Module number 1125




Database revision : gnsdb28.10
Date : Tue Feb 25 17:36:38 2003
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mYNL010W:Unknown ,, Unknown\n Cond912:(99i1)_S150-2B_YPGL_NormInt\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n Cond399:Nitrogen_Depletion_8_h\n Cond432:YPD_stationary_phase_22_d_ypd-1\n mYPR044C:Unknown ,, Unknown\n Cond418:YPD_1_d_ypd-2\n Cond675:MHY1_(dun1)_+_heat_20_min\n mURA5:Fifth step in pyrimidine biosynthesis pathway,orotate phosph\noribosyltransferase 1,Null mutant is viable\n mTIR3:TIP1-related,cell wall mannoprotein,inviable under unaerobic\n conditions\n GCR1.gcr1:Understanding the growth phenotype of the yeast gcr1 mutant \nin terms of global genomic expression patterns. J Bacteriol\n. 2000 Sep;182(17):4970-8.\n Cond362:dtt_000_min__dtt-2\n mAAH1:adenine aminohydrolase (adenine deaminase),adenine aminohydr\nolase (adenine deaminase),Null mutant is viable\n mYHR133C:Unknown ,, Unknown\n Cond883:5\n Cond425:YPD_stationary_phase_12_h_ypd-1\n Cond810:Na45'\n mCYB5:cytochrome b5,cytochrome b5,Null mutant is viable, cyb5 muta\ntions suppress ketoconazole hypersensitivity of a P450 reduc\ntase deficient strain\n Stress.Carbon:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mRPB8:16-kDa RNA polymerase subunit (common to polymerases I, II a\nnd III),16 kDa RNA polymerase subunit (common to polymerases\n I, II and III),Null mutant is inviable\n Cond454:YP_fructose_vs_reference_pool_car-2\n Cond890:G1\n mNOP13:Nucleolar Protein 13,,\n mHNM1:choline transport protein; may also control uptake of nitrog\nen mustard,transporter (permease) for choline and nitrogen m\nustard; share homology with UGA4,Null mutant is viable, but \nhyper-resistant to nitrogen mustard; ctr1,cho1 double null i\ns inviable\n Cond391:aa_starv_1_h\n mYNR021W:Unknown ,, Unknown\n Cond713:t4+Vec\n Cond435:DBYmsn2-4-_37degree_heat_-_20_min\n Cond814:Na+FK45'\n Cond310:Heat_Shock_000_minutes_hs-2\n mYPL245W:Unknown ,, Unknown\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond873:10min\n mRPA12:A12.2 subunit of RNA polymerase I,RNA polymerase I A12.2 sub\nunit,Null mutant is viable but is temperature sensitive; syn\nthetically lethal with RPA14\n Stress.aa_starv:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond429:YPD_stationary_phase_5_d_ypd-1\n Cond318:37C_to_25C_shock_-_60_min\n Cond888:MNNG_2\n Cond894:G2\n mMRPL44:Mitochondrial ribosomal protein MRPL44 (YmL44),ribosomal pro\ntein (YmL44),\n Cond395:Nitrogen_Depletion_30_min.\n mALG8:adds glucose to the dolichol-linked oligosaccharide precurso\nr prior to transfer to protein,glycosyl transferase,Null mut\nant is viable, secretes under-glycosylated proteins\n mRPL18B:Homology to rat ribosomal protein L18,ribosomal protein L18B\n (rp28B),\n Cond479:WT+/-100mM3AT(SetD)(R491)\n Cond306:Heat_Shock_60_minutes_hs-1\n Cond430:YPD_stationary_phase_7_d_ypd-1\n mYOL092W:Unknown ,, Unknown\n mLHP1:Protein homologous to human La (SS-B) autoantigen,,Null muta\nnt is viable\n Cond879:MMC\n mYLR413W:Unknown ,, Unknown\n Stress.Heat1:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond481:WT+/-100mM3AT(SetB)(491)\n Stress.Heat2:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mANB1:hypusine containg protein; ANB1 is expressed under anaerobic\n conditions and repressed under aerobic conditions whereas i\nts homolog HYP2 is inversely regulated,translation initiatio\nn factor eIF-5A, anaerobically expressed form,null mutant is\n viable; a double mutant containing disruptions of both ANB1\n and and the highly homologous HYP2 is inviable\n Cond818:crz1/Na30'\n mPAU7:similar to Pau3, member of Pau1 family,,\n Cond427:YPD_stationary_phase_2_d_ypd-1\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond433:YPD_stationary_phase_28_d_ypd-1\n mRPS31:Homology to rat S27a,ribosomal protein S31 (S37) (YS24),Null\n mutant is viable\n Cond809:Na30'\n Stress.ColdShock:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond965:ndt80_delete_mid_g/r_ratio_\n Cond891:G1MMS\n Cond905:(77i4)_S150-2B_YPGL+G__NormInt\n mYGR106C:Unknown ,, Unknown\n Cond881:4NQO\n Cond303:Heat_Shock_20_minutes_hs-1\n Cond813:Na+FK30'\n mRPA34:RNA polymerase I subunit, not shared (A34.5),,Null mutant is\n viable but its RNA polymerase I lacks subunit A49 (rpa49p);\n synthetically lethal with RPA14; shows synthetic interactio\nns with DNA topoisomerase I (TPO1)\n mTIF6:similar to human translation initiation factor 6 (eIF6); how\never, TIF6 does not act as a true translation initiation fac\ntor.The protein may be involved in the biogenesis and or sta\nbility of the 60S ribosomal subunits,,Null mutant is inviabl\ne; cells are depleted of 60S ribosomal subunits, translation\n initiation is inhibited, and cells arrest in G1\n Cond438:DBYyap1_+_37degree_heat_(repeat)\n mRPL1B:Homology to rat L10a, eubacterial L1, and archaebacterial L1\n; identical to S. cerevisiae L1A (Ssm1p),ribosomal protein L\n1B,\n Stress.dshift:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond899:RPN4_MMS__\n Cond390:aa_starv_0.5_h\n Cond316:37C_to_25C_shock_-_30_min\n Cond396:Nitrogen_Depletion_1_h\n Cond305:Heat_Shock_40_minutes_hs-1\n Cond887:t-BuOOH\n mBRX1:Essential nucleolar protein required for biogenesis of the 6\n0S ribosomal subunit,,inviable\n mRAS1:ras proto-oncogene homolog,ras homolog,\n mRPL13B:Homology to rat L13,ribosomal protein L13B,\n Cond337:constant_0.32_mM_H2O2_(30_min)_redo\n Cond941:SK1_YPD\n mRPS25B:Homology to rat S25; belongs to the S25E family of ribosomal\n proteins,ribosomal protein S25B (S31B) (rp45) (YS23),\n mERG2:sterol biosynthesis,C-8 sterol isomerase,Null mutant is viab\nle\n Stress.YPD:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mYJR116W:Unknown ,, Unknown\n Cond414:YPD_6_h_ypd-2\n Cond892:S\n mPRS5:Phosphoribosylpyrophosphate synthetase (ribose-phosphate pyr\nophosphokinase),phosphoribosylpyrophosphate synthetase (ribo\nse-phosphate pyrophosphokinase),Null mutant is viable but re\nduces the cellular 5-phosphoribosyl-1(alpha)-pyrophosphate s\nynthetase activity by 84%. prs5 mutations are synthetically \nlethal with mutations in prs1 or prs3.\n Stress.YPDStat:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n GCN4.gcn4:Transcriptional profiling shows that Gcn4p is a master regul\nator of gene expression during amino acid starvation in yeas\nt. Mol Cell Biol. 2001 Jul;21(13):4347-68.\n Cond323:heat_shock_29_to_37,_20_minutes\n Cond872:Zero1\n Stress.DTT2:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond889:4NQO_2\n mEFT1:translation elongation factor 2 (EF-2),translation elongatio\nn factor 2 (EF-2),Null mutant is viable (eft1 eft2 double mu\ntant is lethal)\n mGOT1:Golgi Transport,membrane protein,Null mutant is viable but e\nxhibits ER to Golgi transport defects in vitro. got1 is synt\nhetically lethal with mutations in sft2; the got1 sft2 doubl\ne mutant exhibits defects in transport to the Golgi complex.\n Cond437:DBYyap1-_37degree_heat_-_20_min_(redo)\n mRPL21B:Homology to rat L21,ribosomal protein L21B,\n Cond322:heat_shock_25_to_37,_20_minutes\n mYOL002C:Unknown ,, Unknown\n Cond459:YP_sucrose_vs_reference_pool_car-2\n mRPL38:Homology to rat L38,ribosomal protein L38,\n Cond893:SMMS\n Cond466:steady_state_17_dec_C_ct-2\n mTOM7:Involved in mitochondrial protein import,translocase of the \nouter mitochondrial membrane,Null mutant is viable\n Stress.NitroDepl:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n UME6.ume6:The Ume6 regulon coordinates metabolic and meiotic gene expr\nession in yeast. Proc Natl Acad Sci U S A. 2002 Oct 15;99(2\n1):13431-6.\n Stress.H202:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond419:YPD_2_d_ypd-2\n Cond321:heat_shock_21_to_37,_20_minutes\n Cond878:MNNG\n Cond895:G2MMS\n mYIL121W:Unknown ,, Unknown\n Cond882:zero3\n Cond877:MMS\n Sporulation.Series0:The transcriptional program of sporulation in budding yeast.\n Science. 1998 Oct 23;282(5389):699-705.\n mPMT4:Transfers mannose residues from dolichyl phosphate-D-mannose\n to specific serine/threonine residues of proteins in the se\ncretory pathway,dolichyl phosphate-D-mannose:protein O-D-man\nnosyltransferase,Null mutant is viable but shows under glyco\nsylation of chitinase; pmt2 pmt3 pmt4 triple mutant is invia\nble\n Cond875:60min\n Cond417:YPD_12_h_ypd-2\n Cond886:g-ray\n mHPT1:enzyme involved in de novo purine biosynthesis,hypoxanthine \nguanine phosphoribosyltransferase,Null mutant is viable; mut\nants show resistance to 8-azaguanine\n mYJL122W:Unknown ,, Unknown\n mRPS27A:Homology to mammalian S27,ribosomal protein S27A (rp61) (YS2\n0),\n Cond403:Nitrogen_Depletion_3_d\n Cond319:37C_to_25C_shock_-_90_min\n Cond402:Nitrogen_Depletion_2_d\n Cond811:Na60'\n mUTP19:Unknown ,, Unknown\n Cond876:zero2\n Calcin.crz1Na:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n Stress.HeatVar:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mYIL158W:Unknown ,, Unknown\n Cond885:20\n Cond411:diauxic_shift_timecourse_20.5_h\n Stress.Various:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mEGD1:beta subunit of the nascent-polypeptide-associated complex (\nNAC); homologous to human BTF3b; GAL4 enhancer protein,pol I\nI transcribed genes regulator,Null mutant is viable; reduced\n induction of galactose-regulated genes upon shift from gluc\nose to galactose\n Calcin.Na:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n Cond815:Na+FK60'\n Calcin.NaFK:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n Cond428:YPD_stationary_phase_3_d_ypd-1\n Cond304:Heat_Shock_30_minutes_hs-1\n mSCW10:Soluble Cell Wall protein,soluble cell wall protein,Null mut\nant is viable.\n Stress.tempsteady:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond884:10\n Cond436:DBYmsn2/4_(real_strain)_+_37degrees_(20_min)\n
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Computational Genomics Lab, Tel-Aviv uniresity