Module number 1556




Database revision : gnsdb28.10
Date : Tue Feb 25 17:15:08 2003
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mHIS3:imidazoleglycerol-phosphate dehydratase,imidazoleglycerol-ph\nosphate dehydratase,Null mutant is viable and requires histi\ndine\n mFAT2:Fatty acid transporter, very similar to FAT1,,\n Cond102:mrt4\n Cond541:fus3D+50nMaF,30min/wtlog10(intensity)\n mNDC1:dispensable for mitotic spindle pole body duplication, but r\nequired for insertion of nascent spindle pole bodies into th\ne nuclear envelope. ndc1 parental spindle pole bodies form m\nonopolar spindles in mitosis. Required for meiosis II.,multi\nple transmembrane domains (putative) , nuclear envelope prot\nein,Null mutant is inviable. Conditional lethal mutants are \navailable that show asymmetric chromosomal segregation durin\ng mitosis and meiosis II due to a defect in spindle pole bod\ny duplication\n mABP1:Actin binding protein,actin binding protein,Null mutant is v\niable\n mMHP1:Similar to a 250 kD Drosophila microtubule-associated protei\nn (MAP) (which can rescue MHP1 null mutant) and to mammalian\n MAP4 proteins,microtubule-associated protein (MAP) (putativ\ne),Null mutant is inviable; overexpression of the MHP1 C-ter\nminus results in short spindles\n Cond130:rml2(**13)\n Cond711:t2+Vec\n mHHO1:Histone H1,histone H1,Null mutant is viable; other phenotype\n: Increased basal expression of a CYC1-lacz reporter gene; n\nuclear localization of a Hho1-GFP fusion protein\n mPTM1:Putative membrane protein,membrane protein (putative),Null m\nutant is viable, no observable phenotype\n Cond185:ubr2\n mLAT1:Dihydrolipoamide acetyltransferase component (E2) of pyruvat\ne dehydrogenase complex,pyruvate dehydrogenase complex dihyd\nrolipoamide acetyltransferase component (E2),Null mutant is \nviable\n Cond140:rps24a(**9)\n mENO1:enolase I,enolase I,Null mutant is viable\n mRFT1:67 kDa integral membrane protein,67 kDa integral membrane pr\notein,Null mutant is inviable and is defective in cell cycle\n progression\n mADK1:adenylate kinase,adenylate kinase,Null mutant is viable, has\n a petite phenotype\n Cond:\n Cond724:t4+SSD1,H44\n Cond713:t4+Vec\n mLAS21:Local Anesthetics Sensitive: involved in the attachment of g\nlycosylphosphatidylinositol (GPI) anchors to proteins.,major\n facilitator superfamily (putative) , membrane protein (puta\ntive),Null mutant is viable but is temperature-sensitive. Th\ne las21-1 strain is sensitive to tetracaine, but the null la\ns21 mutant is no longer sensitive to tetracaine. Defective i\nn GPI anchor synthesis; sensitive to calcofluor white and hy\ngromycin B \n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Mating.Mating:Signaling and circuitry of multiple MAPK pathways revealed b\ny a matrix of global gene expression profiles. Science. 200\n0 Feb 4;287(5454):873-80\n Cond245:ymr014w\n mOYE2:NAPDH dehydrogenase (old yellow enzyme), isoform 2,NAPDH deh\nydrogenase (old yellow enzyme), isoform 2,Null mutant is via\nble\n Cond285:RHO1(tetpromoter)\n Cond722:t2+SSD1,H44\n mTOM20:Translocase of Outer Mitochondrial membrane,20 kDa mitochond\nrial outer membrane protein import receptor,Null mutant is v\niable but respiration deficient; defective in import of mito\nchondrial preproteins\n Cond709:t0+Vec\n Cond61:fks1(haploid)\n mERV46:ER vesicle protein of 46 kDa,ER-Golgi transport vesicle prot\nein,Null mutant is viable but cold sensitive.\n mYGR031W:Unknown ,, Unknown\n mARP9:involved in transcriptional regulation,actin related protein\n , chromatin remodeling Snf/Swi complex subunit,Null mutant \nis viable, exhibits typical swi/snf phenotypes, including gr\nowth defects on media containing galactose, glycerol, or suc\nrose as sole carbon sources. ARP9 is required for expression\n of an HO-lacZ fusion gene and for full transcriptional enha\nncement by the GAL4 activator\n mMAS6:23 kDa mitochondrial inner membrane protein,23 kDa mitochond\nrial inner membrane protein,Null mutant is inviable; conditi\nonal mutants accumulate mitochondrial precursor proteins at \nrestrictive temperature\n mCPR3:cyclophilin-3 (cyclosporin-sensitive proline rotamase-3),cyc\nlophilin , peptidyl-prolyl cis-trans isomerase (PPIase),Null\n mutant is viable, unable to grow on L-lactate at 37 degrees\n C\n Cond273:yor078w\n mFTH1:FTS3 Homolog 1,,none observed\n mCAM1:Calcium and phospholipid binding protein homologous to trans\nlation elongation factor 1-gamma (EF-1gamma),calcium and pho\nspholipid binding protein homologous to translation elongati\non factor 1-gamma (EF-1gamma),Null mutant is viable under no\nrmal growth conditions\n mUGP1:Uridinephosphoglucose pyrophosphorylase,uridinephosphoglucos\ne pyrophosphorylase,Null mutant is inviable, probably due to\n inability to properly form the cell wall\n mPGK1:3-phosphoglycerate kinase,3-phosphoglycerate kinase,The null\n mutant is viable but unable to use glucose as a carbon sour\nce.\n Cond139:rpl8a\n mYBR206W:Unknown ,, Unknown\n Cond716:t2+SSD1wt\n Cond725:t4-SSD1,M31\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mYIL041W:Unknown ,, Unknown\n mRNQ1:Rich in asparagine (N) and glutamine (Q),transferable epigen\netic modifier,\n Cond134:rpl12a\n Cond26:cka2\n mDPM1:dolichol phosphate mannose synthase,dolichol phosphate manno\nse synthase,Null mutant is inviable\n mYHR083W:Unknown ,, Unknown\n mAHP1:alkyl hydroperoxide reductase,alkyl hydroperoxide reductase,\nhypersensitive to tert-butyl hydroperoxide\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mADE3:Required for the biosynthesis of purines, thymidylate, methi\nonine, histidine, pantothenic acid and formylmethionyl-tRNA,\nC1-tetrahydrofolate synthase,Null mutant is viable, adenine \nauxotroph, histidine auxotroph\n mYEL017W:Unknown ,, Unknown\n Cond205:yel033w\n Cond284:PMA1(tetpromoter)\n Cond714:t0+SSD1wt\n mRVS167:Involved in endocytosis,cytoskeletal protein (putative),Null\n mutant is viable but exhibits reduced viability upon starva\ntion\n mCSR1:chs5 spa2 rescue; isolated as a multicopy suppressor of the \nlethality of chs5 spa2 double mutant at 37 degrees.,,Null mu\ntant is viable\n mMRP1:shows allele-specific genetic interactions with pet122 and p\net123,37 kDa mitochondrial ribosomal protein,defective mitoc\nhondrial protein synthesis; absence of a and b type cytochro\nmes; reduced levels of mitochondrial 15 S rRNA; defective pr\nocessing of apocytochrome b intron; convert to rho- and rho0\n at high frequency\n mMET3:ATP sulfurylase,ATP sulfurylase,Null mutant is viable, and i\ns a methionine auxotroph\n mKTR3:Putative alpha-1,2-mannosyltransferase,alpha-1,2-mannosyltra\nnsferase (putative),\n mEHT1:alcohol acyl transferase,alcohol acyl transferase,Null mutan\nt is viable, temperature sensitive, and contains higher amou\nnts of phosphatidylinositol, phosphatidic acid, and ergoster\nyl esters\n COMP.TE:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mCRN1:coronin, an actin-binding protein originally identified in D\nictyostelium,Dictyostelium and human actin-binding protein c\noronin homolog,Null mutant is viable\n mLCB3:Protein involved in incorporation of exogenous long chain ba\nses in sphingolipids,plasma membrane transporter (putative),\nNull mutant is viable, has reduced rate of exogenous long ch\nain base incorporation into sphingolipids, increased resista\nnce to growth inhibition by long chain bases\n mARC1:associated with tRNA and amino acyl-tRNA synthetases; has af\nfinity for quadruplex nucleic acids,,Null mutant is viable, \nleads to slow growth and reduced MetRS activity; arc1- mutan\nts are synthetic lethals and are complemented by the genes f\nor methionyl-tRNA and glutamyl-tRNA synthetase.\n mABP1 mRVS167
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Computational Genomics Lab, Tel-Aviv uniresity