Module number 1975




Database revision : gnsdb28.10
Date : Tue Feb 25 17:34:11 2003
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Cond498:wtħ500nMaF,30minlog10(intensity)\n Cond541:fus3D+50nMaF,30min/wtlog10(intensity)\n Cond494:wtħ5nMaF,30minlog10(intensity)\n mMCH2:Unknown ,, Unknown\n Cond164:sst2(haploid)\n mGYP8:Unknown ,, Unknown\n mSTE12:Involved in pheromone and pseudohyphal growth signal transdu\nction pathways,transcription factor,Null mutant is viable bu\nt sterile; homozygous mutant diploids exhibit defects in pse\nudohyphal growth\n Cond520:hog1Dħ1Msorbitol,2hrslog10(intensity)\n Cell Cycle.alpha:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion. Mol Biol Cell. 1998 Dec;9(12):3273-97.\n mKAR3:kinesin-like nuclear fusion protein,kinesin-like nuclear fus\nion protein,Null mutant is viable, kar3 mutations prevent ka\nryogamy (nuclear fusion)\n mKAR4:May assist Ste12p in pheromone-dependent expression of KAR3 \nand CIK1,involved in karyogamy , transcription factor,Defect\nive in pheromone-induced expression of KAR3 and CIK1; theref\nore, defective in nuclear fusion because of defect in microt\nubule-dependent movement of nuclei; also required for meiosi\ns\n Cond513:GAL-STE11-4,3hrs.gallog10(intensity)\n mKAR5:appears to be required for the completion of nuclear membran\ne fusion and may play a role in the organization of the memb\nrane fusion complex,coiled-coil membrane protein,Null mutant\n is viable, mating defective, nuclear fusion defective\n mYOL106W:Unknown ,, Unknown\n mCIK1:In vegetative growth, CIK1 is important for proper organizia\ntion of microtubule arrays and establishment of a spindle; C\nIK1 is also essential for karyogamy; expression regulated by\n KAR4 and mating,spindle pole body associated protein,Null m\nutant is viable but is defective in both karyogamy and chrom\nosome maintenance and does not show proper localization of K\nar3p to microtubule-associated structures\n mYDR340W:Unknown ,, Unknown\n mGIC2:Gtpase-interacting component 2,,Null mutant is viable and te\nmperature sensitive at 37 degrees C; gic1 gic2 double null i\ns temperature sensitive at 33 degrees C\n mFUS1:cell-surface protein required for cell fusion,,Null mutant i\ns viable; in fus1 x fus1 matings there is an interruption of\n the mating process just before cytoplasmic fusion\n mFUS2:Involved in cell fusion during mating, also required for the\n alignment of parental nuclei before nuclear fusion,,Null mu\ntant is viable, fus2 mutants have strong defects in karyogam\ny and fail to orient microtubules between parental nuclei in\n zygotes\n mMSG5:Tyrosine protein phosphatase involved in adaptation response\n to pheromone,protein tyrosine phosphatase,Null mutant is vi\nable, shows diminished adaptive response to pheromone\n mFUS3:Required for the arrest of cells in G(sub)1 in response to p\nheromone and cell fusion during conjugation,CDC28/cdc2 relat\ned protein kinase,sterile; divide continuously in the presen\nce of pheromones; form prezygotes with wild-type cells of op\nposite mating type but cannot undergo cell fusion\n Cond505:wtħ50nMaF,120minlog10(intensity)\n Cond522:fus3Dkss1D/wtlog10(intensity)\n mJIP3:Unknown ,, Unknown\n Cond517:sst2D/wtlog10(intensity)\n Cond166:ste11(haploid)\n Mating.Mating:Signaling and circuitry of multiple MAPK pathways revealed b\ny a matrix of global gene expression profiles. Science. 200\n0 Feb 4;287(5454):873-80\n mYLR042C:Unknown ,, Unknown\n mYHR097C:Unknown ,, Unknown\n mYMR304C-A:Unknown ,, Unknown\n mHMI1:Helicase in MItochondria,,\n mYJR026W:Unknown ,, Unknown\n mYNL208W:Unknown ,, Unknown\n Cond508:bni1Dħ50nMaF,120minlog10(intensity)\n mFAR1:Factor arrest protein,Cdc28p kinase inhibitor,\n mYCL076W:Unknown ,, Unknown\n Cond524:ste5D/wtlog10(intensity)\n mPRP39:May function to facilitate or stabilize the interaction betw\neen U1 snRNP and the 5' splice site in pre-mRNAs,RNA splicin\ng factor , U1 snRNP protein,Temperature-sensitive mutant arr\nests at the nonpermissive temperature and shows block in pre\n-mRNA splicing\n mMFA1:a-factor mating pheromone precursor,a-factor mating pheromon\ne precursor,\n mMFA2:mating a-factor pheromone precursor,a-factor mating pheromon\ne precursor,\n mYOR343C:Unknown ,, Unknown\n mYOL166C:Unknown ,, Unknown\n mYDR124W:Unknown ,, Unknown\n Cond542:fus3Dtec1D+50nMaF,30min/wtlog10(intensity)\n mBOP3:bypass of PAM1,,\n mYIL169C:Unknown ,, Unknown\n Cond512:GAL-STE5-CTM,3hrs.gallog10(intensity)\n mAFR1:coordinates regulation of alpha-factor receptor signalling a\nnd induction of morphogenesis during conjugation,cytoskeleta\nl protein , similar to arrestins,defect in alpha-factor-stim\nulated morphogenesis\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mYLR334C:Unknown ,, Unknown\n Cond41:dig1,dig2(haploid)\n mECM18:ExtraCellular Mutant,,A Tn3 insertion into this gene causes \nhypersensitivity to the cell surface polymer perturbing agen\nt calcofluor white.\n mRDI1:Rho GDP dissociation inhibitor with activity toward Rho1p,,\n mHYM1:The homolog in Aspergillus nidulans, hymA, is involved in de\nvelopment, see Karos, M. and Fischer, R. (1996). hymA (hypha\n-like metulae), a new developmental mutant of Aspergillus ni\ndulans. Microbiol. 142:3211-3218.,,Null mutant is inviable\n mPRY2:Pathogen Related in Sc, contains homology to the plant PR-1 \nclass of pathogen related proteins. The protein sequence is \nover 60% identical with the Pry2p & Pry3p over 145 resid. PR\nY1 is >35% identical (50% similar) to tobacco PR-1c protein.\n,,\n Cond499:wtħ50nMaF,0minlog10(intensity)\n Cond492:wt+/-0.5nMalphaF,30minlog10(intensity)\n mKTR2:May be involved in extracellular matrix assembly; involved i\nn N-linked glycosylation of cell wall mannoproteins,mannosyl\ntransferase (putative) , type 2 membrane protein,Null mutant\n is viable, with partial resistance to killer toxin\n mSST2:Protein involved in desensitization to alpha-factor pheromon\ne,GTPase activating protein (GAP) , RGS (regulator of G-prot\nein signalling) family,Null mutants are viable and exhibit i\nncreased sensitivity to mating factors\n Cond66:fus3,kss1(haploid)\n Cond493:wtħ1.5nMaF,30minlog10(intensity)\n Cond173:ste5(haploid)\n mYDR249C:Unknown ,, Unknown\n mYIL060W:Unknown ,, Unknown\n mIME4:IME4 appears to activate IME1 in response to cell-type and n\nutritional signals and thereby regulate meiosis,methyltransf\nerase (putative),Homozygous mutant diploid cannot accumulate\n IME1 mRNA during early stages of meiosis and cannot sporula\nte\n Cond503:wtħ50nMaF,60minlog10(intensity)\n Cond511:GAL-STE4,3hrs.gallog10(intensity)\n mNDJ1:Involved in meiotic chromosome segregation; may stabilize ho\nmologus DNA interactions at telomeres and is required for a \ntelomere activity in distributive segregation; is associated\n with telomeres,,Null allele exhibits errors in meiotic chro\nmosome segregation about 10-fold higher than the wild-type e\nrror rate. Spore viability of homozygous diploids with the n\null allele is approximately 50% of wild-type. Mutant also sh\nows delayed meiotic chromosome synapsis, disrupted crossover\n interference and increased frequency of nonexchange chromos\nomes leading to meiosis I nondisjunction and disruption of d\nistributive disjunction\n mAGA1:anchorage subunit of a-agglutinin,a-agglutinin anchorage sub\nunit,mating defect in liquid medium\n Cond540:fus3Dtec1Dħ50nMaF,30minlog10(intensity)\n mYML048W-A:Unknown ,, Unknown\n mAGA2:adhesion subunit of a-agglutinin,a-agglutinin adhesion subun\nit,Null mutant is viable and shows mating defect\n mSLI15:Mitotic spindle protein involved in chromosome segregation.,\n,Null mutant is inviable; sli15 conditional mutations are sy\nthentically lethal with ipl1-2 alleles.\n mYJR028W:Unknown ,, Unknown\n Cond510:fus3Dħ50nMaF,30minlog10(intensity)\n mYIL082W:Unknown ,, Unknown\n Cond40:dig1,dig2\n Cond526:ste11D/wtlog10(intensity)\n mTEC1:transcription factor of the TEA/ATTS DNA-binding domain fami\nly, regulator of Ty1 expression,TEA/ATTS DNA-binding domain \nfamily, regulator of Ty1 expression , transcription factor,N\null mutant is viable\n mAXL1:determinant in axial budding pattern of haploid cells, invol\nved in processing of a-factor,human insulin-degrading endopr\notease homolog (putative),Null mutant is viable; exhibits re\nduced a-factor expresion; haploid mutants show bipolar buddi\nng pattern (diploid pattern) rather than the normal axial (s\npiral) budding pattern\n mARG4:argininosuccinate lyase,argininosuccinate lyase,Arginine req\nuiring\n mYGL052W:Unknown ,, Unknown\n mGPA1:Involved in the mating pheromone signal transduction pathway\n; component of pheromone response pathway common to both a a\nnd alpha cells.,G protein alpha subunit , coupled to mating \nfactor receptor , G protein alpha subunit , coupled to matin\ng factor receptor , G protein alpha subunit , coupled to mat\ning factor receptor,The null mutation is inviable in haploid\ns but not diploids. Gpa1 mutants exhibit specific defects in\n the pheromone responsiveness of both a and alpha cells.\n mYIL083C:Unknown ,, Unknown\n mINP52:Synaptojanin-like protein,inositol polyphosphate 5-phosphata\nse,Null mutant is viable, has abnormal vacuoles\n Cond500:wtħ50nMaF,15minlog10(intensity)\n Cond504:wtħ50nMaF,90minlog10(intensity)\n mNIS1:Hypothetical ORF,,\n mYDR366C:Unknown ,, Unknown\n Cond519:rst1Drst2Dħ50nMaF,30minlog10(intensity)\n Cond745: mPGU1:Endo-polygalacturonase,endo-polygalacturonase,Null mutant is\n viable; exhibits clear halo around colonies on polygalactur\nonate medium\n Cond516:rst1Drst2D/wtlog10(intensity)\n mYJR029W:Unknown ,, Unknown\n Cond525:ste7D/wtlog10(intensity)\n Cond507:bni1Dħ50nMaF,90minlog10(intensity)\n mYJL107C:Unknown ,, Unknown\n Cond509:kss1Dħ50nMaF,30minlog10(intensity)\n Cond496:wtħ50nMaF,30minlog10(intensity)\n mGFA1:catalyzes first step in hexosamine pathway required for bios\nynthesis of cell wall precursors,glucoseamine-6-phosphate sy\nnthase , glutamine_fructose-6-phosphate amidotransferase,Nul\nl mutant is viable, glucosamine auxotroph\n Cond495:wtħ15.8nMaF,30minlog10(intensity)\n mYLR445W:Unknown ,, Unknown\n Cond515:far1Dħ50nMaF,30minlog10(intensity)\n mYHR145C:Unknown ,, Unknown\n Cond506:bni1Dħ50nMaF,60minlog10(intensity)\n Cond518:ste20Dħ50nMaF,30minlog10(intensity)\n mCHS1:disrupts mating and sporulation efficiently,chitin synthase \n1,Null mutant is viable\n Cond528:ste18D/wtlog10(intensity)\n mTIP1:cold- and heat-shock induced protein of the Srp1p/Tip1p fami\nly of serine-alanine-rich proteins,cell wall mannoprotein,Nu\nll mutant is viable; exhibits increased sensitivity to calco\nflour white and congo red\n mPRM10:pheromone-regulated membrane protein,,\n mYOL155C:Unknown ,, Unknown\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond502:wtħ50nMaF,45minlog10(intensity)\n mPRM1:pheromone-regulated membrane protein,,Null mutant is viable \nbut exhibits a mating defect.\n Cond527:ste12D/wtlog10(intensity)\n mPRM2:pheromone-regulated membrane protein,,\n mPRM3:pheromone-regulated membrane protein,,\n mPRM4:pheromone-regulated membrane protein,,\n mSTE2:alpha-factor pheromone receptor; seven-transmembrane domain \nprotein,alpha-factor pheromone receptor , seven-transmembran\ne domain protein,Null mutant is viable but sterile.\n mPRM5:pheromone-regulated membrane protein,,\n mPRM6:pheromone-regulated membrane protein,,\n mYIL082W-A:Unknown ,, Unknown\n mPRM8:pheromone-regulated membrane protein,,\n mSTE6:ABC transporter, glycoprotein, component of a-factor secreto\nry pathway,ABC transporter , glycoprotein,sterility of MATa \ncells, failure to export a-factor\n mMID2:Protein required for mating,,Null mutant is viable, dies whe\nn exposed to mating pheromone\n mPRM9:pheromone-regulated membrane protein,,\n mTDP1:Unknown ,, Unknown\n Cond501:wt+/-50nMaF,30minlog10(intensity)\n mSPO12:Thought to be a positive regulator of exit from M-phase in m\nitosis and meiosis; interacts with Dbf2p and Dbf20p protein \nkinases,20 kDa protein with negatively charged C-terminus re\nquired for function , positive regulator of exit from M-phas\ne in mitosis and meiosis (putative),sporulation defective; l\noss of function in mitosis results in delay in G2; loss of f\nunction in meiosis results in a prolonged pachytene stage an\nd presence of synaptonemal complexes, a single meiosis II-li\nke equational division at the time of meiosis II, and dyad a\nsci containing two diploid spores. Gain of function in mitos\nis suppresses M-phase anaphase arrest caused by overexpressi\non of CLB2 deg- and mutants (e.g. dbf2-ts). mRNA is cell cyc\nle regulated (with DBF2 ) in mitosis and increases 5-10x in \nmeiosis.\n mFIG1:Factor-Induced Gene 1: expression is induced by the mating p\nheromones, a and alpha factor; required for efficient mating\n,integral membrane protein,Null mutant is viable, deficient \nin mating\n mFIG2:Factor-Induced Gene 2: expression is induced by the mating p\nheromones, a and alpha factor; required for efficient mating\n,GPI-anchored cell wall protein (putative),Null mutant is vi\nable, deficient in mating under non-optimal conditions\n mPCL2:Interacts with cyclin-dependent kinase PHO85 to form kinase \ncomplex with G1-periodic activity involved in cell cycle pro\ngression,G1 cyclin,\n mRVS161:Protein required for viability after N, C, or S starvation,,\nNull mutant is viable, rvs161 mutations result in a delocali\nzation of the actin cytoskeleton, high salt sensitivity, ran\ndom budding pattern in diploid cells, defects in endocytosis\n, and reduced viability upon starvation; rvs161 mutants exhi\nbit synthetic lethality with sst2 mutants\n Cond167:ste12(haploid)\n Cond543:rst1Drst2Dtec1D/wtlog10(intensity)\n mHOP2:HOmologous Pairing,meiosis-specific gene required for the pa\niring of similar chromosomes,Null mutant is viable; homozygo\nus hop2 null diploids arrest in meiotic prophase prior to th\ne first meiotic division\n mASG7:an a-specific gene that is induced to a higher expression le\nvel by alpha factor,,Null mutant is viable\n Cond497:wtħ158nMaF,30minlog10(intensity)\n mPMU1:Phospho MUtase homolog. Small region homologous to active si\nte of phospho-mutases, these move phosphates via a phospho-h\nistidine intermediate. Homologs include: Sc GPM1, bact. Pgm,\n Hs Bpgm & rat fructose-2,6-bisphosphatase,phosphomutase hom\nolog,Null mutant is viable; overproduction suppresses the ts\n growth of a tps2 mutant and prevents accumulation of trehal\nose-6-phosphate in the tps2 mutant\n Cond168:ste18(haploid)\n mYAR068W:Unknown ,, Unknown\n mYER187W:Unknown ,, Unknown\n Cond174:ste7(haploid)\n Cond521:fus3-K42Dħ50nMaF,30minlog10(intensity)\n Cond514:GAL-STE12,3hrs.gallog10(intensity)\n mSCW10:Soluble Cell Wall protein,soluble cell wall protein,Null mut\nant is viable.\n fkh1,2sf.Series0:Two yeast forkhead genes regulate the cell cycle and pseudoh\nyphal growth. Nature. 2000 Jul 6;406(6791):90-4.\n Cond551:alpha0\n mBUD26:Hypothetical ORF,,Null mutant is viable; random budding in d\niploid null mutants\n mFUS3 mMSG5 mTEC1 mSTE12 mCIK1 mKAR3
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Computational Genomics Lab, Tel-Aviv uniresity