Module number 1240




Database revision : gnsdb28.10
Date : Tue Feb 25 17:46:23 2003
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mHST2:Homolog of SIR2,,\n mBDH1:Unknown ,, Unknown\n Cond826:tlc1_Expt.1_Passage_7\n mCAK1:binds and phosphorylates Cdc28p,cyclin-dependent kinase-acti\nvating kinase,Null mutant is inviable; temperature-sensitive\n mutant confers a G2 delay accompanied by low Cdc28p protein\n kinase activity\n mVPS73:Unknown ,, Unknown\n mSDH2:Succinate dehydrogenase (ubiquinone) iron-sulfur protein sub\nunit,succinate dehydrogenase (ubiquinone) iron-sulfur protei\nn subunit,Null mutant is viable\n mYBR012C:Unknown ,, Unknown\n mYMR107W:Unknown ,, Unknown\n Pho85.pho85:Chemical inhibition of the Pho85 cyclin-dependent kinase rev\neals a role in the environmental stress response. Proc Natl\n Acad Sci U S A. 2001 Oct 23;98(22):12578-83.\n Cond829:tlc1_Expt.2_Passage_1\n mGYP7:GTPase-activating protein,GTPase activating protein (GAP),Nu\nll mutant is viable\n mYLR324W:Unknown ,, Unknown\n mVCX1:Similar to sodium/calcium exchangers, including bovine Na+/C\na2+,K+ antiporter; putative vacuolar transmembrane protein,v\nacuolar H+/Ca2+ exchanger,Null mutant is viable, sensitive t\no high Ca2+ conditions\n Cond981:F82G_pho4D_10_mM_1NaPP1\n mYBR230C:Unknown ,, Unknown\n mCBP4:Essential for the expression and activity of ubiquinol-cytoc\nhrome c reductase,,Inability to respire, pleiotropic reducti\non in steady state levels of four subunits of ubiquinol-cyto\nchrome c reductase\n mPDC5:pyruvate decarboxylase,pyruvate decarboxylase,undetectable p\nyruvate decarboxylase activity in pdc1pdc5 double mutants\n mASP3-2:nitrogen catabolite-regulated cell-wall L-asparaginase II,ni\ntrogen catabolite-regulated cell-wall L-asparaginase II,\n mUTR4:Product of gene unknown,,\n Cond834:tlc1_Expt.2_Passage_6\n mENO1:enolase I,enolase I,Null mutant is viable\n Cond976:F82G_1_mM_1NaPP1\n Cond822:tlc1_Expt.1_Passage_3\n mXBP1:DNA-binding transcriptional repressor,transcriptional repres\nsor,Null mutant is viable; overexpression of XBP1 leads to a\n slow-growth phenotype, lengthening of G1, an increase in ce\nll volume, and a repression of G1 cyclin expression\n mYLR202C:Unknown ,, Unknown\n mCWP1:cell wall protein, involved in O and N glycosylation, accept\nor of B1-6 glucan.,cell wall mannoprotein,Null mutant is via\nble, has increased sensitivities to calcoflour white and con\ngo red\n mPEP4:vacuolar proteinase A,vacuolar proteinase A,Null mutant is v\niable, proteinase deficient, phosphatase deficient; pep4 mut\nants exhibit a 60-70% reduction in total protein degradation\n during sporulation\n mSAR1:Secretion-Associated, Ras-related. Component of COPII coat o\nf vesicles; required for ER to Golgi protein transport,ARF f\namily , GTP-binding protein,Null mutant is inviable. When ov\nerexpressed, wild-type SAR1 suppresses a sec12 mutation.\n Cond830:tlc1_Expt.2_Passage_2\n mYKR049C:Unknown ,, Unknown\n mYCL033C:Unknown ,, Unknown\n mYGL072C:Unknown ,, Unknown\n mHSP60:60 kDa heat shock protein,chaperonin , groEL homolog , chape\nronin , groEL homolog,Null mutant is inviable\n mYEL070W:Unknown ,, Unknown\n mSMF3:Putative metal transporter, Nramp homolog, homolog of SMF1 a\nnd SMF2,Nramp homolog , SMF1 and SMF2 homolog , metal transp\norter (putative),Viable\n mRTN2:Unknown ,, Unknown\n mYJL118W:Unknown ,, Unknown\n mAPC9:subunit of the Anaphase Promoting Complex,anaphase promoting\n complex (APC) subunit,Null mutant is viable at 37 C but sho\nw delay in entry into anaphase at 37 C\n mSBH2:Ssh1p-Sss1p-Sbh2p complex component, involved in protein tra\nnslocation into the endoplasmic reticulum,Sbh1p homolog,Null\n mutant is viable. sbh1 sbh2 double deletion mutants exhibit\n synthetic temperature sensitivity and accumulation of secre\ntory protein precursors\n mYJL161W:Unknown ,, Unknown\n mCYC7:iso-2-cytochrome c,iso-2-cytochrome c,Null mutant is viable\n tcl1.tcl1:The genome-wide expression response to telomerase deletion i\nn Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2002 \nJul 9;99(14):9316-21.\n mYJL067W:Unknown ,, Unknown\n Cond825:tlc1_Expt.1_Passage_6\n mYFR017C:Unknown ,, Unknown\n mTTR1:Glutaredoxin (thioltransferase) (glutathione reductase),glut\naredoxin , thioltransferase/glutathione reductase,\n mCOS12:Protein with strong similarity to subtelomerically-encoded p\nroteins including Cos2p, Cos4p, Cos8p, YIR040c, Cos5p, Cos9p\n, and Cos6p,,\n mNDI1:NADH dehydrogenase (ubiquinone),NADH dehydrogenase (ubiquino\nne),\n mGLK1:Glucose phosphorylation,glucokinase,Null mutant is viable wi\nth no discernible difference from wild-type; hxk1, hxk2, glk\n1 triple null mutants are unable to grow on any sugar except\n galactose and fail to sporulate\n mYJL068C:Unknown ,, Unknown\n mTRX2:thioredoxin,thioredoxin,Null mutant is viable; trx1-trx2 dou\nble mutant shows prolonged S phase, shortened G(sub)1 and me\nthionine auxotrophy\n mTRX3:mitochondrial thioredoxin,thioredoxin,Null mutant is viable,\n normal sensitivity to hydrogen peroxide\n mILV6:acetolactate synthase regulatory subunit,,\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mAPD1:actin patches distal,,\n mYPL247C:Unknown ,, Unknown\n mCOR1:44 kDa core protein of yeast coenzyme QH2 cytochrome c reduc\ntase,coenzyme QH2 cytochrome c reductase 44 kDa core protein\n subunit,deficiency in cytochrome b; slow growth on glycerol\n mSDS24:Similar to S. pombe SDS23, suppresses DIS2, localized to the\n nucleus,,Null mutant is viable\n Cond833:tlc1_Expt.2_Passage_5\n mECM15:ExtraCellular Mutant,,A Tn3 insertion into this gene causes \nhypersensitivity to the cell surface polymer perturbing agen\nt calcofluor white.\n mLPP1:Lipid phosphate phosphatase,lipid phosphate phosphatase,\n mGRX1:Glutaredoxin,glutaredoxin,Null mutant is viable but sensitiv\ne to oxidative stress. grx1 grx2 null mutants are viable but\n lack heat-stable oxidoreductase activity.\n mMMS2:Member of error-free postreplication DNA repair pathway,,Nul\nl mutant is viable and is sensitive to MMS and UV\n mYNL144C:Unknown ,, Unknown\n mYDR154C:Unknown ,, Unknown\n mYER066C-A:Unknown ,, Unknown\n Cond975:WT_1_mM_1NaPP1\n Cond821:tlc1_Expt.1_Passage_2\n mAUT4:Autophagy gene essential for breakdown of autophagic vesicle\ns in the vacuole,,Null mutant is viable, but exhibits defect\ns in lysis of autophagic vesicles after delivery to the vacu\nole; vesicles accumulate in the vacuole in the absence of PM\nSF; maturation of the vacuolar protein, aminopeptidase I is \nunaffected in aut4\n mAUT7:Forms a protein complex with Aut2p to mediate attachment of \nautophagosomes to microtubules. Defective in maturation of t\nhe vacuolar protein, aminopeptidase I,similar to LC3, a micr\notubule-associated protein from rat,Null mutant is viable bu\nt lacks autophagocytosis and is unable to sporulate. AUT7 is\n a suppressor of mutant phenotypes of aut2-1 cells. Uptake o\nf precursor Aminopeptidase I into the vacuole depends on Aut\n2p and Aut7p.\n Cond828:tlc1_Expt.1_Passage_9\n Cond977:F82G_pho4D_1_mM_1NaPP1\n Cond973:WT_vs_F82G_1\n mYNL195C:Unknown ,, Unknown\n mYLR356W:Unknown ,, Unknown\n Cond837:tlc1_Expt.2_Passage_9__\n mRPE1:D-ribulose-5-Phosphate 3-epimerase,D-ribulose-5-Phosphate 3-\nepimerase,Null mutants are viable but show no ribulose-5-pho\nsphate epimerase activity, cannot grow on D-xylulose, and ar\ne sensitive to hydrogren peroxide\n mYPR098C:Unknown ,, Unknown\n mCRR1:CRH-Related,,\n Cond836:tlc1_Expt.2_Passage_8\n mKGD2:dihydrolipoyl transsuccinylase component of alpha-ketoglutar\nate dehydrogenase complex in mitochondria,alpha-ketoglutarat\ne dehydrogenase complex dihydrolipoyl transsuccinylase compo\nnent,Null mutant is viable but is respiratory deficient (pet\n-), and its mitochondria are unable to catalyze the reductio\nn of NAD+ by alpha-ketoglutarate\n Cond982:pho85D_10_mM_1NaPP1_\n mYCL042W:Unknown ,, Unknown\n mPGM2:Phosphoglucomutase,phosphoglucomutase,Null mutant is viable,\n pgm1 pgm2 deletion mutants fail to grow on galactose\n mCTT1:cytoplasmic catalase T,catalase T,Null mutant is viable and \nheat sensitive\n Cond824:tlc1_Expt.1_Passage_5\n mLAP4:vacuolar aminopeptidase ysc1,vacuolar aminopeptidase ysc1,Le\nucine aminopeptidase deficient\n mHSP12:induced by heat shock, entry into stationary phase, depletio\nn of glucose, and addition of lipids (fatty acids),heat shoc\nk protein 12,Null mutant is viable, but shows induction of h\neat shock response under conditions normally associated with\n low-level HSP12 expression\n mYBR052C:Unknown ,, Unknown\n mYBR241C:Unknown ,, Unknown\n mYPC1:Yeast Phyto-ceramidase,alkaline ceramidase with reverse acti\nvity,Null mutant is viable and two times more heat resistant\n than the wild-type parental strain.\n mYFL030W:Unknown ,, Unknown\n mYMR31:mitochondrial ribosomal protein (precursor),mitochondrial ri\nbosomal protein,\n mGTT1:Glutathione Transferase,glutathione transferase,Null mutant \nis viable, heat shock sensitive at stationary phase\n mYIR036C:Unknown ,, Unknown\n mYJL055W:Unknown ,, Unknown\n mYDR134C:Unknown ,, Unknown\n mYGL198W:Unknown ,, Unknown\n Cond832:tlc1_Expt.2_Passage_4\n mEMG1:Essential for Mitotic Growth,ribosome biogenesis,Lethal\n mDOG1:2-deoxyglucose-6-phosphate phosphatase,2-deoxyglucose-6-phos\nphate phosphatase,\n Cond820:tlc1_Expt.1_Passage_1\n mYER004W:Unknown ,, Unknown\n mGCY1:Galactose-induced transcript, product is homologous to mamma\nlian aldo/keto reductases, as well as to gamma-crystallin, a\n vertebrate eye lens protein,,Null mutant is viable\n mYDL110C:Unknown ,, Unknown\n mYDL124W:Unknown ,, Unknown\n Cond827:tlc1_Expt.1_Passage_8\n mARA1:D-arabinose dehydrogenase,D-arabinose dehydrogenase,Null mut\nant is viable but cannot produce D-arabinono-1,4-lactone, a \nprecursor of D-erythroascorbic acid\n mHSP26:heat shock protein 26,heat shock protein 26,Null mutant is v\niable; hsp26 hsp42 double deletion mutants are viable\n mPET9:the major mitochondrial ADP/ATP translocator; highly homolog\nous to AAC1 and AAC3,ADP/ATP translocator,null is viable but\n petite (unable to grow on non-fermentable carbon sources); \npet9,aac3 double null mutant is inviable under anaerobic con\nditions; pet9 mutations are lethal in combination with rho- \nmutations\n mYDR411C:Unknown ,, Unknown\n mUGP1:Uridinephosphoglucose pyrophosphorylase,uridinephosphoglucos\ne pyrophosphorylase,Null mutant is inviable, probably due to\n inability to properly form the cell wall\n mUGA1:gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate ami\nnotransferase),gamma-aminobutyrate (GABA) transaminase (4-am\ninobutyrate aminotransferase),\n mTIP1:cold- and heat-shock induced protein of the Srp1p/Tip1p fami\nly of serine-alanine-rich proteins,cell wall mannoprotein,Nu\nll mutant is viable; exhibits increased sensitivity to calco\nflour white and congo red\n mTDH1:Glyceraldehyde-3-phosphate dehydrogenase 1,glyceraldehyde-3-\nphosphate dehydrogenase 1,Null mutant is viable, tdh1 tdh2 a\nnd tdh1 tdh3 double mutants grow at wild type rates when eth\nanol is used as a carbon source\n mTDH2:glyceraldehyde 3-phosphate dehydrogenase,glyceraldehyde 3-ph\nosphate dehydrogenase,Null mutant is viable, grow poorly on \nglucose, grow as well as wild-type on ethanol media, tdh2 td\nh3 double deletion mutants are inviable\n mSPI1:Stationary Phase Induced; strongly expressed during stationa\nry phase, and trancription is dependent on MSN2/MSN4.,,\n Cond835:tlc1_Expt.2_Passage_7\n mYCR061W:Unknown ,, Unknown\n mALD4:Glucose repressed. Utilizes NADP+ or NAD+ as a coenzyme equa\nlly well. (sold by SIGMA under the catalogue number A5550, a\nccording to A. Blomberg).,aldehyde dehydrogenase,\n mSOL4:similar to SOL3,,\n mTPK2:Involved in nutrient control of cell growth and division,cAM\nP-dependent protein kinase catalytic subunit,Null mutant hap\nloids are defective for invasive growth; diploid homozygous \nnull mutants are defective for pseudohyphal growth.\n mYHR181W:Unknown ,, Unknown\n Cond823:tlc1_Expt.1_Passage_4\n mPDI1:protein disulfide isomerase,protein disulfide isomerase,Null\n mutant is inviable\n mYHR080C:Unknown ,, Unknown\n mRPL37A:Homology to rat L37,ribosomal protein L37A (L43) (YL35),\n mYPL004C:Unknown ,, Unknown\n mYJL217W:Unknown ,, Unknown\n Cond974:WT_vs_F82G_2\n mGSY1:Highly similar to GSY2. GSY2 is the predominantly expressed \nglycogen synthase,glycogen synthase (UDP-glucose-starch gluc\nosyltransferase),Null mutant is viable. Mutant lacking both \nGSY1 and GSY2 is viable but lacks glycogen synthase activity\n and glycogen deposition\n mYPL170W:Unknown ,, Unknown\n mSSA2:member of 70 kDa heat shock protein family,HSP70 family,Null\n mutant is viable, temperature sensitive; ssa1 ssa2 ssa4 str\nains are inviable; an intact copy of SSA3 regulated by the c\nonstitutive SSA2 promoter is capable of rescuing the inviabi\nlity of an ssa1 ssa2 ssa4 strain\n mKIP2:kinesin-related protein,kinesin related protein,Null mutant \nis viable\n mAPG10:Involved in autophagy; protein-conjugating enzyme involved i\nn the Apg12p-Apg5p conjugation pathway,protein-conjugating e\nnzyme,Defective autophagy, apg10-1 allele shows reduced viab\nlility under starvation conditions\n mSSA3:heat-inducible cytosolic member of the 70 kDa heat shock pro\ntein family,heat shock protein of HSP70 family,Null mutant i\ns viable; an intact copy of SSA3 regulated by the constituti\nve SSA2 promoter is capable of rescuing the inviability of a\nn ssa1 ssa2 ssa4 strain; an intact copy of SSA3 regulated by\n the constitutive SSA2 promoter is capable of rescuing the i\nnviability of an ssa1 ssa2 ssa4 strain\n mMET28:Transcriptional activator of sulfur amino acid metabolism,tr\nanscriptional activator in the Cbf1p-Met4p-Met28p complex,Nu\nll mutant is viable but is a methionine-auxotroph and resist\nant to toxic analogs of sulfate.\n mYLL023C:Unknown ,, Unknown\n mEMI2:Unknown ,, Unknown\n Cond831:tlc1_Expt.2_Passage_3\n mPNC1:pyrazinamidase and nicotinamidase,nicotinamidase , pyrazinam\nidase,Null mutant is viable\n mYIR016W:Unknown ,, Unknown\n mWTM1:WD repeat containing transcriptional modulator 1,transcripti\nonal modulator,Null mutant is viable\n mSTF2:ATPase stabilizing factor,ATPase stabilizing factor,\n mYMR317W:Unknown ,, Unknown\n mHXT9:High-affinity hexose transporter,hexose permease,Null mutant\n is viable, cycloheximide, sulfomethuron methyl, and 4-NQO (\n4-nitroquinoline-N-oxide) resistant\n mYRO2:Homolog to HSP30 heat shock protein Yro1p,,\n mSRL1:Suppressor of rad53 lethality,,\n Cond980:F82G_10_mM_1NaPP1\n mRPS28A:Homology to mammalian S28,ribosomal protein S28A (S33A) (YS2\n7),\n Cond979:WT_10_mM_1NaPP1\n mYDL046W:Unknown ,, Unknown\n mEMG1 mYPL004C
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Computational Genomics Lab, Tel-Aviv uniresity