Module number 1554




Database revision : gnsdb28.10
Date : Tue Feb 25 17:14:56 2003
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mCIN1:Protein involved in chromosome segregation, required for mic\nrotubule stability,tubulin folding cofactor D,Null mutant is\n viable, exhibits cold sensitivity for viability; defect in \nnuclear migration and nuclear fusion, supersensitivity to be\nnomyl and nocodozole\n mRAD61:Unknown ,, Unknown\n mYLR346C:Unknown ,, Unknown\n Cond698:gal3-gal\n Cond700:gal5-gal\n mSIR2:regulator of silencing at HML, HMR, telomeres, and rDNA,sile\nncing regulator at HML, HMR, telomeres, and rDNA,Null mutant\n is viable; sir2 mutations suppress mitotic and meiotic intr\na- and interchromosomal rDNA recombination (10-15 fold). RAD\n52 and RAD50 are dispensable for basal level rDNA exchange i\nn SIR2 but are required for increased exchange in sir2\n mNDE2:Unknown ,, Unknown\n mSPO69:Required for sporulation; highly induced during sporulation.\n,S. pombe REC8 homolog,Null mutant is viable, does not under\ngo meiotic division and is unable to sporulate. The null mut\nant also exhibits a loss of sister chromatid cohesion, an ab\nsence of the synaptonemal complex, and chaotic chromosome se\ngregation.\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mFET3:FET3 encodes a ferro-O2-oxidoreductase that is part of the h\nigh-affinity iron transport system,multicopper oxidase,The n\null mutant is viable but defective for high affinity Fe(II) \nuptake. The null mutant is inviable when environmental iron \nis limiting.\n gala.+gal:Integrated genomic and proteomic analyses of a systematicall\ny perturbed metabolic network. Science. 2001 May 4;292(5518\n):929-34.\n Cond137:rpl34a(**9)\n gala.-gal:Integrated genomic and proteomic analyses of a systematicall\ny perturbed metabolic network. Science. 2001 May 4;292(5518\n):929-34.\n mREB1:DNA binding protein which binds sites found in genes transcr\nibed by both RNA polymerase I and RNA polymerase II. Reb1p i\ns required for termination of RNA polymerase I transcription\n.,RNA polymerase I enhancer binding protein,Null mutant is i\nnviable\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mFIT3:Facilitator of Iron Transport,Cell wall protein involved in \niron transport,impaired siderophore iron uptake, activation \nof the major iron-dependent transcription factor, AFT1\n mSPC24:Spindle Pole Component of molecular weight 24kDa,spindle pol\ne component,Null mutant is inviable\n mMAL32:Part of the complex locus MAL3; functional in S288C; highly \nhomologous to MAL62 from S. carlsbergenesis strain CB11,malt\nase,Defective maltose fermentation\n Cond686:wt+gal\n mYBR259W:Unknown ,, Unknown\n mYGR067C:Unknown ,, Unknown\n mRAD50:coiled-coil protein, contains a purine-binding domain, two h\neptad repeats and a hydrophobic tail,Mre11-Rad50-Xrs2 protei\nn complex member involved in joining double-stranded breaks \nand DNA recombination,Null mutant is viable but defective fo\nr X-ray damage repair, sporulation, chromosome pairing, form\nation and processing of DS breaks, gene conversion and recip\nrocal recombination in non-rDNA, tripartite synaptonemal com\nplexes and heteroduplex DNA. Exhibits blocked meiotic recomb\nination and formation of synaptonemal complex at early stage\ns. rad50-1 or null is rescued by spo13 and rescues rad52 spo\n13.\n Cond28:cla4(haploid)\n Cond706:gal2gal80-gal\n mYDR360W:Unknown ,, Unknown\n GCN4.gcn4:Transcriptional profiling shows that Gcn4p is a master regul\nator of gene expression during amino acid starvation in yeas\nt. Mol Cell Biol. 2001 Jul;21(13):4347-68.\n mPHO89:Probable Na+/Pi symporter,Na+/Pi symporter (putative),Null m\nutant is viable\n mYPL216W:Unknown ,, Unknown\n Cond:\n Cond702:gal7-gal\n Cond696:gal1-gal\n mYPR027C:Unknown ,, Unknown\n mYJL175W:Unknown ,, Unknown\n mYGR243W:Unknown ,, Unknown\n mYGR035C:Unknown ,, Unknown\n mHXT10:high-affinity hexose transporter,high affinity hexose transp\norter,\n Cond705:gal1gal10+gal\n Cond473:WT+/-MMS(DBY747)\n Cond701:gal6-gal\n mCEP3:Cbf3 kinetochore complex binds CDE III centromere element; C\nep3p contains an N-terminal Zn2Cys6 type zinc finger domain,\n a C-terminal acidic domain and a putative coiled coil dimer\nization domain,Cbf3 kinetochore protein complex subunit b,Nu\nll mutant is inviable; mutations within the zinc finger doma\nin result in cells that exhibit a G2-M cell cycle delay and \nincreased chromosome loss in each mitotic cell division; at \nnonpermissive temperature the cep3 cells arrest with an undi\nvided nucleus and a short mitotic spindle; at permissive tem\nperature cep3 cells are unable to support segregation of min\nichromosomes with mutations in the central part of element I\nII of yeast centromere DNA\n mYNL018C:Unknown ,, Unknown\n
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Computational Genomics Lab, Tel-Aviv uniresity