Module number 1152




Database revision : gnsdb28.10
Date : Tue Feb 25 17:41:02 2003
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Cond626:DY1457_(wild_type)_3_mM_vs._61_nM_zinc_y13-121\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n Cond399:Nitrogen_Depletion_8_h\n Cond338:constant_0.32_mM_H2O2_(40_min)_rescan\n Cond432:YPD_stationary_phase_22_d_ypd-1\n mCIC1:Nop seven associated protein 3,ribosome biogenesis,\n Pho85.pho85:Chemical inhibition of the Pho85 cyclin-dependent kinase rev\neals a role in the environmental stress response. Proc Natl\n Acad Sci U S A. 2001 Oct 23;98(22):12578-83.\n Cond410:diauxic_shift_timecourse_18.5_h\n Cond302:Heat_Shock_15_minutes_hs-1\n Cond418:YPD_1_d_ypd-2\n mFPR4:Homolog of homolog of the nucleolar FKBP, Fpr3,peptidyl-prol\nyl cis-trans isomerase (PPIase),Null mutant is viable\n Cond675:MHY1_(dun1)_+_heat_20_min\n mURA6:uridine-monophosphate kinase (uridylate kinase),uridine-mono\nphosphate kinase (uridylate kinase),uracil requiring\n mRPS0A:Homology to rat Sa,ribosomal protein S0A,Null mutant is viab\nle; yst1 (rps0a) yst2 (rps0b) double deletion mutant is invi\nable; yst1 (rps0a) mutants are defective for filamentous gro\nwth\n GCR1.gcr1:Understanding the growth phenotype of the yeast gcr1 mutant \nin terms of global genomic expression patterns. J Bacteriol\n. 2000 Sep;182(17):4970-8.\n Cond362:dtt_000_min__dtt-2\n Cond913:(99i3)_S150-2B_YPD_NormInt\n Cond400:Nitrogen_Depletion_12_h\n mRPL31A:Homology to rat L31,ribosomal protein L31A (L34A) (YL28),\n Stress.diamide:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond697:gal2-gal\n Cond315:37C_to_25C_shock_-_15_min\n mRKI1:Ribose-5-phosphate ketol-isomerase,ribose-5-phosphate ketol-\nisomerase,Null mutant is inviable\n Cond467:steady_state_21_dec_C_ct-2\n Cond416:YPD_10_h__ypd-2\n Cond674:DES459_(mec1)_+_heat_20_min\n Cond425:YPD_stationary_phase_12_h_ypd-1\n Cond810:Na45'\n Stress.Carbon:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond364:dtt_030_min__dtt-2\n Cond637:DES460_+_0.02%_MMS_-_60_min\n mDYS1:Deoxyhypusine synthase carries out the first step in hypusin\ne biosynthesis, converting lysine and spermidine into deoxyh\nypusine.,deoxyhypusine synthase,Null mutant is inviable\n Cond373:1.5_mM_diamide_(40_min)\n Cond454:YP_fructose_vs_reference_pool_car-2\n Cond445:Msn4_overexpression\n Cond890:G1\n mDIM1:Dimethyladenosine transferase, (rRNA(adenine-N6,N6-)-dimethy\nltransferase),reponsible for m6[2]Am6[2]A dimethylation in 3\n'-terminal loop of 18S rRNA,dimethyladenosine transferase,Nu\nll mutant is inviable\n mPWP1:Protein with periodic trytophan residues that resembles memb\ners of beta-transducin superfamily because of presence of WD\n-40 repeats,,Null mutants are viable but show severely retar\nded growth\n Cond391:aa_starv_1_h\n Cond435:DBYmsn2-4-_37degree_heat_-_20_min\n mRPL6B:Homology to rat and human L6; involved initiation of protein\n synthesis,ribosomal protein L6B (L17B) (rp18) (YL16),Null m\nutant is viable, grows slower than wild-type. rpl6a rpl6b do\nuble mutants are inviable; rpl6 mutants are deficient in 60S\n ribosomal subunits relative to 40S subunits; 43S preinitiat\nion complexes accumulate in half-mer polyribosomes in the ab\nsence of sufficient 60S subunits.\n Cond814:Na+FK45'\n Cond310:Heat_Shock_000_minutes_hs-2\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond873:10min\n Cond805:Ca/Ca+FK30'\n mRPP2A:Homology to rat P2, human P2, and E.coli L12eIB,60S acidic r\nibosomal protein P2A (L44) (A2) (YP2alpha),Null mutant is vi\nable\n Stress.aa_starv:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond480:WT+/-100mM3AT(SetA)(R491)\n Cond429:YPD_stationary_phase_5_d_ypd-1\n Cond318:37C_to_25C_shock_-_60_min\n Cond624:DY1457_(wild_type)_3_mM_vs._10_uM_zinc_y13-75\n Cond894:G2\n Cond673:DES460_(wild_type)_+_heat_20_min\n Cond395:Nitrogen_Depletion_30_min.\n Cond279:ERG11(tetpromoter)\n TorRama.Series0:Partitioning the transcriptional program induced by rapamyci\nn among the effectors of the Tor proteins. Curr Biol. 2000 D\nec 14-28;10(24):1574-81\n Cond312:Heat_Shock_015_minutes_hs-2\n mSSZ1:DnaK homolog, interacts with Zuo1p (DnaJ homolog) to form a \nribosome-associated complex (RAC) that is bound to the ribos\nome via the Zuo1p subunit,HSP70 family,Null mutant is viable\n, cold sensitive; SSZ1 overexpression causes increased expre\nssion of some PDR genes\n Cond683:MHY1_(crt1)_vs._CRY1_(wild_type)_-_log_phase\n mMAK16:putative nuclear protein,nuclear protein (putative),Null mut\nant is inviable, conditional mutants arrest at G(sub)1, are \ndeficient in maintenance of killer M1 double-stranded RNA\n Cond689:gal3+gal\n Cond479:WT+/-100mM3AT(SetD)(R491)\n Cond849:120_min\n Cond914:(99i2)_S150-2B_YPGL+G_NormInt\n Cond306:Heat_Shock_60_minutes_hs-1\n Cond694:gal10+gal\n Cond430:YPD_stationary_phase_7_d_ypd-1\n mCGR1:coiled-coil growth-regulated,coiled-coil protein,Null mutant\n is inviable; CGR1 expression is down-regulated in the postd\niauxic growth phase\n Cond361:2.5mM_DTT_180_min_dtt-1\n mLHP1:Protein homologous to human La (SS-B) autoantigen,,Null muta\nnt is viable\n Cond367:dtt_240_min_dtt-2\n mYJR070C:Unknown ,, Unknown\n mEFB1:Translation elongation factor EF-1beta, GDP/GTP exchange fac\ntor for Tef1p/Tef2p,translation elongation factor EF-1beta, \nGDP/GTP exchange factor for Tef1p/Tef2p,Null mutant is invia\nble\n mTIF11:Translation initiation factor eIF1A,translation initiation f\nactor eIF1A,Null mutant is inviable\n mRPL7A:Homology to rat L7 and E. coli L30,ribosomal protein L7A (L6\nA) (rp11) (YL8),Null mutant is viable; grows more slowly tha\nn wild-type\n mYGL102C:Unknown ,, Unknown\n Cond879:MMC\n Cond313:Heat_Shock_030inutes__hs-2\n mRPL11A:Homology to rat L11 and E. coli L5,ribosomal protein L11A (L\n16A) (rp39A) (YL22),\n Stress.Heat1:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond481:WT+/-100mM3AT(SetB)(491)\n Stress.Heat2:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mANB1:hypusine containg protein; ANB1 is expressed under anaerobic\n conditions and repressed under aerobic conditions whereas i\nts homolog HYP2 is inversely regulated,translation initiatio\nn factor eIF-5A, anaerobically expressed form,null mutant is\n viable; a double mutant containing disruptions of both ANB1\n and and the highly homologous HYP2 is inviable\n Cond818:crz1/Na30'\n mRPS23B:Homology to rat S23 and E. coli S12,ribosomal protein S23B (\nS28B) (rp37) (YS14),Null mutant is viable, rps23a rps23b dou\nble deletion mutants are inviable. Mutations in different pa\nrts of RPS23 have opposite affects on translational accuracy\n or antibiotic sensitivity.\n Cond378:1M_sorbitol_-_15_min\n Cond427:YPD_stationary_phase_2_d_ypd-1\n mYLR435W:Unknown ,, Unknown\n gala.-gal:Integrated genomic and proteomic analyses of a systematicall\ny perturbed metabolic network. Science. 2001 May 4;292(5518\n):929-34.\n mRPL33B:Homology to rat L35a,ribosomal protein L33B (L37B) (rp47) (Y\nL37),Null mutant is viable.\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond443:DBYyap1_+_0.32_mM_H2O2_(20_min)\n mPRP43:Pre-mRNA processing factor involved in disassembly of splice\nosomes after the release of mature mRNA,RNA helicase,\n Cond374:1.5_mM_diamide_(50_min)\n Cond433:YPD_stationary_phase_28_d_ypd-1\n Cond959:t2_g/r_ratio\n Cond809:Na30'\n Calcin.Ca/Ca:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n Stress.ColdShock:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond942:SK1ume6_YPD\n Cond965:ndt80_delete_mid_g/r_ratio_\n mRPL8A:Homolgous to human L7a, mouse L7a, and rat L7a,ribosomal pro\ntein L8A (rp6) (YL5) (L4A),Null mutant is viable, rpl4A rpl4\nB double mutant is inviable; deficient in maintenance of kil\nler\n Cond366:dtt_120_min_dtt-2\n Cond881:4NQO\n Cond813:Na+FK30'\n Cond303:Heat_Shock_20_minutes_hs-1\n mKRI1:KRRI-Interacting protein 1,Krr1p binding protein,\n Cond639:DES460_+_0.02%_MMS_-_120_min\n Cond627:DY1457_(wild_type)_3_mM_vs._76_nM_zinc_y12-122\n Cond441:DBYmsn2/4_(real_strain)_+_0.32_mM_H2O2_(20_min)\n mTIF3:Suppressor of translation mutants,translation initiation fac\ntor eIF-4B,\n Cond438:DBYyap1_+_37degree_heat_(repeat)\n Cond652:wt_plus_gamma_20_min\n Stress.dshift:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond899:RPN4_MMS__\n Cond397:Nitrogen_Depletion_2_h\n mYOL124C:Unknown ,, Unknown\n Cond390:aa_starv_0.5_h\n Cond320:heat_shock_17_to_37,_20_minutes\n mSAM1:S-adenosylmethionine synthetase,,Null mutant is viable.\n Cond316:37C_to_25C_shock_-_30_min\n Cond305:Heat_Shock_40_minutes_hs-1\n Cond396:Nitrogen_Depletion_1_h\n Cond658:DES460_(wt)_-_mock_irradiation_-_5_min\n mNOP7:Required for normal pre-rRNA processing,,Null: lethal.\n Cond982:pho85D_10_mM_1NaPP1_\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts. Nat Genet\n. 2000 Dec;26(4):415-23.\n Cond887:t-BuOOH\n mBRX1:Essential nucleolar protein required for biogenesis of the 6\n0S ribosomal subunit,,inviable\n mTIF34:p39 subunit of translation initiation factor eIF3,translatio\nn initiation factor eIF3 p39 subunit,Null mutant is inviable\n mRPL13B:Homology to rat L13,ribosomal protein L13B,\n Cond363:dtt_015_min_dtt-2\n Cond337:constant_0.32_mM_H2O2_(30_min)_redo\n Cond941:SK1_YPD\n Cond782:Peroxide_40'\n mERG2:sterol biosynthesis,C-8 sterol isomerase,Null mutant is viab\nle\n mRPS18B:Homology to rat S18 and E. coli S13,ribosomal protein S18B,\n Stress.YPD:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond414:YPD_6_h_ypd-2\n mPRS1:ribose-phosphate pyrophosphokinase,ribose-phosphate pyrophos\nphokinase,\n Cond892:S\n Cond447:ethanol_vs._reference_pool_car-1\n Cond745: Cond967:swi1,_YPD_(c)\n Stress.YPDStat:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond463:29_deg_growth_ct-1\n mRPL2B:Homology to rat L8 and E. coli L2,ribosomal protein L2B (L5B\n) (rp8) (YL6),\n Cond323:heat_shock_29_to_37,_20_minutes\n GCN4.gcn4:Transcriptional profiling shows that Gcn4p is a master regul\nator of gene expression during amino acid starvation in yeas\nt. Mol Cell Biol. 2001 Jul;21(13):4347-68.\n Stress.DTT1:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond651:wt_plus_gamma_10_min\n Cond872:Zero1\n Cond940:6h\n Stress.DTT2:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mSQT1:Involved in a late step of 60S ribosomal subunit assembly or\n modification; contains multiple WD repeats; interacts with \nQsr1p,,Null mutant is inviable. Loss of SQT1 function by dow\nn regulation from an inducible promoter results in formation\n of half-mer polyribosomes and descreased levels of Qsr1p on\n free 60S subunits\n Cond426:YPD_stationary_phase_1_d_ypd-1\n Cond638:DES460_+_0.02%_MMS_-_90_min\n Cond437:DBYyap1-_37degree_heat_-_20_min_(redo)\n mRPL30:Homology to rat and mouse L30,ribosomal protein L30 (L32) (r\np73) (YL38) large subunit,Null mutant is inviable.\n mNOP58:57 kDa nucleolar protein involved in the pre-rRNA processing\n steps that lead to formation of 18 S rRNA; interacts with N\nop1p,57 kDa nucleolar protein,Null mutant is inviable; in vi\nvo depletion impairs synthesis of the 40S ribosomal subunit\n Cond934:8h\n Cond322:heat_shock_25_to_37,_20_minutes\n Cond961:t7_g/r_ratio\n Cond420:YPD_3_d_ypd-2\n Cond857:pm38-gtoe\n Cond893:SMMS\n mRPS19A:Homology to rat S19,ribosomal protein S19A (S16aA) (rp55A) (\nYS16A),\n Cond379:1M_sorbitol_-_30_min\n mRPL36A:Homology to rat L36,ribosomal protein L36A (L39) (YL39),\n Cond354:2.5mM_DTT_005_min_dtt-1\n mCBF5:major low affinity 55 kDa Centromere/microtubule binding pro\ntein,major low affinity 55 kDa centromere/microtubule bindin\ng protein,Null mutant is inviable\n mYEF3:contains two ABC cassettes, and binds and hydrolyses ATP,Tra\nnslation elongation factor 3 (EF-3),Null mutant is inviable\n mRRP5:Ribosomal RNA Processing,required for processing of pre-rRNA\n,Overexpression of RRP5 facilitates mitochondrial import of \nhydrophobic proteins; overexpression of an RRP5 mutant compl\nements the rRNA processing defect of the null alllele, but d\noes not facilitate mitochondrial import\n Stress.NitroDepl:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond317:37C_to_25C_shock_-_45_min\n RapamycinDip.dip_ram:Rapamycin-modulated transcription defines the subset of nutr\nient-sensitive signaling pathways directly controlled by the\n Tor proteins. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26)\n:14866-70.\n Cond434:DBY7286_37degree_heat_-_20_min\n UME6.ume6:The Ume6 regulon coordinates metabolic and meiotic gene expr\nession in yeast. Proc Natl Acad Sci U S A. 2002 Oct 15;99(2\n1):13431-6.\n Stress.H202:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond419:YPD_2_d_ypd-2\n Cond321:heat_shock_21_to_37,_20_minutes\n Cond431:YPD_stationary_phase_13_d_ypd-1\n Cond783:Peroxide_60'\n mPUS7:Unknown ,, Unknown\n Cond878:MNNG\n Cond895:G2MMS\n SwiSnf.swisnf:Whole-genome expression analysis of snf/swi mutants of Sacch\naromyces cerevisiae. Proc Natl Acad Sci U S A. 2000 Mar 28;\n97(7):3364-9.\n mPXR1:Unknown ,, Unknown\n mTHS1:Threonyl-tRNA synthetase, cytoplasmic,threonine-tRNA ligase,\n Cond882:zero3\n gala.+gal:Integrated genomic and proteomic analyses of a systematicall\ny perturbed metabolic network. Science. 2001 May 4;292(5518\n):929-34.\n Sporulation.Series0:The transcriptional program of sporulation in budding yeast.\n Science. 1998 Oct 23;282(5389):699-705.\n Cond640:DES459_(mec1-)_+_0.02%_MMS_-_5_min\n Cond875:60min\n Cond417:YPD_12_h_ypd-2\n Cond946:W303ume6_YPD\n Cond886:g-ray\n mYJL122W:Unknown ,, Unknown\n mRPS27A:Homology to mammalian S27,ribosomal protein S27A (rp61) (YS2\n0),\n Stress.Sorbitol:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond415:YPD_8_h_ypd-2\n Cond319:37C_to_25C_shock_-_90_min\n Cond685:wt-gal\n Cond811:Na60'\n Cond372:1.5_mM_diamide_(30_min)\n Cond876:zero2\n Calcin.crz1Na:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n Stress.tempgrow:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Stress.HeatVar:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond336:constant_0.32_mM_H2O2_(20_min)_redo\n Cond360:2.5mM_DTT_120_min_dtt-1\n Cond401:Nitrogen_Depletion_1_d\n mZUO1:Zuotin has region of DnaJ homology,zuotin, Z-DNA binding pro\ntein (putative),Null mutant has slow growth defect\n Cond885:20\n mYLL044W:Unknown ,, Unknown\n Cond411:diauxic_shift_timecourse_20.5_h\n Stress.Various:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mYPL142C:Unknown ,, Unknown\n Calcin.Na:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n Cond815:Na+FK60'\n Cond453:YP_ethanol_vs_reference_pool_car-2\n Cond968:swi1,_YPD_(d)\n Cond699:gal4-gal\n zap1.Series0:Genome-wide characterization of the Zap1p zinc-responsive re\ngulon in yeast. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14)\n:7957-62.\n Cond339:constant_0.32_mM_H2O2_(50_min)_redo\n COMP.TE:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Calcin.NaFK:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n mRPL16A:Homology to rat L13a,ribosomal protein L16A (L21A) (rp22) (Y\nL15),\n Cond421:YPD_5_d_ypd-2\n Y-Stre.Peroxide:Remodeling of yeast genome expression in response to environ\nmental changes. Mol Biol Cell. 2001 Feb;12(2):323-37.\n Cond858:pm71-30\n mRPS28B:Homology to mammalian S28,ribosomal protein S28B (S33B) (YS2\n7),\n mCDC33:Required for START A of cell cycle and sporulation,mRNA cap \nbinding protein eIF-4E,Null mutant is inviable. cdc33 mutant\ns arrest at G(sub)1. cdc33 has normal cAMP pools and is not \nsuppressed by cAPK mutants, suggesting sporulation is indepe\nndent of the cAMP pathway\n Cond428:YPD_stationary_phase_3_d_ypd-1\n Cond304:Heat_Shock_30_minutes_hs-1\n fkh1,2sf.Series0:Two yeast forkhead genes regulate the cell cycle and pseudoh\nyphal growth. Nature. 2000 Jul 6;406(6791):90-4.\n Stress.tempsteady:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond436:DBYmsn2/4_(real_strain)_+_37degrees_(20_min)\n Cond958:t0.5_g/r_ratio\n mNOP7 mRRP5 mCIC1 mNOP58 mPWP1 mBRX1
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Computational Genomics Lab, Tel-Aviv uniresity