Module number 1130




Database revision : gnsdb28.10
Date : Tue Feb 25 17:37:41 2003
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mRPT4:Proteasome Cap Subunit,26S proteasome cap subunit component \n, ATPase , 26S proteasome cap subunit component , ATPase , 2\n6S proteasome cap subunit component , ATPase,Null mutant is \ninviable; ts mutant strain arrests as large-budded cells aft\ner 1, 2, 3 divisions with a G2 content of DNA and a monopola\nr spindle; unduplicated spindle pole body is enlarged as in \nother monopolar mutants; they also fail to arrest at G1 when\n starved for a single amino acid (but do arrest at G1 when d\neprived of all nitrogen), are resistant to cyclohexamide, an\nd are hypersensitive to amino acid analogs, hygromycin B and\n 3-aminotriazole\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n Cond907:(83i1)_S150-2B_YPGL_NormInt\n mSET5:,,\n mYNL047C:Unknown ,, Unknown\n mIKS1:ira1* kinase suppressor,serine/threonine kinase (putative),N\null mutant is heat shock sensitive\n mYJL149W:Unknown ,, Unknown\n mGYP7:GTPase-activating protein,GTPase activating protein (GAP),Nu\nll mutant is viable\n mGYP8:Unknown ,, Unknown\n GCR1.gcr1:Understanding the growth phenotype of the yeast gcr1 mutant \nin terms of global genomic expression patterns. J Bacteriol\n. 2000 Sep;182(17):4970-8.\n mEMP47:47 kDa type I transmembrane protein localized to the Golgi,4\n7 kDa type I transmembrane protein localized to the Golgi,Nu\nll mutant is viable\n mRLF2:Chromatin Assembly Complex, subunit 1: largest (p90) subunit\n of three-subunit protein complex (yeast CAF-I) involved in \nDNA-replication-linked nucleosome assembly. Homol. to p150 s\nubunit human Chromatin Assembly Factor-I (CAF-I),chromatin a\nssembly factor-I (CAF-I) p90 subunit,Null mutant is viable, \nsensitive to UV radiation. Rap1 localization is disrupted an\nd silencing of genes adjacent to telomeric DNA is decreased \nin rfl2 mutants.\n Cond892:S\n Cond883:5\n mYJL103C:Unknown ,, Unknown\n Cond898:RPN4\n Cond890:G1\n mYNR029C:Unknown ,, Unknown\n Cond872:Zero1\n mOCA1:Unknown ,, Unknown\n Cond889:4NQO_2\n mYFR016C:Unknown ,, Unknown\n mYDR003W:Unknown ,, Unknown\n mNUP84:component of nuclear pores; Part of complex with Nup120p, Nu\np85p, Sec13p, and a Sec13p homolog,similar to mammalian Nup1\n07p,Null mutant is viable but has defects in nuclear membran\ne and nuclear pore complex organization and in poly(A)+ RNA \ntransport\n Cond873:10min\n mSHE2:Required for mother cell-specific HO expression,,Null mutant\n is viable\n mASI2:Amino acid Sensor-Independent (ASI) genes encode membrane pr\noteins Asi1p, Asi2p and Asi3p.,,\n mHYS2:Putative role in DNA replication,DNA polymerase delta 55 kDa\n subunit,Null mutant is inviable\n Cond897:STATMMS\n Cond894:G2\n mRMS1:Transcription regulator,,null mutant is viable with no appar\nent defects\n mYDR330W:Unknown ,, Unknown\n Cond893:SMMS\n mYAF9:Yeast homolog of the human leukemogenic protein AF9; member \nof a large protein complex,,Null mutant is viable\n mYHR029C:Unknown ,, Unknown\n mTRP1:Note that the sequence of TRP1 from strain S228C, which is t\nhe sequence stored in SGD, contains an ochre mutation at cod\non 67.,N-(5'-phosphoribosyl)-anthranilate isomerase,tryptoph\nan requiring\n mCWC15:Unknown ,, Unknown\n mDAK1:putative dihydroxyacetone kinase,dihydroxyacetone kinase (pu\ntative),Null mutant is viable and shows no growth defect in \nnormal medium; mutant lacking both dak1 and dak2 is sensitiv\ne to dihydroxyacetone during saline growth\n mGCR2:activates transcription of glycolytic genes; homologous to G\nCR1; may function in complex with Gcr1p,transcription factor\n,Null mutant is viable and has partial growth defect on gluc\nose-containing media\n mENT5:Unknown ,, Unknown\n Cond895:G2MMS\n mUGA3:Transcriptional activator necessary for gamma-aminobutyrate \n(GABA)-dependent induction of GABA genes (such as UGA1, UGA2\n, UGA4),zinc finger transcription factor of the Zn(2)-Cys(6)\n binuclear cluster domain type,Null mutant is viable but exh\nibits defects in activation of UGA1 and UGA4.\n mYLR199C:Unknown ,, Unknown\n mRUD3:Relieves uso1-1 transport defect; golgin-160 related protein\n,,Null mutant shows severe growth defect or inviability in c\nombination with many ER-to-Golgi transport mutants, such as \nuso1-1, sec34, sec35-1, sec22-3, and bos1-1. Overproduction \nsuppresses mutations in many of the same genes.\n Cond877:MMS\n Cond886:g-ray\n mYKL195W:Unknown ,, Unknown\n mYNL136W:Unknown ,, Unknown\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mGTR1:Involved in the function of the Pho84 phosphate transporter,\nsmall GTPase (putative),Null mutant is viable but grows slow\nly, is cold-sensitive, and has defects in phosphate uptake\n mYMR087W:Unknown ,, Unknown\n mYJL144W:Unknown ,, Unknown\n Cond876:zero2\n mFSH3:Unknown ,, Unknown\n mSYF2:SYnthetic lethal with cdcForty,,Null is viable\n Cond885:20\n mYIL137C:Unknown ,, Unknown\n Cond891:G1MMS\n mVPS4:Defective in vacuolar protein sorting; homologous to mouse S\nKD1 and to human hVPS4,AAA ATPase,Null mutant is viable, exh\nibits protein sorting and morphological defects\n Cond881:4NQO\n mYOL032W:Unknown ,, Unknown\n mIOC3:Iswi One Complex,,\n mPNG1:de-N-glycosylation enzyme,peptide:N-glycanase,Null mutant is\n viable and shows no growth or viability defect under experi\nmental conditions\n mPRP12:Integral membrane mitochondrial protein,integral membrane pr\notein,Null mutant is viable but shows increased rate of DNA \nescape from mitochondria to the nucleus and, in some strains\n, shows a growth defect on nonfermentable carbon sources; rn\na12-1 is a dominant, thermosensitive allele that results in \ndefects in RNA maturation at the restrictive temperature; ym\ne1 cold sensitivity is suppressed by prp1; yme1 prp12 double\n mutant has synthetic growth defect on ethanol-glycerol medi\num at 30 degrees\n mPTP1:phosphotyrosine-specific protein phosphatase,phosphotyrosine\n-specific protein phosphatase,viable\n mTGL1:triglyceride lipase-cholesterol esterase,cholesterol esteras\ne , triglyceride lipase,\n mVPS35:Protein involved in vacuolar sorting,retromer complex compon\nent,Null mutant is viable, exhibits defects in sorting of va\ncuolar carboxypeptidase Y, proteinase A, proteinase B, and a\nlkaline phosphatase\n Cond884:10\n
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Computational Genomics Lab, Tel-Aviv uniresity