Module number 1234




Database revision : gnsdb28.10
Date : Tue Feb 25 17:43:49 2003
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mGAC1:Regulatory subunit for phosphoprotein phosphatase type 1 (PP\n-1), also known as Glc7p, which regulates glycogen synthase-\n2,Glc7p regulatory subunit,Reduced glycogen accumulation\n mTOS3:Hypothetical ORF,,\n mHAP5:Regulates respiratory functions; subunit of a heterotrimeric\n complex required for CCAAT binding,CCAAT-binding transcript\nion factor component (along with Hap2p and Hap3p),Null mutan\nt is viable\n mPGI1:Phosphoglucoisomerase,glucose-6-phosphate isomerase,phosphog\nlucose isomerase deficient; exhibits defects in gluconeogene\nsis and sporulation\n mYKL153W:Unknown ,, Unknown\n mTKL1:Transketolase 1,transketolase 1,Null mutant is viable; growt\nh on fermentable carbon sources, but not gluconeogenic carbo\nn sources, is reduced; tkl1 tkl2 mutants are auxotrophic for\n aromatic amino acids\n mTYE7:may be involved in glycolytic gene expression,33 kDa , serin\ne-rich protein, is a potential member of the bHLH/leucine-zi\npper protein family,Null mutant is viable; expression of eno\nlase genes is reduced three-fivefold in null mutant; gcr1 ty\ne7 double deletion mutants exhibit additive defects in enola\nse expression. TYE7 was isolated as a dominant suppressor of\n gcr1 mutations\n mDIA1:may be involved in invasive growth, pseudohyphal growth,,Nul\nl mutant is viable and causes invasive growth in haploids an\nd pseudohyphal growth in diploids\n mASH1:Zinc-finger inhibitor of HO transcription which is asymmetri\ncally localized to the daughter cell nucleus,,Mutant ash1 da\nughters can transcribe HO and switch mating type\n mGYP7:GTPase-activating protein,GTPase activating protein (GAP),Nu\nll mutant is viable\n mYJL171C:Unknown ,, Unknown\n mFET3:FET3 encodes a ferro-O2-oxidoreductase that is part of the h\nigh-affinity iron transport system,multicopper oxidase,The n\null mutant is viable but defective for high affinity Fe(II) \nuptake. The null mutant is inviable when environmental iron \nis limiting.\n mYHL021C:Unknown ,, Unknown\n mATX2:Multi-copy suppressor of SOD-linked defects,manganese-traffi\ncking protein,Null mutant is viable but has reduced levels o\nf intracellular manganese.\n mTPI1:triosephosphate isomerase,triosephosphate isomerase,Null mut\nant is viable.\n mRAS2:Ras proto-oncogene homolog. Ras2 is involved in growth on no\nn-fermentable carbon sources, the starvation response, sporu\nlation, pseudohyphal growth and aging.,small GTP-binding pro\ntein,Loss of function mutants grow poorly on nonfermentable \ncarbon sources, sporulate in rich media, are unable to diffe\nrentiate into a pseudohyphal form and exhibit an increased l\nife span.\n mYCR013C:Unknown ,, Unknown\n mBUD7:bud site selection,,Diploid-specific heterogenous bud site s\nelection\n mAAH1:adenine aminohydrolase (adenine deaminase),adenine aminohydr\nolase (adenine deaminase),Null mutant is viable\n mRAD7:Nucleotide excision repair protein involved in G(sub)2 repai\nr of inactive genes,nucleotide excision NEF4 component,radia\ntion sensitive\n mRPS4A:Homology to rat S4 and human S4,ribosomal protein S4A (YS6) \n(rp5) (S7A),Null mutant is viable; rps4a rps4b double deleti\non is inviable\n mYMD8:similar to vanadate resistance protein Gog5,,\n mENO2:enolase,enolase,Null mutant is inviable\n mMCA1:Unknown ,, Unknown\n mYBR005W:Unknown ,, Unknown\n mPWP1:Protein with periodic trytophan residues that resembles memb\ners of beta-transducin superfamily because of presence of WD\n-40 repeats,,Null mutants are viable but show severely retar\nded growth\n mGPM1:converts 3-phosphoglycerate to 2-phosphoglycerate in glycoly\nsis,phosphoglycerate mutase,Required for sporulation\n mYJL107C:Unknown ,, Unknown\n mYLR194C:Unknown ,, Unknown\n mOLE1:delta-9-fatty acid desaturase,delta-9-fatty acid desaturase,\nThe null mutant is inviable but can be rescued by addition o\nf unsaturarted fatty acids to the growth medium. Some allele\ns are temperature-sensitive for growth and show defective in\ntracellular mitochondrial movement atthe non- permissive tem\nperature.\n mCMK2:Calmodulin-dependent protein kinase,calmodulin-dependent pro\ntein kinase,Null mutant is viable, exhibits slow rate of spo\nre germination\n mYFR055W:Unknown ,, Unknown\n mYLR089C:Unknown ,, Unknown\n mYPK2:protein kinase,protein kinase,Null mutant is viable\n mCLN3:role in cell cycle START; involved in G(sub)1 size control,G\n1 cyclin,Null mutant is viable; dominant mutation causes alp\nha-factor resistance and small cell size; chromosomal deleti\non increases cell volume\n mINO2:Transcription factor required for derepression of inositol-c\nholine-regulated genes involved in phospholipid synthesis,he\nlix-loop-helix protein,The null mutant is viable but auxotro\nphic for inositol and choline. The null mutant can also disp\nlay aberant cell shape and defects in nuclear segregation. H\nomozygous mutant ino2 delta-1 diploids fail to sporulate. Ot\nher mutant alleles show pleiotropic defects in phospholipid \nmetabolism.\n mCRH1:congo red hypersensitive,cell wall protein,Null mutant is vi\nable and hypersensitive to Congo Red and Calcofluor White\n mRPL21B:Homology to rat L21,ribosomal protein L21B,\n mSRY1:Serine Racemase homolog in Yeast,pyridoxal-5'phosphate-depen\ndent enzyme , similar to mouse glial serine racemase,Null mu\ntant is viable\n mYOR385W:Unknown ,, Unknown\n Cond961:t7_g/r_ratio\n mSLT2:Suppressor of lyt2,,Null mutant is viable but temperature se\nnsitive. At elevated temperatures or in the presence of caff\neine, mull mutants exhibit cell wall defects that result in \ncell lysis. Lysis is prevented by addition of 1M sorbitol.\n mRPL38:Homology to rat L38,ribosomal protein L38,\n mHSP26:heat shock protein 26,heat shock protein 26,Null mutant is v\niable; hsp26 hsp42 double deletion mutants are viable\n mYOR389W:Unknown ,, Unknown\n mPCK1:phosphoenolpyruvate carboxylkinase,phosphoenolpyruvate carbo\nxylkinase,Null mutant is viable.\n mRPL18B:Homology to rat ribosomal protein L18,ribosomal protein L18B\n (rp28B),\n mRPS9A:Homology to rat S9 and E.coli S4,ribosomal protein S9A (S13)\n (rp21) (YS11),\n mMLF3:Protein of unknown function,,Null mutant is viable and hyper\nsensitive to leflunomide\n mTDH1:Glyceraldehyde-3-phosphate dehydrogenase 1,glyceraldehyde-3-\nphosphate dehydrogenase 1,Null mutant is viable, tdh1 tdh2 a\nnd tdh1 tdh3 double mutants grow at wild type rates when eth\nanol is used as a carbon source\n mTDH2:glyceraldehyde 3-phosphate dehydrogenase,glyceraldehyde 3-ph\nosphate dehydrogenase,Null mutant is viable, grow poorly on \nglucose, grow as well as wild-type on ethanol media, tdh2 td\nh3 double deletion mutants are inviable\n mRPL7B:Homolog of mammalian ribosomal protein L7 and E. coli L30,ri\nbosomal protein L7B (L6B) (rp11) (YL8),Null mutant is viable\n; disruption of both RPL7A and RPL7B is lethal\n mPRM10:pheromone-regulated membrane protein,,\n mTDH3:Glyceraldehyde-3-phosphate dehydrogenase 3,glyceraldehyde-3-\nphosphate dehydrogenase 3,\n Sporulation.Series0:The transcriptional program of sporulation in budding yeast.\n Science. 1998 Oct 23;282(5389):699-705.\n Cond963:t11.5_g/r_ratio\n mYGP1:may be involved in cellular adaptations prior to stationary \nphase,gp37, a glycoprotein synthesized in response to nutrie\nnt limitation which is homologous to the sporulation-specifi\nc SPS100 gene,\n mADE2:phosphoribosylamino-imidazole-carboxylase,phosphoribosylamin\no-imidazole-carboxylase,Null mutant is viable and requires a\ndenine. ade2 mutants are blocked at a stage in the adenine b\niosynthetic pathway that causes an intermediate to accumulat\ne in the vacuole; the intermediate gives the cell a red colo\nr.\n mYJL213W:Unknown ,, Unknown\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mYLR414C:Unknown ,, Unknown\n mYKL174C:Unknown ,, Unknown\n mZPR1:Involved in nucleolar function; similar to murine ZPR1 prote\nin,zinc finger protein,Null mutant is inviable\n mABZ1:para-aminobenzoate synthase, PABA synthase,para-aminobenzoat\ne synthase (PABA synthase),Null mutant is viable and PABA au\nxotroph\n mFBP1:fructose-1,6-bisphosphatase,fructose-1,6-bisphosphatase,unab\nle to grow with ethanol\n mFBA1:aldolase,aldolase,Null mutant is viable, lacks aldolase enzy\nmatic activity and fails to grow in media containing as a ca\nrbon source metabolites of only one side of the aldolase rea\nction\n mENB1:Siderophore transporter for enterobactin; AFT1 regulon,enter\nobactin transporter,Null mutants are viable but are unable t\no take up and utilize iron from enterobactin\n Cond959:t2_g/r_ratio\n mITR1:member of sugar transporter superfamily,myo-inositol transpo\nrter,Null mutant is viable\n mPRY1:Pathogen Related in Sc, contains homology to the plant PR-1 \nclass of pathogen related proteins. The protein sequence is \nover 60% identical with the Pry2p & Pry3p over 145 resid. PR\nY1 is >35% identical (50% similar) to tobacco PR-1c protein.\n,,\n mPRY2:Pathogen Related in Sc, contains homology to the plant PR-1 \nclass of pathogen related proteins. The protein sequence is \nover 60% identical with the Pry2p & Pry3p over 145 resid. PR\nY1 is >35% identical (50% similar) to tobacco PR-1c protein.\n,,\n mYLL044W:Unknown ,, Unknown\n mEXG1:Exo-1,3-beta-glucanase,exo-1,3-beta-glucanase,Null mutant is\n viable, displays modest increase in killer toxin sensitivit\ny and beta 1,6-glucan levels\n Cond965:ndt80_delete_mid_g/r_ratio_\n mYLR392C:Unknown ,, Unknown\n mKTR2:May be involved in extracellular matrix assembly; involved i\nn N-linked glycosylation of cell wall mannoproteins,mannosyl\ntransferase (putative) , type 2 membrane protein,Null mutant\n is viable, with partial resistance to killer toxin\n mSUR1:Involved in maintenance of phospholipid levels,integral memb\nrane protein , similar to YBR161w, Hoc1p, and Och1p , integr\nal membrane protein , similar to YBR161w, Hoc1p, and Och1p ,\n integral membrane protein , similar to YBR161w, Hoc1p, and \nOch1p,Null mutant is viable, calcium sensitive at 37 degrees\n C on YPD but calcium tolerant at 26 degrees C, accumulates \ngreatly reduced levels of several mannosylated sphingolipids\n; sur1 mutations have been isolated based on their ability t\no suppress certain phenotype of rvs161 mutants including red\nuced viability upon starvation and sensitivies to unrelated \ndrugs; SUR1 is a high copy suppressor of the calcium sensiti\nvity of csg2 mutants\n mSSE1:HSP70 family member, highly homologous to Ssa1p and Sse2p,HS\nP70 family , SSA1 SSE2 homolog , HSP70 family , SSA1 SSE2 ho\nmolog,Null mutant is viable, slow growing, shows no additive\n effects with sse2 null mutation; temperature sensitive in s\nome strain backgrounds\n mYMR295C:Unknown ,, Unknown\n mGPD2:Involved in glycerol production via conversion of glyerol-3-\nphosphate and NAD+ to glycerol phosphate and NADH,glycerol-3\n-phosphate dehydrogenase (NAD+),Null mutant is viable\n mRPL5:Homology to rat ribosomal protein L5; required for assembly \nof stable 60S ribosomal subunits,ribosomal protein L5 (L1a)(\nYL3),Null mutant is inviable.\n mADE13:Adenylosuccinate Lyase,adenylosuccinate lyase,Unable to grow\n on complete media with glucose or fructose as a carbon sour\nce, but can grow with glycerol or ethanol\n Cond960:t5_g/r_ratio\n mYGR146C:Unknown ,, Unknown\n mROD1:Resistance to o-dinitrobenzene, calcium, and zinc,,Null muta\nnt is viable but is hypersensitive to o-dinitrobenzene, calc\nium, and zinc\n mPTP2:protein tyrosine phosphatase,tyrosine phosphatase,Null mutan\nt is viable, grows slowly, is hypersensitive to heat; ptp2 p\ntc1 mutants exhibit synthetic lethality\n Cond962:t9_g/r_ratio\n mHAL5:Protein kinase homolog, mutant is salt and pH sensitive,,\n mSCW10:Soluble Cell Wall protein,soluble cell wall protein,Null mut\nant is viable.\n mPIR1:Protein containing tandem internal repeats,contains tandem i\nnternal repeats,Null mutant is viable; pir1 hsp150 (pir2) do\nuble mutant and pir1 hsp150 (pir2) pir3 triple mutant are sl\now-growing on agar slab and sensitive to heat shock\n mBTN2:Gene/protein whose expression is elevated in a btn1 minus/Bt\nn1p lacking yeast strain.,,Null mutant is viable; expression\n of BTN2 is elevated in yeast lacking BTN1\n Cond958:t0.5_g/r_ratio\n mATP2:F(1)F(0)-ATPase complex beta subunit, mitochondrial,F(1)F(0)\n-ATPase complex beta subunit,Mutant displays a growth defect\n on glycerol\n
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Computational Genomics Lab, Tel-Aviv uniresity