Module number 144




Database revision : gnsdb28.10
Date : Tue Feb 25 17:25:04 2003
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PEX.Pex:Transcriptome profiling to identify genes involved in peroxi\nsome assembly and function. J Cell Biol. 2002 Jul 22;158(2)\n:259-71.\n Cond281:HMG2(tetpromoter)\n Cond163:ssn6(haploid)\n mERG11:cytochrome P450 lanosterol 14a-demethylase,cytochrome P450 l\nanosterol 14a-demethylase,Null mutant is inviable, erg11 nul\nl inviability is suppressed by deletion of ERG3; erg11 mutan\nts are ergosterol biosynthesis defective; many are also nyst\natin resistant\n mYCR049C:Unknown ,, Unknown\n Cond221:yer083c\n mPLB1:Responsible for the production of the deacylation products o\nf phosphatidylcholine and phosphatidylethanolamine but not p\nhosphatidylinositol,phospholipase B (lypophospholipase),Null\n mutant is viable but releases greatly reduced levels of pho\nsphatidylcholine and phosphatidylethanolamine metabolites\n mUPC2:involved in sterol uptake,zinc finger transcription factor o\nf the Zn(2)-Cys(6) binuclear cluster domain type,Null mutant\n is viable; upc2-1 allele shows altered sterol uptake\n mTIR1:cold-shock induced protein of the Srp1p/Tip1p family of seri\nne-alanine-rich proteins,,\n Cond121:qcr2(haploid)\n mTIR2:cold-shock induced protein of the Srp1p/Tip1p family of seri\nne-alanine-rich proteins,,Null mutant is viable.\n Cond188:vma8\n Cond363:dtt_015_min_dtt-2\n Cond730:hda1\n mERG1:Squalene monooxygenase,squalene monooxygenase,Null mutant is\n inviable when cells are grown under aerobic conditions; erg\n1 null mutants are viable under anaerobic conditions during \nwhich ergosterol is taken up by the cells\n mERG2:sterol biosynthesis,C-8 sterol isomerase,Null mutant is viab\nle\n mERG5:cytochrome P450 involved in C-22 denaturation of the ergoste\nrol side-chain,cytochrome P450 , involved in C-22 denaturati\non of the ergosterol side-chain,Null mutant is viable\n mERG6:ergosterol synthesis,,The null mutant is viable, cannot meth\nylate ergosterol precursors at C-24, and lacks ergosterol. T\nhe null mutant shows defective conjugation, diminished capac\nity for transformation, and defective tryptophan uptake. The\n null mutant is hypersensitive to cycloheximide, Li+, and Na\n+, sensitive to anthracyclines, dactinomycin, and bretfeldin\n A, and resistant to nystatin.\n mCYB5:cytochrome b5,cytochrome b5,Null mutant is viable, cyb5 muta\ntions suppress ketoconazole hypersensitivity of a P450 reduc\ntase deficient strain\n mYBR005W:Unknown ,, Unknown\n Cond53:erg2\n mYPR197C:Unknown ,, Unknown\n Stress.DTT2:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond840:expt3\n mYOR338W:Unknown ,, Unknown\n Cond218:yer066c-a\n mERG25:C-4 sterol methyl oxidase,C-4 sterol methyl oxidase,Null mut\nant is inviable\n mATF2:Alcohol acetyltransferase,alcohol acetyltransferase,\n mDAN2:Delayed anaerobic gene,putative cell wall protein,unknown\n mDAN3:delayed anaerobic gene,putative cell wall protein,unknown\n Cond624:DY1457_(wild_type)_3_mM_vs._10_uM_zinc_y13-75\n Cond298:Terbinafine\n Cond279:ERG11(tetpromoter)\n COMP.CH:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond489:PHO81c_vs_WT_exp1\n mYGR176W:Unknown ,, Unknown\n mHSP26:heat shock protein 26,heat shock protein 26,Null mutant is v\niable; hsp26 hsp42 double deletion mutants are viable\n Cond181:top3(haploid)\n Cond229:yhr011w(**14)\n mYPL282C:Unknown ,, Unknown\n Cond216:yer044c(haploid)\n mYGL261C:Unknown ,, Unknown\n mYAL068C:Unknown ,, Unknown\n mYLL025W:Unknown ,, Unknown\n mSNZ1:Snooze: stationary phase-induced gene family; may be involve\nd in cellular response to nutrient limitation and growth arr\nest,highly conserved 35 kDa protein that shows increased exp\nression after entry into stationary phase,Null mutant is via\nble, sensitive to 6-azauracil and methylene blue.\n Cond625:DY1457_(wild_type)_3_mM_vs._10_uM_zinc_y12-121\n mPAU2:member of the seripauperin protein/gene family (see Gene_cla\nss PAU),,\n mPAU3:member of the seripauperin protein/gene family (see Gene_cla\nss PAU),,\n Cond54:erg3(haploid)\n mPAU4:member of the seripauperin protein/gene family (see Gene_cla\nss PAU),,\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mPAU5:member of the seripauperin protein/gene family (see Gene_cla\nss PAU),,\n mYIL176C:Unknown ,, Unknown\n mPRB1:dispensable for haploidization and sporulation, but needed f\nor full protein degradation during sporulation, and proper s\npore morphology,vacuolar protease B,Null mutant is viable, p\nrotease B deficient, has smaller spores than wild-type embed\nded in a thick matrix\n mYPL272C:Unknown ,, Unknown\n mYJL213W:Unknown ,, Unknown\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond80:hmg1(haploid)\n Cond182:tup1(haploid)\n Cond483:Low-Pi_vs_High-Pi_in_WT_(NBW7)_exp1\n Cond294:Itraconazole\n mYDR542W:Unknown ,, Unknown\n pho.Pho:New components of a system for phosphate accumulation and po\nlyphosphate metabolism in Saccharomyces cerevisiae revealed \nby genomic expression analysis. Mol Biol Cell. 2000 Dec;11(\n12):4309-21.\n Cond295:Lovastatin\n mYIR041W:Unknown ,, Unknown\n Cond299:Tunicamycin\n Chromo.chromo:Genomewide studies of histone deacetylase function in yeast.\n Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13708-13.\n mHES1:Protein implicated in ergosterol biosynthesis,similar to hum\nan oxysterol binding protein,pleiotropic sterol-related phen\notypes\n zap1.Series0:Genome-wide characterization of the Zap1p zinc-responsive re\ngulon in yeast. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14)\n:7957-62.\n Cond274:yor080w(**3)\n COMP.TE:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond35:cup5\n mYLL012W:Unknown ,, Unknown\n mYHL046C:Unknown ,, Unknown\n
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Computational Genomics Lab, Tel-Aviv uniresity