Module number 2292




Database revision : gnsdb28.10
Date : Tue Feb 25 17:16:44 2003
How to read this figure?


mYMR316C-A:Unknown ,, Unknown\n Cond663:mec1_plus_gamma_10_min\n mCTP1:citrate transport protein,citrate tranporter,Null mutant is \nviable\n mRPI1:inhibitor of ras,ras inhibitor,Null mutant is viable but sho\nws heat-shock sensitivity\n mBRE4:Product of gene unknown,,null mutant is sensitive to brefeld\nin A\n mSEC31:involved in protein transport from endoplasmic reticulum to \nGolgi,COPII coat of secretory pathway vesicles component (p1\n50),Null mutant is inviable\n mHNT1:Hint homolog, member of the histidine triad superfamily of n\nucleotide-binding proteins,,\n mYDR492W:Unknown ,, Unknown\n mFET5:ferrous iron transport,multicopper oxidase , type 1 integral\n membrane protein,overexpression of FET5 suppresses a fet3 n\null mutant.\n Cond679:DES460(wt)_vs._DES459(mec1)_genomic_DNA_comparison\n mMUP3:methionine uptake,very low affinity methionine permease,\n mYMR325W:Unknown ,, Unknown\n mAZR1:MFS-MDR,,\n mRGM1:Putative transcriptional repressor with proline-rich zinc fi\nngers,transcriptional repressor with proline-rich zinc finge\nrs (putative),Null mutant is viable; overexpression of RGM1 \ngreatly impairs cell growth.\n mYDR391C:Unknown ,, Unknown\n mASP1:Asparaginase I, intracellular isozyme,asparaginase I , intra\ncellular isozyme,Aspartic acid requiring\n mGIC2:Gtpase-interacting component 2,,Null mutant is viable and te\nmperature sensitive at 37 degrees C; gic1 gic2 double null i\ns temperature sensitive at 33 degrees C\n mSCS7:Required for the hydroxylation of the very long chain fatty \nacid (VLCFA), located in the endoplasmic reticulum,desaturas\ne , hydroxylase,Null mutant is viable, suppresses the Ca2+-s\nensitive phenotype of csg2 delta mutants\n mHEX3:Protein involved in hexose metabolism,,null is synthetically\n lethal with sgs1 null\n mYPL013C:Unknown ,, Unknown\n mYBR238C:Unknown ,, Unknown\n mYFL063W:Unknown ,, Unknown\n mYDR275W:Unknown ,, Unknown\n Cond668:mec1_plus_gamma_90_min\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mYJL038C:Unknown ,, Unknown\n mDAN2:Delayed anaerobic gene,putative cell wall protein,unknown\n mPAM1:multicopy suppressor of protein phosphatase 2A,,Multicopy PA\nM1 suppresses loss of protein phosphatase 2A (PP2A, encoded \nby PPH21, PPH21, and PPH3); overexpression of PAM1 inhibits \ngrowth and causes a filamentous phenotype\n mRTN1:Unknown ,, Unknown\n mYMR181C:Unknown ,, Unknown\n mPEX7:May serve as intraperoxisomal receptor for type 2 peroxisoma\nl proteins (such as thiolase),beta-transducin-related (WD-40\n) protein family,Mutant is defective in assembling specific \nproteins into peroxisomes (assembles catalase and acyl-CoA o\nxidase but not thiolase) and cannot utilize oleic acid\n mGAT1:activator of transcription of nitrogen-regulated genes; inac\ntivated by increases in intracellular glutamate levels,trans\ncriptional activator with GATA-1-type Zn finger DNA-binding \nmotif,Null mutant is viable. Required for expression of nitr\nogen catabolite repression-sensitive genes\n mYDR247W:Unknown ,, Unknown\n mYDR094W:Unknown ,, Unknown\n mSTP3:Involved in pre-tRNA splicing and in uptake of branched-chai\nn amino acids,,\n mSTP4:Involved in pre-tRNA splicing and in uptake of branched-chai\nn amino acids,,\n mYDR219C:Unknown ,, Unknown\n mYOR081C:Unknown ,, Unknown\n mSSD1:Product of gene unknown,,Suppressor of regulatory subunit of\n protein kinase\n mYDR095C:Unknown ,, Unknown\n mYLR159W:Unknown ,, Unknown\n mYPL014W:Unknown ,, Unknown\n mYDL187C:Unknown ,, Unknown\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mTPO2:Unknown ,, Unknown\n mTPO3:Unknown ,, Unknown\n mYDR459C:Unknown ,, Unknown\n mYDL129W:Unknown ,, Unknown\n mNPL3:involved as a protein carrier in mRNA export, involved in mi\ntochondrial protein targeting,contains RNA recognition motif\n , nuclear shuttling protein , contains RNA recognition moti\nf , nuclear shuttling protein , contains RNA recognition mot\nif , nuclear shuttling protein,Null mutant is inviable, npl3\n mutants are temperature-sensitive for growth, but do not ex\nhibit a defect in localization of nuclear proteins\n mECM18:ExtraCellular Mutant,,A Tn3 insertion into this gene causes \nhypersensitivity to the cell surface polymer perturbing agen\nt calcofluor white.\n mYLR297W:Unknown ,, Unknown\n mYNL144C:Unknown ,, Unknown\n mYDL071C:Unknown ,, Unknown\n mYER067W:Unknown ,, Unknown\n mHRK1:Unknown ,, Unknown\n mYGR054W:Unknown ,, Unknown\n mYDR445C:Unknown ,, Unknown\n mARN1:Product of gene unknown,,\n mYDR401W:Unknown ,, Unknown\n mYIL177C:Unknown ,, Unknown\n mSEC61:membrane component of ER protein translocation apparatus,,Nu\nll mutant is inviable. Conditional alleles are defective for\n protein translocation and the export of misfolded proteins \nfrom the endoplasmic reticulum at the restrictive temperatur\ne.\n mYDR111C:Unknown ,, Unknown\n mAGP1:broad substrate range permease which transports asparagine a\nnd glutamine with intermediate specificity,amino acid permea\nse,Null mutant is viable; resistant to the amino acid analog\n gamma-hydroxyaspartate, decreased growth on asn, gln and so\nme other amino acids in strains in which Gap1 and Gnp1 are a\nlso missing.\n mSAT4:Protein with similarity to Npr1p protein kinase,,\n mNRG1:involved in regulation of glucose repression,binds to UAS-1 \nin the STA1 promoter and can interact with Ssn6p , transcrip\ntional repressor,Null mutant is viable, relieves glucose rep\nression of SUC2 and STA1; suppresses snf mutations\n mISR1:Inhibition of staurosporine resistance,protein kinase,The nu\nll mutant is viable but exacerbates the phenotypes of a temp\nerature-sensitive allele (stt1-1) of PKC1.\n mYDR387C:Unknown ,, Unknown\n Cond664:mec1_plus_gamma_20_min\n mYDL173W:Unknown ,, Unknown\n mHAP4:Regulates respiratory functions; encodes divergent overlappi\nng transcripts,transcriptional activator protein of CYC1 (co\nmponent of HAP2/HAP3 heteromer),\n mNOP1:nucleolar protein, homologous to mammalian fibrillarin,nucle\nolar protein , similar to mammalian fibrillarin,Null mutant \nis inviable. Temperature-sensitive alleles exhibit various d\nefects in rRNA processing.\n mTOS8:Hypothetical ORF,,\n mYGL045W:Unknown ,, Unknown\n mYDR344C:Unknown ,, Unknown\n mYJL171C:Unknown ,, Unknown\n mECM3:ExtraCellular Mutant,,A Tn3 insertion into this gene causes \nhypersensitivity to the cell surface polymer perturbing agen\nt calcofluor white.\n mIPT1:necessary for synthesis of mannose-(inositol-P)2-ceramide (M\n(IP)2C),inositolphosphotransferase 1,Null mutant is viable b\nut cannot synthesize M(IP)2C, instead accumulates the precur\nsor, mannose-inositol-P-ceramide, and is slightly resistant \nto calcium\n mYDR119W:Unknown ,, Unknown\n mYDR105C:Unknown ,, Unknown\n Cond680:DES460(wt)_vs._DES459(mec1)_genomic_DNA_comparison_,\n2\n Cond669:mec1_plus_gamma_120_min\n mMTH1:Negative regulator of HXT gene expression,Msn3p homolog (61%\n identical),Null mutant is viable; mth1(htr1) mutants are de\nficient in glucose update and transcription of glucose trans\nporters; mth1 (htr1) mutation suppresses glucose sensitivity\n of tpi1 mutant; multicopy expression of HXT genes suppresse\ns some defects of mth1 (htr1) mutants; msn3 mth1 double dele\ntion mutants are impaired in derepression of invertase in re\nsponse to glucose limitation\n mTFP1:Encodes a protein with three regions (ABC) that is spliced t\no yield the extein AC & the intein B; AC is a 69K vacuolar (\nH+)-ATPase & B is a 50K site-specific endonuclease named VDE\n (PI-SceI) that is homologous to HO,protein with three regio\nns (ABC) that are spliced to yield the extein AC and the int\nein B; AC is a 69K vacuolar (H+)-ATPase, and B is a 50K site\n-specfic endonuclease named VDE (PI-SceI) that is homologous\n to HO. Cleavage is meiosis-specific and induces gene conver\nsion at the TFP1 locus. , site-specific endonuclease VDE (PI\n-SceI) , vacuolar ATPase V1 domain subunit A (69 kDa) , prot\nein with three regions (ABC) that are spliced to yield the e\nxtein AC and the intein B; AC is a 69K vacuolar (H+)-ATPase,\n and B is a 50K site-specfic endonuclease named VDE (PI-SceI\n) that is homologous to HO. Cleavage is meiosis-specific and\n induces gene conversion at the TFP1 locus. , site-specific \nendonuclease VDE (PI-SceI) , vacuolar ATPase V1 domain subun\nit A (69 kDa),Null mutant is viable, resistant to trifluoper\nazine, grows slowly under non-acidic conditions and on glyce\nrol and is cold, temperature, and cation-sensitive\n mHEM1:First enzyme in heme biosynthetic pathway,5-aminolevulinate \nsynthase,Null mutant is viable; auxotroph for heme and methi\nonine\n mYLR125W:Unknown ,, Unknown\n mCMK2:Calmodulin-dependent protein kinase,calmodulin-dependent pro\ntein kinase,Null mutant is viable, exhibits slow rate of spo\nre germination\n mAAT2:aspartate aminotransferase, cytosolic,aspartate aminotransfe\nrase,\n mYDR112W:Unknown ,, Unknown\n mSTD1:interacts with the SNF1 protein kinase and TBP in two-hybrid\n and in in vitro binding studies,MTH1 homolog,Null mutant is\n viable, no defects in mating or sporulation. Suppressor of \nTBP deletion; multicopy suppressor of SNF; std1-mth1 has def\nective glucose derepression and sporulation\n mMIR1:Product of gene unknown,,Null mutant is viable on glucose co\nntaining media, but is unable to grow on a non-fermentable c\narbon source, shows reduced levels of mitochondrial proteins\n mYHR130C:Unknown ,, Unknown\n mYGL199C:Unknown ,, Unknown\n mYDR185C:Unknown ,, Unknown\n mHEM13:Oxygen-repressed, sixth step in heme biosynthetic pathway,co\nproporphyrinogen III oxidase,Null mutant is viable; auxotrop\nh for heme and methionine\n mHOG1:osmoregulation,MAP kinase,Null mutant is viable and unable t\no grow in high osmolarity media\n mYDL023C:Unknown ,, Unknown\n mUTH1:Youth, involved in determining yeast longevity,,extension of\n yeast lifespan\n mYPS7:Gpi-anchored aspartic protease (Yapsin 7),GPI-anchored aspar\ntic protease,\n mKES1:Homologous to human oxysterol-binding protein; implicated in\n ergosterol biosynthesis and regulation of Golgi-derived tra\nnsport vesicle biogenesis,,Pleiotropic sterol-related phenot\nypes\n mYDR229W:Unknown ,, Unknown\n mHAC1:Transcription factor that is required for the unfolded prote\nin-response pathway; binds to CRE motif; homologous to ATF/C\nREB 1,bZIP (basic-leucine zipper) protein,Null mutant is via\nble but is sensitive to caffeine (suppressed by high-copy SR\nA5) and stresses that produce unfolded proteins. High-copy H\nAC1 suppresses S. pombe cdc10-129\n mENT4:epsin N-terminal homology-containing protein,,unknown\n mYKR046C:Unknown ,, Unknown\n mYDL183C:Unknown ,, Unknown\n mDBP2:ATP-dependent RNA helicase of DEAD box family,ATP dependent \nRNA helicase , dead box protein,Null mutant is inviable\n mSTE5:Protein of the pheromone pathway,,Null mutant is viable but \nsterile. Overexpression of STE5 suppresses the temperature s\nensitivity of a cdc25 allele.\n Cond666:mec1_plus_gamma_45_min\n mYPR202W:Unknown ,, Unknown\n mYER158C:Unknown ,, Unknown\n mYDR455C:Unknown ,, Unknown\n mYKR075C:Unknown ,, Unknown\n mSNF11:component of SWI/SNF global transcription activator complex,\nSWI/SNF global transcription activator complex component,\n mUGX2:Product of gene unknown,,\n mYNL234W:Unknown ,, Unknown\n mYDR491C:Unknown ,, Unknown\n mYIL056W:Unknown ,, Unknown\n Cond667:mec1_plus_gamma_60_min\n mRGS2:Regulator of G-protein Signalling for gpa2; belongs to the R\nGS protein family and acts on Gpa2,GTPase activating protein\n (GAP),Null mutant is viable but exhibits high PKA phenotype\ns (low trehalose and glycogen levels, heat sensitivity, low \nexpression of HSP12). Overexpression results in low PKA phen\notypes and suppresses the glucose induced cAMP signal.\n mYDR157W:Unknown ,, Unknown\n mYHL012W:Unknown ,, Unknown\n mTPS2:Trehalose-6-phosphate phosphatase,trehalose-6-phosphate phos\nphatase,Null mutant is viable, exhibits complete loss of tre\nhalose-6-phosphate phosphatase activity, measured in vitro, \nand accumulation of excessive amounts of trehalose-6-phospha\nte instead of trehalose upon heat shock or entrance into sta\ntionary phase in vivo; null mutant is temperature sensitive,\n tps2 (pfk3) pfk1 double mutants are glucose negative\n mYGL193C:Unknown ,, Unknown\n mSSA2:member of 70 kDa heat shock protein family,HSP70 family,Null\n mutant is viable, temperature sensitive; ssa1 ssa2 ssa4 str\nains are inviable; an intact copy of SSA3 regulated by the c\nonstitutive SSA2 promoter is capable of rescuing the inviabi\nlity of an ssa1 ssa2 ssa4 strain\n mPCL9:PHO85 cyclin,,Null mutant is viable.\n mISF1:May regulate NAM7 function, possibly at level of mRNA turnov\ner,,Null mutant is viable; overexpression suppresses defects\n in hap2, hap3, and hap3 mutants; isf1 mbr1 double mutant ha\ns synthetic phenotypes\n mYGR022C:Unknown ,, Unknown\n mSUR1:Involved in maintenance of phospholipid levels,integral memb\nrane protein , similar to YBR161w, Hoc1p, and Och1p , integr\nal membrane protein , similar to YBR161w, Hoc1p, and Och1p ,\n integral membrane protein , similar to YBR161w, Hoc1p, and \nOch1p,Null mutant is viable, calcium sensitive at 37 degrees\n C on YPD but calcium tolerant at 26 degrees C, accumulates \ngreatly reduced levels of several mannosylated sphingolipids\n; sur1 mutations have been isolated based on their ability t\no suppress certain phenotype of rvs161 mutants including red\nuced viability upon starvation and sensitivies to unrelated \ndrugs; SUR1 is a high copy suppressor of the calcium sensiti\nvity of csg2 mutants\n mSUR2:Suppressor of rvs161 and rvs167 mutations,sphingosine hydrox\nylase,Null mutant is viable, has altered phospholipid levels\n mHXT1:High-affinity hexose (glucose) transporter,high affinity hex\nose (glucose) transporter,Null mutant is viable\n mHXT3:Low-affinity glucose transporter,low affinity glucose transp\norter,Null mutant is viable but grows slowly on galactose; s\nome mutant alleles confer sodium hypersensitivity.\n mDSE2:Hypothetical ORF,,\n mGPD1:glycerol-3-phosphate dehydrogenase,glycerol-3-phosphate dehy\ndrogenase,lethal under conditions of osmotic stress, unable \nto grow on glycerol\n mHXT5:Member of superfamily of monosaccharide transporters,hexose \ntransporter,Null mutant is viable\n mYDR223W:Unknown ,, Unknown\n mYDL133W:Unknown ,, Unknown\n mHSP42:Similar to HSP26; expression is regulated by stress conditio\nns,,Null mutant is viable; hsp42 hsp26 double deletion mutan\nts are viable; hsp42 null mutants subjected to moderate ther\nmal stress reorganize the actin cytoskeleton more slowly tha\nn wild-type\n mSNA4:Unknown ,, Unknown\n mHAL5:Protein kinase homolog, mutant is salt and pH sensitive,,\n Cond665:mec1_plus_gamma_30_min\n mHTB2:Histone H2B (HTB1 and HTB2 code for nearly identical protein\ns),histone H2B (HTB1 and HTB2 code for nearly identical prot\neins),Null mutant is viable. Deletion of the HTA2-HTB2 (TRT2\n) locus has no reported observable phenotypes, presumably be\ncause HTA1-HTB1 (TRT1) expression is upregulated and can com\npensate in the absence of TRT2\n mHTB2 mYGR054W mNPL3
this is an automaticly generated SAMBA report
Computational Genomics Lab, Tel-Aviv uniresity