Module number 1218




Database revision : gnsdb28.10
Date : Tue Feb 25 17:39:22 2003
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Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n mYPL009C:Unknown ,, Unknown\n mYJR072C:Unknown ,, Unknown\n mQRI1:UDP-N-acetylglucosamine pyrophosphorylase,UDP-N-acetylglucos\namine pyrophosphorylase,\n mYIL112W:Unknown ,, Unknown\n mGOS1:SNARE protein with a C-terminal membrane anchor,,\n mTRS120:targeting complex (TRAPP) component involved in ER to Golgi \nmembrane traffic,,Null mutant is inviable\n mHNT2:Fhit homolog, member of the histidine triad superfamily of n\nucleotide binding-proteins,,\n mNUP116:Involved in nucleocytoplasmic transport; may be required for\n biogenesis of tRNA,nuclear pore complex subunit,Null mutant\n grows slowly, accumulates unspliced pre-tRNAs, acumulates p\noly(A)+ RNA in the nucleus, and is temperature-sensitive; at\n nonpermissive temperature, null mutants show membrane seals\n covering cytoplasmic face of nuclear pore complexes; synthe\ntically lethal with nsp1, nup100, and nup145\n mSTE18:gamma subunit of G protein coupled to mating factor receptor\ns,G protein gamma subunit , coupled to mating factor recepto\nr,The null mutant is viable but sterile. Sst1 sst2 double mu\ntants and scg1 mutants can be suppressed by a null allele of\n ste18.\n mMKS1:Pleiotropic regulatory factor involved in Ras-CAMP and lysin\ne biosynthetic pathways and nitrogen regulation,negative tra\nnsctiptional regulator,Null mutant is viable, fails to grow \non galactose media containing ethidium bromide at 25 degrees\n and on YPglycerol media at 37 degrees\n Cond883:5\n mPEX14:Peroxisomal peripheral membrane protein (peroxin) involved i\nn import of peroxisomal matrix proteins,,Null mutant is viab\nle but is unable to grow on oleate and lacks peroxisomes\n mSPC42:involved in SPB duplication, may facilitate attachment of th\ne SPB to the nuclear membrane,spindle pole body component,Nu\nll mutant is inviable; temperature sensitive mutations show \nSBP duplication\n Cond898:RPN4\n mTFA2:Small subunit of TFIIE transcription factor,transcription fa\nctor TFIIE subunit,Null mutant is inviable\n Cond872:Zero1\n mEND3:Required for endocytosis and organization of the cytoskeleto\nn,,Null mutant is viable and defective in endocytosis\n Cond889:4NQO_2\n mRNA14:Protein with a role in mRNA stability and/or poly(A) tail le\nngth,cleavage and polyadenylation factor CF I component invo\nlved in pre-mRNA 3'-end processing,Null mutant is inviable\n mSRB5:subunit of RNA polymerase II holoenzyme/mediator complex,RNA\n polymerase II holoenzyme/mediator subunit,Null mutant is vi\nable\n mYMR289W:Unknown ,, Unknown\n mNUP85:Protein in nuclear pore complex; may function in nuclear env\nelope integrity; may also be involved in tRNA biogenesis,,Nu\nll mutant is viable but is temperature-sensitive; at nonperm\nissive temperature, null mutant accumulates poly(A)+ RNA and\n has fragmented nucleolus; at permissive temperature, nuclea\nr envelope of null mutant detaches from nucleus\n mYHR003C:Unknown ,, Unknown\n mAPN1:major apurinic/apyrimidinic endonuclease/3'-repair diesteras\ne,major apurinic/apyrimidinic endonuclease/3'-repair diester\nase,hypersensitive to both oxidative and alkylating agents t\nhat damage DNA; higher rate of spontaneous mutation\n mYLR387C:Unknown ,, Unknown\n Cond897:STATMMS\n Cond888:MNNG_2\n Cond894:G2\n mCDC11:involved in proper bud growth,10 nm filament component of mo\nther-bud neck,abnormal cell-wall deposition and bud growth, \ninability to complete cytokinesis, failure to form the ring \nof 10nm filaments in the neck region of budding cells\n Cond893:SMMS\n mMAD1:coiled-coil protein involved in spindle-assembly checkpoint,\n,Null mutant is viable, benomyl sensitive\n mVPS53:Required for Vacuolar Protein Sorting,hydrophilic protein th\nat is peripherally associated with the late Golgi and forms \na stable complex with Vps52p and Vps54p,Null mutant is viabl\ne but is defective for growth at 37^*C. vps53 null mutants h\nave fragmented vacuoles, missort and secrete CPY, and misloc\nalize late Golgi membrane proteins to the vacuole.\n mMDR1:Mac1-dependent regulator,GTPase activating protein (GAP) fo\nr Ypt6,Null mutant is viable\n UME6.ume6:The Ume6 regulon coordinates metabolic and meiotic gene expr\nession in yeast. Proc Natl Acad Sci U S A. 2002 Oct 15;99(2\n1):13431-6.\n mSIN4:involved in positive and negative regualtion of transcriptio\nn, possibly via changes in chromatin structure,RNA polymeras\ne II holoenzyme/mediator subunit,Null mutant is viable, temp\nerature sensitive, displays defects in both positive and neg\native regulation of transcription, suppresses Ty insertion m\nutations (Spt-), exhibits decreased superhelical density of \ncircular DNA molecules, exhibits expression from promoters l\nacking UAS elements; associated with a defect in RME1-depend\nent repression and a methionine or cysteine requirement, exh\nibits flocculant/lacy colony morphology, suppressor of snf/s\nwi mutations\n mPRI2:p58 polypeptide of DNA primase,DNA primase p58 polypeptide,l\nethal\n mOSH6:Oxysterol Binding Protein,,\n Cond895:G2MMS\n mYPL199C:Unknown ,, Unknown\n mCHS5:Involved in chitin synthase III activity, also required for \nhomozygosis in the first stages of mating,,Null mutant is vi\nable, cells exhibit a strong mating defect; sensitive to Cal\ncofluor, reduced amount of chitin in the cell wall\n Cond877:MMS\n Cond886:g-ray\n Cond945:W303_YPD\n mASN2:Asn1p and Asn2p are isozymes,asparagine synthetase,Null muta\nnt is viable; L-asparagine auxotrophy occurs upon mutation o\nf both ASN1 and ASN2\n mYNL136W:Unknown ,, Unknown\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mCAF4:CCR4 associated factor,CCR4 transcriptional complex componen\nt,Null mutant is viable\n mDOA1:Required for normal intracellular ubiquitin metabolism and f\nor normal rates of proteolysis of ubiquitin-dependent proteo\nlytic substrates in vivo,,Null mutant is viable and defectiv\ne in degradation of ubiquitinated proteins; homozygous null \ndiploid shows sporulation defect\n mPRP40:Splicing component that associates with the yeast U1 small n\nuclear ribonucleoprotein particle,U1 snRNP protein,Null muta\nnt is inviable; temperature-sensitive mutants show a splicin\ng defect\n mFOL3:FOLinic acid requiring,dihydrofolate synthetase,Null mutant \nis viable; requires folinic acid for growth\n mRFC1:RFC is a DNA binding protein and ATPase that acts as a proce\nssivity factor for DNA polymerases delta and epsilon and loa\nds proliferating cell nuclear antigen (PCNA) on DNA,replicat\nion factor C subunit 1 , similar to human RFC 140 kDa subuni\nt,Null mutant is inviable, rfc1 conditional mutants arrest b\nefore mitosis\n mPHO85:involved in phosphate and glycogen metabolism and cell cycle\n progression,cyclin-dependent protein kinase,\n mVPS60:vacuolar protein sorting (putative),,Null mutant is viable b\nut a class E vps mutant (missorts vacuolar hydrolases and ac\ncumulates late endosomal compartment).\n mTAF6:TATA-binding protein-associated-factor,TATA-binding protein-\nassociated-factor,Null mutant is inviable\n mVPS63:Unknown ,, Unknown\n mSKI6:superkiller; ExtraCellular Mutant; Ribosomal RNA Processing,\nRNAse PH homolog,Null mutant is inviable; mutants show super\nkiller phenotype, improved translation of non-poly(A) mRNA, \nabnormal 60S ribosomal subunits and defective 3' processing \nof 5.8S rRNA; a Tn3 insertion into this gene causes hypersen\nsitivity to the cell surface polymer perturbing agent calcof\nluor white\n mNUP60:nuclear pore protein,nuclear pore complex subunit,\n mYJL123C:Unknown ,, Unknown\n mTAF8:TBP Associated Factor 65 KDa,TFIID subunit,Null mutant is in\nviable\n Cond885:20\n mCWC22:Unknown ,, Unknown\n mSEH1:Nuclear pore protein, homologous to sec13,,\n mYKL047W:Unknown ,, Unknown\n mGCN20:Positive effector of the EIF-2-alpha kinase activity of GCN2\n; component of a heteromeric complex that includes GCN1 and \nGCN20,ATP-binding cassette (ABC) family,Null mutant is viabl\ne and shows impaired derepression of GCN4 translation and re\nduced levels of eIF-2 alpha phosphorylation\n Cond891:G1MMS\n mNUP100:Participates in nucleocytoplasmic transport; member of GLFG-\ncontaining family of nucleoporins,nuclear pore complex subun\nit,Null mutant is viable with no obvious phenotypes; synthet\nically lethal with nup116 and gle2 mutants\n mISY1:Interacts with Syf1p, Prp39p and Ypl213wp. May play a role i\nn mRNA splicing.,,Null mutant is viable and shows a partial \nsplicing defect. isy1 prp19 double mutants are inviable. is\ny1 ntc20 double mutants are very sick and accumulate pre-mRN\nA.\n mDID4:Hypothetical ORF,class E vacuolar-protein sorting and endocy\ntosis factor,secretion of vacuolar proteins; canavanine-hype\nrsensitive; temperature-sensitive; suppresses defects associ\nated with loss of Doa4\n mYDR267C:Unknown ,, Unknown\n mIOC3:Iswi One Complex,,\n mTRS31:targeting complex (TRAPP) component involved in ER to Golgi \nmembrane traffic,,Null mutant is inviable\n mYLR440C:Unknown ,, Unknown\n mMON1:Product of gene unknown,,null mutant is sensitive to monensi\nn and brefeldin A\n Cond884:10\n mSEH1 mNUP85 mPRP40 mSIN4
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Computational Genomics Lab, Tel-Aviv uniresity