Module number 1168




Database revision : gnsdb28.10
Date : Tue Feb 25 17:45:22 2003
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mRPT3:probable 26S protease subunit and member of the CDC48/PAS1/S\nEC18 family of ATPases,,Null mutant is inviable; yta2 is an \nextragenic suppressor of yme1 mutations\n mRPT4:Proteasome Cap Subunit,26S proteasome cap subunit component \n, ATPase , 26S proteasome cap subunit component , ATPase , 2\n6S proteasome cap subunit component , ATPase,Null mutant is \ninviable; ts mutant strain arrests as large-budded cells aft\ner 1, 2, 3 divisions with a G2 content of DNA and a monopola\nr spindle; unduplicated spindle pole body is enlarged as in \nother monopolar mutants; they also fail to arrest at G1 when\n starved for a single amino acid (but do arrest at G1 when d\neprived of all nitrogen), are resistant to cyclohexamide, an\nd are hypersensitive to amino acid analogs, hygromycin B and\n 3-aminotriazole\n mRPT6:member of the 26 S proteasome,ATPase,Null mutant is inviable\n Cond368:dtt_480_min_dtt-2\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes.  Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n mYMR067C:Unknown ,, Unknown\n mYAP1:jun-like transcription factor,jun-like transcription factor,\npleiotropic drug resistance\n Cond896:STAT\n Cond982:pho85D_10_mM_1NaPP1_\n Cond649:dun1-_+_0.02%_MMS_-_120_min\n mUBC13:ubiquitin-conjugating enzyme,ubiquitin-conjugating enzyme,\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts.  Nat Genet\n. 2000 Dec;26(4):415-23.\n Calcin.CaFK:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n.  J Biol Chem. 2002 Aug 23;277(34):31079-88\n Pho85.pho85:Chemical inhibition of the Pho85 cyclin-dependent kinase rev\neals a role in the environmental stress response.  Proc Natl\n Acad Sci U S A. 2001 Oct 23;98(22):12578-83.\n mMCH4:Unknown ,, Unknown\n Cond654:wt_plus_gamma_45_min\n Cond440:DBYmsn2msn4_(good_strain)_+_0.32_mM_H2O2\n Cond337:constant_0.32_mM_H2O2_(30_min)_redo\n Cond648:dun1-_+_0.02%_MMS_-_90_min\n Stress.diamide:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond647:dun1-_+_0.02%_MMs_-_30_min\n mFIT2:Facilitator of iron transport,Cell wall protein involved in \niron transport,impaired siderophore-iron uptake, activation \nof the major iron -dependent transcription factor, AFT1\n Cond883:5\n Cond898:RPN4\n Cond637:DES460_+_0.02%_MMS_-_60_min\n Cond375:1.5_mM_diamide_(60_min)\n Cond373:1.5_mM_diamide_(40_min)\n Cond371:1.5_mM_diamide_(20_min)\n Cond880:BCNU\n mCDC48:Microsomal protein of CDC48/PAS1/SEC18 family of ATPases; fu\nll length homology to mammalian protein VCP; involved in sec\nretion, peroxisome formation and gene expression,,Null mutan\nt is inviable\n Cond940:6h\n Cond802:CaFK30'\n Stress.DTT2:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond:\n Cond439:DBY7286_+_0.3_mM_H2O2_(20_min)\n mERO1:involved in protein disulfide bond formation in the ER,,Null\n mutant is inviable; in ero1-1(ts) mutants newly synthesized\n carboxypeptidase Y is retained in the ER and lacks disulfid\ne bonds; ero1 mutants are hypersensitive to to the reductant\n DTT, whereas overexpression of ERO1 confers resistance to D\nTT, the oxidant diamide can restore growth and secretion in \nero1 mutants\n Cond435:DBYmsn2-4-_37degree_heat_-_20_min\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mSCL1:Proteasome subunit YC7alpha/Y8 (protease yscE subunit 7),pro\nteasome subunit YC7alpha/Y8 (protease yscE subunit 7),Null m\nutant is inviable, SCL1 is a dominant suppressor of the ts l\nethality of crl3\n Cond346:1_mM_Menadione_(20_min)_redo\n Cond376:1.5_mM_diamide_(90_min)\n Cond638:DES460_+_0.02%_MMS_-_90_min\n mYLR387C:Unknown ,, Unknown\n mPOB3:binds to catalytic subunit of DNA polymerase alpha (Pol1p),D\nNA polymerase delta binding protein,Null mutant is inviable\n Cond894:G2\n mRPN1:Subunit of 26S Proteasome (PA700 subunit),26S proteasome PA7\n00 subunit,Null mutant is inviable; hrd2-1 mutation slows de\ngradation of Hmg2p. hrd2-1 strains are sensitive to canavani\nne and show a global accumulation of ubiquitin-conjugated pr\noteins, but are not temperature-sensitive\n Cond635:DES460_+_0.02%_MMS_-_30_min\n mRPN12:Part of 26S proteasome complex that may activate Cdc28p,32-3\n4 kDa protein,Null mutant is inviable; nin1-1 mutant is temp\nerature-sensitive mutant that shows i) higher rates of recom\nbination and chromosome and plasmid loss; ii) greater sensit\nivity to UV irradiation; iii) at restrictive temperature, ar\nrest in G2, failure to activate histone H1 kinase, and accum\nulation of polyubiquinated proteins\n mRPN3:proteasome subunit,26S proteasome regulatory module componen\nt , similar to human p58 subunit,Null mutant is inviable. RP\nN3 is a high copy suppressor of the nin1-1 temperature sensi\ntive phenotype\n mPRE10:proteasome component YC1 (protease yscE subunit 1),proteasom\ne component YC1 (protease yscE subunit 1),Null mutant is inv\niable\n mRPN5:Regulatory Particle Non-ATPase, homolog of mammalian proteas\nomal subunit p55,proteasome regulatory particle subunit,Null\n mutant is inviable\n mRPN6:Regulatory Particle Non-ATPase, homolog of mammalian proteas\nomal subunit S9/p44.5.,proteasome regulatory particle subuni\nt,Null mutant is inviable\n mYFL057C:Unknown ,, Unknown\n mRPN7:Regulatory Particle Non-ATPase, homolog of mammalian proteas\nomal subunit S10/p44,proteasome regulatory particle subunit,\n Cond893:SMMS\n mRPN8:Regulatory Particle Non-ATPase, homolog of mammalian proteas\nomal subunit S12/p40,proteasome regulatory particle subunit,\n Cond379:1M_sorbitol_-_30_min\n Cond646:DES459_(mec1-)_+_0.02%_MMS_-_120_min\n mPRE3:Proteasome subunit necessary for hydrolysis of peptidylgluta\nmyl-peptide,20S proteasome subunit,Null mutant is inviable\n Cond434:DBY7286_37degree_heat_-_20_min\n Stress.HeatSorbitol:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mYOR052C:Unknown ,, Unknown\n Stress.H202:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mPRE8:proteasome component Y7,proteasome component Y7,\n mPRE9:proteasome component Y13,proteasome component Y13,\n Cond783:Peroxide_60'\n mSGT2:small glutamine-rich tetratricopeptide repeat containing pro\ntein,,\n Cond879:MMC\n mUFD1:Ubiquitin fusion degradation protein,,Homozygous ufd1-1 muta\nnt diploids exhibit sporulation defects.\n Cond333:29C_+1M_sorbitol_to_33C_+_*NO_sorbitol_-_15_minutes\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond882:zero3\n Cond644:DES459_(mec1-)_+_0.02%_MMS_-_60_min\n Cond877:MMS\n Cond640:DES459_(mec1-)_+_0.02%_MMS_-_5_min\n Cond875:60min\n Cond642:DES459_(mec1-)_+_0.02%_MMS_-_30_min\n mYMR090W:Unknown ,, Unknown\n mTRX2:thioredoxin,thioredoxin,Null mutant is viable; trx1-trx2 dou\nble mutant shows prolonged S phase, shortened G(sub)1 and me\nthionine auxotrophy\n Cond236:yjl107c(haploid)\n Stress.Menadione:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Stress.Sorbitol:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mGRE2:induced by osmotic stress; similar to dihydroflavonol 4-redu\nctase from plants,,\n Cond653:wt_plus_gamma_30_min\n mPUP2:Proteasome subunit,proteasome subunit,Null mutant is inviabl\ne\n mPUP3:20S proteasome subunit beta3_sc,20S proteasome subunit beta3\n_sc,\n Cond349:1_mM_Menadione_(50_min)redo\n Cond374:1.5_mM_diamide_(50_min)\n Cond370:1.5_mM_diamide_(10_min)\n Cond372:1.5_mM_diamide_(30_min)\n Cond876:zero2\n mNPL4:Nuclear pore or nuclear pore-associated protein required for\n nuclear membrane integrity and nuclear transport,,Temperatu\nre-sensitive mutants accumulate nuclear-targeted proteins in\n the cytoplasm and poly(A)+RNA in the nucleus and show defec\nts in nuclear membrane integrity at the nonpermissive temper\nature\n Cond885:20\n Cond645:DES459_(mec1-)_+_0.02%_MMS_-_90_min\n Cond891:G1MMS\n Stress.Various:Genomic expression programs in the response of yeast cells t\no environmental changes.  Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond348:1mM_Menadione_(40_min)_redo\n mMRP8:mitochondrial ribosomal protein,ribosomal protein,\n Cond881:4NQO\n Cond636:DES460_+_0.2%_MMS_-_45_min\n Cond442:DBYyap1-_+_0.3_mM_H2O2_(20_min)\n mNBP35:NBP35 encodes an essential evolutionary conserved protein wi\nth homology to bacterial partitioning ATPases,35 kDa nucleot\nide binding protein,Null mutant is inviable\n Cond639:DES460_+_0.02%_MMS_-_120_min\n Cond339:constant_0.32_mM_H2O2_(50_min)_redo\n mYKL091C:Unknown ,, Unknown\n Cond441:DBYmsn2/4_(real_strain)_+_0.32_mM_H2O2_(20_min)\n Cond643:DES459_(mec1-)_+_0.02%_MMS_-_45_min\n Cond347:1_mM_Menadione_(30_min)_redo\n Y-Stre.Peroxide:Remodeling of yeast genome expression in response to environ\nmental changes.  Mol Biol Cell. 2001 Feb;12(2):323-37.\n Cond641:DES459_(mec1-)_+_0.02%_MMS_-_15_min\n Cond438:DBYyap1_+_37degree_heat_(repeat)\n mRPT1:Required for degradation of ubiquitinated substrates and for\n anaphase chromosome separation,26S protease subunit compone\nnt (putative) , ATPase , 26S protease subunit component (put\native) , ATPase,Null mutant is inviable\n mRPT2:Probable 26S protease subunit and member of CDC48/PAS1/SEC18\n family of ATPases,,Null mutant is inviable\n Cond939:4h\n Cond884:10\n Cond436:DBYmsn2/4_(real_strain)_+_37degrees_(20_min)\n mBET4:catalyzes prenylation of Ypt1p (as a subunit of PGGTase-II),\ngeranylgeranyltransferase type II alpha subunit (PGGTase-II,\n alpha subunit),\n mNPL4 mUFD1 mRPT2 mRPN5 mRPT3 mRPN6 mRPN12 mRPN1 mRPT1 mRPN8 mRPN3 mRPT4 mRPN7 mRPT6

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Computational Genomics Lab, Tel-Aviv uniresity