Module number 1482




Database revision : gnsdb28.10
Date : Tue Feb 25 17:15:04 2003
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mCIN1:Protein involved in chromosome segregation, required for mic\nrotubule stability,tubulin folding cofactor D,Null mutant is\n viable, exhibits cold sensitivity for viability; defect in \nnuclear migration and nuclear fusion, supersensitivity to be\nnomyl and nocodozole\n Cond698:gal3-gal\n mCRC1:carnitine carrier,carnitine transporter,Null mutant is viabl\ne\n Cond462:25_deg_growth_ct-1\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts. Nat Genet\n. 2000 Dec;26(4):415-23.\n Cond941:SK1_YPD\n mYOL131W:Unknown ,, Unknown\n mPOX1:fatty-acyl coenzyme A oxidase,fatty-acyl coenzyme A oxidase,\nNull mutant is viable, exhibits diminished ability to use ol\neic acid as a carbon source\n Cond729:sin3\n Cond463:29_deg_growth_ct-1\n mMPC54:Meiotic Plaque Component,,Null: viable. Other phenotypes: sp\norulation deficient.\n Cond940:6h\n Cond:\n Cond702:gal7-gal\n Cond696:gal1-gal\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Mating.Mating:Signaling and circuitry of multiple MAPK pathways revealed b\ny a matrix of global gene expression profiles. Science. 200\n0 Feb 4;287(5454):873-80\n Cond948:W303_ume6_YPA_\n Cond937:t=0\n Cond934:8h\n mMEK1:Disp. for chr. pairing & chr. condensation seen by in situ h\nybrid. Required for full double strand breaks, normal length\n synaptonemal complexes, meiotic recomb. & spore viability. \nmek1 is rescued by spo13 & in early recomb. function,meiosis\n-specific serine/threonine protein kinase,Null mutant is via\nble, however diploids homozygous for a mek1 null mutation pr\noduce only low percentages of viable spores, reduced spore v\niability is rescued by spo13 mutations\n mULP2:Product of gene unknown,,Null mutant is viable but exhibits \ntemperature-sensitive growth, abnormal cell morphology, decr\neased plasmid and chromosome stability, and a severe sporula\ntion defect as well as hypersensitivity to DNA-damaging agen\nts, hydroxyurea, and benomyl. SMT4/ULP2 was also isolated as\n a high copy suppressor of a temperature sensitive mutation \nin MIF2, a putative centromere protein gene\n Cond961:t7_g/r_ratio\n TorRama.Series0:Partitioning the transcriptional program induced by rapamyci\nn among the effectors of the Tor proteins. Curr Biol. 2000 D\nec 14-28;10(24):1574-81\n Cond935:10h\n mMSH5:dispensable for DNA repair and meiotic intrachromosomal reci\nprocal recombination, required for full reciprocal recombina\ntion between homologs, and spore viability,mutS homolog,Null\n mutant is viable. Diploids lacking the MSH5 gene display de\ncreased levels of spore viability, increased levels of meios\nis I chromosome nondisjuction, and decreased levels of recip\nrocal exchange between, but not within, homologs. Gene conve\nrsion is not reduced. Msh5 mutants are phenotypically simila\nr to mutants in the meiosis-specific gene MSH4. msh5 is epis\ntatic to msh4, suggesting they act in the same pathway.\n UME6.ume6:The Ume6 regulon coordinates metabolic and meiotic gene expr\nession in yeast. Proc Natl Acad Sci U S A. 2002 Oct 15;99(2\n1):13431-6.\n Cond871:yhe710-ss\n Cond700:gal5-gal\n Cond465:steady_state_15_dec_C_ct-2\n Cond625:DY1457_(wild_type)_3_mM_vs._10_uM_zinc_y12-121\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n gala.+gal:Integrated genomic and proteomic analyses of a systematicall\ny perturbed metabolic network. Science. 2001 May 4;292(5518\n):929-34.\n Cond692:gal6+gal\n Cond460:17_deg_growth_ct-1\n Cond963:t11.5_g/r_ratio\n Cond114:pet117\n Cond640:DES459_(mec1-)_+_0.02%_MMS_-_5_min\n Sporulation.Series0:The transcriptional program of sporulation in budding yeast.\n Science. 1998 Oct 23;282(5389):699-705.\n gala.-gal:Integrated genomic and proteomic analyses of a systematicall\ny perturbed metabolic network. Science. 2001 May 4;292(5518\n):929-34.\n mPCH2:Pachytene CHeckpoint,ATPase (putative),Null mutant is viable\n and bypasses meiotic arrest of zip1 mutant, resulting in ch\nromosome segregation defects\n Cond945:W303_YPD\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond319:37C_to_25C_shock_-_90_min\n mRIM4:Regulator of IMe2 expression,RNA-binding protein of the RRM \nclass (putative),Null mutant is viable. Homozygous null dipl\noid fails to sporulate, does not form meiosis I or II spindl\nes, and exhibits reduced expression of early and middle spor\nulation-specific genes. Null mutant is suppressed by hyperac\ntive Ime2p derivative, but not by overexpression IME1\n mSPO16:Early meiotic protein required for efficient spore formation\n,,sporulation defective\n mZIP1:Synaptonemal complex protein, component of the central eleme\nnt,,Null mutant is viable and shows defects in meiosis\n Cond959:t2_g/r_ratio\n Stress.tempgrow:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mZIP2:Required for 'ZIPpering' up meiotic chromosomes during chrom\nosome synapsis,,Null mutant is viable but is defective in ch\nromosome synapsis, but not chromosome pairing, and causes me\niosis I non-disjunction and reduced homologous recombination\n Stress.ColdShock:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond965:ndt80_delete_mid_g/r_ratio_\n Chromo.chromo:Genomewide studies of histone deacetylase function in yeast.\n Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13708-13.\n Cond960:t5_g/r_ratio\n mIME2:Positive regulator of meiosis, dispensable for mitosis, stim\nulates early, middle and late gene expression and negatively\n regulates IME1,,Null mutant is viable, homozygous null muta\nnts are sporulation defective. High copy IME2 stimulates mei\notic recombination without starvation and permits meiosis in\n an ime1 null background\n zap1.Series0:Genome-wide characterization of the Zap1p zinc-responsive re\ngulon in yeast. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14)\n:7957-62.\n Cond503:wtħ50nMaF,60minlog10(intensity)\n mMEI5:Meiotic protein required for synapsis and meiotic recombinat\nion,,\n Cond938:2h\n Cond962:t9_g/r_ratio\n mSPO20:DBF2 Interacting Protein; SNAP 25 homolog,DBF2 interacting p\nrotein , SNAP 25 homolog,Null mutant is viable, other mutant\n fails to form spores\n Stress.tempsteady:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond939:4h\n Cond958:t0.5_g/r_ratio\n
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Computational Genomics Lab, Tel-Aviv uniresity