Module number 1442




Database revision : gnsdb28.10
Date : Tue Feb 25 17:08:45 2003
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mTRP1:Note that the sequence of TRP1 from strain S228C, which is t\nhe sequence stored in SGD, contains an ochre mutation at cod\non 67.,N-(5'-phosphoribosyl)-anthranilate isomerase,tryptoph\nan requiring\n mLEU1:leucine biosynthesis,isopropylmalate isomerase,Leucine requi\nring\n mLEU4:leucine biosynthesis,alpha-isopropylmalate synthase (2-isopr\nopylmalate synthase),Null mutant is viable, Leu+\n Cond688:gal2+gal\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond950:TPK1_MT1val\n gala.+gal:Integrated genomic and proteomic analyses of a systematicall\ny perturbed metabolic network. Science. 2001 May 4;292(5518\n):929-34.\n Cond954:TPK2_MT2val\n mALD4:Glucose repressed. Utilizes NADP+ or NAD+ as a coenzyme equa\nlly well. (sold by SIGMA under the catalogue number A5550, a\nccording to A. Blomberg).,aldehyde dehydrogenase,\n TPK.TPK:The yeast A kinases differentially regulate iron uptake and \nrespiratory function. Proc Natl Acad Sci U S A. 2000 May 23\n;97(11):5984-8.\n Cond949:WT1val\n mRCS1:Involved in iron homeostasis and affects cell size regulatio\nn,binds the consensus site PyPuCACCCPu , transcription facto\nr (putative),Null mutant is viable; mutant cells are larger \nthan normal, since critical size for budding is increased; m\nutant shows incorrect regulation of expression of genes invo\nlved in iron uptake; spores from heterozygous diploid have r\neduced ability to germinate;\n mMRP49:16 kDa mitochondrial ribosomal large subunit protein,16 kDa \nmitochondrial ribosomal large subunit protein,Null mutant is\n viable, cold-sensitive, respiration deficient, defective in\n assembly of stable 54S ribosomal subunits\n mYEL015W:Unknown ,, Unknown\n mFIT1:Facilitator of Iron Transport,Cell wall protein involved in \niron uptake,Impaired siderophore-iron uptake, activation of \nthe major iron-dependent transcription factor AFT1.\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mFIT2:Facilitator of iron transport,Cell wall protein involved in \niron transport,impaired siderophore-iron uptake, activation \nof the major iron -dependent transcription factor, AFT1\n Cond99:med2(haploid)\n Cond951:WT2val\n Cond955:TPK3_MT1val\n mOAC1:oxaloacetate carrier,oxaloacetate transport protein,\n mPRY2:Pathogen Related in Sc, contains homology to the plant PR-1 \nclass of pathogen related proteins. The protein sequence is \nover 60% identical with the Pry2p & Pry3p over 145 resid. PR\nY1 is >35% identical (50% similar) to tobacco PR-1c protein.\n,,\n mBAP2:contains 12 predicted transmembrane domains,amino acid perme\nase for leucine, valine, and isoleucine (putative),reduced u\nptake of leucine, isoleucine, and valine\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mTUP1:general repressor of transcription (with Cyc8p); mediates gl\nucose repression,glucose repression regulatory protein, exhi\nbits similarity to beta subunits of G proteins,Null mutant i\ns viable; exhibits flocculent colony morphology\n Cond952:TPK1_MT2val\n mMET6:vitamin B12-(cobalamin)-independent isozyme of methionine sy\nnthase (also called N5-methyltetrahydrofolate homocysteine m\nethyltransferase or 5-methyltetrahydropteroyl triglutamate h\nomocysteine methyltransferase),vitamin B12-(cobalamin)-indep\nendent isozyme of methionine synthase (also called N5-methyl\ntetrahydrofolate homocysteine methyltransferase or 5-methylt\netrahydropteroyl triglutamate homocysteine methyltransferase\n),Null mutant is viable, and is a methionine auxotroph\n mYOR271C:Unknown ,, Unknown\n Cond956:TPK3_MT2val\n mCUP9:homeobox domain similar human proto-oncogene PBX1,DNA bindin\ng protein (putative),Null mutant is viable, associated with \nloss of copper resistance\n mHXT6:Repression of HXT6 expression by glucose requires SNF3,hexos\ne transporter,Null mutant is viable; snf3 hxt1 hxt2 hxt3 hxt\n4 hxt6 hxt7 mutant cannot grow on media containing glucose a\ns sole carbon source\n mHXT7:Hexose transporter,hexose transporter,Null mutant is viable;\n snf3 hxt1 hxt2 hxt3 hxt4 HXT7 hxt7 mutant cannot grow on me\ndia containing glucose as sole carbon source\n mZWF1:Glucose-6-phosphate dehydrogenase,glucose-6-phosphate dehydr\nogenase,sensitive to oxidizing agents; methionine requiring\n Cond683:MHY1_(crt1)_vs._CRY1_(wild_type)_-_log_phase\n mTAT1:Amino acid transport protein for valine, leucine, isoleucine\n, and tyrosine,amino acid transport protein for valine, leuc\nine, isoleucine, and tyrosine,\n mLEO1:Product of gene unknown,,Null mutant is viable\n mWSC3:cell wall integrity and stress response component 3,contains\n novel cysteine motif , integral membrane protein (putative)\n , similar to SLG1 (WSC1), WSC2 and WSC4,Null mutant is viab\nle and shows no phenotypes; slg1 (wsc1)-null WSC3-null doubl\ne mutant shows a lysis defect on YPD at room temperature and\n heat shock sensitivity; overexpression of WSC genes suppres\nses heat shock sensitivity of hyperactivated ras mutant; hea\nt shock sensitivity of wsc mutant strain is suppressed by de\nletion of ras2\n Cond953:TPK2_MT1val\n mFLR1:Fluconazole Resistance 1,major facilitator transporter,Null \nmutant is viable; overexpression confers resistance to fluco\nnazole, cycloheximide, 4-nitroquinoline N-oxide\n
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Computational Genomics Lab, Tel-Aviv uniresity