Module number 1314




Database revision : gnsdb28.10
Date : Tue Feb 25 17:46:29 2003
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Cond626:DY1457_(wild_type)_3_mM_vs._61_nM_zinc_y13-121\n mERG10:acetoacetyl CoA thiolase,acetoacetyl CoA thiolase,Nul mutant\n is inviable; other mutants are ergosterol biosynthesis defe\nctive or nystatin resistant\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n mERG12:mevalonate catabolism,mevalonate kinase,Null mutant is invia\nble and unable to grow vegetatively or germinate spores; mut\nants exhibit increased mitotic stability of plasmids with we\nak ARS elements.\n mTKL1:Transketolase 1,transketolase 1,Null mutant is viable; growt\nh on fermentable carbon sources, but not gluconeogenic carbo\nn sources, is reduced; tkl1 tkl2 mutants are auxotrophic for\n aromatic amino acids\n Cond432:YPD_stationary_phase_22_d_ypd-1\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts. Nat Genet\n. 2000 Dec;26(4):415-23.\n mPGM1:phosphoglucomutase, minor isoform,phosphoglucomutase minor i\nsoform,Null mutant is viable\n Cond418:YPD_1_d_ypd-2\n mFET3:FET3 encodes a ferro-O2-oxidoreductase that is part of the h\nigh-affinity iron transport system,multicopper oxidase,The n\null mutant is viable but defective for high affinity Fe(II) \nuptake. The null mutant is inviable when environmental iron \nis limiting.\n GCR1.gcr1:Understanding the growth phenotype of the yeast gcr1 mutant \nin terms of global genomic expression patterns. J Bacteriol\n. 2000 Sep;182(17):4970-8.\n Cond913:(99i3)_S150-2B_YPD_NormInt\n mLAP3:aminopeptidase of cysteine protease family; bleomycin hydrol\nase,aminopeptidase of cysteine protease family,Null mutant i\ns viable with no obvious growth defects but is leucine amino\npeptidase deficient and hypersensitive to bleomycin; overexp\nression confers resistance to bleomycin\n Cond400:Nitrogen_Depletion_12_h\n mYGL245W:Unknown ,, Unknown\n Stress.YPD:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond140:rps24a(**9)\n Stress.Carbon:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond898:RPN4\n Stress.YPDStat:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond445:Msn4_overexpression\n mYNL247W:Unknown ,, Unknown\n Cond719:t4-SSD1\n Cond724:t4+SSD1,H44\n Cond:\n mRPL6B:Homology to rat and human L6; involved initiation of protein\n synthesis,ribosomal protein L6B (L17B) (rp18) (YL16),Null m\nutant is viable, grows slower than wild-type. rpl6a rpl6b do\nuble mutants are inviable; rpl6 mutants are deficient in 60S\n ribosomal subunits relative to 40S subunits; 43S preinitiat\nion complexes accumulate in half-mer polyribosomes in the ab\nsence of sufficient 60S subunits.\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mERG27:3-keto sterol reductase,3-keto sterol reductase,\n mTHR4:threonine synthase,threonine synthase,threonine requiring\n Cond429:YPD_stationary_phase_5_d_ypd-1\n Cond718:t4+SSD1wt\n Cond934:8h\n Cond298:Terbinafine\n Cond420:YPD_3_d_ypd-2\n COMP.CH:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond404:Nitrogen_Depletion_5_d\n Cond709:t0+Vec\n mMKT1:Protein involved in propagation of M2 dsRNA satellite of L-A\n virus,retroviral protease signature protein,Null mutant is \nviable\n Cond449:glucose_vs._reference_pool_car-1\n mADH3:alcohol dehydrogenase isoenzyme III,alcohol dehydrogenase is\noenzyme III,Null mutant is viable\n Stress.NitroDepl:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond430:YPD_stationary_phase_7_d_ypd-1\n mPAB1:Poly(A) binding protein, cytoplasmic and nuclear,poly(A) bin\nding protein,Null mutant is inviable.\n Cond717:t2-SSD1\n mTRP2:anthranilate synthase Component I,anthranilate synthase comp\nonent I,tryptophan requiring\n Cond431:YPD_stationary_phase_13_d_ypd-1\n Cond405:Diauxic_Shift_Timecourse_-_0_h\n mPDA1:alpha subunit of pyruvate dehydrogenase (E1 alpha),pyruvate \ndehydrogenase alpha subunit (E1 alpha),Null mutant is viable\n, exhibits reduced growth on glucose and increased formation\n of petites\n Cond918:1h\n Cond725:t4-SSD1,M31\n Cond708:t0+SSD1\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond422:YPD_stationary_phase_2_h_ypd-1\n mIMD3:Hypothetical ORF,IMP dehydrogenase homolog,\n mRPS16A:Homology to rat S16,ribosomal protein S16A (rp61R),\n Cond427:YPD_stationary_phase_2_d_ypd-1\n Cond886:g-ray\n Cond26:cka2\n mASN2:Asn1p and Asn2p are isozymes,asparagine synthetase,Null muta\nnt is viable; L-asparagine auxotrophy occurs upon mutation o\nf both ASN1 and ASN2\n Cond403:Nitrogen_Depletion_3_d\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond402:Nitrogen_Depletion_2_d\n mNCP1:NADP-cytochrome P450 reductase,NADP-cytochrome P450 reductas\ne,Null mutant is viable\n Cond723:t2-SSD1,M31\n Cond433:YPD_stationary_phase_28_d_ypd-1\n Cond401:Nitrogen_Depletion_1_d\n mVMA5:42 kDa subunit of V1 sector,V1 sector hydrophilic subunit C \n, vacuolar ATPase V1 domain subunit C (42 kDa) , vacuolar H-\nATPase , V1 sector hydrophilic subunit C , vacuolar ATPase V\n1 domain subunit C (42 kDa) , vacuolar H-ATPase,Null mutant \nis viable; certain vma5 mutations show allele-specific synth\netic lethality with cdc24-ls mutants\n Cond714:t0+SSD1wt\n mGDA1:converts nucleoside diphosphates to nucleoside monophosphate\ns to recycle nucleosides and promote transport of additional\n nucleotide sugars into golgi,guanosine diphosphatase of Gol\ngi membrane,Null mutant is viable and has partial block in m\nannosylation of proteins and sphingolipids\n Stress.Various:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mSEC21:non-clathrin coat protein involved in transport between ER a\nnd Golgi,PEST sequence-containing protein , non-clathrin coa\nt protein,Null mutant is inviable\n zap1.Series0:Genome-wide characterization of the Zap1p zinc-responsive re\ngulon in yeast. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14)\n:7957-62.\n Cond627:DY1457_(wild_type)_3_mM_vs._76_nM_zinc_y12-122\n mVMA13:vacuolar ATPase V1 domain subunit H (54 kDa),vacuolar ATPase\n V1 domain subunit H (54 kDa) , vacuolar H(+) ATPase V1 sect\nor 54 kDa subunit,Null mutant is viable, V-ATPase complex fr\nom null mutants is less stable than from wild-type strains\n Cond938:2h\n Cond421:YPD_5_d_ypd-2\n Cond710:t2+SSD1\n Cond428:YPD_stationary_phase_3_d_ypd-1\n Stress.dshift:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n
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Computational Genomics Lab, Tel-Aviv uniresity