Module number 1158




Database revision : gnsdb28.10
Date : Tue Feb 25 17:42:00 2003
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mMMT2:Protein involved in mitochondrial iron accumulation,,Null mu\ntant is viable, mmt1 mmt2 double deletion mutants exhibit a \ngrowth defect on low iron medium\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n mYKL146W:Unknown ,, Unknown\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts. Nat Genet\n. 2000 Dec;26(4):415-23.\n mMDM34:Hypothetical ORF,,\n mNSP1:Nucleoskeletal protein found in nuclear pores and spindle po\nle body,nuclear pore complex subunit,Null mutant is inviable\n.\n mPEX10:C3HC4 zinc-binding integral peroxisomal membrane protein,C3H\nC4 zinc-binding integral peroxisomal membrane protein,mutant\n lacks morphologically recognizable peroxisomes and shows cy\ntosolic mislocalization of peroxisomal matrix proteins\n Cond892:S\n mYMR002W:Unknown ,, Unknown\n mCDC4:Init. of DNA synthesis & spindle pole body separation; dispe\nnsable for both mitotic and meiotic spindle pole body dupl.;\n essential for mitotic but not premeiotic DNA synth.; wt lev\nels of synaptonemal complexes and intragenic recombination,u\nbiquitin ligase subunit,Null mutant is inviable. cdc4 mutant\ns arrest in meiosis at the mononucleate stage with duplicate\nd spindle pole bodies.\n mYTA12:Mitochondrial ATPase (similar to E. coli FtsH protein) that \nresides in the innner mitochondrial membrane,ATPase , CDC48/\nPAS1/SEC18 (AAA) family,Null mutant is viable, petite grossl\ny deficient in mitochondrial respiratory and ATPase complexe\ns, yet synthesizes all proteins encoded by mitochondrial DNA\n Cond890:G1\n Cond943:SK1_YPA\n Cond872:Zero1\n mYHR122W:Unknown ,, Unknown\n mSTS1:restores protein transport when overexpressed and rRNA stabi\nlity to a sec23 mutation,,Null mutant is inviable\n mMPE1:Unknown ,, Unknown\n mYJU3:Product of gene unknown,,\n mRTF1:Directly or indirectly regulates the DNA-binding properties \nof Spt15p, the TATA box-binding protein, and the relative ac\ntivities of different TATA elements,nuclear protein,Null mut\nant is viable and can suppress TATA box-binding protein muta\nnts (SPT15) in an allele-specific fashion\n mAEP1:Requried for the translation of OLI1 mRNA.,basic hydrophilic\n 59 kDa protein,permanently respiratory defective; unable to\n translate OLI1 transcripts\n Cond897:STATMMS\n mRAT1:RNA trafficking protein; transcription activator,5'-3' exori\nbonuclease,Null mutant is inviable.\n Cond937:t=0\n Cond894:G2\n mNFU1:Nifu-like protein,,Null mutant is viable on YPD 30 degrees C\n, and is synthetically lethal with SSQ1\n mULP1:Ubl (ubiquitin-like protein) - specific protease 1,Ulp1p-spe\ncific protease,Null mutant is lethal. Temperature-sensitive \nmutants accumulate in G2/M at the restrictive temperature\n Cond893:SMMS\n mMAS1:mitochondrial processing protease subunit,mitochondrial proc\nessing protease subunit,Null mutant is inviable; Elevated mi\ntotic recombination and chromosomal missegregation when over\nproduced\n mYKR016W:Unknown ,, Unknown\n mPET8:Member of family of mitochondrial carrier proteins,,petite; \nunable to grow on non-fermentable carbon sources\n mNAB2:nuclear polyadenylated RNA binding protein,polyadenylated RN\nA binding protein,Null mutant is inviable\n UME6.ume6:The Ume6 regulon coordinates metabolic and meiotic gene expr\nession in yeast. Proc Natl Acad Sci U S A. 2002 Oct 15;99(2\n1):13431-6.\n mTRP1:Note that the sequence of TRP1 from strain S228C, which is t\nhe sequence stored in SGD, contains an ochre mutation at cod\non 67.,N-(5'-phosphoribosyl)-anthranilate isomerase,tryptoph\nan requiring\n mAAD14:aryl-alcohol dehydrogenase located on chromosome 14,aryl-alc\nohol dehydrogenase (putative),\n mSSU72:functionally related to TFIIB, affects start site selection \nin vivo,,Null mutant is inviable\n mYPL260W:Unknown ,, Unknown\n mMRPL10:Mitochondrial ribosomal protein MRPL10 (YmL10),ribosomal pro\ntein (YmL10),\n Cond895:G2MMS\n Cond879:MMC\n mMSP1:40 kDa putative membrane-spanning ATPase,40 kDa membrane-spa\nnning ATPase,Null mutant is viable, exhibits no observable g\nrowth defects\n Cond882:zero3\n Cond877:MMS\n Cond875:60min\n Cond886:g-ray\n mYKL195W:Unknown ,, Unknown\n Cond945:W303_YPD\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mUBA1:ubiquitin activating enzyme, similar to Uba2p,ubiquitin acti\nvating enzyme, similar to Uba2p,Null mutant is inviable\n Cond874:30min\n mTAF6:TATA-binding protein-associated-factor,TATA-binding protein-\nassociated-factor,Null mutant is inviable\n Cond876:zero2\n mCOX20:COX: cytochrome oxidase, 20: 20th gene involved in cytochrom\ne oxidase activity,required for maturation and assembly of c\nytochrome oxidase subunit II,Null mutant is respiratory-defi\ncient and has no cytochrome oxidase activity or accumulation\n of precursor of CoxII\n mEAF3:Esa1p-Associated Factor,,\n mYFL061W:Unknown ,, Unknown\n mYNL100W:Unknown ,, Unknown\n Cond885:20\n mPCP1:Unknown ,, Unknown\n mYLR392C:Unknown ,, Unknown\n mRSC9:Remodels the Structure of Chromatin,,Null: Lethal.\n mIDP1:Mitochondrial form of NADP-specific isocitrate dehydrogenase\n,NADP-dependent isocitrate dehydrogenase,Null mutant is viab\nle\n mMRP7:Mitochondrial ribosomal protein MRP7 (YmL2) (E. coli L27),ri\nbosomal protein (YmL2) (E. coli L27),Null mutant is viable\n Cond881:4NQO\n mYKR065C:Unknown ,, Unknown\n mYGL161C:Unknown ,, Unknown\n mPHB2:Possible role in aging,mammalian BAP37 and S. cerevisiae Phb\n1p homolog , prohibitin homolog,Null mutant is viable, exhib\nits a slightly decreased lifes span; phb1 phb2 double deleti\non mutants exhibit a more decreased replicative lifespan and\n a defect in mitochondrial membrane potential\n mCCT2:cytoplasmic chaperonin of the Cct ring complex related to Tc\np1p; subunit beta,,Null mutant is inviable; some mutant alle\nles exhibit defects in microtubule and actin assembly.\n mVPS34:phosphatidylinositol 3-kinase,phosphatidylinositol 3-kinase,\ntemperature sensitive, defective vacuolar protein sorting\n Cond884:10\n
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Computational Genomics Lab, Tel-Aviv uniresity