Module number 2055




Database revision : gnsdb28.10
Date : Tue Feb 25 17:02:15 2003
How to read this figure?


mHSE1:Unknown ,, Unknown\n mRPT4:Proteasome Cap Subunit,26S proteasome cap subunit component \n, ATPase , 26S proteasome cap subunit component , ATPase , 2\n6S proteasome cap subunit component , ATPase,Null mutant is \ninviable; ts mutant strain arrests as large-budded cells aft\ner 1, 2, 3 divisions with a G2 content of DNA and a monopola\nr spindle; unduplicated spindle pole body is enlarged as in \nother monopolar mutants; they also fail to arrest at G1 when\n starved for a single amino acid (but do arrest at G1 when d\neprived of all nitrogen), are resistant to cyclohexamide, an\nd are hypersensitive to amino acid analogs, hygromycin B and\n 3-aminotriazole\n mRPT5:Probable 26S protease subunit and member of the CDC48/PAS1/S\nEC18 family of ATPases,,Null mutant is inviable\n mPEP12:integral membrane protein; c-terminal TMD; located in endoso\nme,c-terminal TMD , integral membrane protein , c-terminal T\nMD , integral membrane protein , c-terminal TMD , integral m\nembrane protein,proteinase deficient\n mHIS5:responsive to control of general amino acid biosynthesis,his\ntidinol-phosphate aminotransferase,Null mutant is viable and\n requires histidine\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n mYMR067C:Unknown ,, Unknown\n mYAP1:jun-like transcription factor,jun-like transcription factor,\npleiotropic drug resistance\n mTOS5:Hypothetical ORF,,\n mOXR1:OXidation Resistance,,Null mutant is sensitive to hydrogen p\neroxide.\n mSNX4:Sorting NeXin,,\n Cond896:STAT\n Cond649:dun1-_+_0.02%_MMS_-_120_min\n mSTE11:involved in the mating signalling pathway,,Null mutant is vi\nable but sterile\n mYDR533C:Unknown ,, Unknown\n Cell Cycle.alpha:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion. Mol Biol Cell. 1998 Dec;9(12):3273-97.\n Cond440:DBYmsn2msn4_(good_strain)_+_0.32_mM_H2O2\n Cond337:constant_0.32_mM_H2O2_(30_min)_redo\n Cond648:dun1-_+_0.02%_MMS_-_90_min\n Stress.diamide:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond647:dun1-_+_0.02%_MMs_-_30_min\n mRFA2:Involved in nucleotide excision repair,29% identical to the \nhuman p34 subunit of RF-A , replication factor RF-A subunit \n2,Null mutant is inviable; arrests as budded and multiply bu\ndded cells; rfa2 (ts) cells have a mutator and a hyper-recom\nbination phenotype and are more sensitive to hydroxyurea and\n methyl-methane-sulfonate than wild-type cells\n Cond892:S\n Cond883:5\n Cond898:RPN4\n mYOR131C:Unknown ,, Unknown\n Cond637:DES460_+_0.02%_MMS_-_60_min\n Cond373:1.5_mM_diamide_(40_min)\n Cond371:1.5_mM_diamide_(20_min)\n Cond890:G1\n mGSH1:Glutathione biosynthesis,gamma-glutamylcysteine synthetase,N\null mutant is viable, exhibits alteration of glutathione con\ntent and reduction in growth rate\n Cond439:DBY7286_+_0.3_mM_H2O2_(20_min)\n mEND3:Required for endocytosis and organization of the cytoskeleto\nn,,Null mutant is viable and defective in endocytosis\n Cond435:DBYmsn2-4-_37degree_heat_-_20_min\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mFBP26:Fructose-2,6-biphosphatase,Fructose-2,6-biphosphatase,Null m\nutant lacks fructose-2,6-biphosphatase activity but can grow\n on glucose, fructose, galactose, pyruvate, glycerol and lac\ntate\n mCAP1:capping - addition of actin subunits,capping protein,Null mu\ntant is viable; severe deficit of actin cables and increased\n number of actin spots in the mother; round, relatively larg\ne cells\n Cond638:DES460_+_0.02%_MMS_-_90_min\n mYLR387C:Unknown ,, Unknown\n mPEP4:vacuolar proteinase A,vacuolar proteinase A,Null mutant is v\niable, proteinase deficient, phosphatase deficient; pep4 mut\nants exhibit a 60-70% reduction in total protein degradation\n during sporulation\n mYOR059C:Unknown ,, Unknown\n Cond894:G2\n mRPN1:Subunit of 26S Proteasome (PA700 subunit),26S proteasome PA7\n00 subunit,Null mutant is inviable; hrd2-1 mutation slows de\ngradation of Hmg2p. hrd2-1 strains are sensitive to canavani\nne and show a global accumulation of ubiquitin-conjugated pr\noteins, but are not temperature-sensitive\n Cond635:DES460_+_0.02%_MMS_-_30_min\n mRPN12:Part of 26S proteasome complex that may activate Cdc28p,32-3\n4 kDa protein,Null mutant is inviable; nin1-1 mutant is temp\nerature-sensitive mutant that shows i) higher rates of recom\nbination and chromosome and plasmid loss; ii) greater sensit\nivity to UV irradiation; iii) at restrictive temperature, ar\nrest in G2, failure to activate histone H1 kinase, and accum\nulation of polyubiquinated proteins\n mPRE10:proteasome component YC1 (protease yscE subunit 1),proteasom\ne component YC1 (protease yscE subunit 1),Null mutant is inv\niable\n mRPN3:proteasome subunit,26S proteasome regulatory module componen\nt , similar to human p58 subunit,Null mutant is inviable. RP\nN3 is a high copy suppressor of the nin1-1 temperature sensi\ntive phenotype\n mGCY1:Galactose-induced transcript, product is homologous to mamma\nlian aldo/keto reductases, as well as to gamma-crystallin, a\n vertebrate eye lens protein,,Null mutant is viable\n mYDR330W:Unknown ,, Unknown\n mYIM1:Mitochondrial inner membrane protease, similar to E. coli le\nader peptidase,protease , similar to E. coli leader peptidas\ne,\n mRPN7:Regulatory Particle Non-ATPase, homolog of mammalian proteas\nomal subunit S10/p44,proteasome regulatory particle subunit,\n Cond893:SMMS\n mRPN8:Regulatory Particle Non-ATPase, homolog of mammalian proteas\nomal subunit S12/p40,proteasome regulatory particle subunit,\n Cond379:1M_sorbitol_-_30_min\n mAIP1:Protein localizes to actin cortical patches. Probable bindin\ng site on actin lies on front surface of subdomain 3 and 4.,\nactin cortical patch component,Null mutant is viable\n mYGR111W:Unknown ,, Unknown\n Cond646:DES459_(mec1-)_+_0.02%_MMS_-_120_min\n mPRE2:proteasome subunit,proteasome subunit,Null mutant is inviabl\ne, pre2 mutants exhibit defects in chymotrypsin-like proteol\nysis, stress response and ubiquitin signaled protein degrada\ntion\n mBRR1:Protein involved in snRNP biogenesis,spliceosomal snRNP comp\nonent,in brr1 mutants, newly synthesized snRNAs are destabil\nized and 3'-end processing is slowed\n mPRE4:B-type subunit of proteasome, euk. & archae. multicatalytic \nproteinase complex likelyinvolved in an ATP/ubiquitin-depend\nent nonlysosomal proteolytic pathway. eukary: the proteasome\n is composed of ~24 subunits forming a ring-shaped structure\n,necessary for peptidyl glutamyl peptide hydrolyzing activit\ny , proteasome subunit,Null mutant is inviable\n Cond434:DBY7286_37degree_heat_-_20_min\n mGLR1:converts oxidized glutathine and NADPH into two glutathiones\n and NADP+,glutathione oxidoreductase,Null mutant is viable\n mVPS55:Unknown ,, Unknown\n mMDR1:Mac1-dependent regulator,GTPase activating protein (GAP) fo\nr Ypt6,Null mutant is viable\n mCPR6:a cyclophilin related to the mammalian CyP-40; physically in\nteracts with RPD3 gene product,cyclophilin 40 , peptidyl-pro\nlyl cis-trans isomerase (PPIase),Null mutant is viable, has \nnormal growth rate\n mYOR052C:Unknown ,, Unknown\n UME6.ume6:The Ume6 regulon coordinates metabolic and meiotic gene expr\nession in yeast. Proc Natl Acad Sci U S A. 2002 Oct 15;99(2\n1):13431-6.\n mPRE6:alpha-type of subunit of 20S proteasome,20S proteasome alpha\n-type subunit,Null mutant is inviable\n Stress.H202:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mPRE8:proteasome component Y7,proteasome component Y7,\n Cond783:Peroxide_60'\n mOSH6:Oxysterol Binding Protein,,\n mYML131W:Unknown ,, Unknown\n Cond895:G2MMS\n mGLC8:Homolog of mammalian protein phosphatase inhibitor 2,protein\n phosphatase 1 (Glc7p) regulator,Null mutant is viable; dele\ntion of glc8 suppresses phenotypes of ipl1 and glc7 mutants\n Cond879:MMC\n mMSP1:40 kDa putative membrane-spanning ATPase,40 kDa membrane-spa\nnning ATPase,Null mutant is viable, exhibits no observable g\nrowth defects\n Cond882:zero3\n Cond644:DES459_(mec1-)_+_0.02%_MMS_-_60_min\n Cond877:MMS\n Cond875:60min\n mRTG2:Protein involved in interorganelle communication between mit\nochondria, peroxisomes, and nucleus,,Null mutant is viable, \nfails to grow on acetate as a sole carbon source, auxotrophi\nc for glutamate and aspartate; respiratory competent\n Cond642:DES459_(mec1-)_+_0.02%_MMS_-_30_min\n Cond946:W303ume6_YPD\n Cond886:g-ray\n Stress.Menadione:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mUBA1:ubiquitin activating enzyme, similar to Uba2p,ubiquitin acti\nvating enzyme, similar to Uba2p,Null mutant is inviable\n Stress.Sorbitol:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mDOA1:Required for normal intracellular ubiquitin metabolism and f\nor normal rates of proteolysis of ubiquitin-dependent proteo\nlytic substrates in vivo,,Null mutant is viable and defectiv\ne in degradation of ubiquitinated proteins; homozygous null \ndiploid shows sporulation defect\n mGLO1:Regulated by HOG (high osmolarity glycerol)-MAP (mitogen-act\nivated protein) kinase pathway in osmotic stress response,la\nctoylglutathione lyase (glyoxalase I),Null mutant is viable;\n sensitive to methylglyoxal\n mPUP1:putative proteasome subunit,proteasome subunit (putative),\n Cond374:1.5_mM_diamide_(50_min)\n Cond370:1.5_mM_diamide_(10_min)\n Cond372:1.5_mM_diamide_(30_min)\n Cond876:zero2\n mNGL2:DNase/RNase (putative); CCR4 C-terminal homolog; displays ho\nmology to drosophila Angelgene; homolog to ngl1 and ngl3 ,DN\nase (putative) , RNase (putative),Null mutant is viable.\n Cond885:20\n mISU2:Iron-sulfur cluster nifU-like protein,,Null mutant is viable\n on YPD at 30 degrees C, and is synthetically lethal with is\nu1 null.\n Cond645:DES459_(mec1-)_+_0.02%_MMS_-_90_min\n Cond891:G1MMS\n Stress.Various:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mARC18:Arp2/3 complex subunit,,\n Cond348:1mM_Menadione_(40_min)_redo\n mIDP1:Mitochondrial form of NADP-specific isocitrate dehydrogenase\n,NADP-dependent isocitrate dehydrogenase,Null mutant is viab\nle\n Cond881:4NQO\n Cond636:DES460_+_0.2%_MMS_-_45_min\n Cond442:DBYyap1-_+_0.3_mM_H2O2_(20_min)\n mMVP1:Protein required for sorting proteins to the vacuole,,MVP1 w\nas identified as a multicopy suppressor of dominant-negative\n vps1 mutations, as well as an extragenic suppressor of a te\nmperature-sensitive pma1 mutation (sop gene)\n Cond639:DES460_+_0.02%_MMS_-_120_min\n Cond339:constant_0.32_mM_H2O2_(50_min)_redo\n mYKL091C:Unknown ,, Unknown\n Cond441:DBYmsn2/4_(real_strain)_+_0.32_mM_H2O2_(20_min)\n Cond643:DES459_(mec1-)_+_0.02%_MMS_-_45_min\n Cond564:alpha91\n Cond347:1_mM_Menadione_(30_min)_redo\n Y-Stre.Peroxide:Remodeling of yeast genome expression in response to environ\nmental changes. Mol Biol Cell. 2001 Feb;12(2):323-37.\n Cond641:DES459_(mec1-)_+_0.02%_MMS_-_15_min\n mRPT1:Required for degradation of ubiquitinated substrates and for\n anaphase chromosome separation,26S protease subunit compone\nnt (putative) , ATPase , 26S protease subunit component (put\native) , ATPase,Null mutant is inviable\n Cond884:10\n Cond436:DBYmsn2/4_(real_strain)_+_37degrees_(20_min)\n mBET4:catalyzes prenylation of Ypt1p (as a subunit of PGGTase-II),\ngeranylgeranyltransferase type II alpha subunit (PGGTase-II,\n alpha subunit),\n
this is an automaticly generated SAMBA report
Computational Genomics Lab, Tel-Aviv uniresity