Module number 1104




Database revision : gnsdb28.10
Date : Tue Feb 25 17:33:07 2003
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mHAA1:Homolog of Ace1 Activator,,\n mARE2:Acyl-CoA cholesterol acyltransferase (sterol-ester synthetas\ne),acyl-CoA cholesterol acyltransferase (sterol-ester synthe\ntase),Null mutant is viable; greatly reduces in vivo and in \nvitro ergosterol esterification (to 15 - 35 % of wild-type).\n Deletion of both ARE1 and ARE2 completely eliminates in viv\no and in vitro ergosterol esterification\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n mYDR306C:Unknown ,, Unknown\n mYNL047C:Unknown ,, Unknown\n Cond896:STAT\n mYFR017C:Unknown ,, Unknown\n mYNR040W:Unknown ,, Unknown\n mGYP7:GTPase-activating protein,GTPase activating protein (GAP),Nu\nll mutant is viable\n mPGM2:Phosphoglucomutase,phosphoglucomutase,Null mutant is viable,\n pgm1 pgm2 deletion mutants fail to grow on galactose\n mYLR199C:Unknown ,, Unknown\n mMRPL16:Mitochondrial ribosomal protein MRPL16,ribosomal protein,\n Cond877:MMS\n mHSP12:induced by heat shock, entry into stationary phase, depletio\nn of glucose, and addition of lipids (fatty acids),heat shoc\nk protein 12,Null mutant is viable, but shows induction of h\neat shock response under conditions normally associated with\n low-level HSP12 expression\n mURE2:Nitrogen catabolite repression regulator that acts by inhibi\ntion of GLN3 in good nitrogen source. Altered form of Ure2p\n creates [URE3] prion.,glutathione transferase (putative) , \nprion , transcriptional regulator,Null mutant is viable but \nexhibits defects in nitrogen catabolite repression (NCR), an\nd null mutant diploids are defective in pseudohyphal growth \nand display an increased incidence of random bud patterns.\n mYMR090W:Unknown ,, Unknown\n Cond886:g-ray\n mGDH2:NAD-dependent glutamate dehydrogenase,NAD-dependent glutamat\ne dehydrogenase,Null mutant is viable, grows very poorly on \nglutamate as a nitrogen source\n mSAS5:Involved in silencing at telomeres, HML and HMR,,Null mutant\n is viable\n mYLR177W:Unknown ,, Unknown\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mPDX1:Plays a structural role in pyruvate dehydrogenase complex,py\nruvate dehydrogenase complex protein X component,Null mutant\n is viable\n mSIW14:Synthetic interaction with Whi2,tyrosine phosphatase,Null mu\ntant fails to show cell cycle arrest upon nutrient starvatio\nn, is sensitive to 5mM caffeine and 1M NaCL, and shows deloc\nalized actin upon nutrient starvation; synthetically lethal \nwith whi2, on minimal medium only\n mTRK1:180 kDa high affinity potassium transporter,180 kDa high aff\ninity potassium transporter,Null mutant is viable, requires \nadded potassium; trk1 trk2 double mutants are viable\n mYIL024C:Unknown ,, Unknown\n mCAF4:CCR4 associated factor,CCR4 transcriptional complex componen\nt,Null mutant is viable\n mOPY2:imparts Far- phenotype,,\n mRIM4:Regulator of IMe2 expression,RNA-binding protein of the RRM \nclass (putative),Null mutant is viable. Homozygous null dipl\noid fails to sporulate, does not form meiosis I or II spindl\nes, and exhibits reduced expression of early and middle spor\nulation-specific genes. Null mutant is suppressed by hyperac\ntive Ime2p derivative, but not by overexpression IME1\n mATO3:Unknown ,, Unknown\n mYNL108C:Unknown ,, Unknown\n mTRM2:tRNA methyltransferase,tRNA methyltransferase,\n mMRL1:Mannose 6-phosphate Receptor Like,,\n mNCA2:Regulates proper expression of subunits 6 (Atp6p) and 8 (Atp\n8p) of the Fo-F1 ATP synthase,,Null mutant is viable\n mRNH70:RNase H(70), a 70 kDa ribonuclease H,ribonuclease H,Null mut\nant is viable.\n mYNL144C:Unknown ,, Unknown\n mYMR278W:Unknown ,, Unknown\n mYIL137C:Unknown ,, Unknown\n mYFR016C:Unknown ,, Unknown\n mYHR033W:Unknown ,, Unknown\n mYLR412W:Unknown ,, Unknown\n mKTR2:May be involved in extracellular matrix assembly; involved i\nn N-linked glycosylation of cell wall mannoproteins,mannosyl\ntransferase (putative) , type 2 membrane protein,Null mutant\n is viable, with partial resistance to killer toxin\n mMOD5:transfer RNA isopentenyl transferase,transfer RNA isopenteny\nl transferase,Null mutant is viable but temperature sensitiv\ne and cannot grow on nonfermentable carbon sources.\n mYPL071C:Unknown ,, Unknown\n mDST1:Meiotic DNA recombination factor,RNA polymerase II elongatio\nn factor , transcription elongation factor,Null mutant is vi\nable; reduced induction of DNA strand transfer; sensitivity \nto 6-azauracil\n mYOP1:Ypt Interacting Protein,,\n mYKR077W:Unknown ,, Unknown\n Cond897:STATMMS\n mTRF5:TRF4 homolog; TRF4/5 function is required for proper mitosis\n,DNA polymerase sigma,Null mutant is viable; trf4 trf5 mutan\nts are inviable; trf4 (ts) trf5 double mutant is hypersensit\nive to the anti-microtubule agent thiabendazole at a semi-pe\nrmissive temperature, overexpression of TRF5 complements the\n inviability of top1 trf4 mutants\n mBNA5:Unknown ,, Unknown\n mYHR029C:Unknown ,, Unknown\n mYKR087C:Unknown ,, Unknown\n mADH2:alcohol dehydrogenase II,alcohol dehydrogenase II,Null mutan\nt is viable\n mNMA2:Unknown ,, Unknown\n mYDR306C mPGM2
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Computational Genomics Lab, Tel-Aviv uniresity