Module number 1166




Database revision : gnsdb28.10
Date : Tue Feb 25 17:45:14 2003
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mCCT7:Required for assembly of microtubules and actin in vivo,chap\neronin containing T-complex subunit seven component,\n mRPT5:Probable 26S protease subunit and member of the CDC48/PAS1/S\nEC18 family of ATPases,,Null mutant is inviable\n mHIS5:responsive to control of general amino acid biosynthesis,his\ntidinol-phosphate aminotransferase,Null mutant is viable and\n requires histidine\n mYDR336W:Unknown ,, Unknown\n mMPS3:Unknown ,, Unknown\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts. Nat Genet\n. 2000 Dec;26(4):415-23.\n mVAC14:Unknown ,, Unknown\n Cond711:t2+Vec\n mURA4:Third step in pyrimidine biosynthesis pathway,dihydrooratase\n,Null mutant is viable and requires uracil\n GCR1.gcr1:Understanding the growth phenotype of the yeast gcr1 mutant \nin terms of global genomic expression patterns. J Bacteriol\n. 2000 Sep;182(17):4970-8.\n mYDR115W:Unknown ,, Unknown\n mSNQ2:ABC transporter,ABC transporter,null mutant is viable; overe\nxpression confers multi-drug resistance\n mYCL039W:Unknown ,, Unknown\n mTUF1:Translation elongation factor Tu, mitochondrial,translation \nelongation factor Tu, mitochondrial,Null mutant is viable, b\nlocks mitochondrial translation and destabilizes mitochondri\nal genome.\n mDLD2:D-lactate dehydrogenase, located in mitochondrial matrix,,Nu\nll mutant is viable\n mROT1:Reversal of tor2 lethality,membrane protein (putative),Null \nmutant is inviable; rot1 mutations can suppress tor2 mutatio\nns; synthetically lethal with rot2\n mYGR012W:Unknown ,, Unknown\n mERG7:carries out complex cyclization step of squalene to lanoster\nol in sterol biosynthesis pathway,2,3-oxidosqualene-lanoster\nol cyclase,Null mutant is inviable\n mHRT2:High level expression reduced Ty3 Transposition,,Null mutant\n is viable; over-expression results in reduced Ty3 transposi\ntion\n mXDJ1:Homolog of E. coli DnaJ, closely related to Ydj1p,,Null muta\nnt is viable, displays no detectable phenotype\n mSSP120:secretory protein,,Null mutant is viable\n mKIN2:Serine/threonine protein kinase,,\n mSNF4:involved in release from glucose repression, invertase expre\nssion, and sporulation,associates with Snf1p,Null mutant is \nviable, sucrose nonfermenting; high copy MSI1 and PDE2 parti\nally suppress sporulation defect\n Cond724:t4+SSD1,H44\n mYPL063W:Unknown ,, Unknown\n mGSH2:Glutathione Synthetase,glutathione synthetase,Null mutant is\n viable, growth was poor under aerobic conditions in minimum\n medium\n Cond713:t4+Vec\n mYPK1:76.5 kDa Serine/threonine protein kinase with similarity to \nprotein kinase C, is 90% identical to Ypk2p,76.5 kDa serine/\nthreonine protein kinase , similarity to protein kinase C, i\ns 90% identical to Ypk2p,Null mutant is viable, slow growing\n, ypk1 ypk2 double deletion mutants are defective for vegeta\ntive growth\n mRAP1:DNA-binding protein involved in either activation or repress\nion of transcription, depending on binding site context. Als\no binds telomere sequences and plays a role in telomeric pos\nition effect (silencing) and telomere structure.,repressor a\nctivator protein,null is inviable; some mutations abolish si\nlencing (at telomeres and at the silent mating-type loci), o\nther mutations or overproduction alter telomere length\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mDDI1:DNA Damage Inducible; binds to T- and V- snare complexes,,Nu\nll mutant is viable\n mERG27:3-keto sterol reductase,3-keto sterol reductase,\n mFPS1:Suppressor of tps1/fdp1 and member of the MIP family of tran\nsmembrane channels; may be involved in glycerol efflux,glyce\nrol channel protein,Null mutant is viable\n mYAR066W:Unknown ,, Unknown\n mCKB1:beta (38kDa) subunit of casein kinase II (CKII),casein kinas\ne II beta subunit,Null mutant is viable, exhibits salt sensi\ntivity specific to NaCl and LiCl\n mCKB2:Casein kinase II, beta' subunit,Casein kinase II beta' subun\nit,Null mutant is viable\n mHEM12:fifth enzyme in the heme biosynthetic pathway,uroporphyrinog\nen decarboxylase,Null mutant is viable; auxotroph for heme a\nnd methionine\n mYNL320W:Unknown ,, Unknown\n mTEL2:Involved in controlling telomere length,telomere binding pro\ntein,point mutant has shorter-than-normal telomeres; there i\ns a long (150 generation) lag time for phenotypic expression\n Cond722:t2+SSD1,H44\n mHRB1:an ORF of unknown function located in a centromeric region d\nuplicated between chromosomes III and XIV,hypothetical RNA-b\ninding protein,\n mMSW1:mitochondrial tryptophanyl-tRNA synthetase,tryptophan-tRNA l\nigase,Null mutant is viable, respiratory deficient, defectiv\ne in mitochondrial protein synthesis\n Cond709:t0+Vec\n mRPN9:Regulatory Particle Non-ATPase,proteasome regulatory particl\ne subunit,Null mutant is viable, temperature sensitive; rpn9\n rpn10 double deletion mutants are viable\n mGAA1:ER protein essential for attaching GPI (glycosylphosphatidyl\ninositol) to protein,GPI:protein transamidase component (put\native),Null mutant is inviable; temperature-sensitive mutant\n, after shifting to restrictive temperature, does not attach\n GPI to protein; also defective in endocytosis and pheromone\n response\n mYLR104W:Unknown ,, Unknown\n mMRPL3:Mitochondrial ribosomal protein MRPL3 (YmL3),ribosomal prote\nin (YmL3),\n mMRPL4:essential for mitochondrial function and for proper cell gro\nwth under non-respiratory conditions,ribosomal protein 60S L\n4,Null mutant is viable, fails to grow on nonfermentable car\nbon sources, has growth defects on fermentable carbon source\ns\n mCOX11:Mitochondrial membrane protein required for insertion of Cu(\nB) and magnesium during assembly of cytochrome c oxidase,,de\nficient in cytochrome oxidase\n mGLR1:converts oxidized glutathine and NADPH into two glutathiones\n and NADP+,glutathione oxidoreductase,Null mutant is viable\n mARE2:Acyl-CoA cholesterol acyltransferase (sterol-ester synthetas\ne),acyl-CoA cholesterol acyltransferase (sterol-ester synthe\ntase),Null mutant is viable; greatly reduces in vivo and in \nvitro ergosterol esterification (to 15 - 35 % of wild-type).\n Deletion of both ARE1 and ARE2 completely eliminates in viv\no and in vitro ergosterol esterification\n mPTC3:protein phosphatase type 2C,protein phosphatase type 2C,\n mSSU72:functionally related to TFIIB, affects start site selection \nin vivo,,Null mutant is inviable\n mYLR224W:Unknown ,, Unknown\n mSEC13:cytoplasmic protein involved in release of transport vesicle\ns from the ER,protein involved in release of transport vesic\nles from the ER,Null mutant is inviable; ts mutants exhibit \ndefects in secretion.\n mCHS5:Involved in chitin synthase III activity, also required for \nhomozygosis in the first stages of mating,,Null mutant is vi\nable, cells exhibit a strong mating defect; sensitive to Cal\ncofluor, reduced amount of chitin in the cell wall\n mYMR134W:Unknown ,, Unknown\n Cond725:t4-SSD1,M31\n Cond708:t0+SSD1\n mYDR287W:Unknown ,, Unknown\n mMNN10:Required for mannan synthesis and for polarized growth and b\nud emergence,galactosyltransferase,Null mutant is viable, is\n larger than wild-type cells, is deficient in bud emergence,\n and depends upon an intact morphogenesis checkpoint control\n to survive\n Cond906:(77i5)_S150-2B_YPD_NormInt\n mNUP2:Localizes to discrete spots in the nuclear envelope; probabl\ny functions in transport through nuclear pore,nuclear pore c\nomplex subunit,Null mutant is viable; some combinations of a\nlleles of nup1, nsp1 and nup2 are synthetically lethal\n mRHC18:Protein involved in recombination repair, homologous to S. p\nombe rad18,,Null mutant is inviable\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond712:t4+SSD1\n mSSL1:Component of RNA polymerase transcription factor TFIIH,RNA p\nolymerase transcription factor TFIIH component,Null mutant i\ns inviable; temperature-sensitive mutants are UV-sensitive a\nnd deficient in nucleotide excision repair.\n mRIM2:Protein of the mitochondrial carrier (MCF) family that is re\nquired for respiration,,Null mutant is viable but lacks mito\nchondrial DNA and grows slowly on glucose\n Cond723:t2-SSD1,M31\n mRFC3:RFC is a DNA binding protein and ATPase that acts as a proce\nssivity factor for DNA polymerases delta and epsilon and loa\nds proliferating cell nuclear antigen (PCNA) on DNA,replicat\nion factor C subunit 3 , similar to human RFC 36 kDa subunit\n,Null mutant is inviable\n mGRX5:Member of a glutaredoxin subfamily in Sc together with GRX3 \n& GRX4. Significant sequence diff. with the other glutaredox\nin subfamily, formed by the previously described GRX1 & GRX2\n glutaredoxins (Luikenhuis MBC 9:1081, 1998),glutaredoxin,Nu\nll mutant is viable and shows high sensitivity to oxidative \nstress and increased sensitivity to osmotic stress, and incr\neased oxidation levels of cell proteins; grx5 is synthetical\nly lethal with grx2.\n mTIM44:48.8 kDa protein involved in mitochondrial protein import,48\n.8 kDa protein involved in mitochondrial protein import,Null\n mutant is inviable\n mSEH1:Nuclear pore protein, homologous to sec13,,\n mMRP4:Involved in mitochondrial protein synthesis,mitochondrial ri\nbosomal protein , mitochondrial ribosome 37 S subunit compon\nent , similar to E. coli ribosomal protein S2,Null mutant is\n viable\n mYLR072W:Unknown ,, Unknown\n Cond721:t0-SSD1,M31\n mATP10:essential for assembly of a functional mitochondrial ATPase \ncomplex,,loss of rutamycin sensitivity in mitochondrial ATPa\nse but no effect on respiratory enzymes\n mCAC2:Involved in DNA-replication-linked nucleosome assembly; homo\nlogous to the p60 subunit of the Human CAF-I,chromatin assem\nbly factor-I (CAF-I) p60 subunit,Null mutant is viable, but \nis sensitive to UV irradiation\n mCSN12:Unknown ,, Unknown\n mYMR262W:Unknown ,, Unknown\n mMMP1:S-MethylMethionine Permease,high affinity S-methylmethionine\n permease,Null mutant is viable but is unable to use S-methy\nlmethionine as a sulfur source\n mTIF5:Translation initiation factor eIF-5,translation initiation f\nactor eIF-5,\n Cond710:t2+SSD1\n mRPO41:mitohcondrial RNA polymerase,mitochondrial RNA polymerase,Nu\nll mutant is viable\n mAPE2:Removal of intron fused YKL158W and YKL157W,aminopeptidase y\nscII,Null mutant is viable\n mCCT3:Homolog of mammalian CCT family of chaperonin proteins; requ\nired for assembly of microtubules and actin in vivo,gamma ch\naperonin subunit,Defects in microtubule and actin assembly i\nn vivo, abberant chromosome segregation, supersensitivity to\n benomyl\n mYFR007W:Unknown ,, Unknown\n mYKL033W:Unknown ,, Unknown\n mCCT4:cytoplasmic chaperonin subunit required for actin cytoskelet\non assembly or function,,Null mutant is inviable; cct4 mutan\nt exhibit allele-specific non-complementing interactions wit\nh different act1 mutations; anc2-1 mutants contain abnormal \nand disorganized actin structures, are defective in cellular\n morphogenesis, and are hypersensitive to the microtubule in\nhibitor benomyl. Overexpression of wild-type Anc2p ameliorat\nes defects in actin organization and cell growth caused by a\nctin overproduction.\n mRPT2:Probable 26S protease subunit and member of CDC48/PAS1/SEC18\n family of ATPases,,Null mutant is inviable\n Cond939:4h\n mCKB1 mCKB2 mSEH1 mSEC13
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Computational Genomics Lab, Tel-Aviv uniresity