Module number 238




Database revision : gnsdb28.10
Date : Tue Feb 25 17:27:08 2003
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mHIS3:imidazoleglycerol-phosphate dehydratase,imidazoleglycerol-ph\nosphate dehydratase,Null mutant is viable and requires histi\ndine\n Cond368:dtt_480_min_dtt-2\n mTRP1:Note that the sequence of TRP1 from strain S228C, which is t\nhe sequence stored in SGD, contains an ochre mutation at cod\non 67.,N-(5'-phosphoribosyl)-anthranilate isomerase,tryptoph\nan requiring\n mARG1:arginosuccinate synthetase,arginosuccinate synthetase,Argini\nne requiring\n mAQY2:aquaporin water channel in yeast,MIP family member , aquapor\nin (putative),\n mLEU2:leucine biosynthesis,beta-IPM (isopropylmalate) dehydrogenas\ne,Null mutant is viable, leucine auxotroph\n mURA1:dihydroorotate dehydrogenase,dihydroorotate dehydrogenase,ur\nacil requiring\n mSIT1:Siderophore Iron Transport,ferrioxamine B permease,Viable. C\nells deleted from the gene are unable to take up ferrioxamin\ne B\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mATX1:antioxidant protein and metal homeostasis factor, protects a\ngainst oxygen toxicity,copper binding homeostasis protein (p\nutative),hypersensitive toward paraquat (a generator of supe\nroxide anion)\n mFET3:FET3 encodes a ferro-O2-oxidoreductase that is part of the h\nigh-affinity iron transport system,multicopper oxidase,The n\null mutant is viable but defective for high affinity Fe(II) \nuptake. The null mutant is inviable when environmental iron \nis limiting.\n Cond950:TPK1_MT1val\n Cond954:TPK2_MT2val\n Cond132:rnr1(haploid**9)\n mMUP1:high affinity methionine permease,high affinity methionine p\nermease,Null mutant is viable but cannot perform high-affini\nty methionine update.\n Cond188:vma8\n TPK.TPK:The yeast A kinases differentially regulate iron uptake and \nrespiratory function. Proc Natl Acad Sci U S A. 2000 May 23\n;97(11):5984-8.\n Cond949:WT1val\n mFTR1:Plasma membrane iron permease,iron permease,Lacks high affin\nity iron uptake\n mYEL015W:Unknown ,, Unknown\n mYEL001C:Unknown ,, Unknown\n mFIT1:Facilitator of Iron Transport,Cell wall protein involved in \niron uptake,Impaired siderophore-iron uptake, activation of \nthe major iron-dependent transcription factor AFT1.\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mFIT2:Facilitator of iron transport,Cell wall protein involved in \niron transport,impaired siderophore-iron uptake, activation \nof the major iron -dependent transcription factor, AFT1\n Cond951:WT2val\n mENB1:Siderophore transporter for enterobactin; AFT1 regulon,enter\nobactin transporter,Null mutants are viable but are unable t\no take up and utilize iron from enterobactin\n Cond955:TPK3_MT1val\n mYCK1:membrane-bound casein kinase I homolog,casein kinase I homol\nog,Null mutant is viable; yck1 yck2 double deletion mutants \nare inviable; yck1 point mutants suppress defective Snf1p ki\nnase activity in snf4 strains\n Stress.DTT2:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mISU2:Iron-sulfur cluster nifU-like protein,,Null mutant is viable\n on YPD at 30 degrees C, and is synthetically lethal with is\nu1 null.\n mNCE103:involved in secretion of proteins that lack classical secret\nory signal sequences,,An uncharacterized allele exhibits def\nects in the export of the mammalian protein galectin-1.\n mBAP2:contains 12 predicted transmembrane domains,amino acid perme\nase for leucine, valine, and isoleucine (putative),reduced u\nptake of leucine, isoleucine, and valine\n mTUP1:general repressor of transcription (with Cyc8p); mediates gl\nucose repression,glucose repression regulatory protein, exhi\nbits similarity to beta subunits of G proteins,Null mutant i\ns viable; exhibits flocculent colony morphology\n Cond952:TPK1_MT2val\n mMDH2:cytosolic malate dehydrogenase,malate dehydrogenase,Null mut\nant is viable; fails to grow on minimal medium with acetate \nor ethanol as carbon source\n mCAR1:arginase,arginase,Null mutant is viable but defective in arg\ninine catabolism\n mMSB2:putative integral membrane protein,integral membrane protein\n (putative),multicopy suppressor of cdc24 ts mutation\n Cond956:TPK3_MT2val\n mARN1:Product of gene unknown,,\n mHXT7:Hexose transporter,hexose transporter,Null mutant is viable;\n snf3 hxt1 hxt2 hxt3 hxt4 HXT7 hxt7 mutant cannot grow on me\ndia containing glucose as sole carbon source\n mHMX1:Unknown ,, Unknown\n mAGP1:broad substrate range permease which transports asparagine a\nnd glutamine with intermediate specificity,amino acid permea\nse,Null mutant is viable; resistant to the amino acid analog\n gamma-hydroxyaspartate, decreased growth on asn, gln and so\nme other amino acids in strains in which Gap1 and Gnp1 are a\nlso missing.\n Cond35:cup5\n mZWF1:Glucose-6-phosphate dehydrogenase,glucose-6-phosphate dehydr\nogenase,sensitive to oxidizing agents; methionine requiring\n mYMR237W:Unknown ,, Unknown\n mTAT1:Amino acid transport protein for valine, leucine, isoleucine\n, and tyrosine,amino acid transport protein for valine, leuc\nine, isoleucine, and tyrosine,\n mIES5:Ino Eighty Subunit 5,,Null: non essential.\n mIES6:Ino Eighty Subunit 6,,Null: non essential.\n mCPA2:carbamyl phosphate synthetase,carbamyl phosphate synthetase,\nNull mutant is viable\n Cond953:TPK2_MT1val\n mPIR3:Protein containing tandem internal repeats,contains tandem i\nnternal repeats,Null mutant is viable; pir1 hsp150 (pir2) pi\nr3 triple mutant is slow-growing on agar slab and sensitive \nto heat shock\n
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Computational Genomics Lab, Tel-Aviv uniresity