Module number 1641




Database revision : gnsdb28.10
Date : Tue Feb 25 17:18:09 2003
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mMSH6:Required for mismatch repair in mitosis & meiosis, low level\ns of postmeiotic segregation & high spore viability; forms c\nomplex with Msh2p to repair both single-base & insertion-del\netion mispairs; redundant with Msh3p in repair of in-dels,hu\nman GTBP protein homolog,Null mutant is viable, msh3 msh6 do\nuble deletion mutants exhibit microsatellite instability and\n mutability similar to that in a msh2 mutant\n mVPS38:involved in vacuolar protein targeting,,\n mARE2:Acyl-CoA cholesterol acyltransferase (sterol-ester synthetas\ne),acyl-CoA cholesterol acyltransferase (sterol-ester synthe\ntase),Null mutant is viable; greatly reduces in vivo and in \nvitro ergosterol esterification (to 15 - 35 % of wild-type).\n Deletion of both ARE1 and ARE2 completely eliminates in viv\no and in vitro ergosterol esterification\n mCRR1:CRH-Related,,\n mYNL047C:Unknown ,, Unknown\n mFLO10:Protein with similarity to flocculation protein Flo1p,,\n mYNR040W:Unknown ,, Unknown\n mUGA4:GABA-specific transport protein,GABA-specific transport prot\nein,Null mutant is viable.\n mPGM2:Phosphoglucomutase,phosphoglucomutase,Null mutant is viable,\n pgm1 pgm2 deletion mutants fail to grow on galactose\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mPAU4:member of the seripauperin protein/gene family (see Gene_cla\nss PAU),,\n mTHI22:THI for thiamine metabolism. Transcribed in the presence of \nlow level of thiamine (10-8M) and turned off in the presence\n of high level (10-6M) of thiamine. Under the positive contr\nol of THI2 and THI3.,,null mutant is viable\n mBOP2:bypass of PAM1,,\n mCLB5:role in DNA replication during S phase; additional functiona\nl role in formation of mitotic spindles along with Clb3 and \nClb4,B-type cyclin,Null mutant is viable, but has an extende\nd S phase\n mBUD9:among a group of genes whose products are necessary for bud-\nsite selection; likely involvement in positioning the proxim\nal pole signal,,In null mutants bipolar-budding cells bud pr\neferentially at distal pole\n mMAL11:Part of MAL1 complex locus; encodes funct. maltose permease \nin all strains, exhibits sign. seq. variability; shows homol\n. to functional maltose permease from S. carlsbergenesis; me\nmber of the 12 tm domain superfamily of sugar transporters,a\nlpha-glucoside transporter , hexose transporter , maltose pe\nrmease,Mutant is defective in maltose fermentation.\n mFRE4:similar to FRE2,,\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mPDX1:Plays a structural role in pyruvate dehydrogenase complex,py\nruvate dehydrogenase complex protein X component,Null mutant\n is viable\n mFRE7:similar to FRE2,,\n mUBR1:Ubiquitin-protein ligase,ubiquitin-protein ligase,Null mutan\nt is viable, unable to degrade substrates of the N-end rule \npathway, partially defective in sporulation\n Cond586:cdc15_210\n mPCL2:Interacts with cyclin-dependent kinase PHO85 to form kinase \ncomplex with G1-periodic activity involved in cell cycle pro\ngression,G1 cyclin,\n mHIR3:Involved in cell-cycle regulation of histone transcription,,\nHTA1-HTB1 transcription is derepressed and is no longer cell\n-cycle regulated\n mSPO16:Early meiotic protein required for efficient spore formation\n,,sporulation defective\n mVPS61:Unknown ,, Unknown\n Cond228:yhl045w\n mYHR033W:Unknown ,, Unknown\n mCTS1:Endochitinase,endochitinase,Null mutant is viable; exhibits \na defect in cell separation\n mYPL071C:Unknown ,, Unknown\n Cond754: mYOP1:Ypt Interacting Protein,,\n mYKR077W:Unknown ,, Unknown\n Cond184:ubr1\n Cell Cycle.cdc15:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion. Mol Biol Cell. 1998 Dec;9(12):3273-97.\n mRPL34B:Homology to rat L34,ribosomal protein L34B,\n mYFL040W:Unknown ,, Unknown\n fkh1,2sf.Series0:Two yeast forkhead genes regulate the cell cycle and pseudoh\nyphal growth. Nature. 2000 Jul 6;406(6791):90-4.\n mYCR045C:Unknown ,, Unknown\n mYHR029C:Unknown ,, Unknown\n
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Computational Genomics Lab, Tel-Aviv uniresity