Module number 1103




Database revision : gnsdb28.10
Date : Tue Feb 25 17:33:01 2003
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mYNL134C:Unknown ,, Unknown\n Cond72:gpa2\n Cond626:DY1457_(wild_type)_3_mM_vs._61_nM_zinc_y13-121\n Cond826:tlc1_Expt.1_Passage_7\n Cond458:YP_raffinose_vs_reference_pool_car-2\n mGUT2:glycerol-3-phosphate dehydrogenase, mitochondrial,glycerol-3\n-phosphate dehydrogenase,Null mutant is viable, unable to ut\nilize glycerol as a carbon source\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n mSDH1:flavoprotein subunit of succinate dehydrogenase,succinate de\nhydrogenase flavoprotein subunit,no growth on glycerol (unab\nle to respire)\n mSDH2:Succinate dehydrogenase (ubiquinone) iron-sulfur protein sub\nunit,succinate dehydrogenase (ubiquinone) iron-sulfur protei\nn subunit,Null mutant is viable\n mSDH3:succinate dehydrogenase cytochrome b,succinate dehydrogenase\n cytochrome b,Null mutant is viable, has impaired mitochondr\nial function, fails to grow on non-fermentable carbon source\ns\n mSDH4:succinate dehydrogenase membrane anchor subunit,succinate de\nhydrogenase membrane anchor subunit,Null mutant is viable, r\netains ability to grow on rich glycerol media\n Cond410:diauxic_shift_timecourse_18.5_h\n Cond418:YPD_1_d_ypd-2\n Cond13:ase1(**12)\n mYBR230C:Unknown ,, Unknown\n Stress.diamide:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond834:tlc1_Expt.2_Passage_6\n mPBI2:Proteinase inhibitor that inhibits protease Prb1p (yscB),pro\nteinase inhibitor I2B (PBI2),Null mutant is viable but shows\n 50% elevation of protein degradation rate when cells are su\nbject to nutritional stress\n Cond416:YPD_10_h__ypd-2\n Cond425:YPD_stationary_phase_12_h_ypd-1\n Stress.Carbon:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond822:tlc1_Expt.1_Passage_3\n Cond454:YP_fructose_vs_reference_pool_car-2\n Cond409:diauxic_shift_timecourse_15.5_h\n Cond802:CaFK30'\n Cond310:Heat_Shock_000_minutes_hs-2\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mCOX4:subunit IV of cytochrome c oxidase,cytochrome c oxidase subu\nnit IV,Null mutant is viable and unable to grow on nonfermen\ntable carbon sources\n Cond805:Ca/Ca+FK30'\n Mating.Mating:Signaling and circuitry of multiple MAPK pathways revealed b\ny a matrix of global gene expression profiles. Science. 200\n0 Feb 4;287(5454):873-80\n mCOX6:subunit VI of cytochrome c oxidase,cytochrome c oxidase subu\nnit,Null mutant is viable, sensitive to H2O2\n mCOX7:subunit VII of cytochrome c oxidase,cytochrome c oxidase sub\nunit VII,Null mutant is viable, lacks cytochrome c oxidase a\nctivity and haem a/a3 spectra; respiratory deficient\n Cond429:YPD_stationary_phase_5_d_ypd-1\n mCOX8:Cytochrome-c oxidase chain VIII,cytochrome c oxidase chain V\nIII,Null mutant is viable, deficient in cellular respiration\n and cytochrome C oxidase activity\n Cond155:she4\n TorRama.Series0:Partitioning the transcriptional program induced by rapamyci\nn among the effectors of the Tor proteins. Curr Biol. 2000 D\nec 14-28;10(24):1574-81\n Cond683:MHY1_(crt1)_vs._CRY1_(wild_type)_-_log_phase\n mINH1:ATPase inhibitor,ATPase inhibitor,Null mutant is viable; exh\nibits marked ATP hydrolysis in response to the uncoupler car\nbonylcyanide-m-chlorophenylhydrazone\n Cond452:sucrose_vs._reference_pool_car-1\n mMRF1':May be transcriptional regulator of genes involved in assemb\nly of mitochondrial respiratory proteins,binds to T-rich str\nand of core consensus sequence of autonomously replicating s\nequence,Null mutant is viable but is respiratory-deficient\n Cond849:120_min\n Cond430:YPD_stationary_phase_7_d_ypd-1\n mRIP1:oxidizes ubiquinol at center P in the protonmotive Q cycle m\nechanism, transferring one electron to cytochrome c1 and gen\nerating a low-potential ubisemiquinone anion which reduces t\nhe low-potential cytochrome b-566 heme group,Rieske iron-sul\nfur protein of the mitochondrial cytochrome bc1 complex,Null\n mutant is viable, unable to grow on nonfermentable carbon s\nources\n mCOX12:essential during assembly for full cytochrome c oxidase acti\nvity,cytochrome c oxidase subunit VIb,Null mutant is viable,\n grows poorly at room temperature, fails to grow on glycerol\n/ethanol media at 37 degrees\n mCOX13:Modulates cytochrome c oxidase activity,cytochrome c oxidase\n subunit VIa , may specifically interact with ATP,Null mutan\nt is viable, shows slightly reduced growth rate on nonfermen\ntable carbon sources\n Cond367:dtt_240_min_dtt-2\n tcl1.tcl1:The genome-wide expression response to telomerase deletion i\nn Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2002 \nJul 9;99(14):9316-21.\n Cond145:rts1\n Cond825:tlc1_Expt.1_Passage_6\n Cond187:vac8\n Stress.Heat1:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Stress.Heat2:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mPOR1:Outer mitochondrial membrane porin (voltage-dependent anion \nchannel, or VDAC),porin , voltage-dependent anion channel (V\nDAC),Null mutant is viable, shows strain-dependent delayed g\nrowth on glycerol\n mYLR312C:Unknown ,, Unknown\n Cond972:anc1\n Cond427:YPD_stationary_phase_2_d_ypd-1\n mNDI1:NADH dehydrogenase (ubiquinone),NADH dehydrogenase (ubiquino\nne),\n mGPG1:Unknown ,, Unknown\n gala.-gal:Integrated genomic and proteomic analyses of a systematicall\ny perturbed metabolic network. Science. 2001 May 4;292(5518\n):929-34.\n Cond945:W303_YPD\n mPRB1:dispensable for haploidization and sporulation, but needed f\nor full protein degradation during sporulation, and proper s\npore morphology,vacuolar protease B,Null mutant is viable, p\nrotease B deficient, has smaller spores than wild-type embed\nded in a thick matrix\n Cond413:YPD_4_h_ypd-2\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mCOR1:44 kDa core protein of yeast coenzyme QH2 cytochrome c reduc\ntase,coenzyme QH2 cytochrome c reductase 44 kDa core protein\n subunit,deficiency in cytochrome b; slow growth on glycerol\n Cond874:30min\n Cond833:tlc1_Expt.2_Passage_5\n mYLR327C:Unknown ,, Unknown\n Cond27:ckb2\n mMCR1:NADH-cytochrome b5 reductase,NADH-cytochrome b5 reductase,\n Cond706:gal2gal80-gal\n Cond370:1.5_mM_diamide_(10_min)\n mCOX20:COX: cytochrome oxidase, 20: 20th gene involved in cytochrom\ne oxidase activity,required for maturation and assembly of c\nytochrome oxidase subunit II,Null mutant is respiratory-defi\ncient and has no cytochrome oxidase activity or accumulation\n of precursor of CoxII\n SSD1.ANC1: mNTH1:hydrolyzes trehalose; may be inolved in growth transition fr\nom glucose to glycerol; shows significant sequence similarit\ny to Nth2p,neutral trehalase,Null mutant is viable\n mPRY1:Pathogen Related in Sc, contains homology to the plant PR-1 \nclass of pathogen related proteins. The protein sequence is \nover 60% identical with the Pry2p & Pry3p over 145 resid. PR\nY1 is >35% identical (50% similar) to tobacco PR-1c protein.\n,,\n mYAL061W:Unknown ,, Unknown\n Calcin.Ca/Ca:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n Cond206:yel044w\n mMDH1:mitochondrial malate dehydrogenase,malate dehydrogenase,Null\n mutant is viable\n mQCR2:40 kDa ubiquinol cytochrome-c reductase core protein 2,40 kD\na ubiquinol cytochrome-c reductase core protein 2,Null mutan\nt is viable and grows slowly on glycerol\n Cond303:Heat_Shock_20_minutes_hs-1\n Cond570:cdc15_30\n mQCR6:ubiquinol-cytochrome c oxidoreductase subunit 6 (17 kDa),ubi\nquinol cytochrome C oxidoreductase subunit 6 (17 kDa),Disrup\ntants are viable but are temperature-sensitive petite, lacki\nng ubiquinol-cytochrome c oxidoreductase activity and showin\ng loss of assembly of cytochrome bc1 complex; qcr6 is suppre\nssed by multicopy QCR9; shows synthetic interactions with qc\nr10; synthetically lethal with grc5 and qsr2\n mQCR7:ubiquinol-cytochrome c oxidoreductase subunit 7 (14 kDa),ubi\nquinol cytochrome C oxidoreductase subunit 7 (14 kDa),Null m\nutant is viable but shows no ubiquinol:cytochrome c oxidored\nuctase activity, is respiratory-deficient, and shows lowered\n levels of other subunits of complex III, such as the 11-kDa\n subunit VIII, the Rieske Fe-S protein and cytochrome b\n mQCR8:Ubiquinol cytochrome-c reductase subunit 8 (11 kDa protein),\nubiquinol cytochrome C reductase subunit 8 (11 kDa),Null mut\nant is viable\n Cond343:constant_0.32_mM_H2O2_(120_min)_redo\n mQCR9:7.3 kDa subunit 9 of the ubiquinol cytochrome c oxidoreducta\nse complex,ubiquinol cytochrome c oxidoreductase complex 7.3\n kDa subunit 9,Null mutant is viable, is unable to grow on n\non-fermentable carbon sources\n mATP15:nuclear gene for ATP synthase epsilon subunit,ATP synthase e\npsilon subunit , nuclear encoded,unable to grow on glycerol \nmedium; no detectable oligomycin-sensitive ATPase activity; \noligomycin-sensitive uncoupling of the mitochondrial respira\ntion rate\n mATP16:ATP synthase delta subunit,ATP synthase delta subunit,cells \nare entirely cytoplasmic petite\n Cond408:diauxic_shift_timecourse_13.5_h\n mATP17:Subunit f of mitochondrial ATP synthase. Homologous to bovin\ne subunit f.,ATP synthase subunit f,No growth on glycerol\n mCYT1:Cytochrome c1,cytochrome c1,\n mATP1:mitochondrial F1F0-ATPase alpha subunit,F1F0-ATPase alpha su\nbunit,null mutant is viable; grows slowly on fermentable car\nbon sources; exhibits delayed kinetics of protein import for\n several mitochondrial precursors\n Cond837:tlc1_Expt.2_Passage_9__\n mATP2:F(1)F(0)-ATPase complex beta subunit, mitochondrial,F(1)F(0)\n-ATPase complex beta subunit,Mutant displays a growth defect\n on glycerol\n Stress.dshift:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mATP3:participates in catalysis of ATP hydrolysis/synthesis and in\n the assembly/stability of F1,ATP synthase gamma subunit,nul\nl mutant is viable; unable to utilize non-fermentable carbon\nd sources\n mATP4:ATP synthase F0 sector subunit 4; analogous to the bovine b \nsubunit,F(1)F(0)-ATPase complex subunit b,Null mutant is via\nble but is oxidative phosphorylation deficient, is unable to\n grow on glycerol, shows an F1 loosely bound to mitochondria\nl membrane, lacks subunit 6 in F0, has a five times lower cy\ntochrome oxidase activity, produces a high percentage of spo\nnteneous rho- mutants, and is oligomycin-insensitive\n mATP5:Subunit 5 of the mitochondrial ATP synthase complex; homolog\nous to bovine OSCP and E. coli delta.,ATP synthase subunit 5\n , oligomycin sensitivity-conferring protein,null mutant is \nviable, but unable to grow on glycerol; exhibits high level \nof genetic instability\n mHAP4:Regulates respiratory functions; encodes divergent overlappi\nng transcripts,transcriptional activator protein of CYC1 (co\nmponent of HAP2/HAP3 heteromer),\n mATP7:ATP synthase d subunit,ATP synthase d subunit,glycerol minus\n phenotype; mitochondria have no detectable oligomycin-sensi\ntive ATPase activity; F1 loosely bound to the membranous por\ntion\n Cond320:heat_shock_17_to_37,_20_minutes\n Cond836:tlc1_Expt.2_Passage_8\n mYBL100C:Unknown ,, Unknown\n mKGD2:dihydrolipoyl transsuccinylase component of alpha-ketoglutar\nate dehydrogenase complex in mitochondria,alpha-ketoglutarat\ne dehydrogenase complex dihydrolipoyl transsuccinylase compo\nnent,Null mutant is viable but is respiratory deficient (pet\n-), and its mitochondria are unable to catalyze the reductio\nn of NAD+ by alpha-ketoglutarate\n Cond896:STAT\n Cond301:Heat_Shock_10_minutes_hs-1\n Calcin.CaFK:Genome-wide analysis of gene expression regulated by the cal\ncineurin/Crz1p signaling pathway in Saccharomyces cerevisiae\n. J Biol Chem. 2002 Aug 23;277(34):31079-88\n mMEF2:mitochondrial elongation factor G-like protein,mitochondrial\n elongation factor G-like protein,\n Cond369:1.5_mM_diamide_(5_min)\n mYDR533C:Unknown ,, Unknown\n Cond824:tlc1_Expt.1_Passage_5\n mMSC1:Meiotic Sister-Chromatid recombination,,\n mRPM2:involved in processing of mitochondrial precursor tRNAs and \nprotein import,mitochondrial RNase P subunit,Null mutant is \nviable, respiratory deficient, accumulate mitochondrial tRNA\n precursors with 5' extensions\n mHSP12:induced by heat shock, entry into stationary phase, depletio\nn of glucose, and addition of lipids (fatty acids),heat shoc\nk protein 12,Null mutant is viable, but shows induction of h\neat shock response under conditions normally associated with\n low-level HSP12 expression\n Stress.YPD:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond414:YPD_6_h_ypd-2\n Cond447:ethanol_vs._reference_pool_car-1\n Cond15:bim1(**15)\n mYBL064C:Unknown ,, Unknown\n Stress.YPDStat:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond323:heat_shock_29_to_37,_20_minutes\n Stress.DTT2:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mYOR215C:Unknown ,, Unknown\n Cond832:tlc1_Expt.2_Passage_4\n Cond855:pm38-30\n Cond426:YPD_stationary_phase_1_d_ypd-1\n Cond457:YP_mannose_vs_reference_pool_car-2\n mYMR206W:Unknown ,, Unknown\n mMIR1:Product of gene unknown,,Null mutant is viable on glucose co\nntaining media, but is unable to grow on a non-fermentable c\narbon source, shows reduced levels of mitochondrial proteins\n Cond322:heat_shock_25_to_37,_20_minutes\n Cond459:YP_sucrose_vs_reference_pool_car-2\n mYDL124W:Unknown ,, Unknown\n mYJR008W:Unknown ,, Unknown\n Cond420:YPD_3_d_ypd-2\n Cond827:tlc1_Expt.1_Passage_8\n mHSP26:heat shock protein 26,heat shock protein 26,Null mutant is v\niable; hsp26 hsp42 double deletion mutants are viable\n Cond449:glucose_vs._reference_pool_car-1\n mPET9:the major mitochondrial ADP/ATP translocator; highly homolog\nous to AAC1 and AAC3,ADP/ATP translocator,null is viable but\n petite (unable to grow on non-fermentable carbon sources); \npet9,aac3 double null mutant is inviable under anaerobic con\nditions; pet9 mutations are lethal in combination with rho- \nmutations\n Cond151:sbp1\n mYPS6:Gpi-anchored aspartic protease (Yapsin 6),GPI-anchored aspar\ntic protease,\n RapamycinDip.dip_ram:Rapamycin-modulated transcription defines the subset of nutr\nient-sensitive signaling pathways directly controlled by the\n Tor proteins. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26)\n:14866-70.\n Stress.HeatSorbitol:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n UME6.ume6:The Ume6 regulon coordinates metabolic and meiotic gene expr\nession in yeast. Proc Natl Acad Sci U S A. 2002 Oct 15;99(2\n1):13431-6.\n Cond450:mannose_vs._reference_pool__car-1\n Stress.H202:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n Cond424:YPD_stationary_phase_8_h_ypd-1\n Cond419:YPD_2_d_ypd-2\n Cond321:heat_shock_21_to_37,_20_minutes\n mNDE1:Unknown ,, Unknown\n mOM45:45-kDa mitochondrial outer membrane protein,45 kDa mitochond\nrial outer membrane protein,Null mutant is viable and shows \nnormal growth, viability, mitochondrial function and mitocho\nndrial protein import\n Cond329:29C_+1M_sorbitol_to_33C_+_1M_sorbitol_-_5_minutes\n mSPI1:Stationary Phase Induced; strongly expressed during stationa\nry phase, and trancription is dependent on MSN2/MSN4.,,\n Cond835:tlc1_Expt.2_Passage_7\n Cond456:YP_glucose_vs_reference_pool_car-2\n mLSC2:beta subunit of succinyl-CoA ligase (synthetase; ATP-forming\n), a mitochondrial enzyme of the TCA cycle,,Null mutant is v\niable but grows slowly on minimal glycerol or pyruvate; muta\nnt suppresses idh2 null mutants for growth on glycerol\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mALD4:Glucose repressed. Utilizes NADP+ or NAD+ as a coenzyme equa\nlly well. (sold by SIGMA under the catalogue number A5550, a\nccording to A. Blomberg).,aldehyde dehydrogenase,\n Cond875:60min\n Cond417:YPD_12_h_ypd-2\n Cond823:tlc1_Expt.1_Passage_4\n mCOX5A:One of two genes (COX5A and COX5B, both nuclear-encoded) cod\ning for subunit V of cytochrome c oxidase; COX5A gene produc\nt is the predominantform of subunit V found in holocytochrom\ne c oxidase under normal growth conditions,cytochrome c oxid\nase chain Va,Null mutant is viable, respires at 10-15% of th\ne wild-type rate due to the presence of COX5B; cox5a cox5b d\nouble deletion mutants are completely non-respiratory\n mACH1:Mannose-containing glycoprotein which binds concanavalin A,a\ncetyl CoA hydrolase,\n Cond415:YPD_8_h_ypd-2\n Stress.HeatVar:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mNCA3:With NCA2, regulates proper expression of subunits 6 (Atp6p)\n and 8 (Atp8p ) of the Fo-F1 ATP synthase,,Null mutant is vi\nable\n Cond682:MHY1_(crt1)_vs_CRY1_(wild_type)\n Cond324:heat_shock_33_to_37,_20_minutes\n mTPS2:Trehalose-6-phosphate phosphatase,trehalose-6-phosphate phos\nphatase,Null mutant is viable, exhibits complete loss of tre\nhalose-6-phosphate phosphatase activity, measured in vitro, \nand accumulation of excessive amounts of trehalose-6-phospha\nte instead of trehalose upon heat shock or entrance into sta\ntionary phase in vivo; null mutant is temperature sensitive,\n tps2 (pfk3) pfk1 double mutants are glucose negative\n mGSY2:Highly similar to GSY1. GSY2 is the predominantly expressed \nglycogen synthase. Activity is probably regulated by cAMP-de\npendent and SNF1 protein kinases and type 1 phosphatase,glyc\nogen synthase (UDP-glucose-starch glucosyltransferase),Null \nmutant is viable. Mutant lacking both GSY1 and GSY2 is viabl\ne but lacks glycogen synthase activity and glycogen depositi\non\n mYLR294C:Unknown ,, Unknown\n Cond411:diauxic_shift_timecourse_20.5_h\n Cond831:tlc1_Expt.2_Passage_3\n Cond453:YP_ethanol_vs_reference_pool_car-2\n mYDC1:Yeast dihydro-ceramidase,alkaline dihydroceramidase with min\nor reverse activity,Null mutant is viable.\n mYDR230W:Unknown ,, Unknown\n zap1.Series0:Genome-wide characterization of the Zap1p zinc-responsive re\ngulon in yeast. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14)\n:7957-62.\n Cond161:sod1(haploid)\n Cond274:yor080w(**3)\n Cell Cycle.cdc15:Comprehensive identification of cell cycle-regulated genes o\nf the yeast Saccharomyces cerevisiae by microarray hybridiza\ntion. Mol Biol Cell. 1998 Dec;9(12):3273-97.\n Cond514:GAL-STE12,3hrs.gallog10(intensity)\n Cond428:YPD_stationary_phase_3_d_ypd-1\n Cond304:Heat_Shock_30_minutes_hs-1\n mYGR182C:Unknown ,, Unknown\n mATP5 mATP4 mATP17
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Computational Genomics Lab, Tel-Aviv uniresity