Module number 1576




Database revision : gnsdb28.10
Date : Tue Feb 25 17:18:33 2003
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mYJL211C:Unknown ,, Unknown\n mYGR001C:Unknown ,, Unknown\n mYOL163W:Unknown ,, Unknown\n mBCK1:bypass requirement for protein kinase C homolog,MEKK,Null mu\ntants are temperature-sensitive and exhibit cell lysis, whic\nh can be rescued by 1M sorbitol; null mutants grow very poor\nly even at the permissive temperature. Some dominant alleles\n suppress a pkc1 null mutant.\n mDCG1:Product of gene unknown,,\n mSWM1:Spore Wall Maturation 1,,Null mutant completes meiotic nucle\nar division but does not show spore wall maturation\n mBUD3:cell cycle regulated protein required for axial bud formatio\nn; co-assembles with Bud4p at bud sites,,Null mutant is viab\nle; bipolar budding pattern in all cell types\n mPDR1:general positive regulator of permeability genes,zinc finger\n transcription factor of the Zn(2)-Cys(6) binuclear cluster \ndomain type,pleiotropic drug resistance, resistant to borrel\nidin, oligomycin, antimycin, cycloheximide, antibiotic, thio\nisoleucine, sulfometuron methyl; accumulation of neutral red\n mYEL048C:Unknown ,, Unknown\n mYJL182C:Unknown ,, Unknown\n mYGR045C:Unknown ,, Unknown\n mSDP1:Unknown ,, Unknown\n mYBR216C:Unknown ,, Unknown\n mTAD1:Deaminates adenosine-37 to inosine in eukaryotic tRNA-Ala.,t\nRNA-specific adenosine deaminase subunit,Null mutant is viab\nle\n mYGR067C:Unknown ,, Unknown\n mYIL058W:Unknown ,, Unknown\n mSUL2:Sulfate uptake,high affinity sulfate permease,\n mPEX18:Peroxin; Pex18p and Pex21p are partially functionally redund\nant.,peroxin,Null mutant is viable but has reduced growth on\n oleate, partial impairment of peroxisome biogenesis\n mYPR153W:Unknown ,, Unknown\n mYPL216W:Unknown ,, Unknown\n Cond:\n mFMT1:Formyl-Methionyl-tRNA Transformylase (consistent with name o\nf bacterial homologs),methionyl-tRNA transformylase,Null mut\nant is viable and lacks mitochondrial formyl-Met-tRNA\n mYBL010C:Unknown ,, Unknown\n mATF1:Alcohol acetyltransferase,alcohol acetyltransferase,\n mSDC25:homologous to cdc25,GDP/GTP exchange factor for Ras,null is \nviable; the C-terminal 584 amino acids (but not the entire p\nrotein) suppresses cdc25 mutations\n mSPR28:Septin-related protein expressed during sporulation,,Null mu\ntant is viable\n mYGL260W:Unknown ,, Unknown\n mYOL085C:Unknown ,, Unknown\n mGAL1:Haploid specific protein localized in the Golgi and plasma m\nembrane,galactokinase,Null mutant is viable and cannot utili\nze galactose.\n mYCR007C:Unknown ,, Unknown\n TorRama.Series0:Partitioning the transcriptional program induced by rapamyci\nn among the effectors of the Tor proteins. Curr Biol. 2000 D\nec 14-28;10(24):1574-81\n mYIM2:Product of gene unknown,,\n mYBR100W:Unknown ,, Unknown\n mYDR015C:Unknown ,, Unknown\n mYDR269C:Unknown ,, Unknown\n mCYC2:Involved in import of cytochrome c into mitochondria,cytochr\nome c mitochondrial import factor,Null mutant is viable. Del\netion of CYC2 leads to accumulation of apocytochrome c in th\ne cytoplasm; strains with deletions of CYC2 still import low\n levels of cytochrome c into mitochondria\n mCAT8:Zinc-cluster protein involved in activating gluconeogenic ge\nnes; related to Gal4p,zinc-cluster protein involved in activ\nating gluconeogenic genes; related to Gal4p,Null mutant is v\niable but unable to grow on non-fermentable carbon sources d\nue to failure to derepress all major gluconeogenic enzymes; \noverexpression of Cat8p suppress inability of snf1 and snf4 \nmutants to grow on ethanol\n mYHL037C:Unknown ,, Unknown\n mPTR2:Functions in transport of small peptides into the cell,pepti\nde transporter,Null mutant is viable\n mFKS3:Protein with similarity to Gls1p and Gls2p (GB:Z49212),,\n mYCL076W:Unknown ,, Unknown\n mREC104:meiosis-specific recombination gene, dispensable for mitotic\n recombination and axial elements in meiosis, required for t\nripartite synaptonemal complexes, meiotic recombination and \nspore viability; classified as an early recombination gene,m\neiosis-specific protein,Null mutant is viable, rec104 mutant\ns exhibit reduced meiotic DNA recombination, executes meiosi\ns I early; rec104 is rescued by spo13 and is epistatic to ra\nd52 spo13\n mNTG2:Endonuclease III-like glycosylase,endonuclease III DNA base \nexcision repair N-glycosylase,\n mPEX7:May serve as intraperoxisomal receptor for type 2 peroxisoma\nl proteins (such as thiolase),beta-transducin-related (WD-40\n) protein family,Mutant is defective in assembling specific \nproteins into peroxisomes (assembles catalase and acyl-CoA o\nxidase but not thiolase) and cannot utilize oleic acid\n mYNR066C:Unknown ,, Unknown\n mYOR364W:Unknown ,, Unknown\n mGDS1:involved in nuclear control of mitochondria,,Null mutant is \nviable, shows partial impairment of growth on medium contain\ning glycerol as the carbon source. Overexpxression suppresse\ns NAM9-1 glycerol deficient phenotype\n mCIT3:Mitochondrial isoform of citrate synthase,citrate synthase,N\null mutant shows severely reduced growth on the respiratory \nsubstrate glycerol in a delta cit1 background\n mPTK1:Putative serine/threonine protein kinase,,Mutant shows decre\nase in total polyamine accumulation and resistance to polyam\nine analogs; ptk1 ptk2 double mutant shows virtually abolish\ned high-affinity spermidine transport\n mCOS10:Protein with strong similarity to subtelomerically-encoded p\nroteins such as Cos5p, Ybr302p, Cos3p, Cos1p, Cos4p, Cos8p, \nCos6p, Cos9p,,\n mYFR046C:Unknown ,, Unknown\n mYGR018C:Unknown ,, Unknown\n mYPR089W:Unknown ,, Unknown\n mYDL187C:Unknown ,, Unknown\n mYNL122C:Unknown ,, Unknown\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mYGL146C:Unknown ,, Unknown\n mPPH3:protein phosphatase type 2A,protein phosphatase type 2A,Null\n mutant is viable, pph3 pph21 pph22 mutants are inviable\n mYBR210W:Unknown ,, Unknown\n mYBR174C:Unknown ,, Unknown\n mZIP2:Required for 'ZIPpering' up meiotic chromosomes during chrom\nosome synapsis,,Null mutant is viable but is defective in ch\nromosome synapsis, but not chromosome pairing, and causes me\niosis I non-disjunction and reduced homologous recombination\n mYDR314C:Unknown ,, Unknown\n mYPR039W:Unknown ,, Unknown\n mYLR232W:Unknown ,, Unknown\n mYFL015C:Unknown ,, Unknown\n mYMR320W:Unknown ,, Unknown\n mAUT7:Forms a protein complex with Aut2p to mediate attachment of \nautophagosomes to microtubules. Defective in maturation of t\nhe vacuolar protein, aminopeptidase I,similar to LC3, a micr\notubule-associated protein from rat,Null mutant is viable bu\nt lacks autophagocytosis and is unable to sporulate. AUT7 is\n a suppressor of mutant phenotypes of aut2-1 cells. Uptake o\nf precursor Aminopeptidase I into the vacuole depends on Aut\n2p and Aut7p.\n mYFR054C:Unknown ,, Unknown\n mYIR020C:Unknown ,, Unknown\n mYOR068C:Unknown ,, Unknown\n mYDR401W:Unknown ,, Unknown\n mYGL262W:Unknown ,, Unknown\n mARO80:Hypothetical ORF,,\n mESC8:Unknown ,, Unknown\n mYNL203C:Unknown ,, Unknown\n mYIL032C:Unknown ,, Unknown\n mGUP2:Involved in active glycerol uptake,active glycerol transport\ner (putative),\n mYLR415C:Unknown ,, Unknown\n mYIL025C:Unknown ,, Unknown\n mYDL050C:Unknown ,, Unknown\n mYCR001W:Unknown ,, Unknown\n mCIN1:Protein involved in chromosome segregation, required for mic\nrotubule stability,tubulin folding cofactor D,Null mutant is\n viable, exhibits cold sensitivity for viability; defect in \nnuclear migration and nuclear fusion, supersensitivity to be\nnomyl and nocodozole\n mKRE23:Killer toxin REsistant,,Null mutant is K1 killer toxin resis\ntent\n mVTH1:vps ten homolog,potential membrane glycoprotein (putative) ,\n strong similarity to Vth2 and Pep1/Vps10,Null mutant is via\nble; overexpression partially suppresses the sorting defect \nof a pep1 null mutant.\n mYLR124W:Unknown ,, Unknown\n mMLH2:Mutl Homolog,,Null mutant is viable but non-Mendelian segreg\nation is elevated and parity is altered during meiosis.\n mYGL132W:Unknown ,, Unknown\n mAQY1:Aquaporin,aquaporin,Null mutant is viable and exhibits impro\nved viability when grown under hypo-osmolar or hyper-osmolar\n stress.\n mYDR438W:Unknown ,, Unknown\n mYMR158W-A:Unknown ,, Unknown\n mYOR366W:Unknown ,, Unknown\n mSMA1:Spore Membrane Assembly,,undergoes meiotic nuclear divisions\n but does not form spores\n mYBL049W:Unknown ,, Unknown\n mYPR077C:Unknown ,, Unknown\n mPHR1:photolyase,photolyase,photoreactivation repair deficient\n mGPX2:Glutathione peroxidase paralogue,,Null mutant is viable\n mYGR012W:Unknown ,, Unknown\n mYOL160W:Unknown ,, Unknown\n mECM34:ExtraCellular Mutant,,A Tn3 insertion into this gene causes \nhypersensitivity to the cell surface polymer perturbing agen\nt calcofluor white.\n mYDR250C:Unknown ,, Unknown\n mSGS1:Involved in maintaining genome stability. Homologous to E. c\noli RecQ and human BLM and WRN proteins that are defective i\nn the cancer-prone disorder Bloom's syndrome and the prematu\nre aging disorder Werner's syndrome, respectively,DNA helica\nse signature motifs,Null mutant is viable; strains lacking S\nGS1 exhibit elevated levels of chromosome misseggregation du\nring both mitotic and meiotic division. sgs1 null strains su\nppress the slow growth of a top3 delta strain lacking topois\nomerase III and show an increase in subtelomeric Y' instabil\nity due to hyperrecombination.\n mYJL216C:Unknown ,, Unknown\n mYDR112W:Unknown ,, Unknown\n mTHI12:thiamine regulated gene, homologous to nmt1a in Schizosaccha\nromyces pombe; putatively involved in pyrimidine biosynthesi\ns,,\n mSTD1:interacts with the SNF1 protein kinase and TBP in two-hybrid\n and in in vitro binding studies,MTH1 homolog,Null mutant is\n viable, no defects in mating or sporulation. Suppressor of \nTBP deletion; multicopy suppressor of SNF; std1-mth1 has def\nective glucose derepression and sporulation\n mYER185W:Unknown ,, Unknown\n mYMR155W:Unknown ,, Unknown\n mNIT2:Nit protein, nitrilase superfamily member,,\n mYLR365W:Unknown ,, Unknown\n mDBF20:kinase required for late nuclear division,kinase required fo\nr late nuclear division,Dumbell formation\n mYOR055W:Unknown ,, Unknown\n mSYT1:Suppressor of Ypt3,,\n mYNL335W:Unknown ,, Unknown\n mYDR215C:Unknown ,, Unknown\n mYJR146W:Unknown ,, Unknown\n mKSP1:Serine/threonine kinase similar to casein kinase II and othe\nr serine/threonine protein kinases,,Null mutant is viable\n Cond871:yhe710-ss\n mENT4:epsin N-terminal homology-containing protein,,unknown\n mYPL025C:Unknown ,, Unknown\n mYKL050C:Unknown ,, Unknown\n mPSY2:Unknown ,, Unknown\n mBTT1:beta subunit of the nascent-polypeptide-associated complex (\nNAC); homologous to human BTF3b; Negative effect on expressi\non of several genes transcribed by RNA polymerase II,,Null m\nutant is viable\n Cond149:sap30\n mYJR038C:Unknown ,, Unknown\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mSNO2:SNZ2 proximal ORF, stationary phase induced gene,,Null mutan\nt is viable.\n mYDR535C:Unknown ,, Unknown\n mYCL023C:Unknown ,, Unknown\n mCDA2:Required for proper formation of the ascospore wall,chitin d\neacetylase,Null mutant is viable, mutant spores disrupted fo\nr both cda1 and cda2 fail to emit natural fluorescence and a\nre sensitive to hydrolyrtic enzymes, ether, and heat shock\n mBFA1:Byr four alike,,Null mutant is viable; mutants are sensitive\n to microtubule inhibitors, exhibit defects in mitotic check\npoints, and exhibit moderate defects in mating efficiency\n mYDL118W:Unknown ,, Unknown\n mYIL042C:Unknown ,, Unknown\n mYPR195C:Unknown ,, Unknown\n mAPG10:Involved in autophagy; protein-conjugating enzyme involved i\nn the Apg12p-Apg5p conjugation pathway,protein-conjugating e\nnzyme,Defective autophagy, apg10-1 allele shows reduced viab\nlility under starvation conditions\n mYDL176W:Unknown ,, Unknown\n mYHL041W:Unknown ,, Unknown\n mYIL057C:Unknown ,, Unknown\n mYFR057W:Unknown ,, Unknown\n mAPG16:autophagy,,Null mutant is viable, defective in autophagy\n mYIL006W:Unknown ,, Unknown\n mYGR051C:Unknown ,, Unknown\n mYIL086C:Unknown ,, Unknown\n mYOR376W:Unknown ,, Unknown\n mLRG1:Expressed most highly in sporulating cells; may also play a \nrole during mating,similar to LIM-domain proteins and to rho\n/rac GTPase-activating family of proteins,Null mutant is via\nble\n mYDR274C:Unknown ,, Unknown\n mYMR244W:Unknown ,, Unknown\n mBNA5:Unknown ,, Unknown\n mYAR047C:Unknown ,, Unknown\n mYNR063W:Unknown ,, Unknown\n mYGR290W:Unknown ,, Unknown\n mYPL077C:Unknown ,, Unknown\n mYMR153C-A:Unknown ,, Unknown\n mARR2:Required for arsenate but not for arsenite resistance,,Null \nmutant is viable but sensitive to arsenate (but not arsenite\n).\n mYBL095W:Unknown ,, Unknown\n mSPR1:Sporulation regulated genes,exo-1,3-beta-glucanase, sporulat\nion-specific,Fail to hydrolyze p-nitrophenyl-beta-D-glucanas\ne or laminarin; mutant spores exhibit reduced thermoresistan\nce\n mARR3:Putative membrane protein involved in arsenite transport,,Ov\nerexpression confers arsenite but not arsenate resistance\n mPPH3 mPSY2 mKSP1 mBCK1 mSTD1 mGDS1 mPEX7 mPEX18
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Computational Genomics Lab, Tel-Aviv uniresity