Module number 1154




Database revision : gnsdb28.10
Date : Tue Feb 25 17:41:21 2003
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mRRP12:Required for normal pre-rRNA processing,,Null: lethal.\n mNOP1:nucleolar protein, homologous to mammalian fibrillarin,nucle\nolar protein , similar to mammalian fibrillarin,Null mutant \nis inviable. Temperature-sensitive alleles exhibit various d\nefects in rRNA processing.\n mNOP2:May participate in nucleolar function during the transition \nfrom stationary phase to rapid growth,90 kDa protein homolog\nous to a human proliferation-associated nucleolar protein, p\n120,Null mutant is inviable; overexpression leads to changes\n in nucleolar morphology\n Cond399:Nitrogen_Depletion_8_h\n mNOP4:RNA recognition motif-containing protein,RNA binding protein\n (putative),Null mutant is inviable; conditional mutant show\ns diminished accumulation of 60S ribosomal subunits due to a\n lack of production of mature 25S rRNA from 27S precursor rR\nNA\n Cond316:37C_to_25C_shock_-_30_min\n mTRR1:Thioredoxin reductase,thioredoxin reductase,Null mutant is v\niable but grow slowly; trr1 mutations are sensitive to hydro\ngen peroxide and activate Mlu1 cell cycle box (MCB)- and Swi\n4/Swi6 cell cycle box (SCB)-dependent reporter genes in swi6\n null mutants.\n Cond432:YPD_stationary_phase_22_d_ypd-1\n mSAM4:S-adenosylmethionine:homocysteine S-methyltransferase,,Slow \ngrowth on S-adenosylmethionine used as a sulfur source\n mPUF4:member of the PUF protein family,,\n Cond711:t2+Vec\n GCR1.gcr1:Understanding the growth phenotype of the yeast gcr1 mutant \nin terms of global genomic expression patterns. J Bacteriol\n. 2000 Sep;182(17):4970-8.\n Cond362:dtt_000_min__dtt-2\n mYDR492W:Unknown ,, Unknown\n mRPL13A:Homology to rat L13,ribosomal protein L13A,Null mutant is vi\nable.\n Cond913:(99i3)_S150-2B_YPD_NormInt\n Cond400:Nitrogen_Depletion_12_h\n mFLO1:cell wall protein involved in flocculation,,Flocculation\n mRPL17B:Homology to rat L17, human L17, and E. coli L22,ribosomal pr\notein L17B (L20B) (YL17),\n mASP1:Asparaginase I, intracellular isozyme,asparaginase I , intra\ncellular isozyme,Aspartic acid requiring\n mRPS29A:Homology to rat S29,ribosomal protein S29A (S36A) (YS29),\n Cond425:YPD_stationary_phase_12_h_ypd-1\n mARO8:aromatic amino acid aminotransferase,aromatic amino acid ami\nnotransferase,Null mutant is viable\n Stress.YPDStat:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mECM33:ExtraCellular Mutant,,A Tn3 insertion into this gene causes \nhypersensitivity to the cell surface polymer perturbing agen\nt calcofluor white.\n mYNL247W:Unknown ,, Unknown\n Cond719:t4-SSD1\n Stress.DTT2:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond724:t4+SSD1,H44\n mDNF2:Drs2 Neo1 Family,Potential aminophospholipid translocase,via\nble\n mNMD3:putative Upf1p-interacting protein,factor required for a lat\ne assembly step of the 60S subunit,Null mutant is inviable, \nat nonpermissive temperature, nmd3 ts mutants exhibit decrea\nsed levels of 60S subunits resulting in formation of half-me\nr polysomes; nmd3 xrn1(kem1) double mutants are inviable\n mHEM1:First enzyme in heme biosynthetic pathway,5-aminolevulinate \nsynthase,Null mutant is viable; auxotroph for heme and methi\nonine\n Cond713:t4+Vec\n Cond435:DBYmsn2-4-_37degree_heat_-_20_min\n Cond310:Heat_Shock_000_minutes_hs-2\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mMAK5:Necessary for maintenance of dsRNA killer plasmids. Is predi\ncted to encode an DEAD-box RNA helicase,,deficient in mainte\nnance of killer\n Cond318:37C_to_25C_shock_-_60_min\n mRPA14:14 kDa subunit of RNA polymerase I,RNA polymerase I subunit,\nNull mutant is viable but is temperature sensitive\n Cond437:DBYyap1-_37degree_heat_-_20_min_(redo)\n mRPL30:Homology to rat and mouse L30,ribosomal protein L30 (L32) (r\np73) (YL38) large subunit,Null mutant is inviable.\n Cond718:t4+SSD1wt\n mSTE24:zinc metallo-protease that catalyzes the first step of N-ter\nminal processing of the yeast a-factor precursor,zinc metall\no-protease,Null mutant is viable, exhibits a mating efficien\ncy of ~5% that of a wild-type strain and an a-factor process\ning defect\n Cond722:t2+SSD1,H44\n Cond404:Nitrogen_Depletion_5_d\n Cond709:t0+Vec\n mMKT1:Protein involved in propagation of M2 dsRNA satellite of L-A\n virus,retroviral protease signature protein,Null mutant is \nviable\n mSHM1:Serine hydroxymethyltransferase, mitochondrial,,Null mutant \nis viable.\n mHXK2:Glucose phosphorylation,hexokinase II (PII) (also called hex\nokinase B),Null mutant is viable and can ferment fructose, b\nut fails to show glucose repression at SUC2, CYC1, GAL10. hx\nk1, hxk2 double null mutant cannot ferment fructose\n mFKS1:Required for viability of calcineurin mutants,1,3-beta-D-glu\ncan synthase,Null mutant is viable, demonstrates slow growth\n, hypersensitivity to FK506 and cyclosporin A, sensitivity t\no echinocandin and a reduction in 1,3-beta-D-glucan synthase\n activity in vitro; sensitivity to papulacandin B\n mCBF5:major low affinity 55 kDa Centromere/microtubule binding pro\ntein,major low affinity 55 kDa centromere/microtubule bindin\ng protein,Null mutant is inviable\n mYEF3:contains two ABC cassettes, and binds and hydrolyses ATP,Tra\nnslation elongation factor 3 (EF-3),Null mutant is inviable\n mFEN1:Involved in synthesis of 1,3-beta-glucan, a component of the\n cell wall, and elongation of fatty acids up to 24 carbons,1\n,3-beta-glucan synthase subunit (putative) , ELO1 homolog , \n1,3-beta-glucan synthase subunit (putative) , ELO1 homolog ,\n 1,3-beta-glucan synthase subunit (putative) , ELO1 homolog,\nNull mutant is viable; slow growth; fenpropimorph resistant;\n resistant to a pneumocandin B0 analog (L-733,560); mating a\nnd sporulation defects; synthetic lethality with ELO3\n Cond914:(99i2)_S150-2B_YPGL+G_NormInt\n Stress.NitroDepl:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond317:37C_to_25C_shock_-_45_min\n mYDL237W:Unknown ,, Unknown\n mPAB1:Poly(A) binding protein, cytoplasmic and nuclear,poly(A) bin\nding protein,Null mutant is inviable.\n Cond717:t2-SSD1\n mYOL092W:Unknown ,, Unknown\n mADE5,7:glycinamide ribotide synthetase and aminoimidazole ribotide \nsynthetase,aminoimidazole ribotide synthetase , glycinamide \nribotide synthetase,Adenine requiring\n Cond716:t2+SSD1wt\n mFUN12:Function unknown now,97 kDa protein,Null mutant is inviable\n mHCA4:putative RNA helicase,RNA helicase (putative),Null mutant is\n inviable. A Tn3 insertion into this gene causes hypersensit\nivity to the cell surface polymer perturbing agent calcofluo\nr white.\n mTHS1:Threonyl-tRNA synthetase, cytoplasmic,threonine-tRNA ligase,\n mSEC14:Required for vesicle budding from the Golgi,phosphatidylinos\nitol transfer protein,Null mutant is inviable; other mutatio\nns are temperature sensitive\n Cond708:t0+SSD1\n Cond725:t4-SSD1,M31\n mYIL121W:Unknown ,, Unknown\n Stress.Heat2:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mSTT3:Required for protein glycosylation,integral ER membrane prot\nein , oligosaccharyltransferase complex subunit (putative),N\null mutant is inviable. sst3 mutants are defective in protei\nn glycosylation, sensitive to hygromycin B, and resistant to\n sodium orthovanadate. Depletion of the STT3 protein results\n in loss of oligosaccharyl transferase activity in vivo and \na deficiency in the assembly of oligosaccharyl transferase c\nomplex.\n mNOG1:Nucleolar G-protein 1; LPG15w (working nomenclature),homolog\ns identified in human and Trypanosoma brucei , nucleolar G-p\nrotein (putative),Null mutant is inviable.\n mSOL3:weak multicopy suppressor of los1-1,,Null mutant is viable\n mIMD3:Hypothetical ORF,IMP dehydrogenase homolog,\n mUTP5:Unknown ,, Unknown\n Cond427:YPD_stationary_phase_2_d_ypd-1\n mMIS1:mitochondrial C1-tetrahydroflate synthase,C1-tetrahydrofolat\ne synthase,Null mutant is viable, exhibits no apparent defec\nts in cell growth\n mASN2:Asn1p and Asn2p are isozymes,asparagine synthetase,Null muta\nnt is viable; L-asparagine auxotrophy occurs upon mutation o\nf both ASN1 and ASN2\n Cond712:t4+SSD1\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond403:Nitrogen_Depletion_3_d\n mIRA2:Negatively regulates cAPK by antagonizing CDC25,GTPase activ\nating protein , highly homologous to Ira1p , neurofibromin h\nomolog , GTPase activating protein , highly homologous to Ir\na1p , neurofibromin homolog,Null mutant is viable, exhibits \nincreased sensitivity to heat shock and nitrogen starvation,\n sporulation defects, and suppression of the lethality of a \ncdc25 mutants\n mSIK1:homology to microtubule binding proteins and to X90565_5.cds\n,similar to microtubule binding proteins and to X90565_5.cds\n,wild-type gene suppresses toxicity of GAL4-I-Kappa-B alpha \nin yeast\n mUTP14:Unknown ,, Unknown\n Cond319:37C_to_25C_shock_-_90_min\n mSPB1:Suppressor of PaB1 mutant; involved in 60S ribosomal subunit\n biogenesis,methyltransferase (putative),Null mutant is invi\nable. The spb1-1 mutant is an extragenic suppressor of a pab\n1 null mutation.\n Cond402:Nitrogen_Depletion_2_d\n mSES1:seryl-tRNA synthetase,serine-tRNA ligase,Null mutant is invi\nable.\n mYNL190W:Unknown ,, Unknown\n Cond723:t2-SSD1,M31\n mNPL3:involved as a protein carrier in mRNA export, involved in mi\ntochondrial protein targeting,contains RNA recognition motif\n , nuclear shuttling protein , contains RNA recognition moti\nf , nuclear shuttling protein , contains RNA recognition mot\nif , nuclear shuttling protein,Null mutant is inviable, npl3\n mutants are temperature-sensitive for growth, but do not ex\nhibit a defect in localization of nuclear proteins\n Cond433:YPD_stationary_phase_28_d_ypd-1\n Cond401:Nitrogen_Depletion_1_d\n mVMA5:42 kDa subunit of V1 sector,V1 sector hydrophilic subunit C \n, vacuolar ATPase V1 domain subunit C (42 kDa) , vacuolar H-\nATPase , V1 sector hydrophilic subunit C , vacuolar ATPase V\n1 domain subunit C (42 kDa) , vacuolar H-ATPase,Null mutant \nis viable; certain vma5 mutations show allele-specific synth\netic lethality with cdc24-ls mutants\n mDED1:ATP-dependent RNA helicase of DEAD box family; suppressor of\n a pre-mRNA splicing mutation, prp8-1,,Null mutant is inviab\nle\n Cond714:t0+SSD1wt\n mGAL80:inhibits transcription activation by Gal4p in hte absence of\n galactose,transcriptional regulator,Null mutant is viable a\nnd cannot utilize galactose.\n Stress.ColdShock:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mSUN4:Protein involved in the aging process,,\n Cond411:diauxic_shift_timecourse_20.5_h\n Stress.Various:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mTEF4:Translation elongation factor EF-1gamma,translation elongati\non factor EF-1gamma,\n mPPA1:vacuolar ATPase V0 domain subunit c'',proteolipid , vacuolar\n ATPase V0 domain subunit c'',Null mutant is inviable in som\ne genetic backgrounds, in others, exhibits no V-ATPase activ\nity and failure to assemble V-ATPase subunits onto the vacuo\nlar membrane\n mHXT2:hexose transporter,high affinity hexose transporter-2,Null m\nutant is viable\n mRPL12B:Homology to rat L12(a) and E. coli L11,ribosomal protein L12\nB (L15B) (YL23),Null mutant is viable.\n mRPS24A:Homology to rat S24,ribosomal protein S24A,\n mYRF1-4:Y'-helicase protein 1,Y'-helicase protein 1,\n mSRL1:Suppressor of rad53 lethality,,\n mYOR108W:Unknown ,, Unknown\n mPHO90:Low-affinity phosphate transporter,,\n Cond710:t2+SSD1\n Cond428:YPD_stationary_phase_3_d_ypd-1\n mFAA4:acyl-CoA synthetase (long-chain fatty acid CoA ligase) (fatt\ny acid activator 2), activates imported fatty acids and prov\nides substrates for N-myristoylation,long chain fatty acyl:C\noA synthetase , long-chain fatty acid:CoA ligase,Not essenti\nal for vegetative growth when fatty acid synthase (fas) is a\nctive\n mCCT5:Required for assembly of microtubules and actin in vivo,chap\neronin subunit epsilon subunit,\n Stress.dshift:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mKRE22:Killer toxin REsistant,,Null mutant is K1 killer toxin resis\ntent\n mNOP1 mSIK1 mNOP2 mNMD3 mCBF5 mUTP5 mFAA4
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Computational Genomics Lab, Tel-Aviv uniresity