Module number 1206




Database revision : gnsdb28.10
Date : Tue Feb 25 17:38:03 2003
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Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n Cond399:Nitrogen_Depletion_8_h\n Cond432:YPD_stationary_phase_22_d_ypd-1\n mRPP1A:Homology to rat P1, human P1, and E.coli L12eIIA,acidic ribo\nsomal protein P1A (YP1alpha) (A1),\n mYPR044C:Unknown ,, Unknown\n mYOR145C:Unknown ,, Unknown\n Pho85.pho85:Chemical inhibition of the Pho85 cyclin-dependent kinase rev\neals a role in the environmental stress response. Proc Natl\n Acad Sci U S A. 2001 Oct 23;98(22):12578-83.\n Cond410:diauxic_shift_timecourse_18.5_h\n Cond302:Heat_Shock_15_minutes_hs-1\n mRPS21A:Homology to rat S21,ribosomal protein S21A (S26A) (YS25),\n Cond418:YPD_1_d_ypd-2\n mRPS21B:Homology to rat S21,ribosomal protein S21B (S26B) (YS25),\n Cond675:MHY1_(dun1)_+_heat_20_min\n Cond981:F82G_pho4D_10_mM_1NaPP1\n Cond362:dtt_000_min__dtt-2\n Cond400:Nitrogen_Depletion_12_h\n mAAH1:adenine aminohydrolase (adenine deaminase),adenine aminohydr\nolase (adenine deaminase),Null mutant is viable\n Stress.diamide:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond315:37C_to_25C_shock_-_15_min\n mYRA1:Yeast RNA Annealing Protein,RNA-binding RNA annealing protei\nn,Null mutant is inviable; overexpression causes growth arre\nst\n Cond467:steady_state_21_dec_C_ct-2\n Cond416:YPD_10_h__ypd-2\n mRPS29A:Homology to rat S29,ribosomal protein S29A (S36A) (YS29),\n Cond425:YPD_stationary_phase_12_h_ypd-1\n Cond674:DES459_(mec1)_+_heat_20_min\n Cond810:Na45'\n Stress.Carbon:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mRPB5:25-kDa RNA polymerase subunit (common to polymerases I, II a\nnd III),25 kDa RNA polymerase subunit (common to polymerases\n I, II and III),Null mutant is inviable\n Cond637:DES460_+_0.02%_MMS_-_60_min\n Cond373:1.5_mM_diamide_(40_min)\n Cond445:Msn4_overexpression\n Cond890:G1\n mRPS15:Homology to rat S15 and E. coli S19,ribosomal protein S15 (S\n21) (rp52) (RIG protein),\n mIPI3:Unknown ,, Unknown\n Cond391:aa_starv_1_h\n Cond435:DBYmsn2-4-_37degree_heat_-_20_min\n Cond814:Na+FK45'\n Cond310:Heat_Shock_000_minutes_hs-2\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond873:10min\n Stress.aa_starv:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond480:WT+/-100mM3AT(SetA)(R491)\n Cond429:YPD_stationary_phase_5_d_ypd-1\n Cond318:37C_to_25C_shock_-_60_min\n mNIP1:Protein required for nuclear import with some similarity to \nNsr1p, another protein involved in nuclear transport,,Null m\nutant is inviable; nip1-1 is a temperature-sensitive mutant \ndefective in nuclear transport\n mRPS1A:Homologous to rat S3A,ribosomal protein S1A (rp10A),\n Cond894:G2\n Cond673:DES460_(wild_type)_+_heat_20_min\n Cond395:Nitrogen_Depletion_30_min.\n TorRama.Series0:Partitioning the transcriptional program induced by rapamyci\nn among the effectors of the Tor proteins. Curr Biol. 2000 D\nec 14-28;10(24):1574-81\n Cond312:Heat_Shock_015_minutes_hs-2\n mSSZ1:DnaK homolog, interacts with Zuo1p (DnaJ homolog) to form a \nribosome-associated complex (RAC) that is bound to the ribos\nome via the Zuo1p subunit,HSP70 family,Null mutant is viable\n, cold sensitive; SSZ1 overexpression causes increased expre\nssion of some PDR genes\n Cond479:WT+/-100mM3AT(SetD)(R491)\n mYPR118W:Unknown ,, Unknown\n Cond306:Heat_Shock_60_minutes_hs-1\n Cond430:YPD_stationary_phase_7_d_ypd-1\n Cond361:2.5mM_DTT_180_min_dtt-1\n Cond367:dtt_240_min_dtt-2\n tcl1.tcl1:The genome-wide expression response to telomerase deletion i\nn Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2002 \nJul 9;99(14):9316-21.\n Cond879:MMC\n Cond313:Heat_Shock_030inutes__hs-2\n Stress.Heat1:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond481:WT+/-100mM3AT(SetB)(491)\n Stress.Heat2:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond818:crz1/Na30'\n Cond378:1M_sorbitol_-_15_min\n Cond427:YPD_stationary_phase_2_d_ypd-1\n mSEC53:involved in synthesis of GDP-mannose and dolichol-phosphate-\nmannose; required for protein assembly in endoplasmic reticu\nlum,phosphomannomutase,null is inviable; ts mutant is defect\nive in glycosylation, accumulating inactive and incompletely\n glycosylated forms of secretory proteins within the ER lume\nn\n mRMT2:Protein Arginine Methyltransferase; R = arginine; MT = methy\nltransferase,arginine methyltransferase,Null mutant is viabl\ne\n Cond945:W303_YPD\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond443:DBYyap1_+_0.32_mM_H2O2_(20_min)\n mRPL26B:Homology to rat L26,ribosomal protein L26B (L33B) (YL33),\n Cond833:tlc1_Expt.2_Passage_5\n Cond374:1.5_mM_diamide_(50_min)\n Cond433:YPD_stationary_phase_28_d_ypd-1\n Cond959:t2_g/r_ratio\n mARF1:implicated in signal transduction and intracellular protein \ntransport to or within the Golgi apparatus,ADP-ribosylation \nfactor,Null mutant is viable and shows slow growth, cold sen\nsitivity and sensitivity to normally sublethal concentration\ns of fluoride ion in the medium.\n Cond809:Na30'\n Stress.ColdShock:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond965:ndt80_delete_mid_g/r_ratio_\n Cond366:dtt_120_min_dtt-2\n Cond881:4NQO\n Cond813:Na+FK30'\n Cond303:Heat_Shock_20_minutes_hs-1\n mKRI1:KRRI-Interacting protein 1,Krr1p binding protein,\n Cond627:DY1457_(wild_type)_3_mM_vs._76_nM_zinc_y12-122\n mYPL146C:Unknown ,, Unknown\n mYDR365C:Unknown ,, Unknown\n mTIF1:translation initiation factor eIF4A,translation initiation f\nactor eIF4A subunit,viable, tif1tif2 double mutant is lethal\n Cond441:DBYmsn2/4_(real_strain)_+_0.32_mM_H2O2_(20_min)\n mTIF2:translation initiation factor eIF4A,translation initiation f\nactor eIF4A subunit,viable, tif1tif2 double mutant is lethal\n mTIF3:Suppressor of translation mutants,translation initiation fac\ntor eIF-4B,\n mELP3:elongator protein; histone and other protein acetyltransfera\nse; has sequence homology to known HATs and NATs,RNA polymer\nase II Elongator subunit , histone acetyltransferase , RNA p\nolymerase II Elongator subunit , histone acetyltransferase,N\null mutant is viable but grows slowly and shows slow adaptat\nion to growth on new media; ts- (39^*C); sensitive to 1 M Na\nCl; zymototxin resistant; slow growth; thermo-sensitive abov\ne 38 0C; caffeine, Calcofluor White and 6-azauracil sensitiv\ne; G1 cell cycle delay\n mTIF5:Translation initiation factor eIF-5,translation initiation f\nactor eIF-5,\n mTIF6:similar to human translation initiation factor 6 (eIF6); how\never, TIF6 does not act as a true translation initiation fac\ntor.The protein may be involved in the biogenesis and or sta\nbility of the 60S ribosomal subunits,,Null mutant is inviabl\ne; cells are depleted of 60S ribosomal subunits, translation\n initiation is inhibited, and cells arrest in G1\n mRLI1:Strong protein homology (68% identical) to human RNase L Inh\nibitor (RLI),ATP-binding cassette (ABC) superfamily nontrans\nporter group (putative),Null mutant is inviable; overexpress\nion of RLI1 from a galactose-inducible promoter has a modera\nte inhibitory effect on growth.\n Cond652:wt_plus_gamma_20_min\n Stress.dshift:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mPUB1:poly(A)+ RNA-binding protein,poly(A) binding protein,Null mu\ntant is viable\n Cond899:RPN4_MMS__\n mYOL124C:Unknown ,, Unknown\n Cond390:aa_starv_0.5_h\n mNOP2:May participate in nucleolar function during the transition \nfrom stationary phase to rapid growth,90 kDa protein homolog\nous to a human proliferation-associated nucleolar protein, p\n120,Null mutant is inviable; overexpression leads to changes\n in nucleolar morphology\n Cond320:heat_shock_17_to_37,_20_minutes\n mNOP4:RNA recognition motif-containing protein,RNA binding protein\n (putative),Null mutant is inviable; conditional mutant show\ns diminished accumulation of 60S ribosomal subunits due to a\n lack of production of mature 25S rRNA from 27S precursor rR\nNA\n Cond316:37C_to_25C_shock_-_30_min\n Cond305:Heat_Shock_40_minutes_hs-1\n Cond396:Nitrogen_Depletion_1_h\n Cond658:DES460_(wt)_-_mock_irradiation_-_5_min\n mNOP7:Required for normal pre-rRNA processing,,Null: lethal.\n mSAM4:S-adenosylmethionine:homocysteine S-methyltransferase,,Slow \ngrowth on S-adenosylmethionine used as a sulfur source\n Cond982:pho85D_10_mM_1NaPP1_\n Cond301:Heat_Shock_10_minutes_hs-1\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts. Nat Genet\n. 2000 Dec;26(4):415-23.\n Cond887:t-BuOOH\n mTIF34:p39 subunit of translation initiation factor eIF3,translatio\nn initiation factor eIF3 p39 subunit,Null mutant is inviable\n mRAS1:ras proto-oncogene homolog,ras homolog,\n Cond363:dtt_015_min_dtt-2\n Cond941:SK1_YPD\n Cond337:constant_0.32_mM_H2O2_(30_min)_redo\n mYKL056C:Unknown ,, Unknown\n mRPS25B:Homology to rat S25; belongs to the S25E family of ribosomal\n proteins,ribosomal protein S25B (S31B) (rp45) (YS23),\n mYNR046W:Unknown ,, Unknown\n mRPS4A:Homology to rat S4 and human S4,ribosomal protein S4A (YS6) \n(rp5) (S7A),Null mutant is viable; rps4a rps4b double deleti\non is inviable\n mRPS18B:Homology to rat S18 and E. coli S13,ribosomal protein S18B,\n mRPL42B:Homology to rat L36a and human L36a,ribosomal protein L42B (\nYL27) (L41B) (YP44),Deficient in maintenance of killer\n Stress.YPD:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mRPA49:49-kDa alpha subunit of RNA polymerase A,RNA polymerase A 49\n kDa alpha subunit,Null mutant is viable but grows slowly an\nd is temperature or cold sensitive; synthetically lethal wit\nh RPA14\n Cond414:YPD_6_h_ypd-2\n mPRS1:ribose-phosphate pyrophosphokinase,ribose-phosphate pyrophos\nphokinase,\n mRPL35A:Homology to rat L35,ribosomal protein L35A,Null mutant is vi\nable.\n Cond892:S\n Cond745: Cond967:swi1,_YPD_(c)\n Stress.YPDStat:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond463:29_deg_growth_ct-1\n mRPL2B:Homology to rat L8 and E. coli L2,ribosomal protein L2B (L5B\n) (rp8) (YL6),\n mYNR054C:Unknown ,, Unknown\n Cond323:heat_shock_29_to_37,_20_minutes\n GCN4.gcn4:Transcriptional profiling shows that Gcn4p is a master regul\nator of gene expression during amino acid starvation in yeas\nt. Mol Cell Biol. 2001 Jul;21(13):4347-68.\n mYNL247W:Unknown ,, Unknown\n mKRE33:Killer toxin REsistant ,,Heterozygous diploid mutant exhibit\n haploinsufficiency K1 killer toxin resistance\n Stress.DTT1:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond651:wt_plus_gamma_10_min\n Cond872:Zero1\n Stress.DTT2:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond426:YPD_stationary_phase_1_d_ypd-1\n mYOR004W:Unknown ,, Unknown\n Cond437:DBYyap1-_37degree_heat_-_20_min_(redo)\n mNOP58:57 kDa nucleolar protein involved in the pre-rRNA processing\n steps that lead to formation of 18 S rRNA; interacts with N\nop1p,57 kDa nucleolar protein,Null mutant is inviable; in vi\nvo depletion impairs synthesis of the 40S ribosomal subunit\n Cond635:DES460_+_0.02%_MMS_-_30_min\n Cond934:8h\n mRPL14A:Homology to mammalian L14,ribosomal protein L14A,\n Cond322:heat_shock_25_to_37,_20_minutes\n Cond420:YPD_3_d_ypd-2\n Cond857:pm38-gtoe\n mRNT1:Ribonuclease III,ribonuclease III,Null mutant is viable, but\n very sick (Abou Elela and Ares 1998, Chanfreau et al 1998).\n mRPL38:Homology to rat L38,ribosomal protein L38,\n Cond893:SMMS\n mRPL43A:Homology to human L37a,ribosomal protein L43A,\n Cond379:1M_sorbitol_-_30_min\n mSUI2:Translation initiation factor eIF-2 alpha subunit,,suppressi\non of initiator codon mutations\n mRPL36A:Homology to rat L36,ribosomal protein L36A (L39) (YL39),\n Cond758:Heat_0'_(A)\n mYPR143W:Unknown ,, Unknown\n Stress.NitroDepl:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond317:37C_to_25C_shock_-_45_min\n mYOR091W:Unknown ,, Unknown\n Cond434:DBY7286_37degree_heat_-_20_min\n mHGH1:HMG1/2 homolog,,\n UME6.ume6:The Ume6 regulon coordinates metabolic and meiotic gene expr\nession in yeast. Proc Natl Acad Sci U S A. 2002 Oct 15;99(2\n1):13431-6.\n Stress.H202:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Y-Stre.Heat:Remodeling of yeast genome expression in response to environ\nmental changes. Mol Biol Cell. 2001 Feb;12(2):323-37.\n Cond419:YPD_2_d_ypd-2\n Cond321:heat_shock_21_to_37,_20_minutes\n Cond431:YPD_stationary_phase_13_d_ypd-1\n Cond783:Peroxide_60'\n Cond878:MNNG\n Cond895:G2MMS\n SwiSnf.swisnf:Whole-genome expression analysis of snf/swi mutants of Sacch\naromyces cerevisiae. Proc Natl Acad Sci U S A. 2000 Mar 28;\n97(7):3364-9.\n Cond882:zero3\n Sporulation.Series0:The transcriptional program of sporulation in budding yeast.\n Science. 1998 Oct 23;282(5389):699-705.\n Cond640:DES459_(mec1-)_+_0.02%_MMS_-_5_min\n Cond875:60min\n mUTP4:Unknown ,, Unknown\n mKEL3:Kelch-repeat protein, similar to Kel1 and Kel2,kelch-repeat \nprotein , similar to Kel1 and Kel2,\n Cond417:YPD_12_h_ypd-2\n mDBP2:ATP-dependent RNA helicase of DEAD box family,ATP dependent \nRNA helicase , dead box protein,Null mutant is inviable\n Cond946:W303ume6_YPD\n Cond886:g-ray\n mYJL122W:Unknown ,, Unknown\n Stress.Sorbitol:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond415:YPD_8_h_ypd-2\n Cond319:37C_to_25C_shock_-_90_min\n Cond811:Na60'\n mRPC82:82-kDa subunit of RNA polymerase III (C),82 kDa subunit of R\nNA polymerase III (C),Null mutant is inviable\n Cond372:1.5_mM_diamide_(30_min)\n Cond876:zero2\n Stress.tempgrow:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Calcin.crz1Na:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n Stress.HeatVar:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond401:Nitrogen_Depletion_1_d\n Cond885:20\n Cond411:diauxic_shift_timecourse_20.5_h\n Stress.Various:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mERB1:conserved eukaryotic protein involved in ribosome biogenesis\n,,Null mutant is inviable.\n mIMP4:Interacts With Mpp10. Imp4p is a specific component of the U\n3 snoRNP and is required for pre-18S rRNA processing.,,Null \nmutant is inviable\n mEGD1:beta subunit of the nascent-polypeptide-associated complex (\nNAC); homologous to human BTF3b; GAL4 enhancer protein,pol I\nI transcribed genes regulator,Null mutant is viable; reduced\n induction of galactose-regulated genes upon shift from gluc\nose to galactose\n Calcin.Na:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n Cond815:Na+FK60'\n Cond453:YP_ethanol_vs_reference_pool_car-2\n mBMS1:BMH1 sensitive,,Null mutant is inviable; a temperature-sensi\ntive allele exhibits a synthetic growth defect with bmh1-del\nta; the temperature-sensitive allele also exhibits diploid s\npecific bud site randomization at the semi-permissive temper\nature\n zap1.Series0:Genome-wide characterization of the Zap1p zinc-responsive re\ngulon in yeast. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14)\n:7957-62.\n Cond339:constant_0.32_mM_H2O2_(50_min)_redo\n Calcin.NaFK:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n Cond421:YPD_5_d_ypd-2\n Y-Stre.Peroxide:Remodeling of yeast genome expression in response to environ\nmental changes. Mol Biol Cell. 2001 Feb;12(2):323-37.\n Cond980:F82G_10_mM_1NaPP1\n Cond858:pm71-30\n mUTP21:Unknown ,, Unknown\n mCDC33:Required for START A of cell cycle and sporulation,mRNA cap \nbinding protein eIF-4E,Null mutant is inviable. cdc33 mutant\ns arrest at G(sub)1. cdc33 has normal cAMP pools and is not \nsuppressed by cAPK mutants, suggesting sporulation is indepe\nndent of the cAMP pathway\n Cond428:YPD_stationary_phase_3_d_ypd-1\n Cond304:Heat_Shock_30_minutes_hs-1\n mSCW10:Soluble Cell Wall protein,soluble cell wall protein,Null mut\nant is viable.\n fkh1,2sf.Series0:Two yeast forkhead genes regulate the cell cycle and pseudoh\nyphal growth. Nature. 2000 Jul 6;406(6791):90-4.\n Stress.tempsteady:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond436:DBYmsn2/4_(real_strain)_+_37degrees_(20_min)\n Cond958:t0.5_g/r_ratio\n mYDR365C mYRA1 mYNR054C mCDC33 mTIF2 mSUI2 mSEC53 mERB1 mNOP7 mNOP2 mTIF6 mYPR143W mNIP1 mTIF5
this is an automaticly generated SAMBA report
Computational Genomics Lab, Tel-Aviv uniresity