Module number 2100




Database revision : gnsdb28.10
Date : Tue Feb 25 17:43:36 2003
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Cond899:RPN4_MMS__\n mRPT5:Probable 26S protease subunit and member of the CDC48/PAS1/S\nEC18 family of ATPases,,Null mutant is inviable\n Cond368:dtt_480_min_dtt-2\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes.  Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n mYGR026W:Unknown ,, Unknown\n Cond896:STAT\n RapamycinHap.hap_ram:Rapamycin-modulated transcription defines the subset of nutr\nient-sensitive signaling pathways directly controlled by the\n Tor proteins.  Proc Natl Acad Sci U S A. 1999 Dec 21;96(26)\n:14866-70.\n Cond649:dun1-_+_0.02%_MMS_-_120_min\n Cond887:t-BuOOH\n Cond711:t2+Vec\n GCR1.gcr1:Understanding the growth phenotype of the yeast gcr1 mutant \nin terms of global genomic expression patterns.  J Bacteriol\n. 2000 Sep;182(17):4970-8.\n mMUP1:high affinity methionine permease,high affinity methionine p\nermease,Null mutant is viable but cannot perform high-affini\nty methionine update.\n Cond440:DBYmsn2msn4_(good_strain)_+_0.32_mM_H2O2\n mSTV1:Stv1p and Vph1p may be equivalent subunits for vacuolar-type\n H(+)-ATPases located on different organelles,110 kDa subuni\nt; not in vacuole membrane , vacuolar H-ATPase,Null mutant i\ns viable, displays additive phenotypes in combination with v\nph1 null mutations\n Cond648:dun1-_+_0.02%_MMS_-_90_min\n Cond647:dun1-_+_0.02%_MMs_-_30_min\n Cond892:S\n Cond883:5\n Cond637:DES460_+_0.02%_MMS_-_60_min\n Stress.YPDStat:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond890:G1\n Cond872:Zero1\n Cond:\n Cond724:t4+SSD1,H44\n Stress.DTT2:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond713:t4+Vec\n Cond873:10min\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mCAP1:capping - addition of actin subunits,capping protein,Null mu\ntant is viable; severe deficit of actin cables and increased\n number of actin spots in the mother; round, relatively larg\ne cells\n Cond718:t4+SSD1wt\n Cond894:G2\n Cond635:DES460_+_0.02%_MMS_-_30_min\n mRPN1:Subunit of 26S Proteasome (PA700 subunit),26S proteasome PA7\n00 subunit,Null mutant is inviable; hrd2-1 mutation slows de\ngradation of Hmg2p. hrd2-1 strains are sensitive to canavani\nne and show a global accumulation of ubiquitin-conjugated pr\noteins, but are not temperature-sensitive\n mCLC1:Clathrin light chain,clathrin light chain,Null mutant is via\nble but slow-growing and shows defects in receptor-mediated \nendocytosis, maturation of alpha factor and levels of clathr\nin heavy chain (Chc1p); high copy suppresses the inviable do\nuble mutant chc1-delete, scd1-i-allele; elevated CHC1 expres\nsion suppresses some clc1-delete phenotypes\n mRPN7:Regulatory Particle Non-ATPase, homolog of mammalian proteas\nomal subunit S10/p44,proteasome regulatory particle subunit,\n mARP2:Involved in endocytosis and membrane growth and polarity,act\nin related protein,Null mutant is inviable\n Cond915:(99i4)_HBY4_YPGL_NormInt\n Cond852:30_min\n mVPS17:Peripheral membrane protein required for vacuolar protein so\nrting,,Null mutant is viable, exhibits defect in vacuolar mo\nrphology and protein sorting\n Cond646:DES459_(mec1-)_+_0.02%_MMS_-_120_min\n mPRE2:proteasome subunit,proteasome subunit,Null mutant is inviabl\ne, pre2 mutants exhibit defects in chymotrypsin-like proteol\nysis, stress response and ubiquitin signaled protein degrada\ntion\n mPRE3:Proteasome subunit necessary for hydrolysis of peptidylgluta\nmyl-peptide,20S proteasome subunit,Null mutant is inviable\n mSSO1:SSO1 and SSO2 encode syntaxin homologs (post-Golgi t-SNAREs)\n; act in late stages of secretion,t-SNARE,SSO1, SSO2 double \nnull mutant is inviable; high copy number of either SSO1 or \nSSO2 suppresses mutations in late-acting sec genes (sec1,3,5\n,9,15)\n Cond434:DBY7286_37degree_heat_-_20_min\n Stress.HeatSorbitol:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond717:t2-SSD1\n Cond720:t0+SSD1,H44\n Cond879:MMC\n Cond716:t2+SSD1wt\n Cond333:29C_+1M_sorbitol_to_33C_+_*NO_sorbitol_-_15_minutes\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond422:YPD_stationary_phase_2_h_ypd-1\n Cond644:DES459_(mec1-)_+_0.02%_MMS_-_60_min\n Cond877:MMS\n Cond875:60min\n Cond906:(77i5)_S150-2B_YPD_NormInt\n Cond642:DES459_(mec1-)_+_0.02%_MMS_-_30_min\n mSTI1:Heat shock protein also induced by canavanine and entry into\n stationary phase,heat shock protein also induced by canavan\nine and entry into stationary phase,Null mutant is viable bu\nt shows slow growth at high or low temperatures; shows synth\netic interactions with hsp82, cpr7, kin28 and sba1\n mUBA1:ubiquitin activating enzyme, similar to Uba2p,ubiquitin acti\nvating enzyme, similar to Uba2p,Null mutant is inviable\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond876:zero2\n Cond575:cdc15_100\n Cond714:t0+SSD1wt\n Cond885:20\n mTPD3:protein phosphatase 2A regulatory subunit A,protein phosphat\nase 2A regulatory subunit A,Null mutant is viable, defective\n in cytokinesis at reduced temperatures, defective in transc\nription by RNA polymerase III at elevated temperatures; noco\ndazole sensitive and exhibits phenotypes of previously ident\nified kinetochore/spindle checkpoint mutants\n Stress.Various:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mRSC9:Remodels the Structure of Chromatin,,Null: Lethal.\n Cond881:4NQO\n Cond721:t0-SSD1,M31\n Cond636:DES460_+_0.2%_MMS_-_45_min\n mRIM11:Required for Ime1p phosphorylation, association of the Ime1p\n-Ume6p meiotic activator, early meiotic gene expression, and\n sporulation,,Null mutant is viable; some alleles are Spo+ a\nnd sporulate slowly; rim11 is epistatic to the lethality of \nIME1 overexpression in haploids and permits Ime1p accumulati\non; RIM11 is a high copy suppressor of mck1 (cs) mutants\n Cond639:DES460_+_0.02%_MMS_-_120_min\n Cell Cycle.cdc15:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion.  Mol Biol Cell. 1998 Dec;9(12):3273-97.\n mVMA13:vacuolar ATPase V1 domain subunit H (54 kDa),vacuolar ATPase\n V1 domain subunit H (54 kDa) , vacuolar H(+) ATPase V1 sect\nor 54 kDa subunit,Null mutant is viable, V-ATPase complex fr\nom null mutants is less stable than from wild-type strains\n Cond441:DBYmsn2/4_(real_strain)_+_0.32_mM_H2O2_(20_min)\n Cond643:DES459_(mec1-)_+_0.02%_MMS_-_45_min\n mCCT2:cytoplasmic chaperonin of the Cct ring complex related to Tc\np1p; subunit beta,,Null mutant is inviable; some mutant alle\nles exhibit defects in microtubule and actin assembly.\n Cond884:10\n Cond436:DBYmsn2/4_(real_strain)_+_37degrees_(20_min)\n mRPT2:Probable 26S protease subunit and member of CDC48/PAS1/SEC18\n family of ATPases,,Null mutant is inviable\n mUBA1 mSTI1

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Computational Genomics Lab, Tel-Aviv uniresity