Module number 1219




Database revision : gnsdb28.10
Date : Tue Feb 25 17:39:29 2003
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Cond547:cln3-1\n mRAD27:DNA repair protein that belongs to the RAD2(pombe)/FEN1 subf\namily,42 kDa 5' to 3' exonuclease required for Okazaki fragm\nent processing,Null mutant is viable, demonstrates temperatu\nre-sensitive growth and sensitivity to UV light and to methy\nlmethane sulfonate\n Cond498:wtħ500nMaF,30minlog10(intensity)\n Cond494:wtħ5nMaF,30minlog10(intensity)\n mHLR1:LRE1 homolog,,Null mutant is viable.\n Cond548:cln3-2\n Cond578:cdc15_130\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts. Nat Genet\n. 2000 Dec;26(4):415-23.\n Cond29:clb2\n Cond500:wtħ50nMaF,15minlog10(intensity)\n Cond751: Cell Cycle.alpha:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion. Mol Biol Cell. 1998 Dec;9(12):3273-97.\n GCR1.gcr1:Understanding the growth phenotype of the yeast gcr1 mutant \nin terms of global genomic expression patterns. J Bacteriol\n. 2000 Sep;182(17):4970-8.\n Cond735: Cond504:wtħ50nMaF,90minlog10(intensity)\n Cond579:cdc15_140\n Stress.YPD:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond414:YPD_6_h_ypd-2\n Cell Cycle.ko:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion. Mol Biol Cell. 1998 Dec;9(12):3273-97.\n Cond425:YPD_stationary_phase_12_h_ypd-1\n Cond519:rst1Drst2Dħ50nMaF,30minlog10(intensity)\n Cond586:cdc15_210\n mPOL12:Required for DNA synthesis and correct progression through S\n phase; plays an essential role at early stage of chromosoma\nl DNA replication, before the hydroxyurea-sensitive step,DNA\n polymerase alpha-primase complex B subunit,Null mutant is i\nnviable\n Stress.YPDStat:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n GCN4.gcn4:Transcriptional profiling shows that Gcn4p is a master regul\nator of gene expression during amino acid starvation in yeas\nt. Mol Cell Biol. 2001 Jul;21(13):4347-68.\n Cond53:erg2\n Cond733: Y-Stre.Acid:Remodeling of yeast genome expression in response to environ\nmental changes. Mol Biol Cell. 2001 Feb;12(2):323-37.\n mCDC9:essential for mitosis and meiosis, dispensable for intrageni\nc recombination, but required for haploidization and spores,\nDNA ligase,cell division cycle blocked at 36 degrees, increa\nsed sensitivity to ultraviolet radiation and bleomycin; temp\nerature sensitive\n Cond509:kss1Dħ50nMaF,30minlog10(intensity)\n Cond562:alpha77\n Cond496:wtħ50nMaF,30minlog10(intensity)\n Cond668:mec1_plus_gamma_90_min\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Mating.Mating:Signaling and circuitry of multiple MAPK pathways revealed b\ny a matrix of global gene expression profiles. Science. 200\n0 Feb 4;287(5454):873-80\n Cond480:WT+/-100mM3AT(SetA)(R491)\n mJEM1:DnaJ-like protein of the endoplasmic reticulum membrane,,Nul\nl mutant is viable but has karyogamy defect; jem1 scj1 doubl\ne mutant is temperature sensitive\n Cond568:alpha119\n mPDS5:Precocious Dissociation of Sister chromatids,,\n Cond920:3h\n mCSI2:chitin synthase involved,chitin synthase 3 complex structura\nl component (putative),Null mutant is viable but shows deloc\nalized chitin deposition\n Cond495:wtħ15.8nMaF,30minlog10(intensity)\n Cond279:ERG11(tetpromoter)\n COMP.CH:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond553:alpha14\n Cond910:(83i4)_S150-2B_YPGL+G_NormInt\n Cond508:bni1Dħ50nMaF,120minlog10(intensity)\n Cond749: Cond768:Acid_60'\n mMSH2:Functions with Pms1p and Pms2/Mlh1p in a complex that intera\ncts with Pms3p/Msh6p to repair single-base and insertion-del\netion mispairs, or Msh3p to repair insertion-deletion mispai\nrs.,mutS homolog,Null mutant is viable. Haploid mutants disp\nlay an 85-fold increased rate of spontaneous mutation to can\navanine resistance. Mutants are defective for gene conversio\nn polarity gradients and high spore viability.\n Cond550:clb2-1\n mMSH6:Required for mismatch repair in mitosis & meiosis, low level\ns of postmeiotic segregation & high spore viability; forms c\nomplex with Msh2p to repair both single-base & insertion-del\netion mispairs; redundant with Msh3p in repair of in-dels,hu\nman GTBP protein homolog,Null mutant is viable, msh3 msh6 do\nuble deletion mutants exhibit microsatellite instability and\n mutability similar to that in a msh2 mutant\n Cond482:WT+/-100mM3AT(SetC)(KNY164)\n Cond506:bni1Dħ50nMaF,60minlog10(intensity)\n Cond580:cdc15_150\n Cond434:DBY7286_37degree_heat_-_20_min\n UME6.ume6:The Ume6 regulon coordinates metabolic and meiotic gene expr\nession in yeast. Proc Natl Acad Sci U S A. 2002 Oct 15;99(2\n1):13431-6.\n mPRI2:p58 polypeptide of DNA primase,DNA primase p58 polypeptide,l\nethal\n Cond767:Acid_40'\n Cond502:wtħ50nMaF,45minlog10(intensity)\n Stress.Heat2:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond581:cdc15_160\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond563:alpha84\n Cond558:alpha49\n Sporulation.Series0:The transcriptional program of sporulation in budding yeast.\n Science. 1998 Oct 23;282(5389):699-705.\n Cond68:gas1\n Cond734: Cond945:W303_YPD\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond775:Alkali_80'\n Cond746: Cond582:cdc15_170\n Cond501:wt+/-50nMaF,30minlog10(intensity)\n Cond250:ymr031w-a\n Cond314:Heat_Shock_060_minutes__hs-2\n Cond98:mbp1\n Y-Stre.Alkali:Remodeling of yeast genome expression in response to environ\nmental changes. Mol Biol Cell. 2001 Feb;12(2):323-37.\n Cond554:alpha21\n Cond738:90\n mPOL30:Accessory factor for DNA polymerase delta, mRNA increases in\n G1, peaks in S in mitosis, & increases prior to DNA synthes\nis in meiosis; required for DNA replication & repair, requir\ned for viability in cdc44, rad50, rad52 or rad57 backgrounds\n,,Null mutant is inviable\n Cond571:cdc15_50\n Cond575:cdc15_100\n Cond776:Alkali_100'\n mDPB2:DNA polymerase epsilon, subunit B,DNA polymerase epsilon sub\nunit B,Null mutant is inviable; conditional mutant shows def\nects in DNA replication\n Cond743: Cond294:Itraconazole\n Cond574:cdc15_90\n Cond965:ndt80_delete_mid_g/r_ratio_\n Stress.Various:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond737: Cond747: mSPT21:involved in trascriptional regulation of Ty1 LTRs,non-specif\nic DNA binding protein,Null mutant is viable, spt21 mutation\ns suppress Ty insertion mutations\n Cond497:wtħ158nMaF,30minlog10(intensity)\n mHSL1:Negative regulator of swe1 kinase (which regulates cdc28),pr\notein kinase (putative) , similar to S. pombe cdr1/nim1,Nul\nl mutant is viable; synthetically lethal with histone H3 mut\nations; G2 delay\n Cond560:alpha63\n Cond576:cdc15_110\n Cond555:alpha28\n Cond570:cdc15_30\n Cond736: Cond503:wtħ50nMaF,60minlog10(intensity)\n Cell Cycle.cdc15:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion. Mol Biol Cell. 1998 Dec;9(12):3273-97.\n COMP.TE:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond559:alpha56\n Cond750: Cond567:alpha112\n fkh1,2sf.Series0:Two yeast forkhead genes regulate the cell cycle and pseudoh\nyphal growth. Nature. 2000 Jul 6;406(6791):90-4.\n Cond551:alpha0\n Cond549:clb2-2\n mPOL30 mCDC9 mRAD27 mMSH6 mMSH2
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Computational Genomics Lab, Tel-Aviv uniresity