Module number 1105




Database revision : gnsdb28.10
Date : Tue Feb 25 17:33:14 2003
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mSRP1:karyopherin alpha homolog of 60 kDa,karyopherin alpha,supres\nsor of rpb1, cold-sensitive\n mPUB1:poly(A)+ RNA-binding protein,poly(A) binding protein,Null mu\ntant is viable\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n mTOS6:Hypothetical ORF,,\n mDIP5:dicarboxylic amino acid permease,dicarboxylic amino acid per\nmease,Null mutant is viable, exhibits loss of L-aspartate an\nd L-glutamate uptake\n mPUF4:member of the PUF protein family,,\n Cond711:t2+Vec\n mFET3:FET3 encodes a ferro-O2-oxidoreductase that is part of the h\nigh-affinity iron transport system,multicopper oxidase,The n\null mutant is viable but defective for high affinity Fe(II) \nuptake. The null mutant is inviable when environmental iron \nis limiting.\n mSEC31:involved in protein transport from endoplasmic reticulum to \nGolgi,COPII coat of secretory pathway vesicles component (p1\n50),Null mutant is inviable\n mPDR5:multidrug resistance transporter,multidrug resistance transp\norter,pleiotropic drug resistance\n Cond400:Nitrogen_Depletion_12_h\n mNEW1:This gene encodes a protein with an Q/N-rich amino terminal \ndomain that acts as a prion, termed [NU]+.,,Null mutant is v\niable\n Cond941:SK1_YPD\n mYGL245W:Unknown ,, Unknown\n mNST1:Unknown ,, Unknown\n mNPY1:hydrolyzes the pyrophosphate linkage in NADH and related nuc\nleotides,NADH pyrophosphatase 1,No readily detected phenotyp\ne\n mCLU1:CLU1 is similar to the Dictyostelium cluA gene,translation i\nnitiation factor eIF3 subunit,Null mutant is viable, growth \nis normal, mitochondrial network is collapsed to one side of\n the cell\n mASP1:Asparaginase I, intracellular isozyme,asparaginase I , intra\ncellular isozyme,Aspartic acid requiring\n Stress.Carbon:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond898:RPN4\n mVAS1:mitochondrial and cytoplasmic valyl-tRNA synthetase,valine-t\nRNA ligase,Null mutant is inviable\n mTFP1:Encodes a protein with three regions (ABC) that is spliced t\no yield the extein AC & the intein B; AC is a 69K vacuolar (\nH+)-ATPase & B is a 50K site-specific endonuclease named VDE\n (PI-SceI) that is homologous to HO,protein with three regio\nns (ABC) that are spliced to yield the extein AC and the int\nein B; AC is a 69K vacuolar (H+)-ATPase, and B is a 50K site\n-specfic endonuclease named VDE (PI-SceI) that is homologous\n to HO. Cleavage is meiosis-specific and induces gene conver\nsion at the TFP1 locus. , site-specific endonuclease VDE (PI\n-SceI) , vacuolar ATPase V1 domain subunit A (69 kDa) , prot\nein with three regions (ABC) that are spliced to yield the e\nxtein AC and the intein B; AC is a 69K vacuolar (H+)-ATPase,\n and B is a 50K site-specfic endonuclease named VDE (PI-SceI\n) that is homologous to HO. Cleavage is meiosis-specific and\n induces gene conversion at the TFP1 locus. , site-specific \nendonuclease VDE (PI-SceI) , vacuolar ATPase V1 domain subun\nit A (69 kDa),Null mutant is viable, resistant to trifluoper\nazine, grows slowly under non-acidic conditions and on glyce\nrol and is cold, temperature, and cation-sensitive\n Cond719:t4-SSD1\n Cond724:t4+SSD1,H44\n mYNR021W:Unknown ,, Unknown\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mCSE1:Protein required for accurate mitotic chromosome segregation\n,,Null mutant is inviable\n mCWP1:cell wall protein, involved in O and N glycosylation, accept\nor of B1-6 glucan.,cell wall mannoprotein,Null mutant is via\nble, has increased sensitivities to calcoflour white and con\ngo red\n Cond718:t4+SSD1wt\n mSAC1:integral membrane protein localizing to the ER and Golgi,int\negral membrane protein,suppressor of actin mutations, suppre\nssor of sec14 alleles, inositol auxotrophy\n mYJR015W:Unknown ,, Unknown\n mTOM1:Temperature dependent Organization in Mitotic nucleus,hect-d\nomain-containing protein, containing kinase motifs , similar\n to Rsp5,Null mutant is viable and temperature sensitive, an\nd arrests at the G2/M boundary of the cell cycle\n Cond404:Nitrogen_Depletion_5_d\n Cond709:t0+Vec\n mMKT1:Protein involved in propagation of M2 dsRNA satellite of L-A\n virus,retroviral protease signature protein,Null mutant is \nviable\n Cond449:glucose_vs._reference_pool_car-1\n Cond756: mFKS1:Required for viability of calcineurin mutants,1,3-beta-D-glu\ncan synthase,Null mutant is viable, demonstrates slow growth\n, hypersensitivity to FK506 and cyclosporin A, sensitivity t\no echinocandin and a reduction in 1,3-beta-D-glucan synthase\n activity in vitro; sensitivity to papulacandin B\n mGCN1:translational activator of GCN4 through activation of GCN2 i\nn response to starvation,translational activator of GCN4 thr\nough activation of GCN2 in response to starvation,Null mutan\nt is viable and sensitive to 3-aminotriazole\n Cond452:sucrose_vs._reference_pool_car-1\n mASK10:transcriptional activator of the SKN7 mediated 'two-componen\nt' regulatory system,transcriptional activator of the SKN7 m\nediated 'two-component' regulatory system,\n Stress.NitroDepl:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n UME6.ume6:The Ume6 regulon coordinates metabolic and meiotic gene expr\nession in yeast. Proc Natl Acad Sci U S A. 2002 Oct 15;99(2\n1):13431-6.\n Cond450:mannose_vs._reference_pool__car-1\n Cond717:t2-SSD1\n Cond716:t2+SSD1wt\n mGDS1:involved in nuclear control of mitochondria,,Null mutant is \nviable, shows partial impairment of growth on medium contain\ning glycerol as the carbon source. Overexpxression suppresse\ns NAM9-1 glycerol deficient phenotype\n mYLR413W:Unknown ,, Unknown\n Cond725:t4-SSD1,M31\n mPMT1:Transfers mannose residues from dolichyl phosphate-D-mannose\n to specific serine/threonine residues of proteins in the se\ncretory pathway; acts in complex with Pmt2p,dolichyl phospha\nte-D-mannose:protein O-D-mannosyltransferase,Null mutant is \nviable but shows decrease by 40-50% of in vivo protein O-man\nnosylation; pmt1 pmt2 double mutant shows severe growth defe\nct but residual O-mannosylation activity; the pmt1 pmt2 pmt3\n pmt4 quadruple mutant is inviable\n Cond708:t0+SSD1\n mSRV2:70-kDa adenylyl cyclase-associated protein,70 kDa adenylyl c\nyclase-associated protein,Null mutant is inviable.\n mGPI12:N-acetylglucosaminylphosphatidylinositol de-N-acetylase,N-ac\netylglucosaminylphosphatidylinositol de-N-acetylase,Null mut\nation is inviable\n mSTT3:Required for protein glycosylation,integral ER membrane prot\nein , oligosaccharyltransferase complex subunit (putative),N\null mutant is inviable. sst3 mutants are defective in protei\nn glycosylation, sensitive to hygromycin B, and resistant to\n sodium orthovanadate. Depletion of the STT3 protein results\n in loss of oligosaccharyl transferase activity in vivo and \na deficiency in the assembly of oligosaccharyl transferase c\nomplex.\n mBOP1:bypass of PAM1,,\n mNCL1:Nuclear protein 1, similar to NOP2 and human proliferation a\nssociated nucleolar protein p120,tRNA:m5C-methyltransferase,\nNull mutant is viable, sensitive to paromomycin, lacks m5C m\nethylation in total yeast tRNA\n Cond945:W303_YPD\n Cond403:Nitrogen_Depletion_3_d\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond712:t4+SSD1\n mRSN1:overexpression Rescues sro7/sop1 in NaCl,,viable in both hig\nh and low salinity\n mOST3:Catalyzes the transfer of oligosaccharide from dolichol-olig\nosaccharide donor to consensus glycosylation acceptor sites \n(asparagines) in newly synth. proteins - ER lumen; may enhan\nce oligosacch. transfer to subset of acceptor substrates,oli\ngosaccharyl transferase glycoprotein complex 34 kDa gamma su\nbunit,Null mutant is viable but shows underglycosylation of \nsoluble and membrane-bound glycoproteins and contains less o\nligosaccharyltransferase activity in vitro\n Cond402:Nitrogen_Depletion_2_d\n mFAS1:pentafunctional enzyme consisting of the following domains :\n acetyl transferase, enoyl reductase, dehydratase and malony\nl/palmityl transferase,acetyl transferase , dehydratase , en\noyl reductase , malonyl/palmityl transferase , pentafunction\nal enzyme,Null mutant is viable\n mCDC60:cytosolic leucyl tRNA synthetase,leucine--tRNA ligase,arrest\n at START point of cell cycle upon shift to restrictive temp\nerature\n Cond723:t2-SSD1,M31\n mHEK2:Unknown ,, Unknown\n Cond401:Nitrogen_Depletion_1_d\n Cond714:t0+SSD1wt\n mTOS11:Hypothetical ORF,,\n mEXG1:Exo-1,3-beta-glucanase,exo-1,3-beta-glucanase,Null mutant is\n viable, displays modest increase in killer toxin sensitivit\ny and beta 1,6-glucan levels\n mSUN4:Protein involved in the aging process,,\n mGCD11:Negative regulator of GCN4 expression,translational initiati\non factor eIF-2 gamma subunit,Null mutant is inviable, gcd11\n mutants have slower growth rate under nonstarvation conditi\nons\n mSEC21:non-clathrin coat protein involved in transport between ER a\nnd Golgi,PEST sequence-containing protein , non-clathrin coa\nt protein,Null mutant is inviable\n mMSB2:putative integral membrane protein,integral membrane protein\n (putative),multicopy suppressor of cdc24 ts mutation\n mCAF40:Hypothetical ORF,,Null mutant is viable\n mSRL1:Suppressor of rad53 lethality,,\n mAGA1:anchorage subunit of a-agglutinin,a-agglutinin anchorage sub\nunit,mating defect in liquid medium\n Cond710:t2+SSD1\n mUTP22:Unknown ,, Unknown\n mELP6:ELongator Protein 6; 30kD subunit,RNA polymerase II Elongato\nr protein subunit,Null:Slow adaptation to growth on new medi\na; <br> ts- (39 oC); sensitive to 1 M NaCl; insensitive to p\nGKL killer toxin\n fkh1,2sf.Series0:Two yeast forkhead genes regulate the cell cycle and pseudoh\nyphal growth. Nature. 2000 Jul 6;406(6791):90-4.\n mCSE1 mSRP1 mNST1 mCAF40 mGDS1
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Computational Genomics Lab, Tel-Aviv uniresity