Module number 1711




Database revision : gnsdb28.10
Date : Tue Feb 25 17:17:54 2003
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Cond292:Glucosamine\n Cond102:mrt4\n mTIM17:Mitochondrial inner membrane protein involved in protein imp\nort,16.5 kDa inner membrane protein required for import of m\nitochondrial precursor proteins,Null mutant is inviable\n Cond541:fus3D+50nMaF,30min/wtlog10(intensity)\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n Cond944:SK1_ume6_YPA\n Cond248:ymr030w\n mHCR1:High Copy suppressor of RPG1,,viable\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts. Nat Genet\n. 2000 Dec;26(4):415-23.\n Cond130:rml2(**13)\n GCR1.gcr1:Understanding the growth phenotype of the yeast gcr1 mutant \nin terms of global genomic expression patterns. J Bacteriol\n. 2000 Sep;182(17):4970-8.\n mESS1:Mitotic regulator; structurally and functionally homologous \nto human PIN1,peptidyl-prolyl cis-trans isomerase (PPIase),N\null mutant is inviable; arrest phenotype of mitotic arrest a\nnd nuclear fragmentation\n Cond280:FKS1(tetpromoter)\n Cond185:ubr2\n Cond140:rps24a(**9)\n Cond105:nrf1\n mTRK2:membrane protein; low affinity potassium transport,low affin\nity potassium transport , membrane protein,Null mutant is vi\nable, requires added potassium; trk1 trk2 double mutants are\n viable\n mMSS51:Protein required for the maturation and translation of COX1\n mRNA,,necessary for cox1 pre-mRNA processing and translati\non\n mSIM1:(putative) invovled in control of DNA replication,,Null muta\nnt is viable; mutant allows an extra round of DNA replicatio\nn without mitosis\n Cond28:cla4(haploid)\n Cond81:hog1(haploid)\n GCN4.gcn4:Transcriptional profiling shows that Gcn4p is a master regul\nator of gene expression during amino acid starvation in yeas\nt. Mol Cell Biol. 2001 Jul;21(13):4347-68.\n Cond880:BCNU\n Cond53:erg2\n Cond940:6h\n Cond:\n Cond889:4NQO_2\n Cond947:W303_YPA\n Mating.Mating:Signaling and circuitry of multiple MAPK pathways revealed b\ny a matrix of global gene expression profiles. Science. 200\n0 Feb 4;287(5454):873-80\n Cond200:yel001c\n Cond245:ymr014w\n Cond888:MNNG_2\n Cond285:RHO1(tetpromoter)\n Cond279:ERG11(tetpromoter)\n COMP.CH:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond893:SMMS\n mTOM22:Translocase of Outer Mitochondrial membrane,mitochondrial im\nport receptor protein,Null mutant is inviable\n Cond61:fks1(haploid)\n mHSP60:60 kDa heat shock protein,chaperonin , groEL homolog , chape\nronin , groEL homolog,Null mutant is inviable\n Cond216:yer044c(haploid)\n mADH1:Alcohol dehydrogenase,alcohol dehydrogenase,Null mutant is v\niable and sensitive to formaldehyde.\n mRET2:coatomer (COPI) complex delta subunit,,ret2-1 mutant is ther\nmosensitive and shows defects in retrieval of dilysine-tagge\nd proteins from the Golgi back to the ER and, at the non-per\nmissive temperature, in forward ER-to-Golgi transport\n mDSK2:Required with RAD23 for duplication of the spindle pole body\n,ubiquitin-like protein,Null mutant is viable\n mARP7:involved in transcriptional regulation,actin related protein\n , chromatin remodeling Snf/Swi complex subunit,Null mutant \nis viable, exhibits typical swi/snf phenotypes, including gr\nowth defects on media containing galactose, glycerol, or suc\nrose as sole carbon sources. ARP7 is required for expression\n of an HO-lacZ fusion gene and for full transcriptional enha\nncement by the GAL4 activator\n mADH2:alcohol dehydrogenase II,alcohol dehydrogenase II,Null mutan\nt is viable\n mMAS6:23 kDa mitochondrial inner membrane protein,23 kDa mitochond\nrial inner membrane protein,Null mutant is inviable; conditi\nonal mutants accumulate mitochondrial precursor proteins at \nrestrictive temperature\n mCPR3:cyclophilin-3 (cyclosporin-sensitive proline rotamase-3),cyc\nlophilin , peptidyl-prolyl cis-trans isomerase (PPIase),Null\n mutant is viable, unable to grow on L-lactate at 37 degrees\n C\n Cond287:2-deoxy-D-glucose\n Cond273:yor078w\n UME6.ume6:The Ume6 regulon coordinates metabolic and meiotic gene expr\nession in yeast. Proc Natl Acad Sci U S A. 2002 Oct 15;99(2\n1):13431-6.\n mOXA1:Mediates the export of proteins from the mitchondrial matrix\n to the intermembrane space. ,,Null mutant is viable but is \nrespiratory-deficient and lacks cytochrome oxidase activity;\n oxa1 mutant can be complemented by human OXA1; multicopy OX\nA1 suppresses afg3 and rca1 mutants\n mMRPL8:Mitochondrial ribosomal protein MRPL8 (YmL8) (E. coli L17),r\nibosomal protein (YmL8) (E. coli L17),Null mutant is viable;\n shows loss of mitochondrial function, instability of mitoch\nondrial DNA\n Cond139:rpl8a\n mSRV2:70-kDa adenylyl cyclase-associated protein,70 kDa adenylyl c\nyclase-associated protein,Null mutant is inviable.\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mPMT2:Transfers mannosyl residues from dolichyl phosphate-D-mannos\ne to seryl and threonyl residues in proteins; acts in comple\nx with Pmt1p,dolichyl phosphate-D-mannose:protein O-D-mannos\nyltransferase,Null mutants are viable but show diminished in\n vitro and in vivo O-mannosylation activity; pmt1 pmt2 doubl\ne mutant shows severe growth defect but has residual O-manno\nsylation activity; pmt2 pmt3 pmt4 triple mutant is inviable\n mYIL041W:Unknown ,, Unknown\n mPTK2:Putative serine/threonine protein kinase that enhances sperm\nine uptake,,Mutant shows reduced spermine and putrescine upt\nake and is resistant to toxic polyamine analogs and Li+ and \nNa+ ions; ptk1 ptk2 double mutant shows virtaully abolished \nhigh-affinity spermidine transport\n Cond134:rpl12a\n Cond58:erp2\n Cond256:ymr141c\n Cond52:erd1\n Cond62:fpr1\n Cond26:cka2\n mDPM1:dolichol phosphate mannose synthase,dolichol phosphate manno\nse synthase,Null mutant is inviable\n mYHR083W:Unknown ,, Unknown\n mADE3:Required for the biosynthesis of purines, thymidylate, methi\nonine, histidine, pantothenic acid and formylmethionyl-tRNA,\nC1-tetrahydrofolate synthase,Null mutant is viable, adenine \nauxotroph, histidine auxotroph\n mAHP1:alkyl hydroperoxide reductase,alkyl hydroperoxide reductase,\nhypersensitive to tert-butyl hydroperoxide\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond205:yel033w\n mPAN1:Involved in actin organization and endocytosis,,Null mutant \nis inviable; conditional mutants show arrest of translation \ninitiation, alterations in mRNA poly(A) tail lengths, and al\ntered cellular location of Mod5p\n Cond284:PMA1(tetpromoter)\n Cond91:kim4\n Cond283:KAR2(tetpromoter)\n mYPL098C:Unknown ,, Unknown\n Cond942:SK1ume6_YPD\n Cond474:gcn4D+/-100mM3AT(KNY124)\n Cond905:(77i4)_S150-2B_YPGL+G__NormInt\n mTUP1:general repressor of transcription (with Cyc8p); mediates gl\nucose repression,glucose repression regulatory protein, exhi\nbits similarity to beta subunits of G proteins,Null mutant i\ns viable; exhibits flocculent colony morphology\n mCAR2:ornithine aminotransferase,ornithine aminotransferase,Catabo\nlism of arginine defective\n Cond570:cdc15_30\n mSEC61:membrane component of ER protein translocation apparatus,,Nu\nll mutant is inviable. Conditional alleles are defective for\n protein translocation and the export of misfolded proteins \nfrom the endoplasmic reticulum at the restrictive temperatur\ne.\n mSLC1:fatty acyltransferase homologous to E. coli plsC gene; funct\nionally complements plsC mutants,1-acyl-sn-gylcerol-3-phosph\nate acyl transferase (putative),slc1-1 mutant suppresses sph\ningolipid long chain biosynthetic defect; the mutant also ma\nkes novel phosphatidylinositol derivatives and lacks sphingo\nlipids\n Cell Cycle.cdc15:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion. Mol Biol Cell. 1998 Dec;9(12):3273-97.\n COMP.TE:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mZWF1:Glucose-6-phosphate dehydrogenase,glucose-6-phosphate dehydr\nogenase,sensitive to oxidizing agents; methionine requiring\n mSYN8:Unknown ,, Unknown\n mLCB1:Involved in sphingolipid biosynthesis; may catalyze the firs\nt step in biosynthesis of long-chain sphingolipids,serine pa\nlmitoyltransferase component (putative),Null mutant is viabl\ne; auxotrophic for long-chain component of sphingolipids; ho\nmozygous lcb1 diploids fail to sporulate\n mPIR1:Protein containing tandem internal repeats,contains tandem i\nnternal repeats,Null mutant is viable; pir1 hsp150 (pir2) do\nuble mutant and pir1 hsp150 (pir2) pir3 triple mutant are sl\now-growing on agar slab and sensitive to heat shock\n Cond884:10\n mTIM17 mMAS6 mESS1 mCAR2
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Computational Genomics Lab, Tel-Aviv uniresity