Module number 2199




Database revision : gnsdb28.10
Date : Tue Feb 25 17:13:16 2003
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Cond899:RPN4_MMS__\n mERG10:acetoacetyl CoA thiolase,acetoacetyl CoA thiolase,Nul mutant\n is inviable; other mutants are ergosterol biosynthesis defe\nctive or nystatin resistant\n mCOX13:Modulates cytochrome c oxidase activity,cytochrome c oxidase\n subunit VIa , may specifically interact with ATP,Null mutan\nt is viable, shows slightly reduced growth rate on nonfermen\ntable carbon sources\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n mERG13:involved in mevalonate synthesis,3-hydroxy-3-methylglutaryl \ncoenzyme A synthase,\n Cond878:MNNG\n Cond895:G2MMS\n mHYP2:Translation initiation factor eIF-5A,translation initiation \nfactor eIF-5A,Null mutant is viable; a double mutant contain\ning disruptions of both HYP2 and and the highly homologous A\nNB1 is inviable\n Cond649:dun1-_+_0.02%_MMS_-_120_min\n Cond879:MMC\n mNDE1:Unknown ,, Unknown\n mRPB10:RNA polymerase II subunit,RNA polymerase II core subunit,Nul\nl mutant is inviable\n mANB1:hypusine containg protein; ANB1 is expressed under anaerobic\n conditions and repressed under aerobic conditions whereas i\nts homolog HYP2 is inversely regulated,translation initiatio\nn factor eIF-5A, anaerobically expressed form,null mutant is\n viable; a double mutant containing disruptions of both ANB1\n and and the highly homologous HYP2 is inviable\n Cond385:Hypo-osmotic_shock_-_15_min\n Cond644:DES459_(mec1-)_+_0.02%_MMS_-_60_min\n Cond877:MMS\n mSCM4:Protein that suppresses ts allele of CDC4 when overexpressed\n,,viable, suppressor of cdc4ts allele\n Cond875:60min\n mYDR492W:Unknown ,, Unknown\n Cond642:DES459_(mec1-)_+_0.02%_MMS_-_30_min\n Cond648:dun1-_+_0.02%_MMS_-_90_min\n Cond647:dun1-_+_0.02%_MMs_-_30_min\n mDBP3:ATP-dependent RNA helicase CA3 of the DEAD/DEAH box family,A\nTP dependent RNA helicase , dead/deah box protein CA3,Null m\nutant is viable\n Cond886:g-ray\n mERG1:Squalene monooxygenase,squalene monooxygenase,Null mutant is\n inviable when cells are grown under aerobic conditions; erg\n1 null mutants are viable under anaerobic conditions during \nwhich ergosterol is taken up by the cells\n mERG2:sterol biosynthesis,C-8 sterol isomerase,Null mutant is viab\nle\n Stress.HypoOsmot:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mYNL211C:Unknown ,, Unknown\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mCOX5A:One of two genes (COX5A and COX5B, both nuclear-encoded) cod\ning for subunit V of cytochrome c oxidase; COX5A gene produc\nt is the predominantform of subunit V found in holocytochrom\ne c oxidase under normal growth conditions,cytochrome c oxid\nase chain Va,Null mutant is viable, respires at 10-15% of th\ne wild-type rate due to the presence of COX5B; cox5a cox5b d\nouble deletion mutants are completely non-respiratory\n mERG5:cytochrome P450 involved in C-22 denaturation of the ergoste\nrol side-chain,cytochrome P450 , involved in C-22 denaturati\non of the ergosterol side-chain,Null mutant is viable\n mRPL35A:Homology to rat L35,ribosomal protein L35A,Null mutant is vi\nable.\n Cond883:5\n mMVD1:involved in the polyisoprene biosynthesis pathway,mevalonate\n pyrophosphate decarboxylase,Null mutant is inviable; a sing\nle leucine to proline mutation causes temperature sensitivit\ny.\n mERG7:carries out complex cyclization step of squalene to lanoster\nol in sterol biosynthesis pathway,2,3-oxidosqualene-lanoster\nol cyclase,Null mutant is inviable\n mCYB5:cytochrome b5,cytochrome b5,Null mutant is viable, cyb5 muta\ntions suppress ketoconazole hypersensitivity of a P450 reduc\ntase deficient strain\n Cond637:DES460_+_0.02%_MMS_-_60_min\n Cond876:zero2\n Cond890:G1\n Cond634:DES460_+_0.02%_MMS_-_15_min\n Cond885:20\n Cond889:4NQO_2\n Cond645:DES459_(mec1-)_+_0.02%_MMS_-_90_min\n Cond891:G1MMS\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond638:DES460_+_0.02%_MMS_-_90_min\n Cond881:4NQO\n Cond624:DY1457_(wild_type)_3_mM_vs._10_uM_zinc_y13-75\n Cond894:G2\n Cond635:DES460_+_0.02%_MMS_-_30_min\n mHMG1:3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase is\nozyme,3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reduct\nase isozyme,Null mutant is viable, sensitive to compactin, a\n competitive inhibitor of HMG-CoA reductase; hmg1 hmg2 doubl\ne deletion mutants are inviable\n Cond636:DES460_+_0.2%_MMS_-_45_min\n zap1.Series0:Genome-wide characterization of the Zap1p zinc-responsive re\ngulon in yeast. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14)\n:7957-62.\n Cond639:DES460_+_0.02%_MMS_-_120_min\n mYOL002C:Unknown ,, Unknown\n mHMX1:Unknown ,, Unknown\n Cond643:DES459_(mec1-)_+_0.02%_MMS_-_45_min\n Cond893:SMMS\n mGUA1:GMP synthase,GMP synthase,Null mutant is viable but is a gua\nnine auxotroph\n Cond641:DES459_(mec1-)_+_0.02%_MMS_-_15_min\n Cond646:DES459_(mec1-)_+_0.02%_MMS_-_120_min\n mIDI1:catalyzes activation step in isoprenoid biosynthetic pathway\n,isopentenyl diphosphate:dimethylallyl diphosphate isomerase\n (IPP isomerase),Null mutant is inviable\n Cond884:10\n
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Computational Genomics Lab, Tel-Aviv uniresity