Module number 2302




Database revision : gnsdb28.10
Date : Tue Feb 25 17:06:01 2003
How to read this figure?


mYGR269W:Unknown ,, Unknown\n mYER130C:Unknown ,, Unknown\n mYJL211C:Unknown ,, Unknown\n mHSP104:involved in thermal and ethanol tolerance, inheritance of [P\nSI+], and reactivation of mRNA splicing after heat shock,hea\nt shock protein 104,Null mutant is viable and defective in i\nnduced thermotolerance\n mGAC1:Regulatory subunit for phosphoprotein phosphatase type 1 (PP\n-1), also known as Glc7p, which regulates glycogen synthase-\n2,Glc7p regulatory subunit,Reduced glycogen accumulation\n mYBR287W:Unknown ,, Unknown\n mTKL1:Transketolase 1,transketolase 1,Null mutant is viable; growt\nh on fermentable carbon sources, but not gluconeogenic carbo\nn sources, is reduced; tkl1 tkl2 mutants are auxotrophic for\n aromatic amino acids\n mMSN4:multicopy suppressor of snf1 mutation,zinc finger protein,Nu\nll mutant is viable; msn2 msn4 double deletion mutants exhib\nit higher sensitivity to different stresses, including carbo\nn source starvation, heat shock and severe osmotic and oxida\ntive stresses\n mFET3:FET3 encodes a ferro-O2-oxidoreductase that is part of the h\nigh-affinity iron transport system,multicopper oxidase,The n\null mutant is viable but defective for high affinity Fe(II) \nuptake. The null mutant is inviable when environmental iron \nis limiting.\n mFYV2:Function required for Yeast Viability on toxin exposure,,K1 \nkiller toxin hypersensitivity\n mHNT1:Hint homolog, member of the histidine triad superfamily of n\nucleotide-binding proteins,,\n mFET5:ferrous iron transport,multicopper oxidase , type 1 integral\n membrane protein,overexpression of FET5 suppresses a fet3 n\null mutant.\n mBUD7:bud site selection,,Diploid-specific heterogenous bud site s\nelection\n mAZR1:MFS-MDR,,\n mRGM1:Putative transcriptional repressor with proline-rich zinc fi\nngers,transcriptional repressor with proline-rich zinc finge\nrs (putative),Null mutant is viable; overexpression of RGM1 \ngreatly impairs cell growth.\n mYPR196W:Unknown ,, Unknown\n mNAP1:nucleosome assembly protein I,nucleosome assembly protein I,\nNull mutant is viable but exhibits defects in Clb2 function.\n mMNN2:Probable type II membrane protein involved in mannan synthes\nis,golgi alpha-1,2-mannosyltransferase (putative),Null mutan\nt is viable. Mannan lacks the main alpha-1,2-linked branches\n mSCS2:Likely to be involved in regulating INO1 expression, suppres\nsor of a dominant nuclear mutation that is inositol-dependen\nt in the presence of choline,,Null mutant is viable but is a\nn inositol auxotroph above 34 deg.\n mGIC1:Gtpase-interacting component 1,,Null mutant is viable; gic1 \ngic2 double null is temperature sensitive at 33 degrees C\n mYHR126C:Unknown ,, Unknown\n mSCS7:Required for the hydroxylation of the very long chain fatty \nacid (VLCFA), located in the endoplasmic reticulum,desaturas\ne , hydroxylase,Null mutant is viable, suppresses the Ca2+-s\nensitive phenotype of csg2 delta mutants\n mSWF5:Unknown ,, Unknown\n mYPL013C:Unknown ,, Unknown\n mSFC1:succinate-fumarate carrier,succinate-fumarate transport prot\nein,\n mZRC1:Zinc- and cadmium-resistance protein,,Null mutant is viable \nand sensitive to zinc\n mSPS4:sporulation-specific protein,,normal sporulation\n mJIP3:Unknown ,, Unknown\n mRRD1:Resistant to Rapamycin Deletion,,Null mutant is viable but s\nhows pleiotropic phenotypes (eg. caffeine and rapamycin resi\nstance, vanadate and calcium sensitivity, etc.); synthetic l\nethal with RRD2 (YPL152w)\n Cond668:mec1_plus_gamma_90_min\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mSMM1:Suppressor of Mitochondrial Mutation in the tRNAasp gene; Di\nhydrouridine synthase 2,tRNA dihydrouridine synthase,Overexp\nression weakly suppresses a mutation affecting the maturatio\nn of mitochondrial tRNA-Asp.\n mYOR342C:Unknown ,, Unknown\n mYJL038C:Unknown ,, Unknown\n mDPH2:Diptheria toxin resistance protein, required for diphthamide\n biosynthesis,,Null mutant is viable\n mHTZ1:Histone-related protein that can suppress histone H4 point m\nutation,evolutionarily conserved member of the histone H2A F\n/Z family of histone variants,Null mutant is viable at 28C; \nhigh copy suppressor of histone H4 point mutant affecting nu\ncleosome structure\n mVID24:also involved in vacuolar protein targeting,peripheral vesic\nle membrane protein,Null mutant is viable, defective in fruc\ntose-1,6-bisphosphatase dergadation\n mSTE24:zinc metallo-protease that catalyzes the first step of N-ter\nminal processing of the yeast a-factor precursor,zinc metall\no-protease,Null mutant is viable, exhibits a mating efficien\ncy of ~5% that of a wild-type strain and an a-factor process\ning defect\n mMAK10:Glucose-repressible protein,,Null mutant is viable, grows po\norly on nonfermentable carbons sources\n mYML090W:Unknown ,, Unknown\n mALG8:adds glucose to the dolichol-linked oligosaccharide precurso\nr prior to transfer to protein,glycosyl transferase,Null mut\nant is viable, secretes under-glycosylated proteins\n mADH2:alcohol dehydrogenase II,alcohol dehydrogenase II,Null mutan\nt is viable\n mGRH1:Yeast (GR)ASP65 (H)omologue,mammalian GRASP protein homolog,\nNull mutation is viable, exhibits defects in spindle checkpo\nint\n mYAL068C:Unknown ,, Unknown\n mYMR181C:Unknown ,, Unknown\n mPEX6:Required for peroxisome assembly,AAA ATPase,lack of peroxiso\nme biogenesis\n mPTC4:Phosphatase type Two C,type 2C protein phosphatase,\n mYPR038W:Unknown ,, Unknown\n mMLF3:Protein of unknown function,,Null mutant is viable and hyper\nsensitive to leflunomide\n mGAT1:activator of transcription of nitrogen-regulated genes; inac\ntivated by increases in intracellular glutamate levels,trans\ncriptional activator with GATA-1-type Zn finger DNA-binding \nmotif,Null mutant is viable. Required for expression of nitr\nogen catabolite repression-sensitive genes\n mPEX8:Required for peroxisome assembly,peroxisome associated prote\nin containing a PTS1 signal,mutant lacks morphologically rec\nognizable peroxisomes and shows cytosolic mislocalization of\n peroxisomal matrix proteins\n mYDR247W:Unknown ,, Unknown\n mGAT2:Product of gene unknown,,\n mCAM1:Calcium and phospholipid binding protein homologous to trans\nlation elongation factor 1-gamma (EF-1gamma),calcium and pho\nspholipid binding protein homologous to translation elongati\non factor 1-gamma (EF-1gamma),Null mutant is viable under no\nrmal growth conditions\n mSTP3:Involved in pre-tRNA splicing and in uptake of branched-chai\nn amino acids,,\n mSTP4:Involved in pre-tRNA splicing and in uptake of branched-chai\nn amino acids,,\n mGDS1:involved in nuclear control of mitochondria,,Null mutant is \nviable, shows partial impairment of growth on medium contain\ning glycerol as the carbon source. Overexpxression suppresse\ns NAM9-1 glycerol deficient phenotype\n mPTK1:Putative serine/threonine protein kinase,,Mutant shows decre\nase in total polyamine accumulation and resistance to polyam\nine analogs; ptk1 ptk2 double mutant shows virtually abolish\ned high-affinity spermidine transport\n mYHL044W:Unknown ,, Unknown\n mSBP1:single stranded nucleic acid binding protein,,\n mCOS10:Protein with strong similarity to subtelomerically-encoded p\nroteins such as Cos5p, Ybr302p, Cos3p, Cos1p, Cos4p, Cos8p, \nCos6p, Cos9p,,\n mYPL261C:Unknown ,, Unknown\n mRCS1:Involved in iron homeostasis and affects cell size regulatio\nn,binds the consensus site PyPuCACCCPu , transcription facto\nr (putative),Null mutant is viable; mutant cells are larger \nthan normal, since critical size for budding is increased; m\nutant shows incorrect regulation of expression of genes invo\nlved in iron uptake; spores from heterozygous diploid have r\neduced ability to germinate;\n mYGR250C:Unknown ,, Unknown\n mDIG1:Down-regulator of Invasive Growth, Regulator of Sterile Twel\nve, binds Fus3 and Ste12,MAP kinase-associated protein,Null \nmutant is viable, shows abnormal bud morphology; dig1 dig2 d\nouble mutants show constitutive mating defect and invasive g\nrowth; overexpression causes pheromone resistance\n mYLR225C:Unknown ,, Unknown\n mYBR246W:Unknown ,, Unknown\n mYPL014W:Unknown ,, Unknown\n mYDL187C:Unknown ,, Unknown\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mTPO1:Polyamine transport protein,,\n mOST3:Catalyzes the transfer of oligosaccharide from dolichol-olig\nosaccharide donor to consensus glycosylation acceptor sites \n(asparagines) in newly synth. proteins - ER lumen; may enhan\nce oligosacch. transfer to subset of acceptor substrates,oli\ngosaccharyl transferase glycoprotein complex 34 kDa gamma su\nbunit,Null mutant is viable but shows underglycosylation of \nsoluble and membrane-bound glycoproteins and contains less o\nligosaccharyltransferase activity in vitro\n mTPO3:Unknown ,, Unknown\n mVPS29:vacuolar protein sorting,,Defective for sorting of soluble h\nydrolases to the vacuole. Mislocalisation of the vacuolar hy\ndrolase sorting receptor Vps10p.\n mYNL144C:Unknown ,, Unknown\n mCAN1:arginine permease,arginine permease,Canavanine resistance\n mDOT6:Derepression Of Telomeric silencing,,\n mSIS2:Involved in cell cycle control and ion homeostasis,,Null mut\nant is viable, displays salt sensitivity\n mARN1:Product of gene unknown,,\n mAGP1:broad substrate range permease which transports asparagine a\nnd glutamine with intermediate specificity,amino acid permea\nse,Null mutant is viable; resistant to the amino acid analog\n gamma-hydroxyaspartate, decreased growth on asn, gln and so\nme other amino acids in strains in which Gap1 and Gnp1 are a\nlso missing.\n mSAT4:Protein with similarity to Npr1p protein kinase,,\n mNRG1:involved in regulation of glucose repression,binds to UAS-1 \nin the STA1 promoter and can interact with Ssn6p , transcrip\ntional repressor,Null mutant is viable, relieves glucose rep\nression of SUC2 and STA1; suppresses snf mutations\n mYGR294W:Unknown ,, Unknown\n mISR1:Inhibition of staurosporine resistance,protein kinase,The nu\nll mutant is viable but exacerbates the phenotypes of a temp\nerature-sensitive allele (stt1-1) of PKC1.\n mYHL046C:Unknown ,, Unknown\n Cond664:mec1_plus_gamma_20_min\n mSSM4:Protein involved in mRNA turnover,integral membrane protein,\nNull mutant is viable, suppresses temperature sensitive rna1\n4 mutations; ssm4 sls1 mutants are inviable\n mHAA1:Homolog of Ace1 Activator,,\n mYDL173W:Unknown ,, Unknown\n mABP1:Actin binding protein,actin binding protein,Null mutant is v\niable\n mTOS8:Hypothetical ORF,,\n mMPS2:Monopolar spindle two, encodes a membrane protein localized \nat the nuclear envelope and the spindle pole body throughout\n the cell cycle. The protein is approximately 45 kDa, and co\nntains a coiled-coil motif and a hydrophobic domain.,,Null m\nutant is inviable, however some null spore clones can surviv\ne with abnormal ploidy; the mps2-1 mutant is incapable of pr\noper duplication of the SPB, resulting in a defective pole t\nhat only nucleates cytoplasmic microtubules. Overexpression \nof MPS2 in a cim5-1 ts mutant is toxic to cells.\n mTYE7:may be involved in glycolytic gene expression,33 kDa , serin\ne-rich protein, is a potential member of the bHLH/leucine-zi\npper protein family,Null mutant is viable; expression of eno\nlase genes is reduced three-fivefold in null mutant; gcr1 ty\ne7 double deletion mutants exhibit additive defects in enola\nse expression. TYE7 was isolated as a dominant suppressor of\n gcr1 mutations\n mDIA1:may be involved in invasive growth, pseudohyphal growth,,Nul\nl mutant is viable and causes invasive growth in haploids an\nd pseudohyphal growth in diploids\n mHMS2:High-copy mep2 suppressor,heat shock transcription factor ho\nmolog,Null mutant is viable; multicopy expression suppresses\n the pseudohyphal defect of mep2/mep2 strains\n mINP53:Synaptojanin-like protein,inositol polyphosphate 5-phosphata\nse,Null mutant is viable but has abnormal vacuoles\n mYJL171C:Unknown ,, Unknown\n mINP54:INositol polyphosphate 5-Phosphatase, fourth one identified;\n has homology to Type I mammalian inositol polyphosphate 5-p\nhosphatases,inositol polyphosphate 5-phosphatase,\n mRAS2:Ras proto-oncogene homolog. Ras2 is involved in growth on no\nn-fermentable carbon sources, the starvation response, sporu\nlation, pseudohyphal growth and aging.,small GTP-binding pro\ntein,Loss of function mutants grow poorly on nonfermentable \ncarbon sources, sporulate in rich media, are unable to diffe\nrentiate into a pseudohyphal form and exhibit an increased l\nife span.\n mYPL067C:Unknown ,, Unknown\n mYKL121W:Unknown ,, Unknown\n mYMR126C:Unknown ,, Unknown\n mMTH1:Negative regulator of HXT gene expression,Msn3p homolog (61%\n identical),Null mutant is viable; mth1(htr1) mutants are de\nficient in glucose update and transcription of glucose trans\nporters; mth1 (htr1) mutation suppresses glucose sensitivity\n of tpi1 mutant; multicopy expression of HXT genes suppresse\ns some defects of mth1 (htr1) mutants; msn3 mth1 double dele\ntion mutants are impaired in derepression of invertase in re\nsponse to glucose limitation\n Cond669:mec1_plus_gamma_120_min\n mYIL135C:Unknown ,, Unknown\n mECM38:ExtraCellular Mutant; cik1 suppressor,gamma-glutamyltransfer\nase homolog,Null mutant is viable. A Tn3 insertion into this\n gene causes hypersensitivity to the cell surface polymer pe\nrturbing agent calcofluor white.\n mCMK2:Calmodulin-dependent protein kinase,calmodulin-dependent pro\ntein kinase,Null mutant is viable, exhibits slow rate of spo\nre germination\n mYOR135C:Unknown ,, Unknown\n mYBL086C:Unknown ,, Unknown\n mYPR084W:Unknown ,, Unknown\n mYLR161W:Unknown ,, Unknown\n mYDR112W:Unknown ,, Unknown\n mAAT2:aspartate aminotransferase, cytosolic,aspartate aminotransfe\nrase,\n mSTD1:interacts with the SNF1 protein kinase and TBP in two-hybrid\n and in in vitro binding studies,MTH1 homolog,Null mutant is\n viable, no defects in mating or sporulation. Suppressor of \nTBP deletion; multicopy suppressor of SNF; std1-mth1 has def\nective glucose derepression and sporulation\n mYGL046W:Unknown ,, Unknown\n mYBR220C:Unknown ,, Unknown\n mYGL235W:Unknown ,, Unknown\n mYGL199C:Unknown ,, Unknown\n mYGR035C:Unknown ,, Unknown\n mBGL2:Cell wall endo-beta-1,3-glucanase,cell wall endo-beta-1,3-gl\nucanase,Null mutant is viable\n mYDR185C:Unknown ,, Unknown\n mHOG1:osmoregulation,MAP kinase,Null mutant is viable and unable t\no grow in high osmolarity media\n mYPR013C:Unknown ,, Unknown\n mKES1:Homologous to human oxysterol-binding protein; implicated in\n ergosterol biosynthesis and regulation of Golgi-derived tra\nnsport vesicle biogenesis,,Pleiotropic sterol-related phenot\nypes\n mKSP1:Serine/threonine kinase similar to casein kinase II and othe\nr serine/threonine protein kinases,,Null mutant is viable\n mENT4:epsin N-terminal homology-containing protein,,unknown\n mSGE1:multi-copy suppressor of gal11 null; member of drug-resistan\nce protein family,,Null mutant is viable; shows decreased ex\npression of galactose-inducible genes; shows increased sensi\ntivity to crystal violet\n mPSY2:Unknown ,, Unknown\n mYGR268C:Unknown ,, Unknown\n mSPI1:Stationary Phase Induced; strongly expressed during stationa\nry phase, and trancription is dependent on MSN2/MSN4.,,\n Cond666:mec1_plus_gamma_45_min\n mGDH1:NADP-specific glutamate dehydrogenase,NADP-specific glutamat\ne dehydrogenase,Null mutant is viable\n mYER158C:Unknown ,, Unknown\n mYLR257W:Unknown ,, Unknown\n mYKR075C:Unknown ,, Unknown\n mLYP1:lysine permease,lysine permease,\n mPDI1:protein disulfide isomerase,protein disulfide isomerase,Null\n mutant is inviable\n mHTA1:Histone H2A (HTA1 and HTA2 code for nearly identical protein\ns),histone H2A (HTA1 and HTA2 code for nearly identical prot\neins),Null mutant is viable\n mMAL31:Part of the complex locus MAL3; functional in S288C; highly \nhomologous to MAL61 from S. cerevisiae, MAL61 from S. carlsb\nergenesis strains JM1901 and CB11, and MAL1T from strain 405\n9,maltose permease,Defective maltose fermentation\n mYIL056W:Unknown ,, Unknown\n mPHO87:May collaborate with Pho86p and Pho84p in inorganic phosphat\ne uptake; protein contains 12 predicted transmembrane domain\ns,phosphate permease,Null mutant is viable; pho86 pho87 doub\nle mutant constitutively synthesizes repressible acid phosph\natase and is aresenate-resistant\n Cond667:mec1_plus_gamma_60_min\n mYOR325W:Unknown ,, Unknown\n mHHF1:Histone H4 (HHF1 and HHF2 code for identical proteins),histo\nne H4 (HHF1 and HHF2 code for identical proteins),\n mMEP2:Ammonia transport protein,ammonia transport protein,Null mut\nant is viable.\n mYHL012W:Unknown ,, Unknown\n mPCL6:PHO85 cyclin,,Null mutant is viable. A Ty insertion mutant e\nxhibits slow growth.\n mPCL8:PHO85 cyclin,cyclin,Null mutant is viable.\n mYGL193C:Unknown ,, Unknown\n mYGR022C:Unknown ,, Unknown\n mBAP2:contains 12 predicted transmembrane domains,amino acid perme\nase for leucine, valine, and isoleucine (putative),reduced u\nptake of leucine, isoleucine, and valine\n mSHR5:Involved in RAS localization and palmitoylation,,Null mutant\n is viable; exhibits normal palmityltransferase activity in \nvitro and attenuates Ras function in cells with mutant Ras2 \nproteins that are not farnesylated or palmitoylated; shr5 mu\ntation originally isolated as suppressor of Ras function\n mKRE1:cell wall beta-glucan assembly,,Null mutant is viable, exhib\nits reduction in cell wall (1--6)-beta-glucan\n mSUR1:Involved in maintenance of phospholipid levels,integral memb\nrane protein , similar to YBR161w, Hoc1p, and Och1p , integr\nal membrane protein , similar to YBR161w, Hoc1p, and Och1p ,\n integral membrane protein , similar to YBR161w, Hoc1p, and \nOch1p,Null mutant is viable, calcium sensitive at 37 degrees\n C on YPD but calcium tolerant at 26 degrees C, accumulates \ngreatly reduced levels of several mannosylated sphingolipids\n; sur1 mutations have been isolated based on their ability t\no suppress certain phenotype of rvs161 mutants including red\nuced viability upon starvation and sensitivies to unrelated \ndrugs; SUR1 is a high copy suppressor of the calcium sensiti\nvity of csg2 mutants\n mSUR2:Suppressor of rvs161 and rvs167 mutations,sphingosine hydrox\nylase,Null mutant is viable, has altered phospholipid levels\n mYIL006W:Unknown ,, Unknown\n mPCT1:phosphorylcholine transferase; or cholinephosphate cytidylyl\ntransferase,cholinephosphate cytidylyltransferase , phosphor\nylcholine transferase,Null mutant is viable\n mUPF3:factor stimulating decay of mRNAs containing premature stop \ncodons; acts with Nmd2p and Nam7p,,Null mutant is viable but\n shows increased accumulation of mRNA containing a premature\n stop codon due to mRNA stabilization\n mHXT3:Low-affinity glucose transporter,low affinity glucose transp\norter,Null mutant is viable but grows slowly on galactose; s\nome mutant alleles confer sodium hypersensitivity.\n mGPD1:glycerol-3-phosphate dehydrogenase,glycerol-3-phosphate dehy\ndrogenase,lethal under conditions of osmotic stress, unable \nto grow on glycerol\n mCUE1:Cue1p assembles with Ubc7p. Cue1p recruits Ubc7p to the cyto\nsolic surface of the endoplasmic reticulum. Assembly with Cu\ne1p is a prerequisite for the function of Ubc7p,Ubc7p bindin\ng and recruitment protein,Null mutant is viable and shows st\nabilization of ER degradation substrates\n mDSE3:Hypothetical ORF,,\n mHXT5:Member of superfamily of monosaccharide transporters,hexose \ntransporter,Null mutant is viable\n mHXT10:high-affinity hexose transporter,high affinity hexose transp\norter,\n mSTF2:ATPase stabilizing factor,ATPase stabilizing factor,\n mYGR290W:Unknown ,, Unknown\n mSNA3:Unknown ,, Unknown\n mCRN1:coronin, an actin-binding protein originally identified in D\nictyostelium,Dictyostelium and human actin-binding protein c\noronin homolog,Null mutant is viable\n mHAL5:Protein kinase homolog, mutant is salt and pH sensitive,,\n mYFR007W:Unknown ,, Unknown\n mFAA4:acyl-CoA synthetase (long-chain fatty acid CoA ligase) (fatt\ny acid activator 2), activates imported fatty acids and prov\nides substrates for N-myristoylation,long chain fatty acyl:C\noA synthetase , long-chain fatty acid:CoA ligase,Not essenti\nal for vegetative growth when fatty acid synthase (fas) is a\nctive\n Cond665:mec1_plus_gamma_30_min\n mYKL051W:Unknown ,, Unknown\n mHHF1 mHTA1 mNAP1 mPTC4 mYDR247W mYHL046C mGDS1 mKSP1 mPSY2 mSTD1
this is an automaticly generated SAMBA report
Computational Genomics Lab, Tel-Aviv uniresity