Module number 213




Database revision : gnsdb28.10
Date : Tue Feb 25 17:24:50 2003
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mYGR269W:Unknown ,, Unknown\n mMAF1:Mod5 protein sorting,,Mislocalizes Mod5p to the nucleus\n mYNL319W:Unknown ,, Unknown\n mYMR316C-A:Unknown ,, Unknown\n mCIN2:involvement in microtubule function,tubulin folding cofactor\n C,Null mutant is viable but shows supersensitivity to benom\nyl and nocodazole, cold sensitivity, defects in karyogamy, a\nnd increased rates of chromosome loss; shows genetic interac\ntion with tubulin mutations\n mBNI4:bud neck involved,required to link Chs3p and Chs4p to the se\nptins,Null mutant is viable, shows delocalized chitin, elong\nated buds, enlarged bud necks\n mAPM2:homologous to the medium chain of mammalian clathrin-associa\nted protein complex,,Null mutant is viable\n mPUF4:member of the PUF protein family,,\n mYDR031W:Unknown ,, Unknown\n mSDL1:L-serine dehydratase,L-serine dehydratase,\n mATX1:antioxidant protein and metal homeostasis factor, protects a\ngainst oxygen toxicity,copper binding homeostasis protein (p\nutative),hypersensitive toward paraquat (a generator of supe\nroxide anion)\n mFYV2:Function required for Yeast Viability on toxin exposure,,K1 \nkiller toxin hypersensitivity\n mELM1:cell morphology,protein kinase,formation of expanded, branch\ned chains of elongated cells; grow invasively under the surf\nace of agar medium\n mYJR097W:Unknown ,, Unknown\n mSSF2:high copy suppressor of G beta subunit temperature sensitive\n mutation,,Null mutant is viable; displays double mutant let\nhality with ssf1 null mutations. Ssfp depletion is associate\nd with arrest of cell division and decreased mating\n mFET4:Putative transmembrane low-affinity Fe(II) transporter,low a\nffinity Fe2+ transport protein,Mutant lacks low affinity Fe(\nII) transport but has more active high affinity Fe(II) trans\nport activity\n mSMA1:Spore Membrane Assembly,,undergoes meiotic nuclear divisions\n but does not form spores\n mYPR077C:Unknown ,, Unknown\n mYDR119W:Unknown ,, Unknown\n mBUL2:a homologue of BUL1,,Null mutant is viable; the bul1 bul2 do\nuble disruptant is sensitive to various stresses\n mCOT1:Protein involved in cobalt accumulation; dosage dependent su\nppressor of cobalt toxicity,,Null mutant is viable, yet incr\neased sensitivity to cobalt\n mYMR057C:Unknown ,, Unknown\n mZRC1:Zinc- and cadmium-resistance protein,,Null mutant is viable \nand sensitive to zinc\n mNCR1:Niemann-Pick Type C homologous gene,transmembrane protein (p\nutative),Null mutant is viable.\n mSPS4:sporulation-specific protein,,normal sporulation\n mCUP1-2:copper-binding metallothionein,copper binding metallothionei\nn,Copper resistance\n mSPO74:Protein involved in sporulation,,undergoes meiotic nuclear d\nivisions but does not form spores\n mJNM1:coiled-coil domain protein required for proper nuclear migra\ntion during mitosis (but not during conjugation),,Null mutan\nt is viable but is cold-sensitive\n mYEL059W:Unknown ,, Unknown\n Mating.Mating:Signaling and circuitry of multiple MAPK pathways revealed b\ny a matrix of global gene expression profiles. Science. 200\n0 Feb 4;287(5454):873-80\n mSMM1:Suppressor of Mitochondrial Mutation in the tRNAasp gene; Di\nhydrouridine synthase 2,tRNA dihydrouridine synthase,Overexp\nression weakly suppresses a mutation affecting the maturatio\nn of mitochondrial tRNA-Asp.\n mMAK3:N-acetyltransferase,N-acetyltransferase,deficient in mainten\nance of killer\n mYDR112W:Unknown ,, Unknown\n mDPH2:Diptheria toxin resistance protein, required for diphthamide\n biosynthesis,,Null mutant is viable\n mJEM1:DnaJ-like protein of the endoplasmic reticulum membrane,,Nul\nl mutant is viable but has karyogamy defect; jem1 scj1 doubl\ne mutant is temperature sensitive\n mGOT1:Golgi Transport,membrane protein,Null mutant is viable but e\nxhibits ER to Golgi transport defects in vitro. got1 is synt\nhetically lethal with mutations in sft2; the got1 sft2 doubl\ne mutant exhibits defects in transport to the Golgi complex.\n mDPH5:diphthamide biosynthesis,,Null mutant is viable\n mVID24:also involved in vacuolar protein targeting,peripheral vesic\nle membrane protein,Null mutant is viable, defective in fruc\ntose-1,6-bisphosphatase dergadation\n mOYE3:Old yellow enzyme,NADPH dehydrogenase,\n mPPR1:Positive regulator of URA1 and URA3,zinc finger transcriptio\nn factor of the Zn(2)-Cys(6) binuclear cluster domain type,N\null mutant is viable, deficient in pyrimidine biosynthetic p\nathway\n mYLR108C:Unknown ,, Unknown\n mYDR221W:Unknown ,, Unknown\n mHOG1:osmoregulation,MAP kinase,Null mutant is viable and unable t\no grow in high osmolarity media\n mTAT2:Tryptophan permease, high affinity,tryptophan permease, high\n affinity,suppressor of chromosome segregation mutation\n mOKP1:Unknown ,, Unknown\n mYMR306C-A:Unknown ,, Unknown\n mYMR029C:Unknown ,, Unknown\n mGIS2:GIG3 suppressor,,\n mYOR055W:Unknown ,, Unknown\n mYCL076W:Unknown ,, Unknown\n mRCK1:Serine/threonine protein kinase,,Null mutant is viable\n mRCK2:Serine/threonine protein kinase,,Null mutant is viable\n Cond528:ste18D/wtlog10(intensity)\n mENT5:Unknown ,, Unknown\n mYDL038C:Unknown ,, Unknown\n mYOL046C:Unknown ,, Unknown\n mYIL012W:Unknown ,, Unknown\n mYIL172C:Unknown ,, Unknown\n mYMR102C:Unknown ,, Unknown\n mYBR071W:Unknown ,, Unknown\n mYLR137W:Unknown ,, Unknown\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mANB1:hypusine containg protein; ANB1 is expressed under anaerobic\n conditions and repressed under aerobic conditions whereas i\nts homolog HYP2 is inversely regulated,translation initiatio\nn factor eIF-5A, anaerobically expressed form,null mutant is\n viable; a double mutant containing disruptions of both ANB1\n and and the highly homologous HYP2 is inviable\n mPTK1:Putative serine/threonine protein kinase,,Mutant shows decre\nase in total polyamine accumulation and resistance to polyam\nine analogs; ptk1 ptk2 double mutant shows virtually abolish\ned high-affinity spermidine transport\n mYBR235W:Unknown ,, Unknown\n mPRM7:pheromone-regulated membrane protein,,\n mBOP2:bypass of PAM1,,\n mYNL089C:Unknown ,, Unknown\n mSEO1:Suppressor of Sulfoxyde Ethionine resistance,permease (putat\nive),\n mLYP1:lysine permease,lysine permease,\n mYNL122C:Unknown ,, Unknown\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mGIT1:permease involved in the uptake of glycerophosphoinositol (G\nroPIns),permease involved in the uptake of glycerophosphoino\nsitol (GroPIns),Null mutant is viable, exhibits decreased Gr\noPIns transport\n mYNL092W:Unknown ,, Unknown\n mOST5:Oligosaccharyltransferase catalyzes the transfer of oligosac\ncharide from a dolichol-oligosaccharide donor to consensus g\nlycosylation acceptor sites (asparagines) in newly synthesiz\ned proteins in ER lumen,oligosaccharyltransferase complex 9.\n5 kDa zeta subunit,\n mPPH3:protein phosphatase type 2A,protein phosphatase type 2A,Null\n mutant is viable, pph3 pph21 pph22 mutants are inviable\n mYOR325W:Unknown ,, Unknown\n mPCL6:PHO85 cyclin,,Null mutant is viable. A Ty insertion mutant e\nxhibits slow growth.\n mYPR064W:Unknown ,, Unknown\n mYDR314C:Unknown ,, Unknown\n mFCY21:identical to FCY2,purine-cytosine permease,\n mYOL093W:Unknown ,, Unknown\n mSBE22:functionally redundant and similar in structure to SBE2,,syn\nthetic lethal with sbe2 mutation\n mYGR022C:Unknown ,, Unknown\n mYBL012C:Unknown ,, Unknown\n mSHR5:Involved in RAS localization and palmitoylation,,Null mutant\n is viable; exhibits normal palmityltransferase activity in \nvitro and attenuates Ras function in cells with mutant Ras2 \nproteins that are not farnesylated or palmitoylated; shr5 mu\ntation originally isolated as suppressor of Ras function\n mSNL1:Suppressor of nup116-C lethal,18.3 kDa integral membrane pro\ntein,Null mutant is viable; SNL1 is a high copy suppressor o\nf nup116, gle2 and nic96 alleles\n Cond168:ste18(haploid)\n mYOL014W:Unknown ,, Unknown\n mDSE3:Hypothetical ORF,,\n mYPT53:Involved in vacuolar protein sorting and endocytosis,GTP-bin\nding protein , rab family,Null mutant is viable\n mCUE2:Unknown ,, Unknown\n mYGR058W:Unknown ,, Unknown\n mYMR244W:Unknown ,, Unknown\n mARN2:Siderophore transporter for triacetylfusarinine C,triacetylf\nusarinine C transporter,YHL047c disrupted cells are unable t\no take up and utilize iron from triacetylfusarinine C und fu\nsigen\n mELA1:similar to mammalian elongin A, interacts with elongin C,elo\nngin A transcription elongation factor,viable\n mRCE1:Protease involved in ras and a-factor terminal proteolysis,p\nrotease,Null mutant is viable, has defects in Ras localizati\non and signaling, and suppresses the activated phenotype of \nthe RAS2val19 allele\n mRER1:Protein involved in retention of membrane proteins, includin\ng Sec12p, in the ER; localized to Golgi, where it may functi\non in returning membrane proteins to the ER,,Null mutant is \nviable and shows mislocalization of transmembrane proteins t\nhat are normally retained in the early secretory compartment\ns\n mRGA2:contains a Rho-GAP domain and two LIM domains, similar to Rg\na1p and all known Rho-GAPs,Rho-GTPase Activating Protein,Nul\nl mutants are viable but increase the restrictive temperatur\ne of a cdc24-4 strain and increase the constitutive activati\non of the pheromone response pathway in conjungtion with mut\nations in RGA1 and BEM3; overexpression of RGA2 causes a dec\nrease in the restrictive temperature of a cdc42-1 strain\n mYDL050C:Unknown ,, Unknown\n mRCK1 mHOG1 mYGR058W mDSE3 mRCK2 mFET4
this is an automaticly generated SAMBA report
Computational Genomics Lab, Tel-Aviv uniresity