Module number 236




Database revision : gnsdb28.10
Date : Tue Feb 25 17:27:06 2003
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mHIS3:imidazoleglycerol-phosphate dehydratase,imidazoleglycerol-ph\nosphate dehydratase,Null mutant is viable and requires histi\ndine\n mYLR346C:Unknown ,, Unknown\n mYBR113W:Unknown ,, Unknown\n mYAL037W:Unknown ,, Unknown\n mHAT2:subunit of histone acetyltransferase; may regulate activity \nof Hat1p, the catalytic subunit of histone acetyltransferase\n,histone acetyltransferase subunit,Null mutant is viable\n mRPS21A:Homology to rat S21,ribosomal protein S21A (S26A) (YS25),\n mURA3:orotidine-5'-phosphate decarboxylase,orotidine-5'-phosphate \ndecarboxylase,Null mutant is viable, uracil auxotroph\n mSEC31:involved in protein transport from endoplasmic reticulum to \nGolgi,COPII coat of secretory pathway vesicles component (p1\n50),Null mutant is inviable\n Cond950:TPK1_MT1val\n mTIR4:Hypothetical ORF,cell wall mannoprotein,inviable under anaer\nobic conditions\n mMUP1:high affinity methionine permease,high affinity methionine p\nermease,Null mutant is viable but cannot perform high-affini\nty methionine update.\n mRPL31A:Homology to rat L31,ribosomal protein L31A (L34A) (YL28),\n mMRPL37:Probable mitochondrial protein L37,ribosomal protein L37 (pu\ntative),\n mYLL053C:Unknown ,, Unknown\n mVMA21:Protein involved in vacuolar H-ATPase assembly or function,,\nNull mutant is viable but grows slowly and exhibits increase\nd calcium sensitivity. Null mutants also cannot grow on glyc\nerol or at pH 7.5\n mFRE4:similar to FRE2,,\n mSCS3:Required for inositol prototrophy,,null is viable but is aux\notrophic for myo-inositol\n mSCS7:Required for the hydroxylation of the very long chain fatty \nacid (VLCFA), located in the endoplasmic reticulum,desaturas\ne , hydroxylase,Null mutant is viable, suppresses the Ca2+-s\nensitive phenotype of csg2 delta mutants\n Cond955:TPK3_MT1val\n mNUP49:localizes to discrete spots in the nuclear envelope,nuclear \npore complex subunit,Null mutant is inviable; some nsp1 nsp4\n9 alleles exhibit synthetic lethality\n mANP1:Mannan 8; Protein of the endoplasmic reticulum with a role i\nn retention of glycosyltransferases in the Golgi, also invol\nved in osmotic sensitivity and resistance to aminonitropheny\nl propanediol,,Null mutant has altered mannoprotein glycosyl\nation and a defect in N-linked outerchain glycan mannosylati\non; other mutant phenotypes include aminonitrophenyl propane\ndiol resistance, vanadate resistance, hygromycin B sensitive\n and a clumpy growth morphology.\n mDAN2:Delayed anaerobic gene,putative cell wall protein,unknown\n mSUT2:Involved in sterol uptake; homologous to SUT1,,\n mHMX1:Unknown ,, Unknown\n mTAT1:Amino acid transport protein for valine, leucine, isoleucine\n, and tyrosine,amino acid transport protein for valine, leuc\nine, isoleucine, and tyrosine,\n mMIG2:Involved in repression, along with Mig1p, of SUC2 (invertase\n) expression by high levels of glucose; binds to Mig1p-bindi\nng sites in SUC2 promoter,contains zinc fingers very similar\n to zinc fingers in Mig1p,Null mutant is viable; a strain th\nat contains a double disruption of MIG1 and MIG2 is defectiv\ne in glucose repression of SUC2 expression\n mIES5:Ino Eighty Subunit 5,,Null: non essential.\n mWSC3:cell wall integrity and stress response component 3,contains\n novel cysteine motif , integral membrane protein (putative)\n , similar to SLG1 (WSC1), WSC2 and WSC4,Null mutant is viab\nle and shows no phenotypes; slg1 (wsc1)-null WSC3-null doubl\ne mutant shows a lysis defect on YPD at room temperature and\n heat shock sensitivity; overexpression of WSC genes suppres\nses heat shock sensitivity of hyperactivated ras mutant; hea\nt shock sensitivity of wsc mutant strain is suppressed by de\nletion of ras2\n mIES6:Ino Eighty Subunit 6,,Null: non essential.\n mYGL079W:Unknown ,, Unknown\n mRET2:coatomer (COPI) complex delta subunit,,ret2-1 mutant is ther\nmosensitive and shows defects in retrieval of dilysine-tagge\nd proteins from the Golgi back to the ER and, at the non-per\nmissive temperature, in forward ER-to-Golgi transport\n mLYS2:alpha aminoadipate reductase,alpha aminoadipate reductase,Nu\nll mutant is viable, lysine auxotroph\n mYMR254C:Unknown ,, Unknown\n mADE5,7:glycinamide ribotide synthetase and aminoimidazole ribotide \nsynthetase,aminoimidazole ribotide synthetase , glycinamide \nribotide synthetase,Adenine requiring\n mYFR024C:Unknown ,, Unknown\n mFLO10:Protein with similarity to flocculation protein Flo1p,,\n mTIF11:Translation initiation factor eIF1A,translation initiation f\nactor eIF1A,Null mutant is inviable\n mGLC7:Glycogen accumulation,protein phosphatase type I,Null mutant\n is inviable\n mYHR214W:Unknown ,, Unknown\n mPAU3:member of the seripauperin protein/gene family (see Gene_cla\nss PAU),,\n mPAU6:member of the seripauperin protein/gene family,,\n mGPI16:Glycosyl Phosphatidyl Inositol 16,GPI transamidase component\n, human PIG-T homologue,Null: inviable.\n Cond949:WT1val\n mRCS1:Involved in iron homeostasis and affects cell size regulatio\nn,binds the consensus site PyPuCACCCPu , transcription facto\nr (putative),Null mutant is viable; mutant cells are larger \nthan normal, since critical size for budding is increased; m\nutant shows incorrect regulation of expression of genes invo\nlved in iron uptake; spores from heterozygous diploid have r\neduced ability to germinate;\n mMUC1:Required for invasion and pseudohyphae formation in response\n to nitrogen starvation,cell surface flocculin with structur\ne similar to serine/threonine-rich GPI-anchored cell wall pr\noteins,Null mutant is viable, does not exhibit pseudohyphal \ndifferentiation as a diploid or invasive growth as a haploid\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mSCP160:May be required during cell division for faithful partitioni\nng of the ER-nuclear envelope membranes, involved in control\n of mitotic chromsome transmission,,Null mutant is viable, b\nut exhibits decreased viability, abnormal morphology, and in\ncreased DNA content.\n mLCP5:Lethal with conditional pap1 allele,,Null mutant is inviable\n; there is also a temperature sensitive mutant defective in \nrRNA processing and translation\n mECM15:ExtraCellular Mutant,,A Tn3 insertion into this gene causes \nhypersensitivity to the cell surface polymer perturbing agen\nt calcofluor white.\n mSWH1:Similar to mammalian oxysterol-binding protein,,Null mutant \nis viable\n Cond951:WT2val\n mENB1:Siderophore transporter for enterobactin; AFT1 regulon,enter\nobactin transporter,Null mutants are viable but are unable t\no take up and utilize iron from enterobactin\n mWBP1:wheat germ agglutinin-binding protein,oligosaccharyl transfe\nrase glycoprotein complex, beta subunit,lethal\n mRFC5:RFC is a multisubunit DNA binding protein and ATPase that ac\nts as a processivity factor for DNA polymerases delta and ep\nsilon and loads proliferating cell nuclear antigen (PCNA) on\n DNA,replication factor C subunit 5 , similar to human RFC 3\n8 kDa subunit,Null mutant is inviable\n mYDR531W:Unknown ,, Unknown\n mYNL100W:Unknown ,, Unknown\n mSPF1:Sensitivity to a killer toxin (SMK toxin) produced by Pichia\n farinosa,P-type ATPase,The null mutant is viable and resist\nant to the SMK toxin, but grows slowly and has glycosylation\n defects.\n Cond952:TPK1_MT2val\n mTUP1:general repressor of transcription (with Cyc8p); mediates gl\nucose repression,glucose repression regulatory protein, exhi\nbits similarity to beta subunits of G proteins,Null mutant i\ns viable; exhibits flocculent colony morphology\n mYGL080W:Unknown ,, Unknown\n mKTR6:similar to KRE2, mannosylphosphate transferase which may rec\nognize any oligosaccharides with at least one alpha-1,2-link\ned mannobiose unit,mannosylphosphate transferase,Null mutant\n is viable, hypersensitive to Calcofluor White and hygromyci\nn B; shows less binding to Alcian blue, and diminished manno\nsylphosphate transferase activity toward the endoplasmic ret\niculum core oligosaccharide acceptors, displays a decrease i\nn polymannose outer chain phosphorylation\n mPKH1:Pkb-activating Kinase Homologue,,Null mutant is viable; pkh1\n, pkh2 double mutant is lethal\n mMSB2:putative integral membrane protein,integral membrane protein\n (putative),multicopy suppressor of cdc24 ts mutation\n mGIM4:Prefoldin subunit 2; putative homolog of subunit 2 of bovine\n prefoldin, a chaperone comprised of six subunits,bovine pre\nfoldin subunit 2 homolog (putative),Null mutant is viable, s\nensitive to anti-microtubule drugs benomyl and nocadazole; s\nynthetically lethal with tub4-1 mutations\n mYOL014W:Unknown ,, Unknown\n mYDR401W:Unknown ,, Unknown\n mYDR365C:Unknown ,, Unknown\n mAGP1:broad substrate range permease which transports asparagine a\nnd glutamine with intermediate specificity,amino acid permea\nse,Null mutant is viable; resistant to the amino acid analog\n gamma-hydroxyaspartate, decreased growth on asn, gln and so\nme other amino acids in strains in which Gap1 and Gnp1 are a\nlso missing.\n mZWF1:Glucose-6-phosphate dehydrogenase,glucose-6-phosphate dehydr\nogenase,sensitive to oxidizing agents; methionine requiring\n mYTM1:microtubule-associated protein,microtubule-associated protei\nn,\n mAKL1:Ark-family kinase-like protein. This protein is the third me\nmber (After Ark1p and Prk1p) of the Ark-family kinases in S.\n cerevisiae.,,Null mutant is viable\n mAPT1:Adenine phosphoribosyltransferase,adenine phosphoribosyltran\nsferase,\n mYLL012W:Unknown ,, Unknown\n mFLR1:Fluconazole Resistance 1,major facilitator transporter,Null \nmutant is viable; overexpression confers resistance to fluco\nnazole, cycloheximide, 4-nitroquinoline N-oxide\n mYGR294W:Unknown ,, Unknown\n mERG10:acetoacetyl CoA thiolase,acetoacetyl CoA thiolase,Nul mutant\n is inviable; other mutants are ergosterol biosynthesis defe\nctive or nystatin resistant\n mAQY2:aquaporin water channel in yeast,MIP family member , aquapor\nin (putative),\n mNOP7:Required for normal pre-rRNA processing,,Null: lethal.\n mRPL20A:Homology to rat L18a,ribosomal protein L20A (L18A),\n mATX1:antioxidant protein and metal homeostasis factor, protects a\ngainst oxygen toxicity,copper binding homeostasis protein (p\nutative),hypersensitive toward paraquat (a generator of supe\nroxide anion)\n Cond954:TPK2_MT2val\n mRAS2:Ras proto-oncogene homolog. Ras2 is involved in growth on no\nn-fermentable carbon sources, the starvation response, sporu\nlation, pseudohyphal growth and aging.,small GTP-binding pro\ntein,Loss of function mutants grow poorly on nonfermentable \ncarbon sources, sporulate in rich media, are unable to diffe\nrentiate into a pseudohyphal form and exhibit an increased l\nife span.\n TPK.TPK:The yeast A kinases differentially regulate iron uptake and \nrespiratory function. Proc Natl Acad Sci U S A. 2000 May 23\n;97(11):5984-8.\n mYER156C:Unknown ,, Unknown\n mFTR1:Plasma membrane iron permease,iron permease,Lacks high affin\nity iron uptake\n mYEL001C:Unknown ,, Unknown\n mYEL015W:Unknown ,, Unknown\n mFIT1:Facilitator of Iron Transport,Cell wall protein involved in \niron uptake,Impaired siderophore-iron uptake, activation of \nthe major iron-dependent transcription factor AFT1.\n mFIT2:Facilitator of iron transport,Cell wall protein involved in \niron transport,impaired siderophore-iron uptake, activation \nof the major iron -dependent transcription factor, AFT1\n mYHR217C:Unknown ,, Unknown\n mYCK1:membrane-bound casein kinase I homolog,casein kinase I homol\nog,Null mutant is viable; yck1 yck2 double deletion mutants \nare inviable; yck1 point mutants suppress defective Snf1p ki\nnase activity in snf4 strains\n mOCA1:Unknown ,, Unknown\n mLSB1:LAs17 Binding protein,,\n mYPT31:probably involved in intra-Golgi transport or in the formati\non of transport vesicles at the most distal Golgi compartmen\nt,GTPase , YPT32 homolog , ras homolog,YPT1 is required for \nviability in some strain backgrounds but not others; ypt31 y\npt32 double deletion mutants are inviable\n mYPR063C:Unknown ,, Unknown\n mYAR066W:Unknown ,, Unknown\n mGOT1:Golgi Transport,membrane protein,Null mutant is viable but e\nxhibits ER to Golgi transport defects in vitro. got1 is synt\nhetically lethal with mutations in sft2; the got1 sft2 doubl\ne mutant exhibits defects in transport to the Golgi complex.\n Cond956:TPK3_MT2val\n mYGR151C:Unknown ,, Unknown\n mNAM8:May be non-essent. part of mito. splicing. Assoc. with splic\neosomal snRNPs. Disp. for mitosis & premeiotic DNA synth. Re\nquired in meiosis-specific splicing of MER2 & MER3, double s\ntrand breaks, synaptonemal complexes,RNA binding protein (pu\ntative) , involved in meiosis-specific splicing of the REC10\n7 transcripts in cooperation with the Mer1 protein , RNA bin\nding protein (putative) , involved in meiosis-specific splic\ning of the REC107 transcripts in cooperation with the Mer1 p\nrotein,Null mutant is viable; defective in meiotic recombina\ntion, formation of viable spores, and formation of meiosis-s\npecific double-strand breaks and crossover and noncrossover \nrecombinants; overexpression suppresses mitochondrial splici\nng defects; impaired association of yeast-specific U1 snRNP \nproteins but hyperstabilized association of Snu65p/Prp42p wi\nth the U1 snRNP; affects in vivo splicing of introns with no\nn-canonical 5'-splice sites; mutant contains a U1 snRNP with\n aberrant migration behaviour on native gels\n mSUI1:translation initiation factor 3 (eIF3),translation initiatio\nn factor 3 (eIF3),Null mutant is inviable\n mTOM7:Involved in mitochondrial protein import,translocase of the \nouter mitochondrial membrane,Null mutant is viable\n mHHT2:Histone H3 (HHT1 and HHT2 code for identical proteins),histo\nne H3 (HHT1 and HHT2 code for identical proteins),\n mPFY1:profilin (actin-binding protein),profilin,Null mutant is eit\nher inviable or viable (but temperature sensitive) under cer\ntain conditions, temperature sensitive null mutants exhibit \ndelocalized chitin deposition and arrest as large, unbudded \ncells with multiple nuclei and delocalized actin\n mMRPL8:Mitochondrial ribosomal protein MRPL8 (YmL8) (E. coli L17),r\nibosomal protein (YmL8) (E. coli L17),Null mutant is viable;\n shows loss of mitochondrial function, instability of mitoch\nondrial DNA\n mPXR1:Unknown ,, Unknown\n mFUN11:Function Unknown Now; similar to Xenopus GTP-binding protein\n DRG,,\n mDBP2:ATP-dependent RNA helicase of DEAD box family,ATP dependent \nRNA helicase , dead box protein,Null mutant is inviable\n mPRM7:pheromone-regulated membrane protein,,\n mYLR184W:Unknown ,, Unknown\n mASN2:Asn1p and Asn2p are isozymes,asparagine synthetase,Null muta\nnt is viable; L-asparagine auxotrophy occurs upon mutation o\nf both ASN1 and ASN2\n mRSN1:overexpression Rescues sro7/sop1 in NaCl,,viable in both hig\nh and low salinity\n mHTA2:Histone H2A (HTA1 and HTA2 code for nearly identical protein\ns),histone H2A (HTA1 and HTA2 code for nearly identical prot\neins),Null mutant is viable. Deletion of the HTA2-HTB2 (TRT2\n) locus has no reported observable phenotypes, presumably be\ncause HTA1-HTB1 (TRT1) expression is upregulated and can com\npensate in the absence of TRT2. Overexpression of TRT2 can s\nuppress Ty insertion mutations\n mFOL2:First enzyme in biosynthetic pathway for folic acid and tetr\nahydrobioptern,GTP-cyclohydrolase I,Folinic acid requiring\n mSFA1:Long-chain alcohol dehydrogenase (glutathione-dependent form\naldehyde dehydrogenase),glutathione-dependent formaldehyde d\nehydrogenase , long-chain alcohol dehydrogenase,Null mutant \nis viable; sensitive to formaldehyde\n mCAJ1:Homologous to E. coli DnaJ; contains leucine zipper-like mot\nif,,\n mBCY1:Involved in heat shock resistance, glycogen accumulation, an\nd sporulation,cAMP-dependent protein kinase regulatory subun\nit,Null mutant is viable; sra1 mutants are associated with r\neduction of glycogen accumulation, temperature sensitivity, \nreduced growth rate on maltose and sucrose, inability to gro\nw on galactose and nonfermentable carbon sources and nitroge\nn starvation intolerance. Cells lacking Sra1p are constituti\nve for cAPK activity resulting in meiotic arrest prior to pr\nemeiotic DNA synthesis\n mYDR157W:Unknown ,, Unknown\n mYDR542W:Unknown ,, Unknown\n mHAS1:Helicase Associated with SET1,RNA-dependent helicase (putati\nve),Null mutant is inviable\n mRVS167:Involved in endocytosis,cytoskeletal protein (putative),Null\n mutant is viable but exhibits reduced viability upon starva\ntion\n mGDA1:converts nucleoside diphosphates to nucleoside monophosphate\ns to recycle nucleosides and promote transport of additional\n nucleotide sugars into golgi,guanosine diphosphatase of Gol\ngi membrane,Null mutant is viable and has partial block in m\nannosylation of proteins and sphingolipids\n mBAP3:branched-chain amino acid permease,valine transporter,\n mIMP4:Interacts With Mpp10. Imp4p is a specific component of the U\n3 snoRNP and is required for pre-18S rRNA processing.,,Null \nmutant is inviable\n mHXT2:hexose transporter,high affinity hexose transporter-2,Null m\nutant is viable\n mCAR1:arginase,arginase,Null mutant is viable but defective in arg\ninine catabolism\n mYAR068W:Unknown ,, Unknown\n mKEM1:Kar1-1 nuclear-fusion-defect Enhancing Mutation. Plays a rol\ne in cytoplasmic mRNA degradation.,5'-3' exonuclease,Null mu\ntant is viable but grows poorly. kem1 mutants exhibit aberra\nnt mRNA turnover and are are thought to be very pleiotropic \nas a result; elongated morphology, defective in spindle-pole\n-body duplication/separation and telomere maintenance, benom\nyl hypersensitive, 10-20-fold elevation in chromosome loss, \ndecreased mitotic recombination and inviable upon nitrogen s\ntarvation includes a partial list of phenotypes.\n mHXT6:Repression of HXT6 expression by glucose requires SNF3,hexos\ne transporter,Null mutant is viable; snf3 hxt1 hxt2 hxt3 hxt\n4 hxt6 hxt7 mutant cannot grow on media containing glucose a\ns sole carbon source\n mHXT7:Hexose transporter,hexose transporter,Null mutant is viable;\n snf3 hxt1 hxt2 hxt3 hxt4 HXT7 hxt7 mutant cannot grow on me\ndia containing glucose as sole carbon source\n mIOC2:Iswi One Complex,,\n mPPT1:serine/threonine phosphatase,,\n mRPC17:Unknown ,, Unknown\n mYMR237W:Unknown ,, Unknown\n mBUD20:Hypothetical ORF,,Null mutant is viable; random budding in d\niploid null mutants\n mLEO1:Product of gene unknown,,Null mutant is viable\n mRAD23:ubiquitin-like protein,ubiquitin-like protein,radiation sens\nitive\n mSCW10:Soluble Cell Wall protein,soluble cell wall protein,Null mut\nant is viable.\n Cond953:TPK2_MT1val\n mYGR182C:Unknown ,, Unknown\n mPIR3:Protein containing tandem internal repeats,contains tandem i\nnternal repeats,Null mutant is viable; pir1 hsp150 (pir2) pi\nr3 triple mutant is slow-growing on agar slab and sensitive \nto heat shock\n mRPL31A mIOC2 mGLC7 mNOP7 mYTM1 mBUD20 mHAS1 mFOL2 mYCK1 mBCY1 mSUI1 mERG10
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Computational Genomics Lab, Tel-Aviv uniresity