Module number 1854




Database revision : gnsdb28.10
Date : Tue Feb 25 17:27:52 2003
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Cond796:Ca5'\n mSOF1:involved in rRNA processing,56 kDa nucleolar snRNP protein t\nhat shows homology to beta subunits of G-proteins and the sp\nlicing factor Prp4,Null mutant is inviable. sof1-56, a domin\nant suppressor of nop1 mutants can restore growth and pre-RN\nA processing at 35 degrees C. In vivo depletion of SOF1 lead\ns to impaired pre-rRNA processing and inhibition of 18S rRNA\n production.\n Pho85.pho85:Chemical inhibition of the Pho85 cyclin-dependent kinase rev\neals a role in the environmental stress response.  Proc Natl\n Acad Sci U S A. 2001 Oct 23;98(22):12578-83.\n Cond302:Heat_Shock_15_minutes_hs-1\n mHO:Homothallic switching,homothallic switching endonuclease,Nul\nl mutant is viable and cannot undergo mating type switching\n Cell Cycle.alpha:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion.  Mol Biol Cell. 1998 Dec;9(12):3273-97.\n GCR1.gcr1:Understanding the growth phenotype of the yeast gcr1 mutant \nin terms of global genomic expression patterns.  J Bacteriol\n. 2000 Sep;182(17):4970-8.\n Cond981:F82G_pho4D_10_mM_1NaPP1\n Cond913:(99i3)_S150-2B_YPD_NormInt\n Stress.diamide:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Stress.HypoOsmot:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mYLR419W:Unknown ,, Unknown\n mYML018C:Unknown ,, Unknown\n Cond315:37C_to_25C_shock_-_15_min\n Cond976:F82G_1_mM_1NaPP1\n Cond425:YPD_stationary_phase_12_h_ypd-1\n Cond674:DES459_(mec1)_+_heat_20_min\n Cond810:Na45'\n Cond637:DES460_+_0.02%_MMS_-_60_min\n Cond373:1.5_mM_diamide_(40_min)\n Cond822:tlc1_Expt.1_Passage_3\n Cond409:diauxic_shift_timecourse_15.5_h\n Cond300:Heat_Shock_05_minutes_hs-1\n Cond310:Heat_Shock_000_minutes_hs-2\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mATF2:Alcohol acetyltransferase,alcohol acetyltransferase,\n Cond245:ymr014w\n Cond480:WT+/-100mM3AT(SetA)(R491)\n Cond395:Nitrogen_Depletion_30_min.\n mSRO77:Suppressor of defect in the small GTPase Rho3p,yeast homolog\n of the Drosophila tumor suppressor, lethal giant larvae,Nul\nl mutant is viable and shows no phenotypes, but is cs- in co\nmbination with sro7/sni1 (YPR032W) null; sro7/sni1 sro77/sni\n2 double mutants have an exocytic defect, accumulate post-Go\nlgi vesicles, have partially delocalized actin, and suppress\n the growth and cell separation defects of myo1 cells.\n Cond553:alpha14\n Cond312:Heat_Shock_015_minutes_hs-2\n TorRama.Series0:Partitioning the transcriptional program induced by rapamyci\nn among the effectors of the Tor proteins. Curr Biol. 2000 D\nec 14-28;10(24):1574-81\n mYDL062W:Unknown ,, Unknown\n mMSH2:Functions with Pms1p and Pms2/Mlh1p in a complex that intera\ncts with Pms3p/Msh6p to repair single-base and insertion-del\netion mispairs, or Msh3p to repair insertion-deletion mispai\nrs.,mutS homolog,Null mutant is viable. Haploid mutants disp\nlay an 85-fold increased rate of spontaneous mutation to can\navanine resistance. Mutants are defective for gene conversio\nn polarity gradients and high spore viability.\n Cond569:cdc15_10\n Cond693:gal7+gal\n mYOR146W:Unknown ,, Unknown\n Cond694:gal10+gal\n mCGR1:coiled-coil growth-regulated,coiled-coil protein,Null mutant\n is inviable; CGR1 expression is down-regulated in the postd\niauxic growth phase\n Cond797:Ca15'\n Cond367:dtt_240_min_dtt-2\n tcl1.tcl1:The genome-wide expression response to telomerase deletion i\nn Saccharomyces cerevisiae.  Proc Natl Acad Sci U S A. 2002 \nJul 9;99(14):9316-21.\n Stress.Heat1:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond481:WT+/-100mM3AT(SetB)(491)\n Stress.Heat2:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond385:Hypo-osmotic_shock_-_15_min\n Cond662:mec1_plus_gamma_5_min\n mYJL010C:Unknown ,, Unknown\n mMAK21:essential for 60s ribosome biogenesis; involved in nuclear e\nxport of pre-ribosomes,,deficient in maintenance of killer\n gala.-gal:Integrated genomic and proteomic analyses of a systematicall\ny perturbed metabolic network.  Science. 2001 May 4;292(5518\n):929-34.\n Cond945:W303_YPD\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond443:DBYyap1_+_0.32_mM_H2O2_(20_min)\n Cond833:tlc1_Expt.2_Passage_5\n mYKR079C:Unknown ,, Unknown\n Cond374:1.5_mM_diamide_(50_min)\n Cond370:1.5_mM_diamide_(10_min)\n Cond706:gal2gal80-gal\n Cond634:DES460_+_0.02%_MMS_-_15_min\n mRCL1:protein similar to the RNA 3' terminal phosphate cyclase (RN\nA 3' terminal phosphate Cyclase-Like),,Null mutant is inviab\nle.\n Cond325:29C_to_33C_-_5_minutes\n Stress.ColdShock:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond965:ndt80_delete_mid_g/r_ratio_\n Cond859:ms221-30\n Cond366:dtt_120_min_dtt-2\n Cond977:F82G_pho4D_1_mM_1NaPP1\n Cond485:Low-Pi_vs_High-Pi_in_WT_(DBY7286)\n Cond303:Heat_Shock_20_minutes_hs-1\n mKRI1:KRRI-Interacting protein 1,Krr1p binding protein,\n Cond636:DES460_+_0.2%_MMS_-_45_min\n Cond570:cdc15_30\n Cond441:DBYmsn2/4_(real_strain)_+_0.32_mM_H2O2_(20_min)\n Cond650:wt_plus_gamma_5_min\n Calcin.Ca:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n.  J Biol Chem. 2002 Aug 23;277(34):31079-88\n Cond408:diauxic_shift_timecourse_13.5_h\n mRPC53:RNA polymerase III (C) subunit, homologus to human BN51 prot\nein,RNA polymerase III subunit,Null mutant is inviable; temp\nerature sensitive mutants show rapid inhibition of tRNA synt\nhesis after shift to restricitive temperature and arrest in \nG1\n mYJR071W:Unknown ,, Unknown\n Cond837:tlc1_Expt.2_Passage_9__\n Cond856:pm38-qtop\n Stress.dshift:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond801:CaFK15'\n Cond320:heat_shock_17_to_37,_20_minutes\n Cond836:tlc1_Expt.2_Passage_8\n mYIL127C:Unknown ,, Unknown\n Cond316:37C_to_25C_shock_-_30_min\n Cond305:Heat_Shock_40_minutes_hs-1\n Cond396:Nitrogen_Depletion_1_h\n Cond658:DES460_(wt)_-_mock_irradiation_-_5_min\n Cond301:Heat_Shock_10_minutes_hs-1\n Cond982:pho85D_10_mM_1NaPP1_\n Calcin.CaFK:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n.  J Biol Chem. 2002 Aug 23;277(34):31079-88\n Cond552:alpha7\n Cond369:1.5_mM_diamide_(5_min)\n Cond440:DBYmsn2msn4_(good_strain)_+_0.32_mM_H2O2\n Cond337:constant_0.32_mM_H2O2_(30_min)_redo\n mGRC3:Product of gene unknown,,\n Cond800:CaFK5'\n Stress.YPD:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond414:YPD_6_h_ypd-2\n mYDL152W:Unknown ,, Unknown\n Cond386:Hypo-osmotic_shock_-_30_min\n Cond375:1.5_mM_diamide_(60_min)\n Stress.YPDStat:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond371:1.5_mM_diamide_(20_min)\n mYNL174W:Unknown ,, Unknown\n Cond323:heat_shock_29_to_37,_20_minutes\n Cond488:pho85_vs_WT\n GCN4.gcn4:Transcriptional profiling shows that Gcn4p is a master regul\nator of gene expression during amino acid starvation in yeas\nt.  Mol Cell Biol. 2001 Jul;21(13):4347-68.\n Stress.DTT2:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond832:tlc1_Expt.2_Passage_4\n Cond326:29C_to_33C_-_15_minutes\n mSGD1:Suppressor of Glycerol Defect,,Null mutant is inviable; mult\ni-copy suppressor of hog1 and pbs2 osmosensitive phenotypes\n Cond855:pm38-30\n mYIL091C:Unknown ,, Unknown\n mPPR1:Positive regulator of URA1 and URA3,zinc finger transcriptio\nn factor of the Zn(2)-Cys(6) binuclear cluster domain type,N\null mutant is viable, deficient in pyrimidine biosynthetic p\nathway\n Stress.WeakHeat:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond635:DES460_+_0.02%_MMS_-_30_min\n Cond322:heat_shock_25_to_37,_20_minutes\n mYIL019W:Unknown ,, Unknown\n Cond857:pm38-gtoe\n Cond758:Heat_0'_(A)\n Cond317:37C_to_25C_shock_-_45_min\n Stress.NitroDepl:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond273:yor078w\n Stress.HeatSorbitol:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mPUS1:Involved in tRNA biogenesis,tRNA pseudouridine synthase,pus1\n los1 double mutant exhibits loss of suppressor tRNA activit\ny; pus1, los1 and nsp1 mutations cause synthetic lethality\n UME6.ume6:The Ume6 regulon coordinates metabolic and meiotic gene expr\nession in yeast.  Proc Natl Acad Sci U S A. 2002 Oct 15;99(2\n1):13431-6.\n Stress.H202:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mSHQ1:Unknown ,, Unknown\n Cond424:YPD_stationary_phase_8_h_ypd-1\n Y-Stre.Heat:Remodeling of yeast genome expression in response to environ\nmental changes.  Mol Biol Cell. 2001 Feb;12(2):323-37.\n Cond321:heat_shock_21_to_37,_20_minutes\n Cond762:Heat_45'\n mYFR035C:Unknown ,, Unknown\n Cond329:29C_+1M_sorbitol_to_33C_+_1M_sorbitol_-_5_minutes\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n gala.+gal:Integrated genomic and proteomic analyses of a systematicall\ny perturbed metabolic network.  Science. 2001 May 4;292(5518\n):929-34.\n Sporulation.Series0:The transcriptional program of sporulation in budding yeast.\n  Science. 1998 Oct 23;282(5389):699-705.\n mUTP6:Unknown ,, Unknown\n mNAN1:Net1-Associated Nucleolar protein 1,,Null mutant is inviable\n mDBP2:ATP-dependent RNA helicase of DEAD box family,ATP dependent \nRNA helicase , dead box protein,Null mutant is inviable\n mHPT1:enzyme involved in de novo purine biosynthesis,hypoxanthine \nguanine phosphoribosyltransferase,Null mutant is viable; mut\nants show resistance to 8-azaguanine\n mUTP9:Unknown ,, Unknown\n mZDS2:multicopy suppressor of a sin4 defect,,Null mutant is viable\n; zds1 zds2 double deletion causes slow growth and defects i\nn bud morphology and cell cycle progression\n mSMC5:Unknown ,, Unknown\n mUTP14:Unknown ,, Unknown\n Cond811:Na60'\n mUTP18:Unknown ,, Unknown\n Cond372:1.5_mM_diamide_(30_min)\n Stress.HeatVar:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond336:constant_0.32_mM_H2O2_(20_min)_redo\n Cond707:gal4gal80-gal\n Cond324:heat_shock_33_to_37,_20_minutes\n pho.Pho:New components of a system for phosphate accumulation and po\nlyphosphate metabolism in Saccharomyces cerevisiae revealed \nby genomic expression analysis.  Mol Biol Cell. 2000 Dec;11(\n12):4309-21.\n Cond334:29C_+1M_sorbitol_to_33C_+_*NO_sorbitol_-_30_minutes\n Cond411:diauxic_shift_timecourse_20.5_h\n Stress.Various:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond831:tlc1_Expt.2_Passage_3\n Calcin.Na:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n.  J Biol Chem. 2002 Aug 23;277(34):31079-88\n Cond699:gal4-gal\n Cond442:DBYyap1-_+_0.3_mM_H2O2_(20_min)\n Cell Cycle.cdc15:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion.  Mol Biol Cell. 1998 Dec;9(12):3273-97.\n Cond473:WT+/-MMS(DBY747)\n mMTR4:Dead-box family helicase required for mRNA export from nucle\nus,RNA helicase,Null mutant is inviable; a temperature-sensi\ntive mtr4 mutant accumulates poly(A)+ RNA in the nucleus at \n37 degrees\n Cond980:F82G_10_mM_1NaPP1\n mRPC19:subunit common to RNA polymerases I (A) and III (C),RNA poly\nmerases I (A) and III (C) subunit,Null mutant is inviable\n Cond858:pm71-30\n mUTP21:Unknown ,, Unknown\n mBUD22:Hypothetical ORF,,Null mutant is viable; random budding in d\niploid null mutants\n mFUR4:uracil permease,uracil permease,Null mutant is viable\n Cond304:Heat_Shock_30_minutes_hs-1\n mYDR521W:Unknown ,, Unknown\n mUTP6 mUTP18 mUTP9 mNAN1 mUTP21 mUTP14

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Computational Genomics Lab, Tel-Aviv uniresity