Module number 1237




Database revision : gnsdb28.10
Date : Tue Feb 25 17:44:42 2003
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mYNL134C:Unknown ,, Unknown\n mPDR12:similar to Pdr5p,multidrug resistance transporter,Null mutan\nt is viable, sensistive to weak organic acids.\n mPLB1:Responsible for the production of the deacylation products o\nf phosphatidylcholine and phosphatidylethanolamine but not p\nhosphatidylinositol,phospholipase B (lypophospholipase),Null\n mutant is viable but releases greatly reduced levels of pho\nsphatidylcholine and phosphatidylethanolamine metabolites\n mYKR033C:Unknown ,, Unknown\n mPLB2:Phospholipase B 2,lysophospholipase , phospholipase B,overex\npression confers resistance to lysophosphatidylcholine\n mYKL153W:Unknown ,, Unknown\n mPLB3:Phospholipase B,phospholipase B (lysophospholipase),Null mut\nant is viable.\n mRPI1:inhibitor of ras,ras inhibitor,Null mutant is viable but sho\nws heat-shock sensitivity\n mASH1:Zinc-finger inhibitor of HO transcription which is asymmetri\ncally localized to the daughter cell nucleus,,Mutant ash1 da\nughters can transcribe HO and switch mating type\n mTIR1:cold-shock induced protein of the Srp1p/Tip1p family of seri\nne-alanine-rich proteins,,\n mTIR2:cold-shock induced protein of the Srp1p/Tip1p family of seri\nne-alanine-rich proteins,,Null mutant is viable.\n mFET3:FET3 encodes a ferro-O2-oxidoreductase that is part of the h\nigh-affinity iron transport system,multicopper oxidase,The n\null mutant is viable but defective for high affinity Fe(II) \nuptake. The null mutant is inviable when environmental iron \nis limiting.\n mEGT2:cell-cycle regulation protein, may be involved in the correc\nt timing of cell separation after cytokinesis,,\n mPDR3:Zinc-finger transcription factor related to Pdr1p,,pleiotrop\nic drug resistance\n mCLB1:Involved in mitotic induction,B-type cyclin,Null mutant is v\niable (lethal in combination with clb2 mutation)\n mASP3-1:nitrogen catabolite-regulated cell-wall L-asparaginase II,ni\ntrogen catabolite-regulated cell-wall L-asparaginase II,\n mYGR139W:Unknown ,, Unknown\n mASP3-2:nitrogen catabolite-regulated cell-wall L-asparaginase II,ni\ntrogen catabolite-regulated cell-wall L-asparaginase II,\n mGFD2:Unknown ,, Unknown\n mAAH1:adenine aminohydrolase (adenine deaminase),adenine aminohydr\nolase (adenine deaminase),Null mutant is viable\n mASP3-3:nitrogen catabolite-regulated cell-wall L-asparaginase II,ni\ntrogen catabolite-regulated cell-wall L-asparaginase II,\n mASP3-4:nitrogen catabolite-regulated cell-wall L-asparaginase II,ni\ntrogen catabolite-regulated cell-wall L-asparaginase II,\n mYOL106W:Unknown ,, Unknown\n mDAL80:Negative regulator of multiple nitrogen catabolic genes,GATA\n family transcriptional repressor,Null mutant is viable, def\nicient in allantoin degradation\n mYDR340W:Unknown ,, Unknown\n mYPL158C:Unknown ,, Unknown\n mENO2:enolase,enolase,Null mutant is inviable\n mFUS3:Required for the arrest of cells in G(sub)1 in response to p\nheromone and cell fusion during conjugation,CDC28/cdc2 relat\ned protein kinase,sterile; divide continuously in the presen\nce of pheromones; form prezygotes with wild-type cells of op\nposite mating type but cannot undergo cell fusion\n mPST1:Protoplasts-secreted,the gene product has been detected amon\ng the proteins secreted by regenerating protoplasts,Viable\n mYBR238C:Unknown ,, Unknown\n mMF(ALPHA)1:mating factor alpha,mating factor alpha,Null mutant is viabl\ne.\n mMF(ALPHA)2:alpha mating factor,alpha mating factor,Null mutant is viabl\ne.\n mGPM1:converts 3-phosphoglycerate to 2-phosphoglycerate in glycoly\nsis,phosphoglycerate mutase,Required for sporulation\n mYGR052W:Unknown ,, Unknown\n Cond966:swi1,_YPD_(a)\n mCWP1:cell wall protein, involved in O and N glycosylation, accept\nor of B1-6 glucan.,cell wall mannoprotein,Null mutant is via\nble, has increased sensitivities to calcoflour white and con\ngo red\n mDDR48:DNA damage inducible; implicated in the production or recove\nry of mutations,contains >35 repeats of the amino acid seque\nnce NNNDSYGS , flocculent specific protein,Null mutant is vi\nable, displays reduced spontaneous mutation rate\n mPHO3:Acid phosphatase, constitutive,acid phosphatase,phosphatase \ndeficient\n mYJR026W:Unknown ,, Unknown\n mPHO5:Acid phosphatase, repressible,acid phosphatase,phosphatase d\neficient\n mTAT1:Amino acid transport protein for valine, leucine, isoleucine\n, and tyrosine,amino acid transport protein for valine, leuc\nine, isoleucine, and tyrosine,\n mWSC4:cell wall integrity and stress response component 4,contains\n novel cysteine motif , integral membrane protein (putative)\n , similar to SLG1 (WSC1), WSC2 and WSC3,\n mFAR1:Factor arrest protein,Cdc28p kinase inhibitor,\n mICY1:Interacting with the cytoskeleton,,\n mEFB1:Translation elongation factor EF-1beta, GDP/GTP exchange fac\ntor for Tef1p/Tef2p,translation elongation factor EF-1beta, \nGDP/GTP exchange factor for Tef1p/Tef2p,Null mutant is invia\nble\n mYOR161C:Unknown ,, Unknown\n mSTP4:Involved in pre-tRNA splicing and in uptake of branched-chai\nn amino acids,,\n mHMLALPHA1:transcription factor involved in the regulation of alpha-spe\ncific genes,involved in the regulation of alpha-specific gen\nes , transcription factor , involved in the regulation of al\npha-specific genes , transcription factor,\n mYLR413W:Unknown ,, Unknown\n mYHR214W:Unknown ,, Unknown\n mGCV1:Required for metabolizing glycine as a nitrogen source,glyci\nne decarboxylase complex T subunit,Null mutant is viable but\n cannot use glycine as sole nitrogen source\n mYLR152C:Unknown ,, Unknown\n mLIF1:Ligase Interacting Factor 1; physically interacts with DNA l\nigase 4 protein (Lig4p),,Null mutant is viable but is defici\nent in non-homologous double-strand break repair; inefficien\nt in sporulation; LIG4 protein destabilization\n mYKL177W:Unknown ,, Unknown\n mYIL169C:Unknown ,, Unknown\n mYPL014W:Unknown ,, Unknown\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mTPO1:Polyamine transport protein,,\n mTPO2:Unknown ,, Unknown\n mATO3:Unknown ,, Unknown\n mYHB1:may play a role in the oxidative stress response,flavohemogl\nobin,Null mutant is viable. A rho+ strain carrying a yhb1(-)\n deletion has normal levels of both cyanide-sensitive and cy\nanide-insensitive respiration. Cells that carry a yhb1(-) de\nletion are sensitive to conditions that promote oxidative st\nress.\n mTPO4:Unknown ,, Unknown\n mYLR297W:Unknown ,, Unknown\n mZRT1:High-affinity zinc transport protein,,disruption viable\n Cond969:swi1,_minimal_(a)\n mSST2:Protein involved in desensitization to alpha-factor pheromon\ne,GTPase activating protein (GAP) , RGS (regulator of G-prot\nein signalling) family,Null mutants are viable and exhibit i\nncreased sensitivity to mating factors\n mCTS1:Endochitinase,endochitinase,Null mutant is viable; exhibits \na defect in cell separation\n mYMR088C:Unknown ,, Unknown\n mBAT2:Branched-Chain Amino Acid Transaminase,branched-chain amino \nacid transaminase,Null mutant is viable; ILV auxotrophy in b\nat1 bat2 double mutants\n mSVS1:involved in vanadate resistance,,Null mutant is viable, show\ns increased sensitivity to vanadate, but not other metallic \nions or drugs\n mDUR3:Urea active transport protein,,Null mutant is viable; urea d\negradation deficient\n Cond970:swi1,_minimal_(c)\n mYIL060W:Unknown ,, Unknown\n mNDJ1:Involved in meiotic chromosome segregation; may stabilize ho\nmologus DNA interactions at telomeres and is required for a \ntelomere activity in distributive segregation; is associated\n with telomeres,,Null allele exhibits errors in meiotic chro\nmosome segregation about 10-fold higher than the wild-type e\nrror rate. Spore viability of homozygous diploids with the n\null allele is approximately 50% of wild-type. Mutant also sh\nows delayed meiotic chromosome synapsis, disrupted crossover\n interference and increased frequency of nonexchange chromos\nomes leading to meiosis I nondisjunction and disruption of d\nistributive disjunction\n mAGA1:anchorage subunit of a-agglutinin,a-agglutinin anchorage sub\nunit,mating defect in liquid medium\n mYJR028W:Unknown ,, Unknown\n mYPL095C:Unknown ,, Unknown\n mYOR315W:Unknown ,, Unknown\n mTEC1:transcription factor of the TEA/ATTS DNA-binding domain fami\nly, regulator of Ty1 expression,TEA/ATTS DNA-binding domain \nfamily, regulator of Ty1 expression , transcription factor,N\null mutant is viable\n mTOS7:Hypothetical ORF,,\n mHMS2:High-copy mep2 suppressor,heat shock transcription factor ho\nmolog,Null mutant is viable; multicopy expression suppresses\n the pseudohyphal defect of mep2/mep2 strains\n mYDR089W:Unknown ,, Unknown\n mDIP5:dicarboxylic amino acid permease,dicarboxylic amino acid per\nmease,Null mutant is viable, exhibits loss of L-aspartate an\nd L-glutamate uptake\n mHSP12:induced by heat shock, entry into stationary phase, depletio\nn of glucose, and addition of lipids (fatty acids),heat shoc\nk protein 12,Null mutant is viable, but shows induction of h\neat shock response under conditions normally associated with\n low-level HSP12 expression\n Cond971:swi1,_minimal_(d)_\n mECM3:ExtraCellular Mutant,,A Tn3 insertion into this gene causes \nhypersensitivity to the cell surface polymer perturbing agen\nt calcofluor white.\n mYNR046W:Unknown ,, Unknown\n mYDR366C:Unknown ,, Unknown\n mERG5:cytochrome P450 involved in C-22 denaturation of the ergoste\nrol side-chain,cytochrome P450 , involved in C-22 denaturati\non of the ergosterol side-chain,Null mutant is viable\n mGPX2:Glutathione peroxidase paralogue,,Null mutant is viable\n mYJR029W:Unknown ,, Unknown\n Cond967:swi1,_YPD_(c)\n mCUP1-1:copper-binding metallothionein,copper binding metallothionei\nn,Copper resistance\n mNCE102:involved in secretion of proteins that lack classical secret\nory signal sequences,,An uncharacterized allele exhibits def\nects in the export of the mammalian protein galectin-1.\n mYFR055W:Unknown ,, Unknown\n mYHR214W-A:Unknown ,, Unknown\n mYLR053C:Unknown ,, Unknown\n mZEO1:Overexpression yields resistance to Zeocin,,Null mutant is v\niable and exhibits slow growth in galactose\n mSAG1:alpha-agglutinin,alpha-agglutinin,Null mutant is viable and \nshows loss of cellular agglutination in alpha cells\n mPHD1:protein similar to StuA of Aspergillus nidulans,transcriptio\nn factor (putative),Null mutant is viable, diploid homozygou\ns null mutants undergo pseudohyphal growth when starved for \nnitrogen. Overexpression of PHD1 in diploids and in bud4 hap\nloids causes precocious and unusually vigorous pseudohyphal \ngrowth\n mYHR145C:Unknown ,, Unknown\n mBRR2:RNA helicase-related protein required for pre-mRNA splicing;\n Snurp 246 kDa protein (Snurp = Small nuclear ribonucleoprot\nein particle),ATP dependent RNA helicase (putative),Null mut\nant is inviable; stabilized splicing intermediates which con\ntain a mutant hammerhead cis-targeted ribozyme, decreased st\neady-state levels of endogneous mRNAs, increased ratio of pr\ne-mRNA to mRNA of specific message(s); synthetic lethal with\n U2 mutants\n mCST13:Chromosome STability,,Null mutant is viable, but grows slowl\ny and shows increased sensitivity to copper ions\n mTDH1:Glyceraldehyde-3-phosphate dehydrogenase 1,glyceraldehyde-3-\nphosphate dehydrogenase 1,Null mutant is viable, tdh1 tdh2 a\nnd tdh1 tdh3 double mutants grow at wild type rates when eth\nanol is used as a carbon source\n SwiSnf.swisnf:Whole-genome expression analysis of snf/swi mutants of Sacch\naromyces cerevisiae. Proc Natl Acad Sci U S A. 2000 Mar 28;\n97(7):3364-9.\n mTIP1:cold- and heat-shock induced protein of the Srp1p/Tip1p fami\nly of serine-alanine-rich proteins,cell wall mannoprotein,Nu\nll mutant is viable; exhibits increased sensitivity to calco\nflour white and congo red\n mTDH2:glyceraldehyde 3-phosphate dehydrogenase,glyceraldehyde 3-ph\nosphate dehydrogenase,Null mutant is viable, grow poorly on \nglucose, grow as well as wild-type on ethanol media, tdh2 td\nh3 double deletion mutants are inviable\n mSPI1:Stationary Phase Induced; strongly expressed during stationa\nry phase, and trancription is dependent on MSN2/MSN4.,,\n mTDH3:Glyceraldehyde-3-phosphate dehydrogenase 3,glyceraldehyde-3-\nphosphate dehydrogenase 3,\n mYOL155C:Unknown ,, Unknown\n mPRM1:pheromone-regulated membrane protein,,Null mutant is viable \nbut exhibits a mating defect.\n mYIL121W:Unknown ,, Unknown\n mMATALPHA1:transcription factor involved in the regulation of alpha-spe\ncific genes,involved in the regulation of alpha-specific gen\nes , transcription factor , involved in the regulation of al\npha-specific genes , transcription factor,\n mSTE3:The a factor receptor encoded by the STE3 gene allows yeast \ncells of the Alpha mating type to recognize cells of the a m\nating type,a-factor receptor,The null mutant is viable. Alph\na cells lacking STE3 are sterile, but a cells lacking STE3 c\nan mate.\n mYDR222W:Unknown ,, Unknown\n mYIL082W-A:Unknown ,, Unknown\n mHSP30:Protein induced by heat shock, ethanol treatment, and entry \ninto stationary phase; located in plasma membrane,,\n mYGP1:may be involved in cellular adaptations prior to stationary \nphase,gp37, a glycoprotein synthesized in response to nutrie\nnt limitation which is homologous to the sporulation-specifi\nc SPS100 gene,\n mMRH1:Membrane protein related to Hsp30p; Localized by immunofluor\nescence to membranes, mainly the plasma membr. punctuate imm\nunofluorescence pattern observed in buds. The nuclear envelo\npe, but not vacuole or mitochondrial membranes also stained,\n,Null mutant is viable\n mPHO84:inorganic phosphate transporter, transmembrane protein,inorg\nanic phosphate transporter,Null mutant is viable\n mSED1:putative cell surface glycoprotein,cell surface glycoprotein\n (putative),Null mutant is viable; during stationary phase, \nnull mutants exhibit increased sensitivity to Zymolyase.\n mCPS1:carboxypeptidase yscS,carboxypeptidase yscS,Null mutant is v\niable; leucine auxotroph\n mRGS2:Regulator of G-protein Signalling for gpa2; belongs to the R\nGS protein family and acts on Gpa2,GTPase activating protein\n (GAP),Null mutant is viable but exhibits high PKA phenotype\ns (low trehalose and glycogen levels, heat sensitivity, low \nexpression of HSP12). Overexpression results in low PKA phen\notypes and suppresses the glucose induced cAMP signal.\n mMEP2:Ammonia transport protein,ammonia transport protein,Null mut\nant is viable.\n mGSY2:Highly similar to GSY1. GSY2 is the predominantly expressed \nglycogen synthase. Activity is probably regulated by cAMP-de\npendent and SNF1 protein kinases and type 1 phosphatase,glyc\nogen synthase (UDP-glucose-starch glucosyltransferase),Null \nmutant is viable. Mutant lacking both GSY1 and GSY2 is viabl\ne but lacks glycogen synthase activity and glycogen depositi\non\n mEXG1:Exo-1,3-beta-glucanase,exo-1,3-beta-glucanase,Null mutant is\n viable, displays modest increase in killer toxin sensitivit\ny and beta 1,6-glucan levels\n mYLR040C:Unknown ,, Unknown\n mPHO11:Acid phosphatase, secreted,acid phosphatase,phosphatase defi\ncient\n mDAL5:allantoate permease,allantoate permease,Null mutant is viabl\ne, unable to transport allontoate or ureidosuccinate\n mPHO12:acid phosphotase, nearly identical to Pho11p,acid phosphatas\ne,\n mSUR1:Involved in maintenance of phospholipid levels,integral memb\nrane protein , similar to YBR161w, Hoc1p, and Och1p , integr\nal membrane protein , similar to YBR161w, Hoc1p, and Och1p ,\n integral membrane protein , similar to YBR161w, Hoc1p, and \nOch1p,Null mutant is viable, calcium sensitive at 37 degrees\n C on YPD but calcium tolerant at 26 degrees C, accumulates \ngreatly reduced levels of several mannosylated sphingolipids\n; sur1 mutations have been isolated based on their ability t\no suppress certain phenotype of rvs161 mutants including red\nuced viability upon starvation and sensitivies to unrelated \ndrugs; SUR1 is a high copy suppressor of the calcium sensiti\nvity of csg2 mutants\n mDAL7:allantoin pathway,malate synthase 2,Null mutant is viable\n mHXT1:High-affinity hexose (glucose) transporter,high affinity hex\nose (glucose) transporter,Null mutant is viable\n mDSE1:Hypothetical ORF,,\n mHXT3:Low-affinity glucose transporter,low affinity glucose transp\norter,Null mutant is viable but grows slowly on galactose; s\nome mutant alleles confer sodium hypersensitivity.\n mDSE2:Hypothetical ORF,,\n mCAR2:ornithine aminotransferase,ornithine aminotransferase,Catabo\nlism of arginine defective\n Cond968:swi1,_YPD_(d)\n mYMR251W:Unknown ,, Unknown\n mYAR068W:Unknown ,, Unknown\n mHXT7:Hexose transporter,hexose transporter,Null mutant is viable;\n snf3 hxt1 hxt2 hxt3 hxt4 HXT7 hxt7 mutant cannot grow on me\ndia containing glucose as sole carbon source\n mPHM8:involved in phosphate metabolism,,\n mYRO2:Homolog to HSP30 heat shock protein Yro1p,,\n mFAA3:acyl-CoA synthetase (long-chain fatty acid CoA ligase) (fatt\ny acid activator 3), activates endogenous but not imported f\natty acids and provides substrates for N-myristoylation,acyl\n-CoA synthase,Not essential for vegetative growth when fatty\n acid synthase (fas) is active\n mSCW11:Soluble Cell Wall protein,soluble cell wall protein,Null mut\nant is viable but exhibits defects in separation after divis\nion and displays flocculant growth.\n mPFK27:6-phosphofructo-2-kinase,6-phosphofructo-2-kinase,Null mutan\nt is viable\n
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Computational Genomics Lab, Tel-Aviv uniresity