Module number 1108




Database revision : gnsdb28.10
Date : Tue Feb 25 17:34:00 2003
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Cond626:DY1457_(wild_type)_3_mM_vs._61_nM_zinc_y13-121\n Cond399:Nitrogen_Depletion_8_h\n mTKL1:Transketolase 1,transketolase 1,Null mutant is viable; growt\nh on fermentable carbon sources, but not gluconeogenic carbo\nn sources, is reduced; tkl1 tkl2 mutants are auxotrophic for\n aromatic amino acids\n Cond432:YPD_stationary_phase_22_d_ypd-1\n mURA1:dihydroorotate dehydrogenase,dihydroorotate dehydrogenase,ur\nacil requiring\n Cond410:diauxic_shift_timecourse_18.5_h\n mFPR4:Homolog of homolog of the nucleolar FKBP, Fpr3,peptidyl-prol\nyl cis-trans isomerase (PPIase),Null mutant is viable\n mURA5:Fifth step in pyrimidine biosynthesis pathway,orotate phosph\noribosyltransferase 1,Null mutant is viable\n mFET3:FET3 encodes a ferro-O2-oxidoreductase that is part of the h\nigh-affinity iron transport system,multicopper oxidase,The n\null mutant is viable but defective for high affinity Fe(II) \nuptake. The null mutant is inviable when environmental iron \nis limiting.\n mSEC31:involved in protein transport from endoplasmic reticulum to \nGolgi,COPII coat of secretory pathway vesicles component (p1\n50),Null mutant is inviable\n Cond675:MHY1_(dun1)_+_heat_20_min\n GCR1.gcr1:Understanding the growth phenotype of the yeast gcr1 mutant \nin terms of global genomic expression patterns. J Bacteriol\n. 2000 Sep;182(17):4970-8.\n Cond362:dtt_000_min__dtt-2\n mDED81:Asparaginyl-tRNA synthetase,asparaginyl-tRNA synthetase,\n Cond400:Nitrogen_Depletion_12_h\n mYGL245W:Unknown ,, Unknown\n Cond416:YPD_10_h__ypd-2\n Cond810:Na45'\n mNOP13:Nucleolar Protein 13,,\n mPWP1:Protein with periodic trytophan residues that resembles memb\ners of beta-transducin superfamily because of presence of WD\n-40 repeats,,Null mutants are viable but show severely retar\nded growth\n Cond724:t4+SSD1,H44\n mYNR021W:Unknown ,, Unknown\n Cond435:DBYmsn2-4-_37degree_heat_-_20_min\n Cond310:Heat_Shock_000_minutes_hs-2\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond873:10min\n mRPP2A:Homology to rat P2, human P2, and E.coli L12eIB,60S acidic r\nibosomal protein P2A (L44) (A2) (YP2alpha),Null mutant is vi\nable\n Cond480:WT+/-100mM3AT(SetA)(R491)\n Cond429:YPD_stationary_phase_5_d_ypd-1\n Cond318:37C_to_25C_shock_-_60_min\n mCWP1:cell wall protein, involved in O and N glycosylation, accept\nor of B1-6 glucan.,cell wall mannoprotein,Null mutant is via\nble, has increased sensitivities to calcoflour white and con\ngo red\n mRPS22B:Homology to rat S15a,ribosomal protein S22B (S24B) (rp50) (Y\nS22),\n Cond718:t4+SSD1wt\n mRNA1:Protein involved in RNA processing and export from nucleus,G\nTPase activating protein (GAP) for Gsp1p,inviable, RNA synth\nesis defective\n Cond312:Heat_Shock_015_minutes_hs-2\n Cond404:Nitrogen_Depletion_5_d\n TorRama.Series0:Partitioning the transcriptional program induced by rapamyci\nn among the effectors of the Tor proteins. Curr Biol. 2000 D\nec 14-28;10(24):1574-81\n mFKS1:Required for viability of calcineurin mutants,1,3-beta-D-glu\ncan synthase,Null mutant is viable, demonstrates slow growth\n, hypersensitivity to FK506 and cyclosporin A, sensitivity t\no echinocandin and a reduction in 1,3-beta-D-glucan synthase\n activity in vitro; sensitivity to papulacandin B\n Cond693:gal7+gal\n Cond849:120_min\n Cond430:YPD_stationary_phase_7_d_ypd-1\n mRPS9B:Homology to rat S9 and E. coli S4,ribosomal protein S9B (S13\n) (rp21) (YS11),Suppression of nonsense mutations\n mGDS1:involved in nuclear control of mitochondria,,Null mutant is \nviable, shows partial impairment of growth on medium contain\ning glycerol as the carbon source. Overexpxression suppresse\ns NAM9-1 glycerol deficient phenotype\n mRPL11A:Homology to rat L11 and E. coli L5,ribosomal protein L11A (L\n16A) (rp39A) (YL22),\n Cond427:YPD_stationary_phase_2_d_ypd-1\n mRPS16A:Homology to rat S16,ribosomal protein S16A (rp61R),\n gala.-gal:Integrated genomic and proteomic analyses of a systematicall\ny perturbed metabolic network. Science. 2001 May 4;292(5518\n):929-34.\n mSIK1:homology to microtubule binding proteins and to X90565_5.cds\n,similar to microtubule binding proteins and to X90565_5.cds\n,wild-type gene suppresses toxicity of GAL4-I-Kappa-B alpha \nin yeast\n mFAS1:pentafunctional enzyme consisting of the following domains :\n acetyl transferase, enoyl reductase, dehydratase and malony\nl/palmityl transferase,acetyl transferase , dehydratase , en\noyl reductase , malonyl/palmityl transferase , pentafunction\nal enzyme,Null mutant is viable\n mFAS2:Trifunctional enzyme,fatty acid synthase alpha subunit,Fatty\n acid synthetase deficient\n mHEK2:Unknown ,, Unknown\n Cond714:t0+SSD1wt\n Stress.ColdShock:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond881:4NQO\n mRPL3:Homology to rat L3,ribosomal protein L3 (rp1) (YL1),Tricoder\nmin resistance\n Cond303:Heat_Shock_20_minutes_hs-1\n mRPL5:Homology to rat ribosomal protein L5; required for assembly \nof stable 60S ribosomal subunits,ribosomal protein L5 (L1a)(\nYL3),Null mutant is inviable.\n mRPS24A:Homology to rat S24,ribosomal protein S24A,\n Cond627:DY1457_(wild_type)_3_mM_vs._76_nM_zinc_y12-122\n mRPS17A:Homology to rat S17,ribosomal protein S17A (rp51A),Null muta\nnt is viable and grows slowly; rps17A rps17B double null mut\nant is inviable\n mTIF1:translation initiation factor eIF4A,translation initiation f\nactor eIF4A subunit,viable, tif1tif2 double mutant is lethal\n mTIF5:Translation initiation factor eIF-5,translation initiation f\nactor eIF-5,\n mGUA1:GMP synthase,GMP synthase,Null mutant is viable but is a gua\nnine auxotroph\n mAPT1:Adenine phosphoribosyltransferase,adenine phosphoribosyltran\nsferase,\n Cond710:t2+SSD1\n Cond438:DBYyap1_+_37degree_heat_(repeat)\n mRPL1A:Homology to rat L10a, eubacterial L1, and archaebacterial L1\n; identical to S. cerevisiae L1B (Ssm2p),ribosomal protein L\n1A, forms part of the 60S ribosomal subunit,Null mutant is v\niable; shows double mutant lethality with rpl1b (ssm2b) null\n mutants\n mRPL1B:Homology to rat L10a, eubacterial L1, and archaebacterial L1\n; identical to S. cerevisiae L1A (Ssm1p),ribosomal protein L\n1B,\n Stress.dshift:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond397:Nitrogen_Depletion_2_h\n Cond390:aa_starv_0.5_h\n Cond320:heat_shock_17_to_37,_20_minutes\n Cond316:37C_to_25C_shock_-_30_min\n mHOM2:threonine and methionine pathway,aspartic beta semi-aldehyde\n dehydrogenase,Homoserine requiring\n Cond887:t-BuOOH\n mRPL20A:Homology to rat L18a,ribosomal protein L20A (L18A),\n Cond941:SK1_YPD\n mNEW1:This gene encodes a protein with an Q/N-rich amino terminal \ndomain that acts as a prion, termed [NU]+.,,Null mutant is v\niable\n mRPS25A:Homology to rat S25,ribosomal protein S25A (S31A) (rp45) (YS\n23),\n mARO2:Chorismate synthase,chorismate synthase,aromatic amino acid \nrequiring; lack of premeiotic DNA synthesis; blocked sporula\ntion in homozygous mutant\n mARO4:3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase \nisoenzyme,3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP)\n synthase isoenzyme,null mutant is viable\n mPRS1:ribose-phosphate pyrophosphokinase,ribose-phosphate pyrophos\nphokinase,\n Cond745: mSIM1:(putative) invovled in control of DNA replication,,Null muta\nnt is viable; mutant allows an extra round of DNA replicatio\nn without mitosis\n mVAS1:mitochondrial and cytoplasmic valyl-tRNA synthetase,valine-t\nRNA ligase,Null mutant is inviable\n mECM33:ExtraCellular Mutant,,A Tn3 insertion into this gene causes \nhypersensitivity to the cell surface polymer perturbing agen\nt calcofluor white.\n mYHR020W:Unknown ,, Unknown\n mRPL2B:Homology to rat L8 and E. coli L2,ribosomal protein L2B (L5B\n) (rp8) (YL6),\n GCN4.gcn4:Transcriptional profiling shows that Gcn4p is a master regul\nator of gene expression during amino acid starvation in yeas\nt. Mol Cell Biol. 2001 Jul;21(13):4347-68.\n Stress.DTT1:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond872:Zero1\n Stress.DTT2:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mNOP58:57 kDa nucleolar protein involved in the pre-rRNA processing\n steps that lead to formation of 18 S rRNA; interacts with N\nop1p,57 kDa nucleolar protein,Null mutant is inviable; in vi\nvo depletion impairs synthesis of the 40S ribosomal subunit\n Cond857:pm38-gtoe\n mGLN4:glutaminyl-tRNA synthetase,glutamine-tRNA ligase,Null mutant\n is inviable\n mCBF5:major low affinity 55 kDa Centromere/microtubule binding pro\ntein,major low affinity 55 kDa centromere/microtubule bindin\ng protein,Null mutant is inviable\n mYEF3:contains two ABC cassettes, and binds and hydrolyses ATP,Tra\nnslation elongation factor 3 (EF-3),Null mutant is inviable\n Stress.NitroDepl:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond317:37C_to_25C_shock_-_45_min\n RapamycinDip.dip_ram:Rapamycin-modulated transcription defines the subset of nutr\nient-sensitive signaling pathways directly controlled by the\n Tor proteins. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26)\n:14866-70.\n UME6.ume6:The Ume6 regulon coordinates metabolic and meiotic gene expr\nession in yeast. Proc Natl Acad Sci U S A. 2002 Oct 15;99(2\n1):13431-6.\n Cond717:t2-SSD1\n Cond419:YPD_2_d_ypd-2\n mKRS1:lysyl-tRNA synthetase,lysine-tRNA ligase,Null mutant is invi\nable; mutants can show resistance to 5-methyltryptophan, 5-f\nluorotryptophan and canavanine; constitutive derepression an\nd slow growth; posttranscriptional increase in histidine bio\nsynthetic enzyme activity\n Cond431:YPD_stationary_phase_13_d_ypd-1\n Cond725:t4-SSD1,M31\n Cond882:zero3\n gala.+gal:Integrated genomic and proteomic analyses of a systematicall\ny perturbed metabolic network. Science. 2001 May 4;292(5518\n):929-34.\n mSPT16:global regulator of transcription,,suppression of Ty inserti\non mutations\n mPMT4:Transfers mannose residues from dolichyl phosphate-D-mannose\n to specific serine/threonine residues of proteins in the se\ncretory pathway,dolichyl phosphate-D-mannose:protein O-D-man\nnosyltransferase,Null mutant is viable but shows under glyco\nsylation of chitinase; pmt2 pmt3 pmt4 triple mutant is invia\nble\n mUTP4:Unknown ,, Unknown\n mDBP2:ATP-dependent RNA helicase of DEAD box family,ATP dependent \nRNA helicase , dead box protein,Null mutant is inviable\n Cond886:g-ray\n mYHM2:Yeast suppressor gene of HM mutant (abf2),DNA binding protei\nn , mtDNA stabilizing protein, mitochondrial inner membrane \nprotein with low homology to RIM2,Null mutant is viable but \nshows slow growth in the presence of non-fermentable carbon \nsources; mutant shows mitochondrial genome unstability\n mASN2:Asn1p and Asn2p are isozymes,asparagine synthetase,Null muta\nnt is viable; L-asparagine auxotrophy occurs upon mutation o\nf both ASN1 and ASN2\n Cond403:Nitrogen_Depletion_3_d\n Cond811:Na60'\n mYLR076C:Unknown ,, Unknown\n Cond372:1.5_mM_diamide_(30_min)\n Stress.HeatVar:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mTIF4631:also called eIF4 (eIF-4) gamma,150 kDa subunit , Tif4632p an\nd mammalian p220 homolog , mRNA cap binding protein eIF-4F,N\null mutant is viable, grows slowly and is cold-sensitive. ti\nf4631 tif4632 double deletion mutants are inviable\n Cond401:Nitrogen_Depletion_1_d\n mZUO1:Zuotin has region of DnaJ homology,zuotin, Z-DNA binding pro\ntein (putative),Null mutant has slow growth defect\n mTOS11:Hypothetical ORF,,\n mTEF1:translational elongation factor EF-1 alpha,translational elo\nngation factor EF-1 alpha,Null mutant is viable\n Calcin.Na:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n Cond815:Na+FK60'\n Cond453:YP_ethanol_vs_reference_pool_car-2\n mRPP0:Homology to rat P0, human P0, and E. coli L10e,ribosomal pro\ntein P0 (A0) (L10E),Null mutant is inviable\n Calcin.NaFK:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n mRPL16B:Homology to rat ribosomal protein L13a,ribosomal protein L16\nB (L21B) (rp23) (YL15),\n Y-Stre.Peroxide:Remodeling of yeast genome expression in response to environ\nmental changes. Mol Biol Cell. 2001 Feb;12(2):323-37.\n mUTP22:Unknown ,, Unknown\n mTOM40:Translocase of Outer Mitochondrial membrane,forms the outer \nmembrane import channel , mitochondrial outer membrane prote\nin , forms the outer membrane import channel , mitochondrial\n outer membrane protein,Null mutant is inviable; cells accum\nulate uncleaved mitochondrial precursor proteins\n Cond304:Heat_Shock_30_minutes_hs-1\n Cond428:YPD_stationary_phase_3_d_ypd-1\n fkh1,2sf.Series0:Two yeast forkhead genes regulate the cell cycle and pseudoh\nyphal growth. Nature. 2000 Jul 6;406(6791):90-4.\n Cond436:DBYmsn2/4_(real_strain)_+_37degrees_(20_min)\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n mSSB2:stress-seventy subfamily B,SSB1 homolog , heat shock protein\n of HSP70 family,Null mutant is viable, ssb1 ssb2 double dis\nruption mutants exhibit poor growth at all temperatures, but\n particularly at low temperatures; as well as hypersensitivi\nty to certain protein synthesis inhibitors, including aminog\nlycosides such as hygromycin B\n Cond302:Heat_Shock_15_minutes_hs-1\n Cond418:YPD_1_d_ypd-2\n mRPS0A:Homology to rat Sa,ribosomal protein S0A,Null mutant is viab\nle; yst1 (rps0a) yst2 (rps0b) double deletion mutant is invi\nable; yst1 (rps0a) mutants are defective for filamentous gro\nwth\n Cond913:(99i3)_S150-2B_YPD_NormInt\n mNSA2:Killer toxin Resistant; Nop seven associated protein 2,ribos\nome biogenesis,Heterozygous diploid mutant exhibit haploinsu\nfficiency K1 killer toxin resistance\n mUTR2:Product of gene unknown,,\n Stress.diamide:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mRPL17A:Homology to rat L17, human L17, and E. coli L22,ribosomal pr\notein L17A (L20A) (YL17),\n Cond467:steady_state_21_dec_C_ct-2\n Cond674:DES459_(mec1)_+_heat_20_min\n Cond425:YPD_stationary_phase_12_h_ypd-1\n Stress.Carbon:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond373:1.5_mM_diamide_(40_min)\n Cond445:Msn4_overexpression\n mPSE1:Functions in nuclear transport of proteins,karyopherin,Null \nmutant is viable but grows very slowly; overexpression of PS\nE1 results in enhanced protein secretion\n mRPS13:Homology to rat S13,ribosomal protein S13 (S27a) (YS15),\n Cond391:aa_starv_1_h\n Cond814:Na+FK45'\n mRPL6B:Homology to rat and human L6; involved initiation of protein\n synthesis,ribosomal protein L6B (L17B) (rp18) (YL16),Null m\nutant is viable, grows slower than wild-type. rpl6a rpl6b do\nuble mutants are inviable; rpl6 mutants are deficient in 60S\n ribosomal subunits relative to 40S subunits; 43S preinitiat\nion complexes accumulate in half-mer polyribosomes in the ab\nsence of sufficient 60S subunits.\n mADO1:adenosine kinase,adenosine kinase,\n Stress.aa_starv:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond894:G2\n Cond704:gal80-gal\n Cond395:Nitrogen_Depletion_30_min.\n Cond701:gal6-gal\n mNIP7:Nip7p is required for 60S ribosome subunit biogenesis,,Null \nmutant is inviable; in the temperature-sensitive mutant nip7\n-1, glycine 71 is replaced by aspartic acid\n mRPL18B:Homology to rat ribosomal protein L18,ribosomal protein L18B\n (rp28B),\n Cond479:WT+/-100mM3AT(SetD)(R491)\n mGCN1:translational activator of GCN4 through activation of GCN2 i\nn response to starvation,translational activator of GCN4 thr\nough activation of GCN2 in response to starvation,Null mutan\nt is viable and sensitive to 3-aminotriazole\n mHTS1:Nuclear gene that specifies two messages for cytoplasmic and\n mitochondrial forms,histidine-tRNA ligase,Certain mutations\n can be made to disrupt either cytoplasmic or mitochondrial \nform of Hts1p; loss of mitochondrial synthetase gives Pet- p\nhenotype; loss of cytoplasmic synthetase can result in letha\nlity or respiratory deficiency\n Cond306:Heat_Shock_60_minutes_hs-1\n mYPR118W:Unknown ,, Unknown\n Cond361:2.5mM_DTT_180_min_dtt-1\n Cond367:dtt_240_min_dtt-2\n mMES1:methionyl tRNA synthetase,methionine-tRNA ligase,no growth a\nt 36 degrees C\n Cond716:t2+SSD1wt\n mYLR413W:Unknown ,, Unknown\n Cond313:Heat_Shock_030inutes__hs-2\n Stress.Heat1:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond708:t0+SSD1\n mGPI12:N-acetylglucosaminylphosphatidylinositol de-N-acetylase,N-ac\netylglucosaminylphosphatidylinositol de-N-acetylase,Null mut\nation is inviable\n mSRV2:70-kDa adenylyl cyclase-associated protein,70 kDa adenylyl c\nyclase-associated protein,Null mutant is inviable.\n Stress.Heat2:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond481:WT+/-100mM3AT(SetB)(491)\n Cond378:1M_sorbitol_-_15_min\n mIMD3:Hypothetical ORF,IMP dehydrogenase homolog,\n mRPL40A:Homology to rat L40,ribosomal protein L40A,Null mutant is vi\nable\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond712:t4+SSD1\n mRPL26A:Homology to rat L26,ribosomal protein L26A (L33A) (YL33),\n mRPS2:Homology to rat S2 and E. coli S5,ribosomal protein S2 (S4) \n(rp12) (YS5),Omnipotent suppressor of nonsense mutations\n mYHB1:may play a role in the oxidative stress response,flavohemogl\nobin,Null mutant is viable. A rho+ strain carrying a yhb1(-)\n deletion has normal levels of both cyanide-sensitive and cy\nanide-insensitive respiration. Cells that carry a yhb1(-) de\nletion are sensitive to conditions that promote oxidative st\nress.\n mCDC60:cytosolic leucyl tRNA synthetase,leucine--tRNA ligase,arrest\n at START point of cell cycle upon shift to restrictive temp\nerature\n Cond433:YPD_stationary_phase_28_d_ypd-1\n Cond374:1.5_mM_diamide_(50_min)\n mRPS5:ribosomal small subunit protein homologous to mammalian S5 (\nhas approx. 70% identity with human, rat and hydrozoan S5). \nIt is the least basic of the non-acidic ribosomal proteins. \nIt is phosphorylated in yeast.,ribosomal protein S5 (S2) (rp\n14) (YS8),null is inviable; transcription of RPS5 is sensiti\nve to heat-shock and carbon source shift.\n Cond965:ndt80_delete_mid_g/r_ratio_\n mSUN4:Protein involved in the aging process,,\n mBAT1:branched-chain amino acid transaminase, highly similar to ma\nmmalian ECA39, which is regulated by the oncogene myc,branch\ned-chain amino acid transaminase , highly similar to mammali\nan ECA39, which is regulated by the oncogene myc , branched-\nchain amino acid transaminase , highly similar to mammalian \nECA39, which is regulated by the oncogene myc,Null mutant is\n viable; ILV auxotrophy in bat1 bat2 double mutant\n mRPL34B:Homology to rat L34,ribosomal protein L34B,\n mELP6:ELongator Protein 6; 30kD subunit,RNA polymerase II Elongato\nr protein subunit,Null:Slow adaptation to growth on new medi\na; <br> ts- (39 oC); sensitive to 1 M NaCl; insensitive to p\nGKL killer toxin\n mSUP45:Recessive omnipotent suppressor. The wild-type gene function\ns in termination of translation.,eRF1 (eukaryotic Release Fa\nctor 1) homolog,The null mutant is inviable. Other mutant al\nleles produce a variety of phenotypes which can include: omn\nipotent nonsense suppression, osmotic sensitivity, benomyl s\nensitivity, paromomycin sensitivity, and novobiocin resistan\nce.\n mRPL27B:Homology to mammalian L27,ribosomal protein L27B,\n mPUB1:poly(A)+ RNA-binding protein,poly(A) binding protein,Null mu\ntant is viable\n mRRP12:Required for normal pre-rRNA processing,,Null: lethal.\n mNOP1:nucleolar protein, homologous to mammalian fibrillarin,nucle\nolar protein , similar to mammalian fibrillarin,Null mutant \nis inviable. Temperature-sensitive alleles exhibit various d\nefects in rRNA processing.\n mNOP2:May participate in nucleolar function during the transition \nfrom stationary phase to rapid growth,90 kDa protein homolog\nous to a human proliferation-associated nucleolar protein, p\n120,Null mutant is inviable; overexpression leads to changes\n in nucleolar morphology\n mNOP4:RNA recognition motif-containing protein,RNA binding protein\n (putative),Null mutant is inviable; conditional mutant show\ns diminished accumulation of 60S ribosomal subunits due to a\n lack of production of mature 25S rRNA from 27S precursor rR\nNA\n Cond396:Nitrogen_Depletion_1_h\n Cond305:Heat_Shock_40_minutes_hs-1\n mNOP7:Required for normal pre-rRNA processing,,Null: lethal.\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts. Nat Genet\n. 2000 Dec;26(4):415-23.\n mRPL9B:Homology to rat L9,ribosomal protein L9B (L8B) (rp24) (YL11)\n,\n Cond363:dtt_015_min_dtt-2\n mRPS4A:Homology to rat S4 and human S4,ribosomal protein S4A (YS6) \n(rp5) (S7A),Null mutant is viable; rps4a rps4b double deleti\non is inviable\n mRPL42A:Homology to rat L36a and human L36a,ribosomal protein L42A (\nYL27) (L41A),\n Stress.YPD:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond414:YPD_6_h_ypd-2\n Cond898:RPN4\n Stress.YPDStat:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond323:heat_shock_29_to_37,_20_minutes\n Cond719:t4-SSD1\n mYNL247W:Unknown ,, Unknown\n Cond426:YPD_stationary_phase_1_d_ypd-1\n mEFT1:translation elongation factor 2 (EF-2),translation elongatio\nn factor 2 (EF-2),Null mutant is viable (eft1 eft2 double mu\ntant is lethal)\n Cond437:DBYyap1-_37degree_heat_-_20_min_(redo)\n Cond934:8h\n mGSP1:maintenance of nuclear organization; homologous to mammalian\n Ran, a small nuclear GTPase of the ras superfamily,GTP-bind\ning protein,Null mutant is inviable\n mCAF20:binds to eIF4E, the mRNA cap-binding protein, and represses \ncap-dependent translation initiation by interfering with the\n interaction of eIF4E and eIF4G,20 kDa subunit , mRNA cap bi\nnding protein eIF-4F , 20 kDa subunit , mRNA cap binding pro\ntein eIF-4F,Null mutant is viable and grows faster; deletion\n of CAF20 partially suppresses mutations in translation init\niation factors; overexpression of CAF20 causes slower growth\n and enhances translation mutation phenotypes\n Cond322:heat_shock_25_to_37,_20_minutes\n Cond420:YPD_3_d_ypd-2\n Cond893:SMMS\n Cond709:t0+Vec\n Cond379:1M_sorbitol_-_30_min\n mMKT1:Protein involved in propagation of M2 dsRNA satellite of L-A\n virus,retroviral protease signature protein,Null mutant is \nviable\n mRPL36A:Homology to rat L36,ribosomal protein L36A (L39) (YL39),\n Cond434:DBY7286_37degree_heat_-_20_min\n Cond321:heat_shock_21_to_37,_20_minutes\n Cond783:Peroxide_60'\n mFUN12:Function unknown now,97 kDa protein,Null mutant is inviable\n mTHS1:Threonyl-tRNA synthetase, cytoplasmic,threonine-tRNA ligase,\n mSEC14:Required for vesicle budding from the Golgi,phosphatidylinos\nitol transfer protein,Null mutant is inviable; other mutatio\nns are temperature sensitive\n mSUB2:Suppressor of the cold-sensitive snRNP biogenesis mutant brr\n1-1,RNA helicase,Null mutant is inviable; sub2 allele suppre\nsses cold-sensitive snRNP phenotype of brr1-1\n Sporulation.Series0:The transcriptional program of sporulation in budding yeast.\n Science. 1998 Oct 23;282(5389):699-705.\n mSTT3:Required for protein glycosylation,integral ER membrane prot\nein , oligosaccharyltransferase complex subunit (putative),N\null mutant is inviable. sst3 mutants are defective in protei\nn glycosylation, sensitive to hygromycin B, and resistant to\n sodium orthovanadate. Depletion of the STT3 protein results\n in loss of oligosaccharyl transferase activity in vivo and \na deficiency in the assembly of oligosaccharyl transferase c\nomplex.\n Cond417:YPD_12_h_ypd-2\n Stress.Sorbitol:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mLYP1:lysine permease,lysine permease,\n Cond415:YPD_8_h_ypd-2\n mRSN1:overexpression Rescues sro7/sop1 in NaCl,,viable in both hig\nh and low salinity\n Cond319:37C_to_25C_shock_-_90_min\n mRPS6A:Homology to rat, mouse, and human S6,ribosomal protein S6A (\nS10A) (rp9) (YS4),\n Cond685:wt-gal\n Cond402:Nitrogen_Depletion_2_d\n Cond723:t2-SSD1,M31\n mSES1:seryl-tRNA synthetase,serine-tRNA ligase,Null mutant is invi\nable.\n Cond876:zero2\n mGDA1:converts nucleoside diphosphates to nucleoside monophosphate\ns to recycle nucleosides and promote transport of additional\n nucleotide sugars into golgi,guanosine diphosphatase of Gol\ngi membrane,Null mutant is viable and has partial block in m\nannosylation of proteins and sphingolipids\n Cond411:diauxic_shift_timecourse_20.5_h\n Stress.Various:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mSEC21:non-clathrin coat protein involved in transport between ER a\nnd Golgi,PEST sequence-containing protein , non-clathrin coa\nt protein,Null mutant is inviable\n mYAR075W:Unknown ,, Unknown\n mSUR4:Required for conversion of 24-carbon fatty acids to 26-carbo\nn species,,Null mutants is viable, not sensitive to UV or ga\nmma radiation. sur4 mutants suppress rad3, rvs161 delta, and\n rvs167 mutations. sur4 fen1 mutants and sur4 elo2 mutants a\nre inviable.\n zap1.Series0:Genome-wide characterization of the Zap1p zinc-responsive re\ngulon in yeast. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14)\n:7957-62.\n Cond421:YPD_5_d_ypd-2\n mRPS7A:Homology to human S7 and Xenopus S8,ribosomal protein S7A (r\np30),Null mutant is viable\n Stress.tempsteady:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mNOP1 mNOP7 mSIK1 mNOP2 mNOP58 mNSA2 mNOP13 mTIF4631 mCAF20 mCBF5 mIMD3 mNIP7 mNOP4 mYEF3 mTEF1 mGSP1 mRNA1 mPSE1
this is an automaticly generated SAMBA report
Computational Genomics Lab, Tel-Aviv uniresity