Module number 145




Database revision : gnsdb28.10
Date : Tue Feb 25 17:25:09 2003
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mERG11:cytochrome P450 lanosterol 14a-demethylase,cytochrome P450 l\nanosterol 14a-demethylase,Null mutant is inviable, erg11 nul\nl inviability is suppressed by deletion of ERG3; erg11 mutan\nts are ergosterol biosynthesis defective; many are also nyst\natin resistant\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n mERG13:involved in mevalonate synthesis,3-hydroxy-3-methylglutaryl \ncoenzyme A synthase,\n Cond649:dun1-_+_0.02%_MMS_-_120_min\n mYJL048C:Unknown ,, Unknown\n mYDR492W:Unknown ,, Unknown\n Cond648:dun1-_+_0.02%_MMS_-_90_min\n Cond647:dun1-_+_0.02%_MMs_-_30_min\n mERG1:Squalene monooxygenase,squalene monooxygenase,Null mutant is\n inviable when cells are grown under aerobic conditions; erg\n1 null mutants are viable under anaerobic conditions during \nwhich ergosterol is taken up by the cells\n mERG2:sterol biosynthesis,C-8 sterol isomerase,Null mutant is viab\nle\n mERG3:C-5 sterol desaturase,C-5 sterol desaturase,Null mutant is i\nnviable; suppresses syringomycin resistant mutant\n mYEL033W:Unknown ,, Unknown\n mERG5:cytochrome P450 involved in C-22 denaturation of the ergoste\nrol side-chain,cytochrome P450 , involved in C-22 denaturati\non of the ergosterol side-chain,Null mutant is viable\n mERG7:carries out complex cyclization step of squalene to lanoster\nol in sterol biosynthesis pathway,2,3-oxidosqualene-lanoster\nol cyclase,Null mutant is inviable\n mCYB5:cytochrome b5,cytochrome b5,Null mutant is viable, cyb5 muta\ntions suppress ketoconazole hypersensitivity of a P450 reduc\ntase deficient strain\n Cond637:DES460_+_0.02%_MMS_-_60_min\n Cond218:yer066c-a\n mERG25:C-4 sterol methyl oxidase,C-4 sterol methyl oxidase,Null mut\nant is inviable\n mATF2:Alcohol acetyltransferase,alcohol acetyltransferase,\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mERG26:C-3 sterol dehydrogenase,C-3 sterol dehydrogenase,\n mERG28:Transmembrane domain containing protein which may facilitate\n protein-protein interactions between the Erg26p dehydrogena\nse and the Erg27p 3-ketoreductase and/or to tether these enz\nymes to the ER,,Null mutant is viable; random budding in dip\nloid null mutants; null cells have an unusual sterol content\n.\n mYGL188C:Unknown ,, Unknown\n Cond638:DES460_+_0.02%_MMS_-_90_min\n Cond624:DY1457_(wild_type)_3_mM_vs._10_uM_zinc_y13-75\n Cond635:DES460_+_0.02%_MMS_-_30_min\n Cond298:Terbinafine\n mHMX1:Unknown ,, Unknown\n COMP.CH:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mYGR176W:Unknown ,, Unknown\n mCYC1:iso-1-cytochrome c,iso-1-cytochrome c,Cytochrome c deficienc\ny\n Cond646:DES459_(mec1-)_+_0.02%_MMS_-_120_min\n mRIP1:oxidizes ubiquinol at center P in the protonmotive Q cycle m\nechanism, transferring one electron to cytochrome c1 and gen\nerating a low-potential ubisemiquinone anion which reduces t\nhe low-potential cytochrome b-566 heme group,Rieske iron-sul\nfur protein of the mitochondrial cytochrome bc1 complex,Null\n mutant is viable, unable to grow on nonfermentable carbon s\nources\n mCOX12:essential during assembly for full cytochrome c oxidase acti\nvity,cytochrome c oxidase subunit VIb,Null mutant is viable,\n grows poorly at room temperature, fails to grow on glycerol\n/ethanol media at 37 degrees\n mCOX13:Modulates cytochrome c oxidase activity,cytochrome c oxidase\n subunit VIa , may specifically interact with ATP,Null mutan\nt is viable, shows slightly reduced growth rate on nonfermen\ntable carbon sources\n mHYP2:Translation initiation factor eIF-5A,translation initiation \nfactor eIF-5A,Null mutant is viable; a double mutant contain\ning disruptions of both HYP2 and and the highly homologous A\nNB1 is inviable\n mNDE1:Unknown ,, Unknown\n mYMR134W:Unknown ,, Unknown\n Cond54:erg3(haploid)\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond644:DES459_(mec1-)_+_0.02%_MMS_-_60_min\n mANB1:hypusine containg protein; ANB1 is expressed under anaerobic\n conditions and repressed under aerobic conditions whereas i\nts homolog HYP2 is inversely regulated,translation initiatio\nn factor eIF-5A, anaerobically expressed form,null mutant is\n viable; a double mutant containing disruptions of both ANB1\n and and the highly homologous HYP2 is inviable\n mSCM4:Protein that suppresses ts allele of CDC4 when overexpressed\n,,viable, suppressor of cdc4ts allele\n Cond877:MMS\n mYKR046C:Unknown ,, Unknown\n mACS2:one of 2 acetyl-coA synthetases in yeast,acetyl CoA syntheta\nse,Null mutant is viable, and grows on ethanol or acetate as\n sole carbon source, but is unable to grow on glucose as sol\ne carbon source; acs1 acs2 double null mutant is inviable\n mSNO1:SNZ1 proximal ORF, stationary phase induced gene,,Null mutan\nt is viable, sensitive to 6-azauracil and methylene blue.\n Cond642:DES459_(mec1-)_+_0.02%_MMS_-_30_min\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond80:hmg1(haploid)\n mCOX5A:One of two genes (COX5A and COX5B, both nuclear-encoded) cod\ning for subunit V of cytochrome c oxidase; COX5A gene produc\nt is the predominantform of subunit V found in holocytochrom\ne c oxidase under normal growth conditions,cytochrome c oxid\nase chain Va,Null mutant is viable, respires at 10-15% of th\ne wild-type rate due to the presence of COX5B; cox5a cox5b d\nouble deletion mutants are completely non-respiratory\n mMVD1:involved in the polyisoprene biosynthesis pathway,mevalonate\n pyrophosphate decarboxylase,Null mutant is inviable; a sing\nle leucine to proline mutation causes temperature sensitivit\ny.\n mNCP1:NADP-cytochrome P450 reductase,NADP-cytochrome P450 reductas\ne,Null mutant is viable\n Cond571:cdc15_50\n Cond634:DES460_+_0.02%_MMS_-_15_min\n Cond294:Itraconazole\n Cond645:DES459_(mec1-)_+_0.02%_MMS_-_90_min\n mHMG1:3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase is\nozyme,3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reduct\nase isozyme,Null mutant is viable, sensitive to compactin, a\n competitive inhibitor of HMG-CoA reductase; hmg1 hmg2 doubl\ne deletion mutants are inviable\n Cond636:DES460_+_0.2%_MMS_-_45_min\n Cond570:cdc15_30\n zap1.Series0:Genome-wide characterization of the Zap1p zinc-responsive re\ngulon in yeast. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14)\n:7957-62.\n Cond639:DES460_+_0.02%_MMS_-_120_min\n Cell Cycle.cdc15:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion. Mol Biol Cell. 1998 Dec;9(12):3273-97.\n Cond643:DES459_(mec1-)_+_0.02%_MMS_-_45_min\n Cond641:DES459_(mec1-)_+_0.02%_MMS_-_15_min\n mCYT1:Cytochrome c1,cytochrome c1,\n
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Computational Genomics Lab, Tel-Aviv uniresity