Module number 1512




Database revision : gnsdb28.10
Date : Tue Feb 25 17:08:32 2003
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mYPR143W:Unknown ,, Unknown\n UME6.ume6:The Ume6 regulon coordinates metabolic and meiotic gene expr\nession in yeast. Proc Natl Acad Sci U S A. 2002 Oct 15;99(2\n1):13431-6.\n Cond128:rgt1\n mSLK19:synthetic lethal KAR3,leucine zipper (putative),Null mutant \nexibits long astral microtubules, short spindles, bypass mei\nosis I, partial mitotic arrest; synthetic lethal with kar3*,\n loss of both produces mitotic arrest\n Cond278:CDC42(tetpromoter)\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts. Nat Genet\n. 2000 Dec;26(4):415-23.\n Cond918:1h\n Cond369:1.5_mM_diamide_(5_min)\n mYLR123C:Unknown ,, Unknown\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond640:DES459_(mec1-)_+_0.02%_MMS_-_5_min\n mYGR228W:Unknown ,, Unknown\n mCTR9:CTR9 is required for normal CLN1 and CLN2 G1 cyclin expressi\non,,Null mutant is viable, loses chromosomes and shows tempe\nrature sensitivity\n mKAR3:kinesin-like nuclear fusion protein,kinesin-like nuclear fus\nion protein,Null mutant is viable, kar3 mutations prevent ka\nryogamy (nuclear fusion)\n mKEL3:Kelch-repeat protein, similar to Kel1 and Kel2,kelch-repeat \nprotein , similar to Kel1 and Kel2,\n Stress.diamide:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond946:W303ume6_YPD\n gala.-gal:Integrated genomic and proteomic analyses of a systematicall\ny perturbed metabolic network. Science. 2001 May 4;292(5518\n):929-34.\n Cond185:ubr2\n mSGM1:Product of gene unknown,,\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mSLF1:Associates with translating ribosomes; may function in cytop\nlasm to modulate mRNA translation; regulates the copper-depe\nndent mineralization of copper sulfide complexes on cell sur\nface in cells cultured in medium containing copper salts,,Nu\nll mutant is viable, copper sensitive, has lost ability to d\neplete Cu, but not Cd ions from surrounding medium; SLF1 ove\nrexpression confers copper superresistance and enhances Ca d\nepletion ability\n mTOP1:topoisomerase I,topoisomerase I,Null mutant is viable\n mRFC2:RFC is a DNA binding protein and ATPase that acts as a proce\nssivity factor for DNA polymerases delta and epsilon and loa\nds proliferating cell nuclear antigen (PCNA) on DNA,replicat\nion factor C subunit 2 , similar to human RFC 37 kDa subunit\n,Null mutant is inviable\n Cond73:gyp1\n mRAD50:coiled-coil protein, contains a purine-binding domain, two h\neptad repeats and a hydrophobic tail,Mre11-Rad50-Xrs2 protei\nn complex member involved in joining double-stranded breaks \nand DNA recombination,Null mutant is viable but defective fo\nr X-ray damage repair, sporulation, chromosome pairing, form\nation and processing of DS breaks, gene conversion and recip\nrocal recombination in non-rDNA, tripartite synaptonemal com\nplexes and heteroduplex DNA. Exhibits blocked meiotic recomb\nination and formation of synaptonemal complex at early stage\ns. rad50-1 or null is rescued by spo13 and rescues rad52 spo\n13.\n Cond706:gal2gal80-gal\n mYNL224C:Unknown ,, Unknown\n mRSM18:protein similar to bacterial ribosomal subunit S18,mitochond\nrial ribosome small subunit component,null is unable to grow\n on glycerol\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mPEP3:vacuolar membrane protein,vacuolar membrane protein,Null mut\nant is viable, exhibits growth defects at 37 degrees celsius\n, exhibits vacuolar protein sorting and processing and defec\nts, exhibits decreased levels of protease A, protease B, and\n carboxylpeptidase Y antigens; decreased repressible alkalin\ne phosphatase activity; null mutants contain very few normal\n vacuolelike organelles; homozygous null mutants are sporula\ntion defective\n Cond681:DES460_genomic_DNA_vs._MHY26_(dun1)_genomic_DNA\n mYMR132C:Unknown ,, Unknown\n mPDS5:Precocious Dissociation of Sister chromatids,,\n Cond920:3h\n mYKL082C:Unknown ,, Unknown\n COMP.TE:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mSEC63:Protein involved in protein import into ER,,lethal\n Cond938:2h\n mBUD22:Hypothetical ORF,,Null mutant is viable; random budding in d\niploid null mutants\n mMAD1:coiled-coil protein involved in spindle-assembly checkpoint,\n,Null mutant is viable, benomyl sensitive\n mMTG1:Unknown ,, Unknown\n mRTN1:Unknown ,, Unknown\n Cond939:4h\n
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Computational Genomics Lab, Tel-Aviv uniresity