Module number 1645




Database revision : gnsdb28.10
Date : Tue Feb 25 17:18:24 2003
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UME6.ume6:The Ume6 regulon coordinates metabolic and meiotic gene expr\nession in yeast. Proc Natl Acad Sci U S A. 2002 Oct 15;99(2\n1):13431-6.\n Cond936:12h\n Cond698:gal3-gal\n Cond871:yhe710-ss\n Cond465:steady_state_15_dec_C_ct-2\n Cond700:gal5-gal\n mSRT1:cis-prenyltransferase homologue,cis-prenyltransferase,Null m\nutant is viable, grows at all temperatures tested and is not\n hygromycin B sensitive; srt1 rer2 double disruption mutants\n are inviable; overexpression of SRT1 suppresses the tempera\nture sensitive and slow growth phenotypes of rer2 mutants\n mDIN7:DNA-damage inducible gene,,\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts. Nat Genet\n. 2000 Dec;26(4):415-23.\n Cond187:vac8\n mSPO69:Required for sporulation; highly induced during sporulation.\n,S. pombe REC8 homolog,Null mutant is viable, does not under\ngo meiotic division and is unable to sporulate. The null mut\nant also exhibits a loss of sister chromatid cohesion, an ab\nsence of the synaptonemal complex, and chaotic chromosome se\ngregation.\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond460:17_deg_growth_ct-1\n Cond563:alpha84\n Sporulation.Series0:The transcriptional program of sporulation in budding yeast.\n Science. 1998 Oct 23;282(5389):699-705.\n Cell Cycle.alpha:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion. Mol Biol Cell. 1998 Dec;9(12):3273-97.\n Cond963:t11.5_g/r_ratio\n Cond941:SK1_YPD\n mPCH2:Pachytene CHeckpoint,ATPase (putative),Null mutant is viable\n and bypasses meiotic arrest of zip1 mutant, resulting in ch\nromosome segregation defects\n gala.-gal:Integrated genomic and proteomic analyses of a systematicall\ny perturbed metabolic network. Science. 2001 May 4;292(5518\n):929-34.\n Cond945:W303_YPD\n mYOR365C:Unknown ,, Unknown\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mSPO11:Dispensable for mitosis, premeiotic DNA synthesis, spindle p\nole body duplication, meiosis I, meiosis II & spores. Requir\ned for chromosome pairing seen by in situ hybridization, dou\nble strand breaks, synaptonemal complexes.,early meiosis-spe\ncific recombination protein,Null mutant is viable, sporulati\non defective; spo11 executes meiosis I early, is rescued by \nspo13 and is epistatic to rad52 spo13; and is classified as \nan early recombination function. It fails to form any recomb\nination intermediates and is partially suppressed by X-irrad\niation (by induced double strand breaks), in meiosis. The sp\no11-1 temperature sensitive mutant is double strand break-, \nrecombination-, and exhibits tripartite synaptonemal complex\n structures at a restrictive temperature, suggesting synapto\nnemal complex formation may be partially independent of doub\nle strand breaks and recombination. mRNA is induced early in\n meiosis; meiosis-specific regulation is dependent on a URS1\n element within the coding region.\n Cond319:37C_to_25C_shock_-_90_min\n Cond365:dtt_060_min_dtt-2\n mYNL019C:Unknown ,, Unknown\n Stress.tempgrow:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond959:t2_g/r_ratio\n mSPS4:sporulation-specific protein,,normal sporulation\n mSPO19:sporulation-defective; SPO19 was found as a weak high-copy s\nuppressor of the spo1-1 ts mutation. The gene is specificall\ny induced late in meiosis (Primig et al. (2000) Nat Genet 26\n:415-423),meiosis-specific GPI-protein,Null mutant is viable\n; unable to form spores\n Cond940:6h\n Cond:\n mSRO7:Suppressor of rho3,yeast homolog of the Drosophila tumor sup\npressor, lethal giant larvae,Null mutant is viable but is cs\n- in combination with sni2(YBL106c) null; sni1 sni2 double m\nutant has exocytic defect, accumulating post-Golgi vesicles.\n Acts as a multicopy suppressor of rho3.\n Stress.DTT2:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mYKL187C:Unknown ,, Unknown\n Cond702:gal7-gal\n mSGS1:Involved in maintaining genome stability. Homologous to E. c\noli RecQ and human BLM and WRN proteins that are defective i\nn the cancer-prone disorder Bloom's syndrome and the prematu\nre aging disorder Werner's syndrome, respectively,DNA helica\nse signature motifs,Null mutant is viable; strains lacking S\nGS1 exhibit elevated levels of chromosome misseggregation du\nring both mitotic and meiotic division. sgs1 null strains su\nppress the slow growth of a top3 delta strain lacking topois\nomerase III and show an increase in subtelomeric Y' instabil\nity due to hyperrecombination.\n Cond696:gal1-gal\n mYPL033C:Unknown ,, Unknown\n Stress.ColdShock:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond965:ndt80_delete_mid_g/r_ratio_\n mSPR28:Septin-related protein expressed during sporulation,,Null mu\ntant is viable\n Cond948:W303_ume6_YPA_\n Cond937:t=0\n mMIP6:RNA-binding protein, interacts with MEX67,,\n Cond934:8h\n Cond960:t5_g/r_ratio\n Cond701:gal6-gal\n Cond938:2h\n Cond961:t7_g/r_ratio\n Cond964:ndt80_delete_early_g/r_ratio\n TorRama.Series0:Partitioning the transcriptional program induced by rapamyci\nn among the effectors of the Tor proteins. Curr Biol. 2000 D\nec 14-28;10(24):1574-81\n mYLR445W:Unknown ,, Unknown\n mHUL4:ubiquitin-protein ligase (E3),ubiquitin ligase (E3),Null mut\nant is viable\n mSCC2:Sister chromatid cohesion protein,,\n Cond935:10h\n mCAT8:Zinc-cluster protein involved in activating gluconeogenic ge\nnes; related to Gal4p,zinc-cluster protein involved in activ\nating gluconeogenic genes; related to Gal4p,Null mutant is v\niable but unable to grow on non-fermentable carbon sources d\nue to failure to derepress all major gluconeogenic enzymes; \noverexpression of Cat8p suppress inability of snf1 and snf4 \nmutants to grow on ethanol\n Cond962:t9_g/r_ratio\n mSPO20:DBF2 Interacting Protein; SNAP 25 homolog,DBF2 interacting p\nrotein , SNAP 25 homolog,Null mutant is viable, other mutant\n fails to form spores\n Stress.tempsteady:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mMSH4:dispensable for DNA repair, required for full levels of reci\nprocal exchange and spore viability,meiosis specific protein\n, E.coli MutS protein, localizes to discrete sites on meioti\nc chromosomes,Null mutant is viable, has no apparent defect \nin mismatch repair, wild-type levels of gene conversion and \npostmeiotic segregation\n mMSH5:dispensable for DNA repair and meiotic intrachromosomal reci\nprocal recombination, required for full reciprocal recombina\ntion between homologs, and spore viability,mutS homolog,Null\n mutant is viable. Diploids lacking the MSH5 gene display de\ncreased levels of spore viability, increased levels of meios\nis I chromosome nondisjuction, and decreased levels of recip\nrocal exchange between, but not within, homologs. Gene conve\nrsion is not reduced. Msh5 mutants are phenotypically simila\nr to mutants in the meiosis-specific gene MSH4. msh5 is epis\ntatic to msh4, suggesting they act in the same pathway.\n Cond939:4h\n
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Computational Genomics Lab, Tel-Aviv uniresity