Module number 1533




Database revision : gnsdb28.10
Date : Tue Feb 25 17:12:54 2003
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mYGR269W:Unknown ,, Unknown\n mCPT1:Phospholipid biosynthesis,sn-1,2-diacylglycerol cholinephosp\nhotransferase,Null mutant is viable, cpt1 ept1 double deleti\non mutants are viable\n mBNI4:bud neck involved,required to link Chs3p and Chs4p to the se\nptins,Null mutant is viable, shows delocalized chitin, elong\nated buds, enlarged bud necks\n Cond944:SK1_ume6_YPA\n mSIP3:Interacts with SNF1 protein kinase,transcriptional activator\n (putative),Null mutant is viable; does not confer snf1 phen\notypes\n mPUF4:member of the PUF protein family,,\n mFYV2:Function required for Yeast Viability on toxin exposure,,K1 \nkiller toxin hypersensitivity\n mSLY41:multicopy suppressor of ypt1 deletion,chloroplast phosphate \ntransporter homolog,Null mutant is viable\n mYJR097W:Unknown ,, Unknown\n mYGL231C:Unknown ,, Unknown\n mDFG16:Involved in cell wall maintenance, filamentous growth,,Null \nmutant is viable, a Tn3 insertion into this gene causes hype\nrsensitivity to the cell surface polymer perturbing agent ca\nlcofluor white.\n mFLO1:cell wall protein involved in flocculation,,Flocculation\n mTAD1:Deaminates adenosine-37 to inosine in eukaryotic tRNA-Ala.,t\nRNA-specific adenosine deaminase subunit,Null mutant is viab\nle\n mFUS1:cell-surface protein required for cell fusion,,Null mutant i\ns viable; in fus1 x fus1 matings there is an interruption of\n the mating process just before cytoplasmic fusion\n mFRE7:similar to FRE2,,\n mYPL150W:Unknown ,, Unknown\n mYLR041W:Unknown ,, Unknown\n mYOL114C:Unknown ,, Unknown\n mYNR029C:Unknown ,, Unknown\n mZRC1:Zinc- and cadmium-resistance protein,,Null mutant is viable \nand sensitive to zinc\n mNMD2:Protein involved in decay of mRNA containing nonsense codons\n,,Null mutant is viable, exhibits stabilization of nonsense-\ncontaining mRNAs\n mMOD5:transfer RNA isopentenyl transferase,transfer RNA isopenteny\nl transferase,Null mutant is viable but temperature sensitiv\ne and cannot grow on nonfermentable carbon sources.\n mNDT80:Meiosis-specific gene; mRNA is sporulation specific; require\nd for exit from pachytene and for full meiotic recombination\n,DNA binding transcription factor that activates middle spor\nulation genes,Null mutant is viable, arrests in pachytene st\nage of meiosis at the mononucleate stage with duplicated spi\nndle pole bodies and no spindles, is not rescued by spo11 or\n rad50; no mitotic phenotype detected, dispensable for doubl\ne-stranded breaks\n mRTF1:Directly or indirectly regulates the DNA-binding properties \nof Spt15p, the TATA box-binding protein, and the relative ac\ntivities of different TATA elements,nuclear protein,Null mut\nant is viable and can suppress TATA box-binding protein muta\nnts (SPT15) in an allele-specific fashion\n mDPH2:Diptheria toxin resistance protein, required for diphthamide\n biosynthesis,,Null mutant is viable\n mAMD1:putative alpha-mannosidase,alpha-mannosidase (putative),Null\n mutant is viable\n mDPH5:diphthamide biosynthesis,,Null mutant is viable\n mYOR059C:Unknown ,, Unknown\n mYOR385W:Unknown ,, Unknown\n mSPL2:Suppressor of plc1-delta. Isolated as a dosage suppressor of\n the temperature-sensitive phenotype of a plc1 null mutant. \nAlso suppresses the hyperosmotic-sensitive phenotype of the \nplc1 null mutant.,,Null mutant is viable and shows no obviou\ns phenotype; spl2-delta plc1-delta double mutant fails to gr\now on SCD complete media, but grows on YPD at 25 degrees C\n mALG6:Required for glucosylation in the N-linked glycosylation pat\nhway,glucosyltransferase,Null mutant is viable and defective\n in protein glycosylation.\n mTAT2:Tryptophan permease, high affinity,tryptophan permease, high\n affinity,suppressor of chromosome segregation mutation\n mALG8:adds glucose to the dolichol-linked oligosaccharide precurso\nr prior to transfer to protein,glycosyl transferase,Null mut\nant is viable, secretes under-glycosylated proteins\n mWSC2:cell wall integrity and stress response component 2,contains\n novel cysteine motif , integral membrane protein (putative)\n , similar to SLG1 (WSC1), WSC3 and WSC4,Null mutant is viab\nle and shows no phenotypes; slg1 (wsc1)-null wsc2-null doubl\ne mutant shows a lysis defect on YPD at room temperature and\n heat shock sensitivity; overexpression of WSC genes suppres\nses heat shock sensitivity of hyperactivated ras mutant; hea\nt shock sensitivity of wsc mutant strain is suppressed by de\nletion of ras2\n mALG9:catalyzes the transfer of mannose from Dol-P-Man to lipid-li\nnked oligosaccharides,mannosyltransferase,accumulation of li\npid-linked Man6GlcNAc2; hypoglycosylation of secreted protei\nns\n mSPC19:Spindle Pole Component of molecular weight 23kDa,spindle pol\ne component,Null mutant is inviable\n mDPP1:contains a novel phosphatase sequence motif found in a super\n family of phosphatases including mammalian PAP2,diacylglyce\nrol pyrophosphate phosphatase,Null mutant is viable, does no\nt exhibit any obvious growth defects\n mSNZ2:Snooze: stationary phase-induced gene family,,hypersporulati\non\n mSNZ3:Snooze: stationary phase-induced gene family,,hypersporulati\non\n mYBR071W:Unknown ,, Unknown\n mYLR137W:Unknown ,, Unknown\n mANB1:hypusine containg protein; ANB1 is expressed under anaerobic\n conditions and repressed under aerobic conditions whereas i\nts homolog HYP2 is inversely regulated,translation initiatio\nn factor eIF-5A, anaerobically expressed form,null mutant is\n viable; a double mutant containing disruptions of both ANB1\n and and the highly homologous HYP2 is inviable\n mPTK1:Putative serine/threonine protein kinase,,Mutant shows decre\nase in total polyamine accumulation and resistance to polyam\nine analogs; ptk1 ptk2 double mutant shows virtually abolish\ned high-affinity spermidine transport\n mYHL044W:Unknown ,, Unknown\n mRTT106:Regulator of Ty1 Transposition - same phenotype as RTT101 - \nRTT105, disruption causes increase in Ty1 transposition. Iso\nlated from the same screen as the other named RTT genes.,,Nu\nll mutant is viable, but Ty1 retrotransposition is increased\n.\n mYNL122C:Unknown ,, Unknown\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mSDC1:YDR469W,,\n mYOR118W:Unknown ,, Unknown\n mYOR154W:Unknown ,, Unknown\n mYDL129W:Unknown ,, Unknown\n mRDI1:Rho GDP dissociation inhibitor with activity toward Rho1p,,\n mYNL144C:Unknown ,, Unknown\n mYOR322C:Unknown ,, Unknown\n mYOL093W:Unknown ,, Unknown\n mSBE22:functionally redundant and similar in structure to SBE2,,syn\nthetic lethal with sbe2 mutation\n mYSW1:Spore-specific protein,,\n mYGL080W:Unknown ,, Unknown\n mYGR033C:Unknown ,, Unknown\n mYGR287C:Unknown ,, Unknown\n mYGR106C:Unknown ,, Unknown\n mMCK1:Disp. for mitosis, required for chr. segregation, benomyl re\nsist., basal IME1 transcript. in mitosis, IME1 induction in \nmeiosis & ascus mat. independ. of IME1; maybe in mitotic chr\n. segregation specific to CDEIII,43.1 kDa serine/threonine/t\nyrosine protein kinase,Null mutant is viable, cold sensitive\n, temperature sensitive, and benomyl sensitive; associated w\nith delays and decreased levels of sporulation. High copy MC\nK1 acclerates early gene expression.\n mYDR539W:Unknown ,, Unknown\n mESC8:Unknown ,, Unknown\n mYOR053W:Unknown ,, Unknown\n mTRS33:Trapp subunit of 33 kDa,,Null mutant is viable\n mYIR042C:Unknown ,, Unknown\n mRGA2:contains a Rho-GAP domain and two LIM domains, similar to Rg\na1p and all known Rho-GAPs,Rho-GTPase Activating Protein,Nul\nl mutants are viable but increase the restrictive temperatur\ne of a cdc24-4 strain and increase the constitutive activati\non of the pheromone response pathway in conjungtion with mut\nations in RGA1 and BEM3; overexpression of RGA2 causes a dec\nrease in the restrictive temperature of a cdc42-1 strain\n mMKC7:protease involved in protein processing that shares function\ns with Yap3 and Kex2,aspartyl protease , related to Yap3p,Nu\nll mutant is viable, mkc7 yap3 double mutants are temperatur\ne sensitive, and mkc7 yap3 kex2 triple mutants are temperatu\nrea nd cold-sensitive\n mYCR001W:Unknown ,, Unknown\n mYDL050C:Unknown ,, Unknown\n mYBR262C:Unknown ,, Unknown\n mYMR074C:Unknown ,, Unknown\n mYNL319W:Unknown ,, Unknown\n mKRE27:Killer toxin REsistant,,K1 killer toxin resistance\n mYGR026W:Unknown ,, Unknown\n mYAP3:bZIP protein; transcription factor,,\n mMPD1:Disulfide isomerase related protein,disulfide isomerase rela\nted protein,Null mutant is viable. MPD1 overexpression can s\nuppress the maturation defect of carboxypeptidase Y caused b\ny PDI1 deletion\n mATX1:antioxidant protein and metal homeostasis factor, protects a\ngainst oxygen toxicity,copper binding homeostasis protein (p\nutative),hypersensitive toward paraquat (a generator of supe\nroxide anion)\n mSSF2:high copy suppressor of G beta subunit temperature sensitive\n mutation,,Null mutant is viable; displays double mutant let\nhality with ssf1 null mutations. Ssfp depletion is associate\nd with arrest of cell division and decreased mating\n mYKL063C:Unknown ,, Unknown\n mSMA1:Spore Membrane Assembly,,undergoes meiotic nuclear divisions\n but does not form spores\n mMDM39:Unknown ,, Unknown\n mRDR1:Unknown ,, Unknown\n mYLR364W:Unknown ,, Unknown\n mSYS1:Multicopy suppressor of ypt6 null mutation,,Null mutant is v\niable. sys1 ypt6 double mutant displays enhanced defects in \nvacuolar sorting and cell growth\n mYPL052W:Unknown ,, Unknown\n mCOT1:Protein involved in cobalt accumulation; dosage dependent su\nppressor of cobalt toxicity,,Null mutant is viable, yet incr\neased sensitivity to cobalt\n mYIP3:Interacts with YPT proteins,,\n mEND3:Required for endocytosis and organization of the cytoskeleto\nn,,Null mutant is viable and defective in endocytosis\n mSNF8:appears to be functionally related to SNF7,,Null mutant is v\niable, sporulation defective, grows poorly on raffinose as a\n carbon source, shows a five-fold decrease in invertase dere\npression\n mTSA1:antioxidant enzyme that provides protection against oxidatio\nn systems capable of generating reactive oxygen and sulfur s\npecies,thioredoxin-peroxidase (TPx); reduces H2O2 and alkyl \nhydroperoxides with the use of hydrogens provided by thiored\noxin, thioredoxin reductase, and NADPH,Null mutant is viable\n, grows slower than wild-type under aerobic conditions\n mJNM1:coiled-coil domain protein required for proper nuclear migra\ntion during mitosis (but not during conjugation),,Null mutan\nt is viable but is cold-sensitive\n mPMS1:Required for mismatch repair in mitosis and meiosis, low lev\nels of postmeiotic segregation, and high spore viability, di\nspensable for homeologous recombination,mutL homolog , simil\nar to Mlh1p, associates with Mlh1p, possibly forming a heter\nodimer, Pms1p and Msh1p act in concert to bind to a Msh2p-he\nteroduplex complex containing a G-T mismatch,Null mutant is \nviable; postmeiotic segregation increased\n mYEL059W:Unknown ,, Unknown\n mMAK3:N-acetyltransferase,N-acetyltransferase,deficient in mainten\nance of killer\n mYDR112W:Unknown ,, Unknown\n mYOR164C:Unknown ,, Unknown\n mSTD1:interacts with the SNF1 protein kinase and TBP in two-hybrid\n and in in vitro binding studies,MTH1 homolog,Null mutant is\n viable, no defects in mating or sporulation. Suppressor of \nTBP deletion; multicopy suppressor of SNF; std1-mth1 has def\nective glucose derepression and sporulation\n mTHI12:thiamine regulated gene, homologous to nmt1a in Schizosaccha\nromyces pombe; putatively involved in pyrimidine biosynthesi\ns,,\n mGOT1:Golgi Transport,membrane protein,Null mutant is viable but e\nxhibits ER to Golgi transport defects in vitro. got1 is synt\nhetically lethal with mutations in sft2; the got1 sft2 doubl\ne mutant exhibits defects in transport to the Golgi complex.\n mYNL168C:Unknown ,, Unknown\n mPPR1:Positive regulator of URA1 and URA3,zinc finger transcriptio\nn factor of the Zn(2)-Cys(6) binuclear cluster domain type,N\null mutant is viable, deficient in pyrimidine biosynthetic p\nathway\n mSRY1:Serine Racemase homolog in Yeast,pyridoxal-5'phosphate-depen\ndent enzyme , similar to mouse glial serine racemase,Null mu\ntant is viable\n mYHR180W:Unknown ,, Unknown\n mRDS1:Unknown ,, Unknown\n mLEM3:Product of gene unknown,,null mutant is sensitive to brefeld\nin A and shows increased glucocorticoid receptor activity in\n response to dexamethasone\n mYJR088C:Unknown ,, Unknown\n mYMR306C-A:Unknown ,, Unknown\n mYOR041C:Unknown ,, Unknown\n mYOR055W:Unknown ,, Unknown\n mKES1:Homologous to human oxysterol-binding protein; implicated in\n ergosterol biosynthesis and regulation of Golgi-derived tra\nnsport vesicle biogenesis,,Pleiotropic sterol-related phenot\nypes\n mTLG1:member of the syntaxin family of t-SNAREs,tSNARE that affect\ns a late Golgi compartment,Endocytosis defect and loss of Ke\nx2p in SEY6210 background; Deletion may be lethal in some ge\nnetic backgrounds\n mYMR031W-A:Unknown ,, Unknown\n mTLG2:member of the syntaxin family of t-SNAREs,tSNARE that affect\ns a late Golgi compartment,Null mutant is viable in SEY6210,\n exhibits endocytosis defect and loss of Kex2p\n UME6.ume6:The Ume6 regulon coordinates metabolic and meiotic gene expr\nession in yeast. Proc Natl Acad Sci U S A. 2002 Oct 15;99(2\n1):13431-6.\n mENT5:Unknown ,, Unknown\n mSGE1:multi-copy suppressor of gal11 null; member of drug-resistan\nce protein family,,Null mutant is viable; shows decreased ex\npression of galactose-inducible genes; shows increased sensi\ntivity to crystal violet\n mYOL046C:Unknown ,, Unknown\n mPSY2:Unknown ,, Unknown\n mYMR258C:Unknown ,, Unknown\n mERP4:Emp24p/Erv25p related protein 4,p24 protein involved in memb\nrane trafficking,viable\n mYGR050C:Unknown ,, Unknown\n mCHS7:The seventh gene identified that is involved in chitin synth\nesis; involved in Chs3p export from the ER,,Null mutant is v\niable but exhibit reduced chitin synthesis due to a severe r\neduction of Chitin Synthase III activity.\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mYDR287W:Unknown ,, Unknown\n mCUS2:cold sensitive U2 snRNA Supressor,,Null mutant is viable, en\nhances U2 mutations; mutations in this gene suppress the col\nd sensitive phenotype of U2 RNA mutation G53A\n mSNO2:SNZ2 proximal ORF, stationary phase induced gene,,Null mutan\nt is viable.\n mIDS2:IME2-Dependent Signalling,,Null mutations reduce or abolish \nthe ability of IME2p to activate expression of early, middle\n, and late meiotic genes. Recessive and null ids2 mutants pr\nevent toxicity of Ime2p expression in rad52 haploids, but do\n not affect Ime2p polypeptide accumulation.\n mYNL089C:Unknown ,, Unknown\n mYOL003C:Unknown ,, Unknown\n mPHO80:Negative regulator of PHO81 and PHO5,Pho80p cyclin,The null \nmutant is viable but constitutively derepresses PHO5 (acid p\nhosphatase) transcription and is postive for deoxythymidine \nmonophosphate uptake. The null mutant is supersensitive to a\nminoglycoside.\n mLYP1:lysine permease,lysine permease,\n mMLC2:putative light chain for Myo1p,light chain for Myo1p (putati\nve),Null mutant is viable\n mPHO84:inorganic phosphate transporter, transmembrane protein,inorg\nanic phosphate transporter,Null mutant is viable\n mMAL33:Part of complex locus MAL3; nonfunctional in S288C, shows ho\nmology to both functional & nonfunctional MAL-activator prot\neins in other Sc strains & to other nonfunctional MAL-activa\ntor sequences from S288C (i.e. MAL33, YPR196W, & YFL052W),MA\nL-activator protein,Defective maltose fermentation\n mUBP7:Ubiquitin-specific protease,ubiquitin-specific protease,\n mYOR325W:Unknown ,, Unknown\n mNGL1:DNase/RNase (putative); CCR4 C-terminal homolog, homology to\n drosophila Angel gene,DNase (putative) , RNase (putative),N\null mutant is viable.\n mYPR064W:Unknown ,, Unknown\n mYTA6:Member of CDC48/PAS1/SEC18 family of ATPases,AAA ATPase,\n mYOR238W:Unknown ,, Unknown\n mCOG6:Unknown ,, Unknown\n mSHR5:Involved in RAS localization and palmitoylation,,Null mutant\n is viable; exhibits normal palmityltransferase activity in \nvitro and attenuates Ras function in cells with mutant Ras2 \nproteins that are not farnesylated or palmitoylated; shr5 mu\ntation originally isolated as suppressor of Ras function\n mAPG13:autophagy,,Defective in autophagy\n mDSE3:Hypothetical ORF,,\n mHXT5:Member of superfamily of monosaccharide transporters,hexose \ntransporter,Null mutant is viable\n mYOR166C:Unknown ,, Unknown\n mYGR117C:Unknown ,, Unknown\n Cond133:rpd3(haploid)\n mSCW10:Soluble Cell Wall protein,soluble cell wall protein,Null mut\nant is viable.\n mARR4:Unknown ,, Unknown\n mARR4 mMDM39 mTLG1 mYIP3 mTLG2 mSNZ3 mSNZ2 mSNO2 mPSY2 mSTD1
this is an automaticly generated SAMBA report
Computational Genomics Lab, Tel-Aviv uniresity