Module number 1151




Database revision : gnsdb28.10
Date : Tue Feb 25 17:40:47 2003
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Cond626:DY1457_(wild_type)_3_mM_vs._61_nM_zinc_y13-121\n mSOF1:involved in rRNA processing,56 kDa nucleolar snRNP protein t\nhat shows homology to beta subunits of G-proteins and the sp\nlicing factor Prp4,Null mutant is inviable. sof1-56, a domin\nant suppressor of nop1 mutants can restore growth and pre-RN\nA processing at 35 degrees C. In vivo depletion of SOF1 lead\ns to impaired pre-rRNA processing and inhibition of 18S rRNA\n production.\n Cond399:Nitrogen_Depletion_8_h\n Cond432:YPD_stationary_phase_22_d_ypd-1\n Pho85.pho85:Chemical inhibition of the Pho85 cyclin-dependent kinase rev\neals a role in the environmental stress response. Proc Natl\n Acad Sci U S A. 2001 Oct 23;98(22):12578-83.\n Cond410:diauxic_shift_timecourse_18.5_h\n mFPR4:Homolog of homolog of the nucleolar FKBP, Fpr3,peptidyl-prol\nyl cis-trans isomerase (PPIase),Null mutant is viable\n mURA5:Fifth step in pyrimidine biosynthesis pathway,orotate phosph\noribosyltransferase 1,Null mutant is viable\n Cond675:MHY1_(dun1)_+_heat_20_min\n GCR1.gcr1:Understanding the growth phenotype of the yeast gcr1 mutant \nin terms of global genomic expression patterns. J Bacteriol\n. 2000 Sep;182(17):4970-8.\n Cond362:dtt_000_min__dtt-2\n mDED81:Asparaginyl-tRNA synthetase,asparaginyl-tRNA synthetase,\n Cond400:Nitrogen_Depletion_12_h\n mYGL245W:Unknown ,, Unknown\n Cond697:gal2-gal\n Stress.HypoOsmot:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mNUC1:mitochondrial nuclease,nuclease,Null mutant is viable\n Cond416:YPD_10_h__ypd-2\n Cond810:Na45'\n mDYS1:Deoxyhypusine synthase carries out the first step in hypusin\ne biosynthesis, converting lysine and spermidine into deoxyh\nypusine.,deoxyhypusine synthase,Null mutant is inviable\n Cond637:DES460_+_0.02%_MMS_-_60_min\n mPWP1:Protein with periodic trytophan residues that resembles memb\ners of beta-transducin superfamily because of presence of WD\n-40 repeats,,Null mutants are viable but show severely retar\nded growth\n Cond724:t4+SSD1,H44\n Cond435:DBYmsn2-4-_37degree_heat_-_20_min\n mYDR341C:Unknown ,, Unknown\n Cond310:Heat_Shock_000_minutes_hs-2\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond873:10min\n mRPP2A:Homology to rat P2, human P2, and E.coli L12eIB,60S acidic r\nibosomal protein P2A (L44) (A2) (YP2alpha),Null mutant is vi\nable\n Cond480:WT+/-100mM3AT(SetA)(R491)\n Cond429:YPD_stationary_phase_5_d_ypd-1\n Cond318:37C_to_25C_shock_-_60_min\n Cond718:t4+SSD1wt\n TorRama.Series0:Partitioning the transcriptional program induced by rapamyci\nn among the effectors of the Tor proteins. Curr Biol. 2000 D\nec 14-28;10(24):1574-81\n Cond404:Nitrogen_Depletion_5_d\n Cond312:Heat_Shock_015_minutes_hs-2\n mSSZ1:DnaK homolog, interacts with Zuo1p (DnaJ homolog) to form a \nribosome-associated complex (RAC) that is bound to the ribos\nome via the Zuo1p subunit,HSP70 family,Null mutant is viable\n, cold sensitive; SSZ1 overexpression causes increased expre\nssion of some PDR genes\n Cond693:gal7+gal\n Cond914:(99i2)_S150-2B_YPGL+G_NormInt\n Cond430:YPD_stationary_phase_7_d_ypd-1\n mCGR1:coiled-coil growth-regulated,coiled-coil protein,Null mutant\n is inviable; CGR1 expression is down-regulated in the postd\niauxic growth phase\n mYJR070C:Unknown ,, Unknown\n mRPL11B:Homology to rat L11 and E. coli L5; involved in protein synt\nhesis,ribosomal protein L11B (L16B) (rp39B) (YL22),Null muta\nnt is viable, rp111b rp111a mutants are inviable. rpl11 muta\nnts are deficient in 60S ribosomal subunits relative to 40S \nsubunits. 43S preinitiation complexes accumulate in half-mer\n polyribosomes in the absence of sufficient 60S subunits.\n mNOG2:Nuclear/Nucleolar GTP-binding protein 2,part of a pre-60S co\nmplex,Null: lethal. Other phenotypes: A gal1::nog2 mutant sh\nows 60S maturation defect in glucose repressive conditions.\n Cond427:YPD_stationary_phase_2_d_ypd-1\n mNCL1:Nuclear protein 1, similar to NOP2 and human proliferation a\nssociated nucleolar protein p120,tRNA:m5C-methyltransferase,\nNull mutant is viable, sensitive to paromomycin, lacks m5C m\nethylation in total yeast tRNA\n gala.-gal:Integrated genomic and proteomic analyses of a systematicall\ny perturbed metabolic network. Science. 2001 May 4;292(5518\n):929-34.\n Cond945:W303_YPD\n Cond443:DBYyap1_+_0.32_mM_H2O2_(20_min)\n mSIK1:homology to microtubule binding proteins and to X90565_5.cds\n,similar to microtubule binding proteins and to X90565_5.cds\n,wild-type gene suppresses toxicity of GAL4-I-Kappa-B alpha \nin yeast\n Cond714:t0+SSD1wt\n Stress.ColdShock:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mSXM1:Suppressor of mRNA export mutant; Importin-beta like gene,ka\nryopherin beta family member,Null mutant is viable, does not\n exhibit growth defects at any temperature examined or exhib\nit marked defects in tRNA processing\n Cond813:Na+FK30'\n Cond303:Heat_Shock_20_minutes_hs-1\n mRPL5:Homology to rat ribosomal protein L5; required for assembly \nof stable 60S ribosomal subunits,ribosomal protein L5 (L1a)(\nYL3),Null mutant is inviable.\n Cond636:DES460_+_0.2%_MMS_-_45_min\n Cond639:DES460_+_0.02%_MMS_-_120_min\n Cond627:DY1457_(wild_type)_3_mM_vs._76_nM_zinc_y12-122\n Cond441:DBYmsn2/4_(real_strain)_+_0.32_mM_H2O2_(20_min)\n Cond710:t2+SSD1\n Stress.dshift:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond390:aa_starv_0.5_h\n Cond320:heat_shock_17_to_37,_20_minutes\n Cond316:37C_to_25C_shock_-_30_min\n mHOM2:threonine and methionine pathway,aspartic beta semi-aldehyde\n dehydrogenase,Homoserine requiring\n Cond982:pho85D_10_mM_1NaPP1_\n Cond301:Heat_Shock_10_minutes_hs-1\n Cond711:t2+Vec\n Cond337:constant_0.32_mM_H2O2_(30_min)_redo\n mNEW1:This gene encodes a protein with an Q/N-rich amino terminal \ndomain that acts as a prion, termed [NU]+.,,Null mutant is v\niable\n mRPL25:Homology to E. coli L23 and rat L23a,ribosomal protein L25 (\nrpl6L) (YL25),\n mARO2:Chorismate synthase,chorismate synthase,aromatic amino acid \nrequiring; lack of premeiotic DNA synthesis; blocked sporula\ntion in homozygous mutant\n mERG4:Sterol C-24 reductase,sterol C-24 reductase,Null mutant is v\niable\n mPRS1:ribose-phosphate pyrophosphokinase,ribose-phosphate pyrophos\nphokinase,\n Cond745: mARO8:aromatic amino acid aminotransferase,aromatic amino acid ami\nnotransferase,Null mutant is viable\n Cond371:1.5_mM_diamide_(20_min)\n mYHR020W:Unknown ,, Unknown\n GCN4.gcn4:Transcriptional profiling shows that Gcn4p is a master regul\nator of gene expression during amino acid starvation in yeas\nt. Mol Cell Biol. 2001 Jul;21(13):4347-68.\n Stress.DTT1:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond651:wt_plus_gamma_10_min\n Stress.DTT2:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mSQT1:Involved in a late step of 60S ribosomal subunit assembly or\n modification; contains multiple WD repeats; interacts with \nQsr1p,,Null mutant is inviable. Loss of SQT1 function by dow\nn regulation from an inducible promoter results in formation\n of half-mer polyribosomes and descreased levels of Qsr1p on\n free 60S subunits\n Cond326:29C_to_33C_-_15_minutes\n mNRP1:asparagine-rich protein,,\n mYLR198C:Unknown ,, Unknown\n mHMT1:hnRNP methyltransferase,arginine methyltransferase , mono- a\nnd asymmetrically dimethylating enzyme , arginine methyltran\nsferase , mono- and asymmetrically dimethylating enzyme , ar\nginine methyltransferase , mono- and asymmetrically dimethyl\nating enzyme,Null mutant is viable, hmt1 npl3-1 mutants are \ninviable\n mMAK5:Necessary for maintenance of dsRNA killer plasmids. Is predi\ncted to encode an DEAD-box RNA helicase,,deficient in mainte\nnance of killer\n mRPL30:Homology to rat and mouse L30,ribosomal protein L30 (L32) (r\np73) (YL38) large subunit,Null mutant is inviable.\n mNOP58:57 kDa nucleolar protein involved in the pre-rRNA processing\n steps that lead to formation of 18 S rRNA; interacts with N\nop1p,57 kDa nucleolar protein,Null mutant is inviable; in vi\nvo depletion impairs synthesis of the 40S ribosomal subunit\n Cond857:pm38-gtoe\n mGLN1:glutamine synthetase,glutamine synthetase,Glutamine syntheta\nse non-derepressible\n mSUI3:beta subunit of translation initiation factor eIF-2,translat\nion initiation factor eIF-2 beta subunit,suppression of init\niator codon mutations\n mYEF3:contains two ABC cassettes, and binds and hydrolyses ATP,Tra\nnslation elongation factor 3 (EF-3),Null mutant is inviable\n mCBF5:major low affinity 55 kDa Centromere/microtubule binding pro\ntein,major low affinity 55 kDa centromere/microtubule bindin\ng protein,Null mutant is inviable\n Stress.NitroDepl:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond317:37C_to_25C_shock_-_45_min\n UME6.ume6:The Ume6 regulon coordinates metabolic and meiotic gene expr\nession in yeast. Proc Natl Acad Sci U S A. 2002 Oct 15;99(2\n1):13431-6.\n Cond717:t2-SSD1\n Y-Stre.Heat:Remodeling of yeast genome expression in response to environ\nmental changes. Mol Biol Cell. 2001 Feb;12(2):323-37.\n Cond419:YPD_2_d_ypd-2\n mKRS1:lysyl-tRNA synthetase,lysine-tRNA ligase,Null mutant is invi\nable; mutants can show resistance to 5-methyltryptophan, 5-f\nluorotryptophan and canavanine; constitutive derepression an\nd slow growth; posttranscriptional increase in histidine bio\nsynthetic enzyme activity\n Cond431:YPD_stationary_phase_13_d_ypd-1\n mPXR1:Unknown ,, Unknown\n Cond882:zero3\n gala.+gal:Integrated genomic and proteomic analyses of a systematicall\ny perturbed metabolic network. Science. 2001 May 4;292(5518\n):929-34.\n mUTP4:Unknown ,, Unknown\n mMIS1:mitochondrial C1-tetrahydroflate synthase,C1-tetrahydrofolat\ne synthase,Null mutant is viable, exhibits no apparent defec\nts in cell growth\n mYHM2:Yeast suppressor gene of HM mutant (abf2),DNA binding protei\nn , mtDNA stabilizing protein, mitochondrial inner membrane \nprotein with low homology to RIM2,Null mutant is viable but \nshows slow growth in the presence of non-fermentable carbon \nsources; mutant shows mitochondrial genome unstability\n mUTP9:Unknown ,, Unknown\n mASN2:Asn1p and Asn2p are isozymes,asparagine synthetase,Null muta\nnt is viable; L-asparagine auxotrophy occurs upon mutation o\nf both ASN1 and ASN2\n Cond403:Nitrogen_Depletion_3_d\n mDBP7:Dead-box protein,RNA helicase (putative),Null mutant is viab\nle but shows slow growth\n mDBP9:Dead-Box Protein 9,,Null mutant is inviable\n Cond811:Na60'\n Cond372:1.5_mM_diamide_(30_min)\n Stress.HeatVar:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond401:Nitrogen_Depletion_1_d\n mVMA5:42 kDa subunit of V1 sector,V1 sector hydrophilic subunit C \n, vacuolar ATPase V1 domain subunit C (42 kDa) , vacuolar H-\nATPase , V1 sector hydrophilic subunit C , vacuolar ATPase V\n1 domain subunit C (42 kDa) , vacuolar H-ATPase,Null mutant \nis viable; certain vma5 mutations show allele-specific synth\netic lethality with cdc24-ls mutants\n mRPL4B:Highly similar to ribosomal protein L4A,ribosomal protein L4\nB (L2B) (rp2) (YL2),\n mYER049W:Unknown ,, Unknown\n Calcin.Na:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n Cond815:Na+FK60'\n Cond453:YP_ethanol_vs_reference_pool_car-2\n mFRS1:Phenylalanyl-tRNA synthetase, alpha subunit, cytoplasmic,phe\nnylalanine-tRNA ligase subunit,\n mMTR4:Dead-box family helicase required for mRNA export from nucle\nus,RNA helicase,Null mutant is inviable; a temperature-sensi\ntive mtr4 mutant accumulates poly(A)+ RNA in the nucleus at \n37 degrees\n Calcin.NaFK:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n Y-Stre.Peroxide:Remodeling of yeast genome expression in response to environ\nmental changes. Mol Biol Cell. 2001 Feb;12(2):323-37.\n Cond980:F82G_10_mM_1NaPP1\n Cond304:Heat_Shock_30_minutes_hs-1\n Cond428:YPD_stationary_phase_3_d_ypd-1\n fkh1,2sf.Series0:Two yeast forkhead genes regulate the cell cycle and pseudoh\nyphal growth. Nature. 2000 Jul 6;406(6791):90-4.\n Cond958:t0.5_g/r_ratio\n Cond436:DBYmsn2/4_(real_strain)_+_37degrees_(20_min)\n Cond330:29C_+1M_sorbitol_to_33C_+_1M_sorbitol_-_15_minutes\n mGAR1:small nucleolar RNP proteins,small nucleolar RNP protein,Nul\nl mutant is inviable\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n mYBR266C:Unknown ,, Unknown\n mSSB2:stress-seventy subfamily B,SSB1 homolog , heat shock protein\n of HSP70 family,Null mutant is viable, ssb1 ssb2 double dis\nruption mutants exhibit poor growth at all temperatures, but\n particularly at low temperatures; as well as hypersensitivi\nty to certain protein synthesis inhibitors, including aminog\nlycosides such as hygromycin B\n Cond302:Heat_Shock_15_minutes_hs-1\n Cond418:YPD_1_d_ypd-2\n mRPS0A:Homology to rat Sa,ribosomal protein S0A,Null mutant is viab\nle; yst1 (rps0a) yst2 (rps0b) double deletion mutant is invi\nable; yst1 (rps0a) mutants are defective for filamentous gro\nwth\n Cond913:(99i3)_S150-2B_YPD_NormInt\n mUTR2:Product of gene unknown,,\n Stress.diamide:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mSDA1:Severe Depolymerization of Actin,,Null mutant is inviable; s\nda1-1 temperature-sensitive mutants arrest with defects in t\nhe organization of the actin cytoskeleton.\n Cond315:37C_to_25C_shock_-_15_min\n Cond467:steady_state_21_dec_C_ct-2\n mASP1:Asparaginase I, intracellular isozyme,asparaginase I , intra\ncellular isozyme,Aspartic acid requiring\n Cond674:DES459_(mec1)_+_heat_20_min\n Cond425:YPD_stationary_phase_12_h_ypd-1\n Stress.Carbon:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond911:(83i5)_S150-2B_YPD_NormInt\n mRPS29B:Homology to rat S29,ribosomal protein S29B (S36B) (YS29),\n Cond373:1.5_mM_diamide_(40_min)\n Cond445:Msn4_overexpression\n mDIM1:Dimethyladenosine transferase, (rRNA(adenine-N6,N6-)-dimethy\nltransferase),reponsible for m6[2]Am6[2]A dimethylation in 3\n'-terminal loop of 18S rRNA,dimethyladenosine transferase,Nu\nll mutant is inviable\n mRPS13:Homology to rat S13,ribosomal protein S13 (S27a) (YS15),\n mIPI3:Unknown ,, Unknown\n Cond814:Na+FK45'\n mRPL6B:Homology to rat and human L6; involved initiation of protein\n synthesis,ribosomal protein L6B (L17B) (rp18) (YL16),Null m\nutant is viable, grows slower than wild-type. rpl6a rpl6b do\nuble mutants are inviable; rpl6 mutants are deficient in 60S\n ribosomal subunits relative to 40S subunits; 43S preinitiat\nion complexes accumulate in half-mer polyribosomes in the ab\nsence of sufficient 60S subunits.\n mADO1:adenosine kinase,adenosine kinase,\n Stress.aa_starv:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mDPH2:Diptheria toxin resistance protein, required for diphthamide\n biosynthesis,,Null mutant is viable\n mNIP1:Protein required for nuclear import with some similarity to \nNsr1p, another protein involved in nuclear transport,,Null m\nutant is inviable; nip1-1 is a temperature-sensitive mutant \ndefective in nuclear transport\n Cond894:G2\n Cond395:Nitrogen_Depletion_30_min.\n Cond479:WT+/-100mM3AT(SetD)(R491)\n Cond306:Heat_Shock_60_minutes_hs-1\n Cond797:Ca15'\n Cond361:2.5mM_DTT_180_min_dtt-1\n Cond367:dtt_240_min_dtt-2\n mEFB1:Translation elongation factor EF-1beta, GDP/GTP exchange fac\ntor for Tef1p/Tef2p,translation elongation factor EF-1beta, \nGDP/GTP exchange factor for Tef1p/Tef2p,Null mutant is invia\nble\n mRPL7B:Homolog of mammalian ribosomal protein L7 and E. coli L30,ri\nbosomal protein L7B (L6B) (rp11) (YL8),Null mutant is viable\n; disruption of both RPL7A and RPL7B is lethal\n mYLR413W:Unknown ,, Unknown\n Cond313:Heat_Shock_030inutes__hs-2\n Stress.Heat1:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond708:t0+SSD1\n Stress.Heat2:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond481:WT+/-100mM3AT(SetB)(491)\n Cond378:1M_sorbitol_-_15_min\n mILV1:threonine deaminase,threonine deaminase,Isoleucine-plus-vali\nne requiring\n mRPC40:RNA polymerase III (C) subunit,RNA polymerase III subunit,Nu\nll mutant is inviable.\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond712:t4+SSD1\n mRPL26B:Homology to rat L26,ribosomal protein L26B (L33B) (YL33),\n mCYS4:Cystathionine beta-synthase,cystathionine beta-synthase,Null\n mutant is viable, exhibits vacuolar acidification defects; \ncys2 and cys4 mutations are linked together and co-operative\nly confer cysteine dependence\n mCDC60:cytosolic leucyl tRNA synthetase,leucine--tRNA ligase,arrest\n at START point of cell cycle upon shift to restrictive temp\nerature\n mPRP43:Pre-mRNA processing factor involved in disassembly of splice\nosomes after the release of mature mRNA,RNA helicase,\n Cond433:YPD_stationary_phase_28_d_ypd-1\n Cond374:1.5_mM_diamide_(50_min)\n Cond959:t2_g/r_ratio\n Cond809:Na30'\n Cond965:ndt80_delete_mid_g/r_ratio_\n mSUN4:Protein involved in the aging process,,\n mGCD11:Negative regulator of GCN4 expression,translational initiati\non factor eIF-2 gamma subunit,Null mutant is inviable, gcd11\n mutants have slower growth rate under nonstarvation conditi\nons\n mDRS1:ribosome assembly,ATP dependent RNA helicase (putative),Null\n mutant is inviable; cold sensitive mutant with a deficit of\n 60S ribosomal subunits\n Cond366:dtt_120_min_dtt-2\n mBAT1:branched-chain amino acid transaminase, highly similar to ma\nmmalian ECA39, which is regulated by the oncogene myc,branch\ned-chain amino acid transaminase , highly similar to mammali\nan ECA39, which is regulated by the oncogene myc , branched-\nchain amino acid transaminase , highly similar to mammalian \nECA39, which is regulated by the oncogene myc,Null mutant is\n viable; ILV auxotrophy in bat1 bat2 double mutant\n mYDR365C:Unknown ,, Unknown\n Calcin.Ca:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n mYTM1:microtubule-associated protein,microtubule-associated protei\nn,\n mLCB2:Involved in sphingolipid biosynthesis; may catalyze the firs\nt step in biosynthesis of long-chain sphingolipids,serine pa\nlmitoyltransferase component (putative),Auxotrophic for long\n-chain component of sphingolipids; some mutations can suppre\nss the Ca2+-sensitive mutant csg2\n Cond652:wt_plus_gamma_20_min\n mRRP12:Required for normal pre-rRNA processing,,Null: lethal.\n mYOL124C:Unknown ,, Unknown\n mNOP1:nucleolar protein, homologous to mammalian fibrillarin,nucle\nolar protein , similar to mammalian fibrillarin,Null mutant \nis inviable. Temperature-sensitive alleles exhibit various d\nefects in rRNA processing.\n mSAM1:S-adenosylmethionine synthetase,,Null mutant is viable.\n mNOP4:RNA recognition motif-containing protein,RNA binding protein\n (putative),Null mutant is inviable; conditional mutant show\ns diminished accumulation of 60S ribosomal subunits due to a\n lack of production of mature 25S rRNA from 27S precursor rR\nNA\n Cond396:Nitrogen_Depletion_1_h\n Cond305:Heat_Shock_40_minutes_hs-1\n Cond658:DES460_(wt)_-_mock_irradiation_-_5_min\n mNOP7:Required for normal pre-rRNA processing,,Null: lethal.\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts. Nat Genet\n. 2000 Dec;26(4):415-23.\n Cond363:dtt_015_min_dtt-2\n Cond782:Peroxide_40'\n mYNR046W:Unknown ,, Unknown\n Stress.YPD:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond414:YPD_6_h_ypd-2\n Cond386:Hypo-osmotic_shock_-_30_min\n Stress.YPDStat:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond323:heat_shock_29_to_37,_20_minutes\n Cond719:t4-SSD1\n mSNU13:RNA binding protein (putative), similar to Nhp2p,U4/U6.U5 sn\nRNP component,the null mutant is inviable\n Cond426:YPD_stationary_phase_1_d_ypd-1\n mEFT1:translation elongation factor 2 (EF-2),translation elongatio\nn factor 2 (EF-2),Null mutant is viable (eft1 eft2 double mu\ntant is lethal)\n mBCP1:Hypothetical ORF,,Null mutant is inviable\n Cond437:DBYyap1-_37degree_heat_-_20_min_(redo)\n Stress.WeakHeat:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond934:8h\n mCAF20:binds to eIF4E, the mRNA cap-binding protein, and represses \ncap-dependent translation initiation by interfering with the\n interaction of eIF4E and eIF4G,20 kDa subunit , mRNA cap bi\nnding protein eIF-4F , 20 kDa subunit , mRNA cap binding pro\ntein eIF-4F,Null mutant is viable and grows faster; deletion\n of CAF20 partially suppresses mutations in translation init\niation factors; overexpression of CAF20 causes slower growth\n and enhances translation mutation phenotypes\n Cond322:heat_shock_25_to_37,_20_minutes\n mGRS1:Glycyl-tRNA synthase,glycine-tRNA ligase,\n Cond420:YPD_3_d_ypd-2\n Cond709:t0+Vec\n Cond379:1M_sorbitol_-_30_min\n mRPL43B:Homology to human L37a,ribosomal protein L43B,\n mRRP1:involved in processing rRNA precursor species to mature rRNA\ns,,Null mutant is inviable, cannot be suppressed by srd1 mut\nations. rrp1-1 mutations are associated with temperature-sen\nsitive growth, a conditional defect in processing of 27S pre\n-rRNA to mature 25S rRNA, and a nonconditional increase in s\nensitivity to several aminoglycoside antibiotics. srd1 is an\n allele-specific suppressor of rrp1-1.\n Cond758:Heat_0'_(A)\n mRRP5:Ribosomal RNA Processing,required for processing of pre-rRNA\n,Overexpression of RRP5 facilitates mitochondrial import of \nhydrophobic proteins; overexpression of an RRP5 mutant compl\nements the rRNA processing defect of the null alllele, but d\noes not facilitate mitochondrial import\n Stress.HeatSorbitol:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond434:DBY7286_37degree_heat_-_20_min\n mRRP8:Hypothetical ORF,nucleolar protein required for efficient pr\nocessing of pre-rRNA at site A2; methyltransferase homolog,i\nmpaired growth at lower temperatures (19 to 130C) , defect i\nn pre-rRNA processing at site A2, synthetically lethal with \nmutants alleles of GAR1\n Stress.H202:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond321:heat_shock_21_to_37,_20_minutes\n Cond783:Peroxide_60'\n mARX1:Unknown ,, Unknown\n mPUS7:Unknown ,, Unknown\n mFUN12:Function unknown now,97 kDa protein,Null mutant is inviable\n mTHS1:Threonyl-tRNA synthetase, cytoplasmic,threonine-tRNA ligase,\n Sporulation.Series0:The transcriptional program of sporulation in budding yeast.\n Science. 1998 Oct 23;282(5389):699-705.\n mSTT3:Required for protein glycosylation,integral ER membrane prot\nein , oligosaccharyltransferase complex subunit (putative),N\null mutant is inviable. sst3 mutants are defective in protei\nn glycosylation, sensitive to hygromycin B, and resistant to\n sodium orthovanadate. Depletion of the STT3 protein results\n in loss of oligosaccharyl transferase activity in vivo and \na deficiency in the assembly of oligosaccharyl transferase c\nomplex.\n Cond417:YPD_12_h_ypd-2\n Cond946:W303ume6_YPD\n mYJL122W:Unknown ,, Unknown\n Stress.Sorbitol:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond415:YPD_8_h_ypd-2\n Cond319:37C_to_25C_shock_-_90_min\n mSPB1:Suppressor of PaB1 mutant; involved in 60S ribosomal subunit\n biogenesis,methyltransferase (putative),Null mutant is invi\nable. The spb1-1 mutant is an extragenic suppressor of a pab\n1 null mutation.\n Cond402:Nitrogen_Depletion_2_d\n mSES1:seryl-tRNA synthetase,serine-tRNA ligase,Null mutant is invi\nable.\n Cond723:t2-SSD1,M31\n mRPC82:82-kDa subunit of RNA polymerase III (C),82 kDa subunit of R\nNA polymerase III (C),Null mutant is inviable\n mPHO88:May be a membrane protein involved in inorganic phosphate tr\nansport and regulation of Pho81p function,,Null mutant is vi\nable; pho88 pho86 double mutant shows enhanced synthesis of \nrepressible acid phosphatase in high phosphate media and ars\nenate resistance; disruption or high dosage of PHO88 results\n in reduced phosphate intake\n Cond876:zero2\n Cond360:2.5mM_DTT_120_min_dtt-1\n mYLL044W:Unknown ,, Unknown\n mROK1:contains domains found in the DEAD protein family of ATP-dep\nendent RNA helicases; high-copy suppressor of kem1 null muta\nnt,,Null mutant is inviable\n mGCD1:general control of amino acid biosynthesis and cell cycle in\nitiation,gamma subunit , negative regulator in the general c\nontrol of amino acid biosynthesis , translation initiation f\nactor eIF2B subunit,affect growth rate under nonstarvation c\nonditions\n Cond411:diauxic_shift_timecourse_20.5_h\n Stress.Various:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mBMS1:BMH1 sensitive,,Null mutant is inviable; a temperature-sensi\ntive allele exhibits a synthetic growth defect with bmh1-del\nta; the temperature-sensitive allele also exhibits diploid s\npecific bud site randomization at the semi-permissive temper\nature\n zap1.Series0:Genome-wide characterization of the Zap1p zinc-responsive re\ngulon in yeast. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14)\n:7957-62.\n mEMP70:identified as a 24 kDa cleavage product in endosome-enriched\n membrane fractions,,\n Cond421:YPD_5_d_ypd-2\n Cond858:pm71-30\n Stress.tempsteady:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mSPB1 mNOP7 mNOP1 mSOF1 mSIK1 mNOP58 mRRP1 mRRP5 mYTM1 mCBF5 mSXM1 mRPL25 mGCD11 mGCD1 mRPC40 mYGL245W mCDC60 mRPC82
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Computational Genomics Lab, Tel-Aviv uniresity