unknown\n mYNL100W:Unknown ,, Unknown\n mGRX5:Member of a glutaredoxin subfamily in Sc together with GRX3 \n& GRX4. Significant sequence diff. with the other glutaredox\nin subfamily, formed by the previously described GRX1 & GRX2\n glutaredoxins (Luikenhuis MBC 9:1081, 1998),glutaredoxin,Nu\nll mutant is viable and shows high sensitivity to oxidative \nstress and increased sensitivity to osmotic stress, and incr\neased oxidation levels of cell proteins; grx5 is synthetical\nly lethal with grx2.\n mSNT309:Synergistic to prp19 (NineTeen) mutation. Essential for mRNA\n splicing.,protein complex component associated with the spl\nicing factor Prp19p,Null mutant is viable, temperature sensi\ntive, exhibits defects in splicing at elevated temperature; \nsnt309 prp19 mutants are synthetically lethal\n Cond714:t0+SSD1wt\n mRAD57:Required for X-ray damage repair, meiotic recombination, wil\nd-type levels of sporulation and viable spores,RecA homolog \n, interacts with Rad 55p by two-hybrid analysis , similar to\n DMC1, RAD51, and RAD55,Null mutant is viable, radiation sen\nsitive\n mMAI1:Unknown ,, Unknown\n mPCP1:Unknown ,, Unknown\n mYKL047W:Unknown ,, Unknown\n mRIB7:Protein involved in the biosynthesis of riboflavin, second s\ntep in the riboflavin biosynthesis pathway,,\n mYGL117W:Unknown ,, Unknown\n mYLR072W:Unknown ,, Unknown\n mYJL184W:Unknown ,, Unknown\n mYCR051W:Unknown ,, Unknown\n mUSA1:Identified by its interaction with the U1 snRNP-specific pro\ntein, Snp1p.,pre-mRNA splicing factor (putative),\n mYMR160W:Unknown ,, Unknown\n mYJR013W:Unknown ,, Unknown\n mMSB3:Multicopy Suppressor of Bud Emergence,GTPase activating prot\nein (GAP) for Ypt6,Null mutant is viable. msb3/msb4 double \nmutant exhibits slow growth and disorganized actin cytoskele\nton\n mMSB4:Multicopy Suppressor of Bud Emergence,,Null mutant is viable\n. msb3/msb4 double mutant exhibits slow growth and disorgani\nzed actin cytoskeleton\n mCSN12:Unknown ,, Unknown\n mERF2:Mutation has an Effect on Ras Function,,Null mutant is viabl\ne, but has a synthetic growth defect in the absence of RAS2;\n Deletion of ERF2 results in the reduction of steady-state l\nevels of Ras2p palmitoylation.\n mPET100:cytochrome c oxidase-specific assembly factor,cytochrome c o\nxidase-specific assembly factor,Respiration deficient\n mSUV3:putative ATP-dependent helicase,ATP dependent helicase (puta\ntive),Null mutant is viable\n mMAK32:Protein necessary for structural stability of L-A double-str\nanded RNA-containing particles,,\n mYGR011W:Unknown ,, Unknown\n mYBL077W:Unknown ,, Unknown\n Cond710:t2+SSD1\n mYGR004W:Unknown ,, Unknown\n mYLR349W:Unknown ,, Unknown\n mHRD3:HMG-CoA Reductase Degradation,,Null mutant is viable, slows \ndegradation of Hmg2p\n mYNL057W:Unknown ,, Unknown\n mKRE21:Killer toxin REsistant,,Null mutant is K1 killer toxin resis\ntent\n mYDL180W:Unknown ,, Unknown\n mCIN4:Protein involved in chromosome segregation and microtubule f\nunction; homologue of human Arl2,GTP-binding protein,Null m\nutant is viable; supersensitivity to benomyl and nocodozole\n mYDR336W:Unknown ,, Unknown\n mMCM16:Involved in a nonessential role that governs the kinetochore\n-microtubule mediated process of chromosome segregation,,Nul\nl mutant is viable, exhibits increased sensitivity to the an\nitmitotic drugs benomyl and thiabenzadole; exhibits a high r\nate of chromosome III loss without a significant increase in\n recombination frequency, may exhibit altered kinetochore as\nsembly\n mYNL275W:Unknown ,, Unknown\n mLOT5:LOw Temperature responsive,,\n mLOT6:LOw Temperature responsive,,\n mFIL1:Putative mitochondrial ribosome recycling factor,mitochondri\nal ribosome recycling factor (putative),Null mutant is viabl\ne but grows slowly; growth is further impaired by addition o\nf diepoxybutane or mitomycin C to medium. Null mutant also e\nxhibits decreased abundance of mitochondrial proteins.\n mVAC14:Unknown ,, Unknown\n Cond711:t2+Vec\n mSCO2:Originally identified as a multicopy suppressor of a respira\ntory defective mutant; homolog of Sco1p,,\n mERV1:Protein essential for mitochondrial biogenesis and cell viab\nility,,Null mutant is inviable; mutants demonstrate defects \nin mitochondrial biogenesis\n mYOL008W:Unknown ,, Unknown\n mCBT1:Subunit of complex involved in processing of the 3' end of c\nytochrome b pre-mRNA,,Null mutant is viable, shows results i\nn a respiratory deficiency\n mYLR364W:Unknown ,, Unknown\n mYGR012W:Unknown ,, Unknown\n mHRT1:High level expression Reduces Ty3 Transposition,Skp1-Cullin-\nF-box ubiquitin protein ligase (SCF) subunit,Null mutant is \ninviable.\n mPGU1:Endo-polygalacturonase,endo-polygalacturonase,Null mutant is\n viable; exhibits clear halo around colonies on polygalactur\nonate medium\n mECM31:ExtraCellular Mutant,,A Tn3 insertion into this gene causes \nhypersensitivity to the cell surface polymer perturbing agen\nt calcofluor white.\n mPET117:Required for assembly of active cytochrome c oxidase,,petite\n; unable to grow on non-fermentable carbon sources\n mYFL052W:Unknown ,, Unknown\n mMCM21:Involved in minichromosome maintenance,,Null mutant is viabl\ne but exhibits defects in the stability of minichromosomes. \nMutants also exhibit elevated rates of chromosome loss (but \nnot those of recombination) and are hypersensitive to the an\nti-mitotic drug benomyl.\n mYML014W:Unknown ,, Unknown\n mYAL027W:Unknown ,, Unknown\n mYDR003W:Unknown ,, Unknown\n mSRB6:involved in transcription as part of Srb/Mediator complex,pa\nrt of Srb/Mediator complex , transcription factor,Null mutan\nt is inviable; temperature sensitive mutants are associated \nwith decreased total polyA+ RNA levels\n mHEM4:catalyzes the fourth step in the heme biosynthesis pathway,u\nroporphyrinogen III synthase,respiratory deficiency, accumul\nation of porphyrins, and heme auxotrophy\n mDDI1:DNA Damage Inducible; binds to T- and V- snare complexes,,Nu\nll mutant is viable\n mSEY1:Unknown ,, Unknown\n mAAT1:aspartate aminotransferase, mitochondrial,aspartate aminotra\nnsferase,Null mutant is viable; aat1 leu2 double mutant is i\nnviable.\n mMAK3:N-acetyltransferase,N-acetyltransferase,deficient in mainten\nance of killer\n mYPT32:probably involved in intra-Golgi transport or in the formati\non of transport vesicles at the most distal Golgi compartmen\nt,GTPase , YPT31 homolog , ras homolog,Null mutant is viable\n; ypt31 ypt32 double deletion mutants are inviable\n mYCR060W:Unknown ,, Unknown\n mACN9:Hypothetical ORF,,\n mMSD1:Aspartyl-tRNA synthetase, mitochondrial,aspartyl-tRNA synthe\ntase,Null mutant is viable but shows pleiotropic phenotypes \nconsistent with a lesion in mitochondrial protein synthesis \nand is unable to acylate mitochondrial aspartyl-tRNA\n mMSS4:Involved in actin cytoskeleton organization; multicopy suppr\nessor of stt4 mutation,phosphatidylinositol 4-phosphate kina\nse,Null mutant is inviable\n mYMR155W:Unknown ,, Unknown\n mYDR061W:Unknown ,, Unknown\n mRRN10:subunit of UAF (upstream activation factor); involved in pro\nmoting high level transcription of rDNA,upstream activation \nfactor subunit,Mutant shows reduction in the transcription o\nf rDNA\n mYKR016W:Unknown ,, Unknown\n mPET123:May be component of mitochondrial translation appartus and m\nay interact with small subunit of mitochondrial ribosomes or\n with Pet122p to promote translational initiation of cytochr\nome c oxidase subunit III mRNA,mitochondrial ribosomal prote\nin of small subunit,Null mutant is viable but is rho- (with \nlarge deletions in mtDNA); pet123 mutations can suppress pet\n122 mutations; some pet123 alleles show synthetic phenotypes\n with mrp1 mutations\n mNMA2:Unknown ,, Unknown\n mMRPL3:Mitochondrial ribosomal protein MRPL3 (YmL3),ribosomal prote\nin (YmL3),\n mMRPL4:essential for mitochondrial function and for proper cell gro\nwth under non-respiratory conditions,ribosomal protein 60S L\n4,Null mutant is viable, fails to grow on nonfermentable car\nbon sources, has growth defects on fermentable carbon source\ns\n mMNS1:specific alpha-mannosidase,alpha-mannosidase,Null mutant is \nviable\n mPPZ2:serine-threonine phosphatase Z,,Null mutant is viable but sh\nows increase in cell size and cell lysis (remediated by 1 M \nsorbitol); ppz1 ppz2 double mutant shows increased expressio\nn of ENA1, resistance to sodium and lithium, and sensitivity\n to 5 mM caffeine (which is suppressed by 1 M sorbitol)\n mMRPL7:Mitochondrial ribosomal protein MRPL7 (YmL7),ribosomal prote\nin (YmL7),\n mSIN4:involved in positive and negative regualtion of transcriptio\nn, possibly via changes in chromatin structure,RNA polymeras\ne II holoenzyme/mediator subunit,Null mutant is viable, temp\nerature sensitive, displays defects in both positive and neg\native regulation of transcription, suppresses Ty insertion m\nutations (Spt-), exhibits decreased superhelical density of \ncircular DNA molecules, exhibits expression from promoters l\nacking UAS elements; associated with a defect in RME1-depend\nent repression and a methionine or cysteine requirement, exh\nibits flocculant/lacy colony morphology, suppressor of snf/s\nwi mutations\n Cond717:t2-SSD1\n mTFB3:Transcription/repair factor TFIIH subunit,TFIIH subunit,Null\n mutant is inviable\n mAPG7:autophagy,,Null mutant is viable, defective in autophagy\n mYKL071W:Unknown ,, Unknown\n mMET18:Involved in nucleotide excision repair and regulation of TFI\nIH,TFIIH regulator,Null mutant is viable but is temperature-\nsensitive, defective in ability to remove UV_induced dimers \nfrom nuclear DNA, and shows enhanced UV-induced mutations; e\nxtracts from mutant exhibit thermolabile defect in RNA Pol I\nI transcription; methionine auxotroph\n mYLR402W:Unknown ,, Unknown\n mTFB4:RNA polymerase transcription initiation TFIIH (factor b), 37\n kDa subunit,transcription initiation factor TFIIH subunit,N\null mutant is inviable\n mYFL046W:Unknown ,, Unknown\n mMRPL11:Mitochondrial ribosomal protein MRPL11 (YmL11),ribosomal pro\ntein (YmL11),Null mutant is viable, respiratory deficient ac\ncompanied by a loss of mitochondrial DNA\n mYNR040W:Unknown ,, Unknown\n mLEU5:mitochondrial carrier protein, involved in the accumulation \nof CoA in the mitochondrial matrix; homologue of human Grave\ns disease protein; LEU5 does not encode an alpha-IPM syntha\nse, as was first hypothesized.,,Null mutant is viable; leu5 \nmutant is not a leucine auxotroph unless in a leu4 backgroun\nd; glycerol auxotrophy\n mABC1:multicopy suppressor of a cytochrome b mRNA translation defe\nct, essential for the electron transfer in the bc1 complex,,\nnull mutant is viable, no oxygen uptake and no growth on non\n-fermentable media\n mCHS6:Involved in chitin biosynthesis and/or its regulation,,Reduc\ned levels of chitin, temperature-sensitive growth on rich me\ndium in certain genetic backgrounds\n Cond725:t4-SSD1,M31\n mYGR064W:Unknown ,, Unknown\n mMRPL16:Mitochondrial ribosomal protein MRPL16,ribosomal protein,\n mYGL047W:Unknown ,, Unknown\n mMSE1:Mitochondrial glutamyl-tRNA synthetase,glutamine-tRNA ligase\n,An uncharacterized allele is respiratory deficient.\n mYKL195W:Unknown ,, Unknown\n mNUP170:Component of yeast nuclear pore complex; may play a role in \nlocalizing specific nucleoporins to nuclear pore complex; Hi\ngh identity with Sc nucleoporin NUP157 & to mammalian nucleo\nporin Nup155p. Complemented with Nup155p,nuclear pore comple\nx subunit,Null mutant is viable; synthetically lethal with n\nup157, nup188, and pom152; changing NUP170 expression causes\n morphological abnormalities in nuclear envelope\n mRHC18:Protein involved in recombination repair, homologous to S. p\nombe rad18,,Null mutant is inviable\n mYDR128W:Unknown ,, Unknown\n mYGR021W:Unknown ,, Unknown\n mPSR2:Plasma membrane Sodium Response 2,,Mutant is sensitive to so\ndium ions.\n mGLO2:Cytoplasmic glyoxylase-II,glyoxylase-II,Null mutant is viabl\ne but shows increased sensitivity to methylglyoxal\n mFOL3:FOLinic acid requiring,dihydrofolate synthetase,Null mutant \nis viable; requires folinic acid for growth\n mYML030W:Unknown ,, Unknown\n mYMR040W:Unknown ,, Unknown\n mYPL170W:Unknown ,, Unknown\n mHSH49:Human SAP Homolog 49. A yeast homolog of a human spliceosome\n associated protein (SAP) called SAP 49.,mammalian splicing \nfactor/U2 snRNP protein homolog,\n mAPG12:autophagy,,Null mutant is viable, defective in autophagy\n mIMP2:Inner membrane protease (mitochondrial protein),protease,\n mYKE2:Yeast nuclear gene encoding a protein showing homology to mo\nuse KE2 and containing a putative leucine-zipper motif,bovin\ne NABC complex component homolog , non-native actin binding \ncomplex polypeptide 6 , bovine NABC complex component homolo\ng , non-native actin binding complex polypeptide 6,Null muta\nnt is viable\n mEMI5:Unknown ,, Unknown\n mMRPL23:mitochondrial ribosomal protein of the large subunit,ribosom\nal protein large subunit,\n mMRPL24:Mitochondrial ribosomal protein MRPL24 (YmL24),ribosomal pro\ntein (YmL24),\n mYBR047W:Unknown ,, Unknown\n mMRPL27:essential for mitochondrial function,ribosomal protein (YmL2\n7),Null mutant is viable, fails to grow on nonfermentable ca\nrbon sources\n mYER187W:Unknown ,, Unknown\n mMTR4:Dead-box family helicase required for mRNA export from nucle\nus,RNA helicase,Null mutant is inviable; a temperature-sensi\ntive mtr4 mutant accumulates poly(A)+ RNA in the nucleus at \n37 degrees\n mHXT9:High-affinity hexose transporter,hexose permease,Null mutant\n is viable, cycloheximide, sulfomethuron methyl, and 4-NQO (\n4-nitroquinoline-N-oxide) resistant\n mYDL133W:Unknown ,, Unknown\n mSMD1:Homolog of human core snRNP protein D1, involved in snRNA ma\nturation,,Null mutant is inviable\n mPTP1:phosphotyrosine-specific protein phosphatase,phosphotyrosine\n-specific protein phosphatase,viable\n mYFR007W:Unknown ,, Unknown\n mYBL095W:Unknown ,, Unknown\n mYBR178W:Unknown ,, Unknown\n mCDC36:Required for Start B in mitosis and for meiosis I spindle po\nle body separation,basal transcription inhibitor , transcrip\ntional regulator , basal transcription inhibitor , transcrip\ntional regulator,Null mutant is viable, cdc36 mutant arrests\n in G(sub)1; forms shmoo morphology at restrictive temperatu\nre, arrests at pachytene at the mononucleate stage with dupl\nicated spindle pole bodies and no spindles\n mYJL152W:Unknown ,, Unknown\n mYPR109W:Unknown ,, Unknown\n mMET30:F-box protein involved in sulfur metabolism and protein ubiq\nuitination,contains five copies of WD40 motif and interacts \nwith and regulates Met4p,Null mutant is inviable\n mSTN1:involved in telomere length regulation, function in telomere\n metabolism during late S phase,,Null mutant is inviable\n mPEP12:integral membrane protein; c-terminal TMD; located in endoso\nme,c-terminal TMD , integral membrane protein , c-terminal T\nMD , integral membrane protein , c-terminal TMD , integral m\nembrane protein,proteinase deficient\n mVPS75:Unknown ,, Unknown\n mSIP2:Member of a family of proteins, including Sip1p and Gal83p, \nthat interact with Snf1p and Snf4p and are involved in the r\nesponse to glucose starvation,,Null mutant is viable\n mYKL153W:Unknown ,, Unknown\n mYLR404W:Unknown ,, Unknown\n mYDR013W:Unknown ,, Unknown\n mYPL157W:Unknown ,, Unknown\n mPOP3:RNase P and RNase MRP subunit,,Null mutant is inviable.\n mYAT2:The Yat2p protein shows significant homology with the known \ncarnitine acetyltransferase associated with the outer-mitoch\nondrial membrane, Yat1p, and also functions as a carnitine a\ncetyltransferase.,carnitine acetyltransferase,Null: viable. \nOther phenotypes: The cit2yat2 double mutant does not grow o\nn ethanol, glycerol and acetate in the presence of carnitine\n.\n mMRPL32:Mitochondrial ribosomal protein MRPL32 (YmL32),ribosomal pro\ntein (YmL32),\n mPOP5:Processing Of Precursors - refer to a group of proteins that\n appear to be components of both RNase P and RNase MRP,RNase\n MRP subunit (putative) , RNase P integral subunit,Null muta\nnt is inviable; transient depletion of Pop5p causes loss of \nRNase P and RNase MRP function\n mDNM1:involved in receptor-mediated endocytosis and mitochondrial \norganization,similar to dynamin GTPase,Null mutant is viable\n, shows mating defects consistent with a delay in receptor-m\nediated endocytosis\n mYSC83:similar to S. douglasii YSD83,,Null mutant is viable\n mBUD7:bud site selection,,Diploid-specific heterogenous bud site s\nelection\n mHNT3:Unknown ,, Unknown\n mMRPL35:Mitochondrial ribosomal protein MRPL35 (YmL35),ribosomal pro\ntein (YmL35),\n mMUP3:methionine uptake,very low affinity methionine permease,\n mMRPL37:Probable mitochondrial protein L37,ribosomal protein L37 (pu\ntative),\n mYLR077W:Unknown ,, Unknown\n mMRPL38:mitochondrial ribosomal protein L14,ribosomal protein L14,\n mTAD1:Deaminates adenosine-37 to inosine in eukaryotic tRNA-Ala.,t\nRNA-specific adenosine deaminase subunit,Null mutant is viab\nle\n mYJR018W:Unknown ,, Unknown\n mPET54:translational activator of cytochrome c oxidase subunit III;\n required for splicing of cytochrome c oxidase subunit I mRN\nA,translational activator of cytochrome C oxidase subunit II\nI; required for splicing of cytochrome c oxidase subunit I \nmRNA,petite; unable to grow on non-fermentable carbon source\ns\n mYCL039W:Unknown ,, Unknown\n mDLD2:D-lactate dehydrogenase, located in mitochondrial matrix,,Nu\nll mutant is viable\n mROT1:Reversal of tor2 lethality,membrane protein (putative),Null \nmutant is inviable; rot1 mutations can suppress tor2 mutatio\nns; synthetically lethal with rot2\n mYMR158W:Unknown ,, Unknown\n mYGR110W:Unknown ,, Unknown\n mRSM10:mitochondrial ribosome small subunit component,mitochondrial\n ribosome small subunit component,\n mMSS18:Protein involved in splicing intron a15beta of COX1,,blocked\n in splicing of cox1 pre-mRNA\n mKIN28:serine-threonine kinase, subunit of transcription factor TFI\nIK, a subcomplex of TFIIH,,Null mutant is inviable\n mYPL034W:Unknown ,, Unknown\n mRPB4:fourth-largest subunit of RNA polymerase II,RNA polymerase I\nI fourth largest subunit,Null mutant is viable, rbp4 mutants\n are heat and cold sensitive, exhibit slow growth at interme\ndiate temperatures\n mYNL083W:Unknown ,, Unknown\n mYPR117W:Unknown ,, Unknown\n mARD2:Unknown ,, Unknown\n mCDC7:Required for mitotic DNA synthesis but dispensable for preme\niotic DNA synthesis and spindle pole body duplication; requi\nred for synaptonemal complexes, meiotic recombination, spind\nle pole body separation and spindles,,Null mutant is inviabl\ne. cdc7 mutant arrests at G(sub)1/S phase with duplicated sp\nindle pole bodies and no spindles; the spindle pole bodies e\nventually enlarge, invaginate from the nuclear envelope into\n the center of the nucleus, sometimes fragmenting into three\n or four smaller spindle pole bodies. In heterozygotes, cdc7\n spores fail to germinate.\n mHIT1:Protein required for growth at high temperature,,no growth a\nt high temperature; confers pet phenotype\n mCDC8:essential for mitotic DNA synthesis. Required for premeiotic\n DNA synthesis, synaptonemal complexes, recombination, meios\nis I, meiosis II, and spores,thymidylate kinase,Null mutant \nis inviable. cdc8 mutants are defective in continued replica\ntion during S phase of the cell cycle. cdc8 arrests at the m\nononucleate stage with duplicated spindle pole bodies and no\n spindles.\n mSUL2:Sulfate uptake,high affinity sulfate permease,\n mSSP120:secretory protein,,Null mutant is viable\n mTAF10:TFIID subunit (TBP-associated factor) with predicted molecul\nar weight of 23 kD.,TFIID subunit,Null mutant is inviable\n mYMR115W:Unknown ,, Unknown\n mYMR289W:Unknown ,, Unknown\n mMOD5:transfer RNA isopentenyl transferase,transfer RNA isopenteny\nl transferase,Null mutant is viable but temperature sensitiv\ne and cannot grow on nonfermentable carbon sources.\n mTAF14:Protein required for actin cytoskeleton assembly or function\n,transcription initiation factor TFIIF small subunit,Null mu\ntant is viable but has a depolarized actin cytoskeleton.\n mYLR405W:Unknown ,, Unknown\n mYLR252W:Unknown ,, Unknown\n mCSE2:Protein required for accurate mitotic chromosome segregation\n,RNA polymerase II mediator subcomplex component,Null mutant\n is viable, accumulates large-budded cells, results in signi\nficant increase in chromosome missegregation, slower growth,\n and defective meiosis\n mAMS1:vacuolar alpha mannosidase,alpha mannosidase,null mutant is \nviable\n mMRPL40:Mitochondrial ribosomal protein MRPL40 (YmL40),ribosomal pro\ntein (YmL40),\n mYBL046W:Unknown ,, Unknown\n mHOC1:Homologous to OCH1, an alpha-1,6-mannosyltransferase; Golgi-\nlocalized, type II integral membrane protein,mannosyltransfe\nrase (putative),Null mutant is viable but is hypersensitive \nto calcofluor white and hygromycin B and has lowered restric\ntive temperature in a pkc1-371 background; high copy suppres\nsor of pkc1-371\n mPNT1:Involved in targeting of proteins to the mitochondrial inner\n membrane; Pentamidine resistance protein,,Null mutant is vi\nable and shows slightly increased susceptibility to pentamid\nine (an anti-Pneumocystis carinii drug) and related compound\ns; confers resistance to pentamidine when present in high co\npy number\n mYUH1:ubiquitin hydrolase,ubiquitin hydrolase,\n mPOB3:binds to catalytic subunit of DNA polymerase alpha (Pol1p),D\nNA polymerase delta binding protein,Null mutant is inviable\n mYNL026W:Unknown ,, Unknown\n mYDR493W:Unknown ,, Unknown\n mPEP8:Plays a role in delivery of proteins to the vacuole,vacuolar\n protein similar to mouse gene H<beta>58,Null mutant is viab\nle but is defective in processing of soluble vacuole proteas\nes due to inability of soluble vacuolar hydrolase to reach t\nhe vacuole\n mDCP1:Decapping protein involved in mRNA degradation,,Null mutant \nis inviable in the FY1679 background, but viable, though gro\nws slowly, in the CEN.PK141 background.\n mMRPL49:mitochondrial ribosomal protein of the large subunit,ribosom\nal protein large subunit,\n mMSW1:mitochondrial tryptophanyl-tRNA synthetase,tryptophan-tRNA l\nigase,Null mutant is viable, respiratory deficient, defectiv\ne in mitochondrial protein synthesis\n mYAF9:Yeast homolog of the human leukemogenic protein AF9; member \nof a large protein complex,,Null mutant is viable\n mCYC1:iso-1-cytochrome c,iso-1-cytochrome c,Cytochrome c deficienc\ny\n mCYC2:Involved in import of cytochrome c into mitochondria,cytochr\nome c mitochondrial import factor,Null mutant is viable. Del\netion of CYC2 leads to accumulation of apocytochrome c in th\ne cytoplasm; strains with deletions of CYC2 still import low\n levels of cytochrome c into mitochondria\n mYGL101W:Unknown ,, Unknown\n mYMR086W:Unknown ,, Unknown\n mCNE1:Functions in endoplasmic reticulum protein quality control,c\nalnexin and calreticulin homolog,Null mutant is viable, incr\nease of cell-surface expression of ste2-3p, increase in secr\netion of heterologously expressed mammalian alpha 1-antitryp\nsin\n mYBR194W:Unknown ,, Unknown\n mYGR111W:Unknown ,, Unknown\n mYLR456W:Unknown ,, Unknown\n mSLX1:Hypothetical ORF,,\n mBPT1:bile pigment transporter,ABC transporter , highly homologous\n to human MRP1 and to C. elegans mrp-1,Null mutant is viable\n but lacks approximately 40% of the trasport activity of unc\nonjugated bilirubin into the vacuolar system of yeast\n mCDC53:acts together with Cdc4p and Cdc34p to control the G1-S phas\ne transition, assists in mediating the proteolysis of the Cd\nk inhibitor Sic1p in late G1,,Cells arrest in G1 with active\n Cln kinases but no Clb-associated Cdc28p kinase activity\n mCOX11:Mitochondrial membrane protein required for insertion of Cu(\nB) and magnesium during assembly of cytochrome c oxidase,,de\nficient in cytochrome oxidase\n mPTC3:protein phosphatase type 2C,protein phosphatase type 2C,\n mARE2:Acyl-CoA cholesterol acyltransferase (sterol-ester synthetas\ne),acyl-CoA cholesterol acyltransferase (sterol-ester synthe\ntase),Null mutant is viable; greatly reduces in vivo and in \nvitro ergosterol esterification (to 15 - 35 % of wild-type).\n Deletion of both ARE1 and ARE2 completely eliminates in viv\no and in vitro ergosterol esterification\n mRSM26:mitochondrial ribosome small subunit component,mitochondrial\n ribosome small subunit component,\n mNUP53:Component of karyopherin docking complex of the nuclear pore\n complex,karyopherin docking complex component of the nuclea\nr pore complex,Null mutant is viable but disrupts Kap121 loc\nalization to the nuclear envelope.\n mYMR210W:Unknown ,, Unknown\n mRSM27:mitochondrial ribosome small subunit component,mitochondrial\n ribosome small subunit component,\n mRSM28:Unknown ,, Unknown\n mYMR130W:Unknown ,, Unknown\n mPTC7:Unknown ,, Unknown\n mYPL260W:Unknown ,, Unknown\n mPRI2:p58 polypeptide of DNA primase,DNA primase p58 polypeptide,l\nethal\n mMRP21:Mitochondrial Ribosomal Protein,mitochondrial ribosome small\n subunit component,Null mutant is viable, exhibits completel\ny blocked mitochondrial gene expression; missense mutations \nsuppress 5'-UTL mutations in at least 2 mitochondrial mRNAs\n mYIL110W:Unknown ,, Unknown\n mFLX1:Nuclear-encoded mitochondrial protein involved in transport \nof flavine into mitochondria,FAD carrier protein,Null mutant\n is viable and unable to grow on nonfermentable carbon sourc\nes\n mCTR1:High affinity copper transporter into the cell, probable int\negral membrane protein,copper transport protein,Null mutant \nis viable, deficient in ferrous iron uptake\n mCTR3:integral membrane protein that functions in high affinity co\npper transport,copper transporter,Null mutant is viable, gro\nws slower than w.t. under conditons of copper limitation on \nnon-fermentable carbon source; strains with a deletion of bo\nth CTR1 and CTR3 are unable to grow on nonfermentable carbon\n sources\n Cond708:t0+SSD1\n mYLR253W:Unknown ,, Unknown\n mMNN10:Required for mannan synthesis and for polarized growth and b\nud emergence,galactosyltransferase,Null mutant is viable, is\n larger than wild-type cells, is deficient in bud emergence,\n and depends upon an intact morphogenesis checkpoint control\n to survive\n mGPI15:Glysosyl Phosphatidyl Inositol,human Pig-H homolog (function\nal and sequence homolog),Null mutant is inviable; required f\nor N-acetylglucosaminyl phosphatidylinositol synthesis.\n mYBR137W:Unknown ,, Unknown\n mCOS12:Protein with strong similarity to subtelomerically-encoded p\nroteins including Cos2p, Cos4p, Cos8p, YIR040c, Cos5p, Cos9p\n, and Cos6p,,\n mYJR107W:Unknown ,, Unknown\n Cond712:t4+SSD1\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mMTF1:Mitochondrial RNA polymerase specificity factor,mitochondria\nl RNA polymerase specificity factor,Null mutant is viable, d\nefective in respiration, and lacks mtDNA.\n mYPR140W:Unknown ,, Unknown\n mAPC11:subunit of the Anaphase Promoting Complex; all known APC sub\nunits co-immunoprecipitate with epitope-tagged Apc11p,anapha\nse promoting complex (APC) subunit,Null mutant is inviable a\nt 25 C\n mRFC1:RFC is a DNA binding protein and ATPase that acts as a proce\nssivity factor for DNA polymerases delta and epsilon and loa\nds proliferating cell nuclear antigen (PCNA) on DNA,replicat\nion factor C subunit 1 , similar to human RFC 140 kDa subuni\nt,Null mutant is inviable, rfc1 conditional mutants arrest b\nefore mitosis\n mRFC2:RFC is a DNA binding protein and ATPase that acts as a proce\nssivity factor for DNA polymerases delta and epsilon and loa\nds proliferating cell nuclear antigen (PCNA) on DNA,replicat\nion factor C subunit 2 , similar to human RFC 37 kDa subunit\n,Null mutant is inviable\n mRFC3:RFC is a DNA binding protein and ATPase that acts as a proce\nssivity factor for DNA polymerases delta and epsilon and loa\nds proliferating cell nuclear antigen (PCNA) on DNA,replicat\nion factor C subunit 3 , similar to human RFC 36 kDa subunit\n,Null mutant is inviable\n mYNL165W:Unknown ,, Unknown\n mMRL1:Mannose 6-phosphate Receptor Like,,\n mRFC5:RFC is a multisubunit DNA binding protein and ATPase that ac\nts as a processivity factor for DNA polymerases delta and ep\nsilon and loads proliferating cell nuclear antigen (PCNA) on\n DNA,replication factor C subunit 5 , similar to human RFC 3\n8 kDa subunit,Null mutant is inviable\n mREF2:RNA-binding protein involved in cleavage step of mRNA 3'-end\n formation, prior to polyadenylation,,mutants grow slowly\n mCCH1:calcium channel,calcium channel (putative),Null mutant is vi\nable; exhibits reduced growth rate, viability and calcium up\ntake; exhibits a defect in pheromone-induced Ca2+ uptake; su\nppressor of cdc1 temperature-sensitive mutant\n mYNL158W:Unknown ,, Unknown\n mYFH1:Yeast Frataxin Homologue,,Null mutant is viable, grows poorl\ny on glucose, fails to grown on respiratory substrates\n mTAF9:TFIID subunit (TBP-associated factor) with predicted molecul\nar weight of 17 kD.,TFIID subunit,Null mutant is inviable\n mCBK1:cell wall biosynthesis kinase,protein kinase,Null mutation i\ns viable; shows alpha factor resistance; in liquid culture l\narge aggregates of cells are formed\n mSKM1:Serine/threonine protein kinase with similarity to Ste20p an\nd Cla4p,,Null mutant is viable. skm1 null mutations show no \ndouble mutant phenotypes in combination with Ste20 or Cla4 m\nutations. Skm1p can complement the mating defect of a ste20 \nmutant strain\n mYHR040W:Unknown ,, Unknown\n mYDR291W:Unknown ,, Unknown\n mMET1:Methionine metabolism,,Null mutant is viable, and is a methi\nonine auxotroph\n mMET3:ATP sulfurylase,ATP sulfurylase,Null mutant is viable, and i\ns a methionine auxotroph\n mNVJ1:Vac8p binding protein; nucleus-vacuole junction,,Null mutant\n is viable; cells do not form nucleus-vacuole junctions\n mOSM1:osmotic growth protein,osmotic growth protein,Null mutant is\n viable, sensitive to hypertonic medium\n mYBR225W:Unknown ,, Unknown\n mYGL226W:Unknown ,, Unknown\n mYLR407W:Unknown ,, Unknown\n mPPA2:mitochondrial inorganic pyrophosphatase,inorganic pyrophosph\natase,Null mutant is viable but is unable to grow on respira\ntory carbon sources and lacks mitochondrial DNA\n mYMR262W:Unknown ,, Unknown\n mPNG1:de-N-glycosylation enzyme,peptide:N-glycanase,Null mutant is\n viable and shows no growth or viability defect under experi\nmental conditions\n mATP17:Subunit f of mitochondrial ATP synthase. Homologous to bovin\ne subunit f.,ATP synthase subunit f,No growth on glycerol\n mLCB3:Protein involved in incorporation of exogenous long chain ba\nses in sphingolipids,plasma membrane transporter (putative),\nNull mutant is viable, has reduced rate of exogenous long ch\nain base incorporation into sphingolipids, increased resista\nnce to growth inhibition by long chain bases\n mRGA1:putative GTPase-activating protein for the polarity-establis\nhment protein Cdc42p or Rho1p; activates the pheromone-respo\nnse pathway,rho GTPase activating protein (GAP),Null mutant \nis viable but shows increased signaling in the pheromone pat\nhway; haploid null mutants bud predominantly in a bipolar, r\nather than the normal axial, manner\n mYSP3:subtilisin-like protease III,subtilisin-like protease III,\n mMSY1:Tyrosyl-tRNA synthetase,tyrosine-tRNA ligase,\n mLCB5:involved in sphingolipid biosynthesis,sphingoid long chain b\nase (LCB) kinase,Null mutant is viable, exhibits approximate\nly 97% of wild-type LCB kinase activity; lcb4 lcb5 double de\nletion mutants exhibit no LCB kinase activity\n mYBR022W:Unknown ,, Unknown\n mYDL057W:Unknown ,, Unknown\n mCOS7:Protein with strong similarity to other subtelomerically-enc\noded proteins such as Cos5p, Ybr302p, Cos3p, Cos1p, Cos4p, C\nos8p, Cos6p, Cos9p,,\n mHAP5:Regulates respiratory functions; subunit of a heterotrimeric\n complex required for CCAAT binding,CCAAT-binding transcript\nion factor component (along with Hap2p and Hap3p),Null mutan\nt is viable\n mCOS9:Protein with similarity to subtelomerically-encoded proteins\n such as Cos5p, Ybr302p, Cos3p, Cos1p, Cos4p, Cos8p, Cos6p, \nCos9p,,\n mMRPS18:Unknown ,, Unknown\n mARO10:Hypothetical ORF,,\n mPSH1:Unknown ,, Unknown\n mOAF1:transcription factor,transcription factor,\n mTRR2:mitochondrial thioredoxin reductase,thioredoxin reductase,Nu\nll mutant is viable, increased sensitivity to hydrogen perox\nide\n mMDM30:Unknown ,, Unknown\n mMPS3:Unknown ,, Unknown\n mYDR031W:Unknown ,, Unknown\n mMOG1:Required for nuclear-protein import,nuclear protein that int\neracts with GTP-Gsp1p,Null mutant is viable, temperature sen\nsitive, exhibits defects in nuclear-protein import; MOG1 ove\nrexpression supresses the temperature sensitivity of gsp1 st\nrains; overexpression of NTF2 or GSP1 can suppress the ts ph\nenotype of mog1\n mDRE3:Unknown ,, Unknown\n mSSF2:high copy suppressor of G beta subunit temperature sensitive\n mutation,,Null mutant is viable; displays double mutant let\nhality with ssf1 null mutations. Ssfp depletion is associate\nd with arrest of cell division and decreased mating\n mRAD3:DNA helicase component of transcription factor b (yeast homo\nlog of human TFIIH),,Null mutant is inviable; rad3 mutants a\nre radiation sensitive\n mCRZ1:calcineurin responsive zinc-finger,transcription factor (put\native),Null mutant is viable\n mATP20:Protein associated with mitochondrial ATP Synthase; essentia\nl for dimeric state of ATP synthase,ATP synthase subunit g h\nomolog,Null mutant is viable but exhibits a reduced growth r\nate on respiratory substrates\n mYEL015W:Unknown ,, Unknown\n mCAF17:CCR4 associated factor,CCR4 transcriptional complex componen\nt,Null mutant is viable, shows petite phenotype\n mNSE1:Unknown ,, Unknown\n mBIM1:binding to microtubules,,Null mutant is viable, causes cold \nsensitivity, benomyl supersensitivity, aberrant microtubule \nmorphology\n mDCS1:Unknown ,, Unknown\n mYKR051W:Unknown ,, Unknown\n mSPO7:dispensable for mitosis, but required for a normal mutation \nrate, required for premeiotic DNA synthesis, recombination, \nmeiosis I, meiosis II, glycogen degradation and spores,,Null\n mutant is viable, sporulation defective\n mPAP1:poly(A) polymerase,poly(A) polymerase,lethal\n mRNH35:RNase H(35), a 35 kDa ribonuclease H,,Null mutant is viable \nbut shows 75% reduction of RNase H activity in cell extracts\n mMSK1:mitochondrial lysine-tRNA synthetase,lysine-tRNA ligase,An u\nncharacterized allele is respiratory deficient.\n mYKL027W:Unknown ,, Unknown\n Cond719:t4-SSD1\n mYGL024W:Unknown ,, Unknown\n mYHR202W:Unknown ,, Unknown\n mARH1:adrenodoxin oxidoreductase homolog,adrenodoxin oxidoreductas\ne homolog,Null mutant is inviable\n mMRPS28:Mitochondrial ribosomal protein MRPS28 (E. coli S15),ribosom\nal protein (E. coli S15),Null mutant is viable, unable to re\nspire, spontaneously loses portions of its mitochondrial gen\nomes at a high frequencY\n mNNT1:Unknown ,, Unknown\n mPET191:Required for assembly of active cytochrome c oxidase,,petite\n; unable to grow on non-fermentable carbon sources\n mYML050W:Unknown ,, Unknown\n mCAP1:capping - addition of actin subunits,capping protein,Null mu\ntant is viable; severe deficit of actin cables and increased\n number of actin spots in the mother; round, relatively larg\ne cells\n mCKB1:beta (38kDa) subunit of casein kinase II (CKII),casein kinas\ne II beta subunit,Null mutant is viable, exhibits salt sensi\ntivity specific to NaCl and LiCl\n mLSB5:LAs17 Binding protein,,\n mSUA5:Protein involved in translation initiation,,Null mutant is v\niable, lack cytochrome a/a3, suppresses a cyc1 mutation and \nconfers slow growth, fails to grow on lactate or glycerol\n mYML036W:Unknown ,, Unknown\n mLSB6:LAs17 Binding protein,,\n mMRP51:Mitochondrial Ribosomal Protein,mitochondrial ribosome small\n subunit component,Null mutant is viable, exhibits completel\ny blocked mitochondrial gene expression; missense mutations \nsuppress 5'-UTL mutations in at least 2 mitochondrial mRNAs\n mMRPS5:Probable mitochondrial ribosomal protein S5,ribosomal protei\nn S5 (putative),\n mSIF2:Sir4p-Interacting Factor,,Null mutant is viable, exhibits in\ncreased telomeric silencing\n mYGL082W:Unknown ,, Unknown\n mYGR165W:Unknown ,, Unknown\n mMRPS9:Probable mitochondrial ribosomal protein S9,ribosomal protei\nn S9 (putative),Null mutant is viable, respiration deficient\n, exhibits defects in mitochondrial protein synthesis as ind\nicated by a loss of cytochrome c oxidase activity\n mTEL2:Involved in controlling telomere length,telomere binding pro\ntein,point mutant has shorter-than-normal telomeres; there i\ns a long (150 generation) lag time for phenotypic expression\n mCHK1:checkpoint kinase 1; homolog of the S. pombe and mammalian C\nhk1 checkpoint kinases,protein kinase,Mutants are defective \nin the DNA damage checkpoint operating at metaphase\n mYGL068W:Unknown ,, Unknown\n mLEM3:Product of gene unknown,,null mutant is sensitive to brefeld\nin A and shows increased glucocorticoid receptor activity in\n response to dexamethasone\n mNIT2:Nit protein, nitrilase superfamily member,,\n mORC5:May be subunit of origin recognition complex (ORC) that medi\nates the ATP-dependent binding to origins; the ORC binds to \norigins of replication and thereby directs DNA replication a\nnd is also involved in transcriptional silencing,ATP-binding\n site (putative) , origin recognition complex fifth largest \nsubunit,orc5-1 mutant is temperature-sensitive, has defects \nin transcriptional silencing, has elevated rate of plasmid l\noss and inefficient initiation of DNA replication at the per\nmissive temperature, and arrests at the nonpermissive temper\nature; CDC6 is multicopy suppressor of orc5-1\n mYOL125W:Unknown ,, Unknown\n Cond709:t0+Vec\n mYDR316W:Unknown ,, Unknown\n mMAD2:spindle checkpoint complex subunit,spindle checkpoint comple\nx subunit,Null mutant is viable, mitotic arrest deficient, s\nensitive to the anti-microtubule drug benomyl\n mSER2:phosphoserine phosphatase,phosphoserine phosphatase,serine-r\nequiring\n mYMR003W:Unknown ,, Unknown\n mRHO4:ras homolog--GTP binding protein,GTP-binding protein , ras h\nomolog,Null mutant is viable; rho3 rho4 cells are inviable a\nt 30 degrees C\n mYNL335W:Unknown ,, Unknown\n mYDL146W:Unknown ,, Unknown\n mBRR1:Protein involved in snRNP biogenesis,spliceosomal snRNP comp\nonent,in brr1 mutants, newly synthesized snRNAs are destabil\nized and 3'-end processing is slowed\n mSEC4:Involved in transport and fusion of post-Golgi secretory ves\nicles to the plasma membrane,ras homolog , small GTP binding\n protein,null is inviable; conditional mutants show defects \nin secretion and accumulation of post-Golgi vesicles under n\non-permissive conditions\n mSDF1:SDF1 the first obserwed null phenotype was Sporulation DeFic\niency,,Homozygous null mutants did not sporulate, showed res\nistance to benomyl; homozygous and haploid deletants were se\nnsitive to thiabendazol\n mSMY1:not believed to act as a kinesin, colocalizes with Myo2p,kin\nesin heavy chain homolog,high copy suppressor of myosin\n mYGR042W:Unknown ,, Unknown\n mCPR8:Shows similarity to the secretory pathway cyclophilin Cpr4,c\nyclophilin , peptidyl-prolyl cis-trans isomerase (PPIase),Nu\nll mutant is viable\n mREX3:RNA EXonuclease; member of 3'->5' exonuclease family. See Mo\nser et al. 1997 Nucleic acids Res. 25:5110-5118,,Mutants exh\nibit RNase MRP RNA processing defect; functions redundantly \nwith REX1 and REX2 in U5 snRNA and RNase P RNA processing\n mUGA2:involved in utilization of GABA as a nitrogen source,succina\nte semialdehyde dehydrogenase,Null mutant is viable but cann\not grow with GABA as the only nitrogen source.\n mYCR105W:Unknown ,, Unknown\n mNNF1:Involved in nuclear function,,Null mutant is inviable; cells\n depleted of Nnf1p or containing a temperature-sensitive nnf\n1 mutation have elongated microtubules and become bi- and mu\nltinucleate\n mYLL029W:Unknown ,, Unknown\n mYHR116W:Unknown ,, Unknown\n mYMR134W:Unknown ,, Unknown\n mYBR242W:Unknown ,, Unknown\n mYPR100W:Unknown ,, Unknown\n mYDR287W:Unknown ,, Unknown\n mCUS2:cold sensitive U2 snRNA Supressor,,Null mutant is viable, en\nhances U2 mutations; mutations in this gene suppress the col\nd sensitive phenotype of U2 RNA mutation G53A\n mTHI22:THI for thiamine metabolism. Transcribed in the presence of \nlow level of thiamine (10-8M) and turned off in the presence\n of high level (10-6M) of thiamine. Under the positive contr\nol of THI2 and THI3.,,null mutant is viable\n mYPL257W:Unknown ,, Unknown\n mYBL065W:Unknown ,, Unknown\n mNUP2:Localizes to discrete spots in the nuclear envelope; probabl\ny functions in transport through nuclear pore,nuclear pore c\nomplex subunit,Null mutant is viable; some combinations of a\nlleles of nup1, nsp1 and nup2 are synthetically lethal\n mSNF12:73 kDa subunit of the SWI/SNF transcription activation compl\nex, homolog of Rsc6p subunit of the RSC chromatin remodeling\n complex,RSC chromatin remodeling complex Rsc6p subunit homo\nlog , SWI/SNF transcription activation complex 73 kDa subuni\nt,Null mutant is viable but is temperature-sensitive, fails \nto transcribe SWI/SNF-dependent genes such as SUC2 and INO1,\n sucrose non-fermenting, defective in transcriptional activa\ntion by the glucocorticoid receptor; snf12 mutants are insen\nsitive to expression of Adenovirus E1A protein\n mYOR223W:Unknown ,, Unknown\n mCOX5A:One of two genes (COX5A and COX5B, both nuclear-encoded) cod\ning for subunit V of cytochrome c oxidase; COX5A gene produc\nt is the predominantform of subunit V found in holocytochrom\ne c oxidase under normal growth conditions,cytochrome c oxid\nase chain Va,Null mutant is viable, respires at 10-15% of th\ne wild-type rate due to the presence of COX5B; cox5a cox5b d\nouble deletion mutants are completely non-respiratory\n mABZ1:para-aminobenzoate synthase, PABA synthase,para-aminobenzoat\ne synthase (PABA synthase),Null mutant is viable and PABA au\nxotroph\n mYOL053W:Unknown ,, Unknown\n mRIM2:Protein of the mitochondrial carrier (MCF) family that is re\nquired for respiration,,Null mutant is viable but lacks mito\nchondrial DNA and grows slowly on glucose\n mUBA4:Unknown ,, Unknown\n mYKL123W:Unknown ,, Unknown\n mYTP1:Yeast putative Transmembrane Protein,,Null mutant is viable\n mTWF1:Twinfilin A is a member of a conserved family of actin monom\ner sequestering proteins. TWF1 is comprised almost entirely \nof two tandem repeats, each having sequence homology with co\nfilin (COF1).,twinfilin A, an actin monomer sequestering pro\ntein,Null mutant is viable, twf1 null cof1-22 mutants exhibi\nt synthetic lethality\n Cond723:t2-SSD1,M31\n mSYF1:SYnthetic lethal with cdcForty,,Null mutant is inviable.\n mYMR178W:Unknown ,, Unknown\n mPLP1:Phosducin-Like Protein,,Null mutant is viable\n mNGL1:DNase/RNase (putative); CCR4 C-terminal homolog, homology to\n drosophila Angel gene,DNase (putative) , RNase (putative),N\null mutant is viable.\n mPCL8:PHO85 cyclin,cyclin,Null mutant is viable.\n Cond715:t0-SSD1\n mPAC2:Required for viability in the absence of the kinesin-related\n mitotic motor Cin8p; required for normal microtubule stabil\nity,tubulin folding cofactor E,Null mutant is viable but has\n cold-sensitive microtubule structures and is sensitive to b\nenomyl\n mMRP1:shows allele-specific genetic interactions with pet122 and p\net123,37 kDa mitochondrial ribosomal protein,defective mitoc\nhondrial protein synthesis; absence of a and b type cytochro\nmes; reduced levels of mitochondrial 15 S rRNA; defective pr\nocessing of apocytochrome b intron; convert to rho- and rho0\n at high frequency\n mYLL044W:Unknown ,, Unknown\n mCOG5:Unknown ,, Unknown\n mRRP45:Ribosomal RNA Processing,3'->5' exoribonuclease,Null mutant \nis inviable; mutant is defective in 3' processing of 5.8S rR\nNA\n mDJP1:DnaJ-like protein required for Peroxisome biogenesis; Djp1p \nis located in the cytosol,,Null mutant is viable but shows p\nartial mislocalisation of peroxisomal matrix proteins to the\n cytosol\n mPCL10:PHO85 cyclin,,Null mutant is viable.\n mYOR013W:Unknown ,, Unknown\n mUFE1:t-SNARE that resides on the endoplasmic reticulum and mediat\nes retrograde traffic from the Golgi complex,t-SNARE (ER),Nu\nll mutant is inviable\n mTAH11:Product of gene unknown,,tah11-1 mutant is hypersensitive to\n hydroxyurea, camptothecin when overexpressing wild-type TOP\n1\n mDST1:Meiotic DNA recombination factor,RNA polymerase II elongatio\nn factor , transcription elongation factor,Null mutant is vi\nable; reduced induction of DNA strand transfer; sensitivity \nto 6-azauracil\n mYDR288W:Unknown ,, Unknown\n mCUE1:Cue1p assembles with Ubc7p. Cue1p recruits Ubc7p to the cyto\nsolic surface of the endoplasmic reticulum. Assembly with Cu\ne1p is a prerequisite for the function of Ubc7p,Ubc7p bindin\ng and recruitment protein,Null mutant is viable and shows st\nabilization of ER degradation substrates\n mMGM101:Involved in mitochondrial genome maintenance,,Null mutant is\n viable\n mDID4:Hypothetical ORF,class E vacuolar-protein sorting and endocy\ntosis factor,secretion of vacuolar proteins; canavanine-hype\nrsensitive; temperature-sensitive; suppresses defects associ\nated with loss of Doa4\n mCAC2:Involved in DNA-replication-linked nucleosome assembly; homo\nlogous to the p60 subunit of the Human CAF-I,chromatin assem\nbly factor-I (CAF-I) p60 subunit,Null mutant is viable, but \nis sensitive to UV irradiation\n mYLR345W:Unknown ,, Unknown\n mAOS1:along with Uba2p forms a heterodimeric activating enzyme for\n Smt3p,,Null mutant is inviable\n mPFD1:Prefoldin subunit 1; putative homolog of subunit 1 of bovine\n prefoldin, a chaperone comprised of six subunits,bovine pre\nfoldin subunit 1 homolog (putative),\n mYBL059W:Unknown ,, Unknown\n mMMP1:S-MethylMethionine Permease,high affinity S-methylmethionine\n permease,Null mutant is viable but is unable to use S-methy\nlmethionine as a sulfur source\n mOGG1:Excises 7,8-dihydro-8-oxoguanine (8-OxoG) when 8-OxoG is opp\nposite cytosine or thymine (but not adenine),43 kDa 8-oxo-gu\nanine DNA glycosylase,\n mMLS1:carbon-catabolite sensitive malate synthase,carbon-catabolit\ne sensitive malate synthase,Null mutant is viable\n mSEN34 mSEN15 mPTC3 mYGR205W mRFC5 mRFC2 mRFC3 mROM2 mSIF2 mYMR155W mHSH49 mAPG12 mPTC7 mAPG7 mMET18 mKIN28 mRAD3 mYDR316W mTHI22 mTFB3 mCHK1 mCTR1 mCSM1 mYDR061W mAPC11 mAPC1 mCDC7 mCDC53 mECM10 mTEL2 mVAC14 mMET30 mMDM30 mHRT1 mYEL015W mCBK1 mTRR2 mMNS1 mIMP2 mYDR128W mYER182W mTAF10 mTAF9 mTAF14 mMNN10 mHOC1 mSMD1 mLOT5 mMAD2 mSIN4 mPET191 mPOB3 mPSH1
this is an automaticly generated SAMBA report
Computational Genomics Lab, Tel-Aviv uniresity