Module number 2150




Database revision : gnsdb28.10
Date : Tue Feb 25 17:05:09 2003
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mSBH2:Ssh1p-Sss1p-Sbh2p complex component, involved in protein tra\nnslocation into the endoplasmic reticulum,Sbh1p homolog,Null\n mutant is viable. sbh1 sbh2 double deletion mutants exhibit\n synthetic temperature sensitivity and accumulation of secre\ntory protein precursors\n mYHR049C-A:Unknown ,, Unknown\n mCOX12:essential during assembly for full cytochrome c oxidase acti\nvity,cytochrome c oxidase subunit VIb,Null mutant is viable,\n grows poorly at room temperature, fails to grow on glycerol\n/ethanol media at 37 degrees\n mTHO1:Suppressor of the Transcriptional (T) defect of Hpr1 (H) by \nOverexpression (O),,Null mutant is viable; wild-type levels \nof transcription and recombination; overexpression of THO1 s\nuppresses the temperature-sensitive phenotype of hpr1-delta \nmutants and their incapacity to transcribe lacZ sequences.\n mYML059C:Unknown ,, Unknown\n Cond901:(11i2)_HBY4_YPGL_NormInt\n mSSS1:involved in transfer of secretory precursors through the end\noplasmic reticulum membrane,ER protein , Sec61 trimeric comp\nlex component , Ssh1 trimeric complex component,Null mutant \nis inviable. Depletion of the Sss1 protein rapidly results i\nn accumulation of multiple secretory or membrane proteins de\nvoid of post-translational modifications. SSS1 overexpressio\nn restores translocation in sec61 mutants.\n mSKP1:Involved in kinetochore function and ubiquitin-mediated prot\neolysis,,Null mutant is inviable, temperature-sensitive muta\ntions in SKP1 arrest in G1 or G2\n Pho85.pho85:Chemical inhibition of the Pho85 cyclin-dependent kinase rev\neals a role in the environmental stress response. Proc Natl\n Acad Sci U S A. 2001 Oct 23;98(22):12578-83.\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n GCR1.gcr1:Understanding the growth phenotype of the yeast gcr1 mutant \nin terms of global genomic expression patterns. J Bacteriol\n. 2000 Sep;182(17):4970-8.\n mYER030W:Unknown ,, Unknown\n mYAL045C:Unknown ,, Unknown\n mCBC2:cap binding complex,nuclear cap binding complex subunit,muta\nnts exhibit promiscuous 3'-end formation; sae-1 mutation cau\nses temporary cell cycle arrest in meiotic prophase\n Cond806:crz1/Ca15'\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mENO1:enolase I,enolase I,Null mutant is viable\n mPDI1:protein disulfide isomerase,protein disulfide isomerase,Null\n mutant is inviable\n mRPL37A:Homology to rat L37,ribosomal protein L37A (L43) (YL35),\n mYJL055W:Unknown ,, Unknown\n mYPT7:Gtp-binding protein of the rab family; required for homotypi\nc fusion event in vacuole inheritance, for endosome-endosome\n fusion, and for fusion of endosomes to vacuoles when expres\nsed from high copy plasmid,GTP-binding protein , rab family \n, GTP-binding protein , rab family,Null mutant is viable, ch\naracterized by highly fragmented vacuoles and differential d\nefects of vacuolar transport and maturation\n mTFP3:vacuolar ATPase V0 domain subunit c' (17 kDa),vacuolar ATPas\ne V0 domain subunit c' (17 kDa) , vacuolar H(+) ATPase 17 kD\na subunit C , vacuolar ATPase V0 domain subunit c' (17 kDa) \n, vacuolar H(+) ATPase 17 kDa subunit C,Null mutant is viabl\ne, defective in vacuolar acidification, high copy TFP3 confe\nrs resistance to trifluoperazine\n mHHF2:Histone H4 (HHF1 and HHF2 code for identical proteins),histo\nne H4 (HHF1 and HHF2 code for identical proteins),\n Cond974:WT_vs_F82G_2\n Cond:\n mCSN9:Unknown ,, Unknown\n mLSM7:Like Sm-G protein,snRNP protein,Null mutant is viable but gr\nows slowly at 23deg and 30deg, and is required for growth at\n 37deg\n Cond975:WT_1_mM_1NaPP1\n mYDR056C:Unknown ,, Unknown\n mARC15:Arp complex subunit,,Null mutant is viable, but exhibits sev\nere growth defects\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond587:cdc15_220\n mCAP2:capping - addition of actin subunits,capping protein beta su\nbunit,Null mutant is viable, exhibits abnormal actin distrib\nution (including loss of actin cables); round, large cells w\nith heterogeneous size distribution; slower growing; chitin \nfound over entire mother cell surface rather than restricted\n to the mother-bud junction\n mYPR063C:Unknown ,, Unknown\n Calcin.crz1:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n mSHG1:YBR258C,,\n mFCY1:cytosine deaminase highly homologous to Candida albicans cyt\nosine deaminase,cytosine deaminase,Mutant is resistant to 5-\nfluorocytosine and shows total loss of cytosine deaminase ac\ntivity\n mSAR1:Secretion-Associated, Ras-related. Component of COPII coat o\nf vesicles; required for ER to Golgi protein transport,ARF f\namily , GTP-binding protein,Null mutant is inviable. When ov\nerexpressed, wild-type SAR1 suppresses a sec12 mutation.\n mYPT52:rab5-like GTPase involved in vacuolar protein sorting and en\ndocytosis,,Null mutant is viable; ypt51 ypt52 double deletio\nn exacerbates the temperature sensitivity and vacuolar prote\nin sorting defects of ypt51 deletion\n mYDR230W:Unknown ,, Unknown\n Cond973:WT_vs_F82G_1\n Cell Cycle.cdc15:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion. Mol Biol Cell. 1998 Dec;9(12):3273-97.\n mTOM20:Translocase of Outer Mitochondrial membrane,20 kDa mitochond\nrial outer membrane protein import receptor,Null mutant is v\niable but respiration deficient; defective in import of mito\nchondrial preproteins\n Cond672:DES459_(mec1)_-_mock_irradiation_-_60_min\n Cond671:DES459_(mec1)_-_mock_irradiation_-_30_min\n Cond749: fkh1,2sf.Series0:Two yeast forkhead genes regulate the cell cycle and pseudoh\nyphal growth. Nature. 2000 Jul 6;406(6791):90-4.\n mHTB1:Histone H2B (HTB1 and HTB2 code for nearly identical protein\ns),histone H2B (HTB1 and HTB2 code for nearly identical prot\neins),Null mutant is viable\n mRET3:vesicle coat component,vesicle coat component,ret3-1 mutant \nis thermosensitive and shows defects in retrieval of dilysin\ne-tagged proteins from the Golgi back to the ER\n mYJL152W:Unknown ,, Unknown\n
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Computational Genomics Lab, Tel-Aviv uniresity