Module number 1390




Database revision : gnsdb28.10
Date : Tue Feb 25 17:13:00 2003
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Cond547:cln3-1\n Cond498:wtħ500nMaF,30minlog10(intensity)\n mMCD1:Mitotic Chromosome Determinant; similar to S. pombe RAD21; m\nay function in chromosome morphogenesis from S phase through\n mitosis,,Null mutant is inviable; temperature sensitive mut\nants are defective in mitotic sister chromatid cohesion and \nmitotic chromosome condensation; multicopy suppressor of smc\n1-2 mutation\n Cond541:fus3D+50nMaF,30min/wtlog10(intensity)\n mTOS4:Hypothetical ORF,,\n Cond494:wtħ5nMaF,30minlog10(intensity)\n Cond548:cln3-2\n Cond500:wtħ50nMaF,15minlog10(intensity)\n Cond751: Cell Cycle.alpha:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion. Mol Biol Cell. 1998 Dec;9(12):3273-97.\n mYIL141W:Unknown ,, Unknown\n Cond504:wtħ50nMaF,90minlog10(intensity)\n Cond579:cdc15_140\n mCLB6:role in DNA replication during S phase,B-type cyclin,Null mu\ntant is viable\n mMIF2:centromere protein required for normal chromosome segregatio\nn and spindle integrity,,Null mutant is inviable, temperatur\ne sensitive mutants accumulate large budded cells and broken\n spindles at the restricitive temperature\n mRFA2:Involved in nucleotide excision repair,29% identical to the \nhuman p34 subunit of RF-A , replication factor RF-A subunit \n2,Null mutant is inviable; arrests as budded and multiply bu\ndded cells; rfa2 (ts) cells have a mutator and a hyper-recom\nbination phenotype and are more sensitive to hydroxyurea and\n methyl-methane-sulfonate than wild-type cells\n Cell Cycle.ko:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion. Mol Biol Cell. 1998 Dec;9(12):3273-97.\n Cond519:rst1Drst2Dħ50nMaF,30minlog10(intensity)\n Cond669:mec1_plus_gamma_120_min\n Cond586:cdc15_210\n mPOL12:Required for DNA synthesis and correct progression through S\n phase; plays an essential role at early stage of chromosoma\nl DNA replication, before the hydroxyurea-sensitive step,DNA\n polymerase alpha-primase complex B subunit,Null mutant is i\nnviable\n GCN4.gcn4:Transcriptional profiling shows that Gcn4p is a master regul\nator of gene expression during amino acid starvation in yeas\nt. Mol Cell Biol. 2001 Jul;21(13):4347-68.\n Cond733: Y-Stre.Acid:Remodeling of yeast genome expression in response to environ\nmental changes. Mol Biol Cell. 2001 Feb;12(2):323-37.\n Cond507:bni1Dħ50nMaF,90minlog10(intensity)\n Cond509:kss1Dħ50nMaF,30minlog10(intensity)\n Cond562:alpha77\n Cond496:wtħ50nMaF,30minlog10(intensity)\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Mating.Mating:Signaling and circuitry of multiple MAPK pathways revealed b\ny a matrix of global gene expression profiles. Science. 200\n0 Feb 4;287(5454):873-80\n Cond568:alpha119\n Cond753: mYPL267W:Unknown ,, Unknown\n Cond495:wtħ15.8nMaF,30minlog10(intensity)\n Cond279:ERG11(tetpromoter)\n COMP.CH:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond553:alpha14\n Cond508:bni1Dħ50nMaF,120minlog10(intensity)\n mMSH2:Functions with Pms1p and Pms2/Mlh1p in a complex that intera\ncts with Pms3p/Msh6p to repair single-base and insertion-del\netion mispairs, or Msh3p to repair insertion-deletion mispai\nrs.,mutS homolog,Null mutant is viable. Haploid mutants disp\nlay an 85-fold increased rate of spontaneous mutation to can\navanine resistance. Mutants are defective for gene conversio\nn polarity gradients and high spore viability.\n Cond216:yer044c(haploid)\n Cond550:clb2-1\n Cond557:alpha42\n Cond226:yhl029c\n mYBR089W:Unknown ,, Unknown\n Cond506:bni1Dħ50nMaF,60minlog10(intensity)\n Cond580:cdc15_150\n Cond65:fus3(haploid)\n mBUB1:checkpoint gene involved in permitting entry into mitosis de\npending upon the assembly state of microtubules,,Mutants are\n unable to recover from transient loss of spindle function. \nOverexpression of BUB1 rescues the cold sensitivity of tub1-\n729.\n mERP3:Emp24p/Erv25p related protein 2,p24 protein involved in memb\nrane trafficking,viable\n Cond767:Acid_40'\n mYBR071W:Unknown ,, Unknown\n Cond502:wtħ50nMaF,45minlog10(intensity)\n Cond581:cdc15_160\n Cond54:erg3(haploid)\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond563:alpha84\n Cond558:alpha49\n Cond734: SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond746: Cond501:wt+/-50nMaF,30minlog10(intensity)\n Cond582:cdc15_170\n Cond98:mbp1\n Cond554:alpha21\n mHCM1:Dosage-dependent suppressor of cmd1-1 mutation; shows homolo\ngy to fork head family of DNA-binding proteins,,Null mutant \nis viable; exacerbates temperature-sensitivity of a cmd1-1 (\ncalmodulin) mutant\n mRAD51:Involved in processing ds breaks, synaptonemal complex forma\ntion, meiotic gene conversion and reciprocal recombination.,\nRad51p colocalizes to ~ 65 spots with Dmc1p prior to synapsi\ns (independently of ZIP1 and DMC1), and interacts with Rad52\np and Rad55p; human Rad51p homolog interacts with Brca2 prot\nein which has been implicated in causing breast cancer , Rec\nA homolog,Null mutant is viable; accumulates meiosis-specifi\nc double strand breaks at a recombination hotspot and reduce\ns the formation of physical recombinants and processed doubl\ne strand breaks with long heterogeneous tails; rad51 mutants\n are also defective for X-ray damage repair and gene convers\nions; rad51 rad27 mutants are inviable.\n Cond738:90\n Cond571:cdc15_50\n Cond575:cdc15_100\n Cond294:Itraconazole\n Cond574:cdc15_90\n Cond737: Cond538:fus3D/wtlog10(intensity)\n Cond747: mSPT21:involved in trascriptional regulation of Ty1 LTRs,non-specif\nic DNA binding protein,Null mutant is viable, spt21 mutation\ns suppress Ty insertion mutations\n Cond497:wtħ158nMaF,30minlog10(intensity)\n Cond576:cdc15_110\n Cond555:alpha28\n Cond493:wtħ1.5nMaF,30minlog10(intensity)\n Cond299:Tunicamycin\n Cond570:cdc15_30\n mRNR1:ribonucleotide reductase,ribonucleotide reductase, large (R1\n) subunit,Null mutant is inviable\n Cond736: Cell Cycle.cdc15:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion. Mol Biol Cell. 1998 Dec;9(12):3273-97.\n Cond473:WT+/-MMS(DBY747)\n COMP.TE:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond559:alpha56\n mDNA2:DNA replication helicase,DNA replication helicase,Null mutan\nt is inviable\n Cond750: Cond510:fus3Dħ50nMaF,30minlog10(intensity)\n Cond567:alpha112\n fkh1,2sf.Series0:Two yeast forkhead genes regulate the cell cycle and pseudoh\nyphal growth. Nature. 2000 Jul 6;406(6791):90-4.\n Cond551:alpha0\n Cond549:clb2-2\n
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Computational Genomics Lab, Tel-Aviv uniresity