Module number 1242




Database revision : gnsdb28.10
Date : Tue Feb 25 17:46:37 2003
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mCAK1:binds and phosphorylates Cdc28p,cyclin-dependent kinase-acti\nvating kinase,Null mutant is inviable; temperature-sensitive\n mutant confers a G2 delay accompanied by low Cdc28p protein\n kinase activity\n mSAP30:Hypothetical ORF,,\n mCTP1:citrate transport protein,citrate tranporter,Null mutant is \nviable\n mSDH2:Succinate dehydrogenase (ubiquinone) iron-sulfur protein sub\nunit,succinate dehydrogenase (ubiquinone) iron-sulfur protei\nn subunit,Null mutant is viable\n mYKL153W:Unknown ,, Unknown\n mYBR012C:Unknown ,, Unknown\n mRPP1B:Homology to rat P1, human P1, and E. coli L12eIIB,ribosomal \nprotein P1B (L44') (YP1beta) (Ax),Null mutant is viable\n Pho85.pho85:Chemical inhibition of the Pho85 cyclin-dependent kinase rev\neals a role in the environmental stress response. Proc Natl\n Acad Sci U S A. 2001 Oct 23;98(22):12578-83.\n Cond829:tlc1_Expt.2_Passage_1\n mFPR2:binds the immunosuppressant drug FK506,FKBP13 (FK506 binding\n protein) , peptidyl-prolyl cis-trans isomerase (PPIase),Nul\nl mutant is viable\n mYBL111C:Unknown ,, Unknown\n mHYR1:Hydroperoxide resistance conferring gene,glutathione-peroxid\nase (putative),Null mutant is hypersensitive to oxidative st\nress\n mVCX1:Similar to sodium/calcium exchangers, including bovine Na+/C\na2+,K+ antiporter; putative vacuolar transmembrane protein,v\nacuolar H+/Ca2+ exchanger,Null mutant is viable, sensitive t\no high Ca2+ conditions\n mYCR013C:Unknown ,, Unknown\n mKAR2:Involved in translocation of nascent polypeptides across the\n ER membrane,HSP70 family , mammalian BiP (GPR78) homolog , \nHSP70 family , mammalian BiP (GPR78) homolog,null mutants ar\ne inviable; other mutants block karyogamy (nuclear fusion) d\nuring mating\n mYBR230C:Unknown ,, Unknown\n mPDR5:multidrug resistance transporter,multidrug resistance transp\norter,pleiotropic drug resistance\n mCBP4:Essential for the expression and activity of ubiquinol-cytoc\nhrome c reductase,,Inability to respire, pleiotropic reducti\non in steady state levels of four subunits of ubiquinol-cyto\nchrome c reductase\n mYAL045C:Unknown ,, Unknown\n mYDR115W:Unknown ,, Unknown\n mSDP1:Unknown ,, Unknown\n mYLR462W:Unknown ,, Unknown\n mENO1:enolase I,enolase I,Null mutant is viable\n Cond976:F82G_1_mM_1NaPP1\n mCDC42:cell division cycle blocked at 36 degree C,Rho subfamily of \nRas-like proteins,Null mutant is inviable; temperature sensi\ntive mutations unable to form buds and display delocalized c\nell-surface deposition at the restrictive temperature\n mTSL1:123 kD regulatory subunit of trehalose-6-phosphate synthase/\nphosphatase complex; homologous to TPS3 gene product,similar\n to TPS3 gene product , trehalose-6-phosphate synthase/phosp\nhatase complex 123 kDa regulatory subunit,Null mutant is via\nble\n mPST1:Protoplasts-secreted,the gene product has been detected amon\ng the proteins secreted by regenerating protoplasts,Viable\n mYNR036C:Unknown ,, Unknown\n mRPS8A:Homology to mammalian S8,ribosomal protein S8A (S14A) (rp19)\n (YS9),\n mYPL013C:Unknown ,, Unknown\n mILM1:Product of gene unknown,,\n mCDC48:Microsomal protein of CDC48/PAS1/SEC18 family of ATPases; fu\nll length homology to mammalian protein VCP; involved in sec\nretion, peroxisome formation and gene expression,,Null mutan\nt is inviable\n mYGR016W:Unknown ,, Unknown\n mRPS12:Homology to rat S12,ribosomal protein S12,\n mRHR2:DL-glycerol-3-phosphatase,DL-glycerol-3-phosphatase,\n mIPI1:Unknown ,, Unknown\n mGAS3:Unknown ,, Unknown\n mXBP1:DNA-binding transcriptional repressor,transcriptional repres\nsor,Null mutant is viable; overexpression of XBP1 leads to a\n slow-growth phenotype, lengthening of G1, an increase in ce\nll volume, and a repression of G1 cyclin expression\n mTAL1:Transaldolase, enzyme in the pentose phosphate pathway,trans\naldolase, enzyme in the pentose phosphate pathway,Null mutan\nt is viable\n mYLR202C:Unknown ,, Unknown\n mRPP2A:Homology to rat P2, human P2, and E.coli L12eIB,60S acidic r\nibosomal protein P2A (L44) (A2) (YP2alpha),Null mutant is vi\nable\n mCWP1:cell wall protein, involved in O and N glycosylation, accept\nor of B1-6 glucan.,cell wall mannoprotein,Null mutant is via\nble, has increased sensitivities to calcoflour white and con\ngo red\n mPEP4:vacuolar proteinase A,vacuolar proteinase A,Null mutant is v\niable, proteinase deficient, phosphatase deficient; pep4 mut\nants exhibit a 60-70% reduction in total protein degradation\n during sporulation\n mERD2:ER protein retention,HDEL receptor,Null mutant is inviable\n mSAR1:Secretion-Associated, Ras-related. Component of COPII coat o\nf vesicles; required for ER to Golgi protein transport,ARF f\namily , GTP-binding protein,Null mutant is inviable. When ov\nerexpressed, wild-type SAR1 suppresses a sec12 mutation.\n mYNL026W:Unknown ,, Unknown\n mRPN13:Proteasome subunit,,Null mutant is viable but defective in d\negradation of ubiquitinated substrates.\n mYER189W:Unknown ,, Unknown\n mAPC1:anaphase-promoting complex component,ubiquitin ligase subuni\nt,\n mYCL033C:Unknown ,, Unknown\n mCYR1:Required for START A of cell cycle, and glucose and nitrogen\n repression of sporulation,adenylate cyclase,Null mutant is \ninviable. cyr1 transiently arrests in G1 and sporulates prec\nociously. N-terminal domain is dispensable for mitotic G1 ar\nrest after nitrogen starvation, but required for sporulation\n. When altered, cAMP levels remain high and cells continue t\no bud with abnormal spindles\n mYGL072C:Unknown ,, Unknown\n mSNC1:Involved in mediating targeting and transport of secretory p\nroteins; forms a complex with Snc2p and Sec9p,Snc2p homolog \n, synaptobrevin homolog,Null mutant is viable; snc1 snc2 mut\nants are deficient in normal bulk secretion, accumulate larg\ne numbers of post-Golgi vesicles, and display a variety of c\nonditional lethal phenotypes; snc1 mutations suppress loss o\nf cap in strains possessing an activated ras2 allele\n mSNC2:mediate the targeting and transport of secretory proteins,ve\nsicle-associated membrane protein (synaptobrevin) homolog,Nu\nll mutant is viable, snc1 snc2 double mutants are deficient \nin normal bulk secretion, accumulate large numbers of post-G\nolgi vesicles, and display a variety of conditional lethal p\nhenotypes\n mHSP60:60 kDa heat shock protein,chaperonin , groEL homolog , chape\nronin , groEL homolog,Null mutant is inviable\n mRTN1:Unknown ,, Unknown\n mRTN2:Unknown ,, Unknown\n mSBH2:Ssh1p-Sss1p-Sbh2p complex component, involved in protein tra\nnslocation into the endoplasmic reticulum,Sbh1p homolog,Null\n mutant is viable. sbh1 sbh2 double deletion mutants exhibit\n synthetic temperature sensitivity and accumulation of secre\ntory protein precursors\n mYJL161W:Unknown ,, Unknown\n mCYC7:iso-2-cytochrome c,iso-2-cytochrome c,Null mutant is viable\n mYDR327W:Unknown ,, Unknown\n mTHO1:Suppressor of the Transcriptional (T) defect of Hpr1 (H) by \nOverexpression (O),,Null mutant is viable; wild-type levels \nof transcription and recombination; overexpression of THO1 s\nuppresses the temperature-sensitive phenotype of hpr1-delta \nmutants and their incapacity to transcribe lacZ sequences.\n mYLL025W:Unknown ,, Unknown\n mYMR173W-A:Unknown ,, Unknown\n mCOX15:cytochrome oxidase assembly factor,cytochrome oxidase assemb\nly factor,fail to synthesize cytochrome oxidase\n mTRA1:TRA1 is the homolog of the human protein TRRAP which we have\n isolated as an essential cofactor of c-Myc.,ATM/Mec1/TOR1/T\nOR2-related,Null mutant is inviable.\n mCOX16:Unknown ,, Unknown\n tcl1.tcl1:The genome-wide expression response to telomerase deletion i\nn Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2002 \nJul 9;99(14):9316-21.\n mSSS1:involved in transfer of secretory precursors through the end\noplasmic reticulum membrane,ER protein , Sec61 trimeric comp\nlex component , Ssh1 trimeric complex component,Null mutant \nis inviable. Depletion of the Sss1 protein rapidly results i\nn accumulation of multiple secretory or membrane proteins de\nvoid of post-translational modifications. SSS1 overexpressio\nn restores translocation in sec61 mutants.\n mYFR017C:Unknown ,, Unknown\n mSNZ3:Snooze: stationary phase-induced gene family,,hypersporulati\non\n mYDL172C:Unknown ,, Unknown\n mYCP4:Protein with similarity to S. pombe brefeldin A resistance p\nrotein obr1 and E. coli WrbA protein which stimulates bindin\ng of Trp repressor to DNA,,\n mTTR1:Glutaredoxin (thioltransferase) (glutathione reductase),glut\naredoxin , thioltransferase/glutathione reductase,\n mEMP24:type I transmembrane protein, component of COPII-coated, ER-\nderived transport vesicles,type I transmembrane protein,Null\n mutant is viable\n mGCV3:H-protein subunit of the glycine cleavage system,glycine cle\navage system H-protein subunit,Null mutant is viable but doe\ns not grow if glycine is the sole nitrogen source\n mNDI1:NADH dehydrogenase (ubiquinone),NADH dehydrogenase (ubiquino\nne),\n mGLK1:Glucose phosphorylation,glucokinase,Null mutant is viable wi\nth no discernible difference from wild-type; hxk1, hxk2, glk\n1 triple null mutants are unable to grow on any sugar except\n galactose and fail to sporulate\n mYBR116C:Unknown ,, Unknown\n mYJL068C:Unknown ,, Unknown\n mTRX2:thioredoxin,thioredoxin,Null mutant is viable; trx1-trx2 dou\nble mutant shows prolonged S phase, shortened G(sub)1 and me\nthionine auxotrophy\n mTRX3:mitochondrial thioredoxin,thioredoxin,Null mutant is viable,\n normal sensitivity to hydrogen peroxide\n mILV6:acetolactate synthase regulatory subunit,,\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mAPD1:actin patches distal,,\n mSDS24:Similar to S. pombe SDS23, suppresses DIS2, localized to the\n nucleus,,Null mutant is viable\n mYLR464W:Unknown ,, Unknown\n mCYS3:cystathionine gamma-lyase,cystathionine gamma-lyase,Null mut\nant is viable, cysteine auxotroph\n mFBA1:aldolase,aldolase,Null mutant is viable, lacks aldolase enzy\nmatic activity and fails to grow in media containing as a ca\nrbon source metabolites of only one side of the aldolase rea\nction\n mECM15:ExtraCellular Mutant,,A Tn3 insertion into this gene causes \nhypersensitivity to the cell surface polymer perturbing agen\nt calcofluor white.\n mPUP3:20S proteasome subunit beta3_sc,20S proteasome subunit beta3\n_sc,\n mYFR003C:Unknown ,, Unknown\n mGRX1:Glutaredoxin,glutaredoxin,Null mutant is viable but sensitiv\ne to oxidative stress. grx1 grx2 null mutants are viable but\n lack heat-stable oxidoreductase activity.\n mMMS2:Member of error-free postreplication DNA repair pathway,,Nul\nl mutant is viable and is sensitive to MMS and UV\n mARF1:implicated in signal transduction and intracellular protein \ntransport to or within the Golgi apparatus,ADP-ribosylation \nfactor,Null mutant is viable and shows slow growth, cold sen\nsitivity and sensitivity to normally sublethal concentration\ns of fluoride ion in the medium.\n mZRT2:Low-affinity zinc transport protein,low affinity zinc transp\nort protein,Null mutant is viable; ZRT2 overexpression incre\nases rate of zinc uptake\n mYAL061W:Unknown ,, Unknown\n mCHA4:Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear \ncluster domain,DNA binding transcriptional activator of CHA1\n,Unable to grow with serine or threonine as the sole nitroge\nn source, suppresses ilv1 mutant by causing inducer-independ\nent, constitutive expression of CHA1\n mYNR074C:Unknown ,, Unknown\n mYDR154C:Unknown ,, Unknown\n Cond975:WT_1_mM_1NaPP1\n mKEX2:prohormone processing; golgi localization marker, dispensabl\ne for meiotic recombination but partially required for meios\nis I and/or meiosis II,Ca2+-dependent serine protease,Null m\nutant is viable and defective in killer expression\n mTUP1:general repressor of transcription (with Cyc8p); mediates gl\nucose repression,glucose repression regulatory protein, exhi\nbits similarity to beta subunits of G proteins,Null mutant i\ns viable; exhibits flocculent colony morphology\n mAUT7:Forms a protein complex with Aut2p to mediate attachment of \nautophagosomes to microtubules. Defective in maturation of t\nhe vacuolar protein, aminopeptidase I,similar to LC3, a micr\notubule-associated protein from rat,Null mutant is viable bu\nt lacks autophagocytosis and is unable to sporulate. AUT7 is\n a suppressor of mutant phenotypes of aut2-1 cells. Uptake o\nf precursor Aminopeptidase I into the vacuole depends on Aut\n2p and Aut7p.\n Cond973:WT_vs_F82G_1\n mYIL177C:Unknown ,, Unknown\n mYNL028W:Unknown ,, Unknown\n mYFL066C:Unknown ,, Unknown\n mYAL004W:Unknown ,, Unknown\n mYLR356W:Unknown ,, Unknown\n mBMH1:Brain Modulosignalin Homolog,member of conserved eukaryotic \n14-3-3 gene family,Null mutant is viable; bmh1 bmh2 double m\nutant is inviable; (in strain Sigma-1278b, required for pseu\ndohyphal development but not for viability)\n mBMH2:Brain Modulosignalin Homolog,member of conserved eukaryotic \n14-3-3 gene family,Null mutant is viable; bmh1 bmh2 double m\nutant is inviable; (in strain Sigma-1278b, required for pseu\ndohyphal development but not for viability)\n mRPL1B:Homology to rat L10a, eubacterial L1, and archaebacterial L1\n; identical to S. cerevisiae L1A (Ssm1p),ribosomal protein L\n1B,\n mYPR098C:Unknown ,, Unknown\n mERG10:acetoacetyl CoA thiolase,acetoacetyl CoA thiolase,Nul mutant\n is inviable; other mutants are ergosterol biosynthesis defe\nctive or nystatin resistant\n mYDL173W:Unknown ,, Unknown\n mYDL072C:Unknown ,, Unknown\n Cond982:pho85D_10_mM_1NaPP1_\n mINP52:Synaptojanin-like protein,inositol polyphosphate 5-phosphata\nse,Null mutant is viable, has abnormal vacuoles\n mYDR344C:Unknown ,, Unknown\n mPGM2:Phosphoglucomutase,phosphoglucomutase,Null mutant is viable,\n pgm1 pgm2 deletion mutants fail to grow on galactose\n mYCL042W:Unknown ,, Unknown\n mTPI1:triosephosphate isomerase,triosephosphate isomerase,Null mut\nant is viable.\n mYDR533C:Unknown ,, Unknown\n mUIP4:Unknown ,, Unknown\n mHSP10:Homolog of E. coli GroES protein; regulates Hsp60, the yeast\n mitochondrial chaperonin, and is thereby involved in protei\nn folding and sorting in mitochondria,heat shock protein 10,\nNull mutant is inviable; temperature-sensitive mutants are a\nvailable\n mMSC1:Meiotic Sister-Chromatid recombination,,\n mICT1:Increased Copper Tolerance; Similar to Ecm18p,,\n mHSP12:induced by heat shock, entry into stationary phase, depletio\nn of glucose, and addition of lipids (fatty acids),heat shoc\nk protein 12,Null mutant is viable, but shows induction of h\neat shock response under conditions normally associated with\n low-level HSP12 expression\n mYBR052C:Unknown ,, Unknown\n mRPL28:Homology to rat, mouse L27a,ribosomal protein L28 (L29) (rp4\n4) (YL24),Cycloheximide resistance\n mYPC1:Yeast Phyto-ceramidase,alkaline ceramidase with reverse acti\nvity,Null mutant is viable and two times more heat resistant\n than the wild-type parental strain.\n mYMR31:mitochondrial ribosomal protein (precursor),mitochondrial ri\nbosomal protein,\n mYMR002W:Unknown ,, Unknown\n mGTT1:Glutathione Transferase,glutathione transferase,Null mutant \nis viable, heat shock sensitive at stationary phase\n mYNL174W:Unknown ,, Unknown\n mYJL055W:Unknown ,, Unknown\n mTFP3:vacuolar ATPase V0 domain subunit c' (17 kDa),vacuolar ATPas\ne V0 domain subunit c' (17 kDa) , vacuolar H(+) ATPase 17 kD\na subunit C , vacuolar ATPase V0 domain subunit c' (17 kDa) \n, vacuolar H(+) ATPase 17 kDa subunit C,Null mutant is viabl\ne, defective in vacuolar acidification, high copy TFP3 confe\nrs resistance to trifluoperazine\n mYDR134C:Unknown ,, Unknown\n mSHP1:isolated as a suppressor of the lethality caused by overexpr\nession of the phosphoprotein phosphatase 1 catalytic subuniu\nt encoded by GLC7,,Null mutant is viable; sporulation defect\nive, slow growth; is deficient in glycogen accumulation; low\n Glc7p specific activity\n mSSN8:Component of RNA polymerase II holoenzyme, involved in RNA p\nol II carboxy-terminal domain phosphorylation. Activity of t\nhe kinase (SSN3)/cyclin (SSN8) pair required, along with SSN\n6 & TUP1, for transcriptional repression of a-specific genes\n,C-type cyclin , associates with the Ssn3p cyclin-dependent \nkinase , C-type cyclin , associates with the Ssn3p cyclin-de\npendent kinase , C-type cyclin , associates with the Ssn3p c\nyclin-dependent kinase , C-type cyclin , associates with the\n Ssn3p cyclin-dependent kinase,null is viable, exhibits set \nof phenotypes common to strains defective in SSN6/TUP1-media\nted transcriptional repression. Other mutations show unsched\nuled meiotic gene expression (derepression of early meiotic \ngenes), suppression of SNF1.\n mEMG1:Essential for Mitotic Growth,ribosome biogenesis,Lethal\n mTSA1:antioxidant enzyme that provides protection against oxidatio\nn systems capable of generating reactive oxygen and sulfur s\npecies,thioredoxin-peroxidase (TPx); reduces H2O2 and alkyl \nhydroperoxides with the use of hydrogens provided by thiored\noxin, thioredoxin reductase, and NADPH,Null mutant is viable\n, grows slower than wild-type under aerobic conditions\n mSRB7:Suppressor of RNA polymerase II, possible component of the h\noloenzyme,RNA polymerase II holoenzyme/mediator subunit,Null\n mutant is inviable\n mCAP2:capping - addition of actin subunits,capping protein beta su\nbunit,Null mutant is viable, exhibits abnormal actin distrib\nution (including loss of actin cables); round, large cells w\nith heterogeneous size distribution; slower growing; chitin \nfound over entire mother cell surface rather than restricted\n to the mother-bud junction\n mACN9:Hypothetical ORF,,\n mYER004W:Unknown ,, Unknown\n mGSP1:maintenance of nuclear organization; homologous to mammalian\n Ran, a small nuclear GTPase of the ras superfamily,GTP-bind\ning protein,Null mutant is inviable\n mGCY1:Galactose-induced transcript, product is homologous to mamma\nlian aldo/keto reductases, as well as to gamma-crystallin, a\n vertebrate eye lens protein,,Null mutant is viable\n mYDL110C:Unknown ,, Unknown\n mTOM20:Translocase of Outer Mitochondrial membrane,20 kDa mitochond\nrial outer membrane protein import receptor,Null mutant is v\niable but respiration deficient; defective in import of mito\nchondrial preproteins\n mYDL124W:Unknown ,, Unknown\n mRPS26B:Homology to rat S26,ribosomal protein S26B,Null mutant is vi\nable\n mRPN6:Regulatory Particle Non-ATPase, homolog of mammalian proteas\nomal subunit S9/p44.5.,proteasome regulatory particle subuni\nt,Null mutant is inviable\n mARA1:D-arabinose dehydrogenase,D-arabinose dehydrogenase,Null mut\nant is viable but cannot produce D-arabinono-1,4-lactone, a \nprecursor of D-erythroascorbic acid\n mHSP26:heat shock protein 26,heat shock protein 26,Null mutant is v\niable; hsp26 hsp42 double deletion mutants are viable\n mYLR169W:Unknown ,, Unknown\n mPET9:the major mitochondrial ADP/ATP translocator; highly homolog\nous to AAC1 and AAC3,ADP/ATP translocator,null is viable but\n petite (unable to grow on non-fermentable carbon sources); \npet9,aac3 double null mutant is inviable under anaerobic con\nditions; pet9 mutations are lethal in combination with rho- \nmutations\n mYDL016C:Unknown ,, Unknown\n mHHT1:Histone H3 (HHT1 and HHT2 code for identical proteins),histo\nne H3 (HHT1 and HHT2 code for identical proteins),Null mutan\nt is viable\n mCDC19:Required for START A in the cell cycle and sporulation,pyruv\nate kinase,Null mutant is inviable. cdc19 mutants are pyruva\nte kinase deficient and show cell division cycle blocked at \n36 degrees C\n mPRE4:B-type subunit of proteasome, euk. & archae. multicatalytic \nproteinase complex likelyinvolved in an ATP/ubiquitin-depend\nent nonlysosomal proteolytic pathway. eukary: the proteasome\n is composed of ~24 subunits forming a ring-shaped structure\n,necessary for peptidyl glutamyl peptide hydrolyzing activit\ny , proteasome subunit,Null mutant is inviable\n mNAF1:Unknown ,, Unknown\n mPRE7:proteasome subunit,proteasome subunit,Null mutant is inviabl\ne\n mPRE8:proteasome component Y7,proteasome component Y7,\n mUGP1:Uridinephosphoglucose pyrophosphorylase,uridinephosphoglucos\ne pyrophosphorylase,Null mutant is inviable, probably due to\n inability to properly form the cell wall\n mYML059C:Unknown ,, Unknown\n mUGA1:gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate ami\nnotransferase),gamma-aminobutyrate (GABA) transaminase (4-am\ninobutyrate aminotransferase),\n mTIP1:cold- and heat-shock induced protein of the Srp1p/Tip1p fami\nly of serine-alanine-rich proteins,cell wall mannoprotein,Nu\nll mutant is viable; exhibits increased sensitivity to calco\nflour white and congo red\n mTDH1:Glyceraldehyde-3-phosphate dehydrogenase 1,glyceraldehyde-3-\nphosphate dehydrogenase 1,Null mutant is viable, tdh1 tdh2 a\nnd tdh1 tdh3 double mutants grow at wild type rates when eth\nanol is used as a carbon source\n mTDH2:glyceraldehyde 3-phosphate dehydrogenase,glyceraldehyde 3-ph\nosphate dehydrogenase,Null mutant is viable, grow poorly on \nglucose, grow as well as wild-type on ethanol media, tdh2 td\nh3 double deletion mutants are inviable\n mSKP1:Involved in kinetochore function and ubiquitin-mediated prot\neolysis,,Null mutant is inviable, temperature-sensitive muta\ntions in SKP1 arrest in G1 or G2\n mSPI1:Stationary Phase Induced; strongly expressed during stationa\nry phase, and trancription is dependent on MSN2/MSN4.,,\n mYKL036C:Unknown ,, Unknown\n mYBL109W:Unknown ,, Unknown\n mNHP2:HMG-like nuclear protein,HMG-like protein,Null mutant is inv\niable\n mYFL068W:Unknown ,, Unknown\n mSOL4:similar to SOL3,,\n mALD6:Utilizes NADP+ as the preferred coenzyme. Activated by Mg2+.\n,aldehyde dehydrogenase,Null mutant is viable, grows at appr\noximately one-third the rate of wild-type, unable to grow on\n ethanol as a carbon source\n mYFR020W:Unknown ,, Unknown\n mYHR218W:Unknown ,, Unknown\n mYHR181W:Unknown ,, Unknown\n mGRE2:induced by osmotic stress; similar to dihydroflavonol 4-redu\nctase from plants,,\n mYPT1:involved in the secretion pathway at the ER-to-Golgi step; r\nequired for sporulation,GTP-binding protein , ras homolog , \nsimilar to mammalian Rab1A protein,Null mutant is inviable, \nat non-permissive temp, ts and cs mutants accumulate ER memb\nranes and small vesicles, fail to process invertase and othe\nr secreted proteins, and show cytoskeletal defects; ypt1 cau\nses lethality during nitrogen starvation\n mPDI1:protein disulfide isomerase,protein disulfide isomerase,Null\n mutant is inviable\n mPHO84:inorganic phosphate transporter, transmembrane protein,inorg\nanic phosphate transporter,Null mutant is viable\n mYLL066C:Unknown ,, Unknown\n mYHR080C:Unknown ,, Unknown\n mRPL37A:Homology to rat L37,ribosomal protein L37A (L43) (YL35),\n mYPL004C:Unknown ,, Unknown\n mSTM1:Multicopy suppressor of tom1 and pop2 mutations,affinity for\n quadruplex nucleic acids,Null mutant is viable; overexpress\nion of STM1 suppresses some phenotypes of pop2 null mutation\ns and the temperature sensitivity of tom1 and htr1 mutants\n Cond974:WT_vs_F82G_2\n mSSA1:Stress-seventy subfamily A,heat shock protein of HSP70 famil\ny,Null mutant is viable, temperature sensitive; ssa1 ssa2 ss\na4 strains are inviable; an intact copy of SSA3 regulated by\n the constitutive SSA2 promoter is capable of rescuing the i\nnviability of an ssa1 ssa2 ssa4 strain\n mTPS2:Trehalose-6-phosphate phosphatase,trehalose-6-phosphate phos\nphatase,Null mutant is viable, exhibits complete loss of tre\nhalose-6-phosphate phosphatase activity, measured in vitro, \nand accumulation of excessive amounts of trehalose-6-phospha\nte instead of trehalose upon heat shock or entrance into sta\ntionary phase in vivo; null mutant is temperature sensitive,\n tps2 (pfk3) pfk1 double mutants are glucose negative\n mGSY1:Highly similar to GSY2. GSY2 is the predominantly expressed \nglycogen synthase,glycogen synthase (UDP-glucose-starch gluc\nosyltransferase),Null mutant is viable. Mutant lacking both \nGSY1 and GSY2 is viable but lacks glycogen synthase activity\n and glycogen deposition\n mSSA2:member of 70 kDa heat shock protein family,HSP70 family,Null\n mutant is viable, temperature sensitive; ssa1 ssa2 ssa4 str\nains are inviable; an intact copy of SSA3 regulated by the c\nonstitutive SSA2 promoter is capable of rescuing the inviabi\nlity of an ssa1 ssa2 ssa4 strain\n mTPS3:115 kD regulatory subunit of trehalose-6-phosphate synthase/\nphosphatase complex,trehalose-6-phosphate synthase/phosphata\nse complex 115 kDa regulatory subunit,Null mutant is viable\n mTEF1:translational elongation factor EF-1 alpha,translational elo\nngation factor EF-1 alpha,Null mutant is viable\n mTEF2:translational elongation factor EF-1 alpha,translational elo\nngation factor EF-1 alpha,Null mutant is viable, tef1 tef2 d\nouble deletion mutants are inviable\n mACP1:mitochondrial acyl carrier protein,acyl carrier protein,The \nnull mutant is viable but respiratory-deficient and contains\n only 5-10% of the wild-type amount of lipoic acid.\n mARC18:Arp2/3 complex subunit,,\n mYER093C-A:Unknown ,, Unknown\n mEMI2:Unknown ,, Unknown\n mPNC1:pyrazinamidase and nicotinamidase,nicotinamidase , pyrazinam\nidase,Null mutant is viable\n mYAR075W:Unknown ,, Unknown\n mWTM1:WD repeat containing transcriptional modulator 1,transcripti\nonal modulator,Null mutant is viable\n mHXT3:Low-affinity glucose transporter,low affinity glucose transp\norter,Null mutant is viable but grows slowly on galactose; s\nome mutant alleles confer sodium hypersensitivity.\n mYRF1-2:Y'-helicase protein 1,Y'-helicase protein 1,\n mYAR068W:Unknown ,, Unknown\n mYDR230W:Unknown ,, Unknown\n mHXT7:Hexose transporter,hexose transporter,Null mutant is viable;\n snf3 hxt1 hxt2 hxt3 hxt4 HXT7 hxt7 mutant cannot grow on me\ndia containing glucose as sole carbon source\n mPHM6:Phosphate metabolism; transcription is regulated by PHO syst\nem,,\n mMDL1:ATP-binding cassette (ABC) transporter family member,,Null m\nutant is viable\n mPHM8:involved in phosphate metabolism,,\n mYML133C:Unknown ,, Unknown\n mSRL1:Suppressor of rad53 lethality,,\n mRPS28A:Homology to mammalian S28,ribosomal protein S28A (S33A) (YS2\n7),\n mYDL046W:Unknown ,, Unknown\n mARC1:associated with tRNA and amino acyl-tRNA synthetases; has af\nfinity for quadruplex nucleic acids,,Null mutant is viable, \nleads to slow growth and reduced MetRS activity; arc1- mutan\nts are synthetic lethals and are complemented by the genes f\nor methionyl-tRNA and glutamyl-tRNA synthetase.\n mHTB2:Histone H2B (HTB1 and HTB2 code for nearly identical protein\ns),histone H2B (HTB1 and HTB2 code for nearly identical prot\neins),Null mutant is viable. Deletion of the HTA2-HTB2 (TRT2\n) locus has no reported observable phenotypes, presumably be\ncause HTA1-HTB1 (TRT1) expression is upregulated and can com\npensate in the absence of TRT2\n mYLL067C:Unknown ,, Unknown\n mILV6 mPUP3 mTPS2 mTSL1 mTPS3 mBMH1 mYFR017C mEMP24 mSAR1 mYJL068C mTAL1 mEMG1 mYPL004C mHSP60 mHSP10
this is an automaticly generated SAMBA report
Computational Genomics Lab, Tel-Aviv uniresity