Module number 1093




Database revision : gnsdb28.10
Date : Tue Feb 25 17:45:06 2003
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Cond626:DY1457_(wild_type)_3_mM_vs._61_nM_zinc_y13-121\n Cond158:sir2\n Cond277:AUR1(tetpromoter)\n Cond698:gal3-gal\n Cond476:GCN4C/GCN4(R4760/R6257)\n Jelinski.Jelinski:Regulatory networks revealed by transcriptional profiling of\n damaged Saccharomyces cerevisiae cells: Rpn4 links base exc\nision repair with proteasomes. Mol Cell Biol. 2000 Nov;20(2\n1):8157-67.\n Cond221:yer083c\n mSAM4:S-adenosylmethionine:homocysteine S-methyltransferase,,Slow \ngrowth on S-adenosylmethionine used as a sulfur source\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts. Nat Genet\n. 2000 Dec;26(4):415-23.\n Cond29:clb2\n Cond13:ase1(**12)\n mURE2:Nitrogen catabolite repression regulator that acts by inhibi\ntion of GLN3 in good nitrogen source. Altered form of Ure2p\n creates [URE3] prion.,glutathione transferase (putative) , \nprion , transcriptional regulator,Null mutant is viable but \nexhibits defects in nitrogen catabolite repression (NCR), an\nd null mutant diploids are defective in pseudohyphal growth \nand display an increased incidence of random bud patterns.\n Cond224:CMD1(tetpromoter)\n Cond730:hda1\n Cond647:dun1-_+_0.02%_MMs_-_30_min\n mARO2:Chorismate synthase,chorismate synthase,aromatic amino acid \nrequiring; lack of premeiotic DNA synthesis; blocked sporula\ntion in homozygous mutant\n Cond190:vps8\n mARO3:DAHP synthase; a.k.a. phospho-2-dehydro-3-deoxyheptonate ald\nolase, phenylalanine-inhibited; phospho-2-keto-3-deoxyhepton\nate aldolase; 2-dehydro-3-deoxyphosphoheptonate aldolase; 3-\ndeoxy-D-arabine-heptulosonate-7-phosphate synthase,DAHP synt\nhase; a.k.a. phospho-2-dehydro-3-deoxyheptonate aldolase, ph\nenylalanine-inhibited; phospho-2-keto-3-deoxyheptonate aldol\nase; 2-dehydro-3-deoxyphosphoheptonate aldolase; 3-deoxy-D-a\nrabine-heptulosonate-7-phosphate synthase,null mutant is via\nble\n mARO4:3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase \nisoenzyme,3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP)\n synthase isoenzyme,null mutant is viable\n Cond244:ymr010w\n Cond90:jnm1\n GCN4.gcn4:Transcriptional profiling shows that Gcn4p is a master regul\nator of gene expression during amino acid starvation in yeas\nt. Mol Cell Biol. 2001 Jul;21(13):4347-68.\n mTFA1:Large subunit of transcription factor tfIIE,transcription fa\nctor tfIIE large subunit,Null mutant is inviable\n Cond53:erg2\n Cond:\n Cond702:gal7-gal\n mFRM2:Protein involved in the integration of lipid signaling pathw\nays with cellular homeostatis,,Null mutant is viable and sen\nsitive to arachidonic acid\n mYOL118C:Unknown ,, Unknown\n COMP.:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond873:10min\n Cond948:W303_ume6_YPA_\n mHOC1:Homologous to OCH1, an alpha-1,6-mannosyltransferase; Golgi-\nlocalized, type II integral membrane protein,mannosyltransfe\nrase (putative),Null mutant is viable but is hypersensitive \nto calcofluor white and hygromycin B and has lowered restric\ntive temperature in a pkc1-371 background; high copy suppres\nsor of pkc1-371\n Cond184:ubr1\n Cond6:anp1\n Cond123:rad57\n Cond298:Terbinafine\n Cond78:hir2\n Cond701:gal6-gal\n COMP.CH:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond201:yel008w\n Cond229:yhr011w(**14)\n Cond216:yer044c(haploid)\n Cond86:imp2'(**12)\n Cond693:gal7+gal\n mECM40:ExtraCellular Mutant,acetylornithine acetyltransferase,A Tn3\n insertion into this gene causes hypersensitivity to the cel\nl surface polymer perturbing agent calcofluor white.\n Cond226:yhl029c\n Cond694:gal10+gal\n mPKR1:Pichia farinosa Killer toxin Resistance,,Confers resistance \nto Pichia farinosa killer toxin (SMK toxin) when overexpress\ned\n UME6.ume6:The Ume6 regulon coordinates metabolic and meiotic gene expr\nession in yeast. Proc Natl Acad Sci U S A. 2002 Oct 15;99(2\n1):13431-6.\n Cond478:WT+/-10mM3AT(R491)\n mLYS7:Involved in lysine biosynthesis, oxidative stress protection\n,copper chaperone for superoxide dismutase Sod1p,Null mutant\n is viable, methionine and lysine auxotroph, pH and temperat\nure sensitive; sensitive to superoxide generating drugs and \nlight irradiation, exhibits diminution of calcineurin activi\nty\n mTRP2:anthranilate synthase Component I,anthranilate synthase comp\nonent I,tryptophan requiring\n mTRP3:anthranilate synthase Component II and indole-3-phosphate (m\nultifunctional enzyme),anthranilate synthase component II , \nindole-3-phosphate,Null mutant is viable, tryptophan auxotro\nph\n Cond145:rts1\n mTRP4:anthranilate phosphoribosyl transferase,anthranilate phospho\nribosyl transferase,tryptophan requiring\n Cond144:rtg1\n mTRP5:tryptophan synthetase,tryptophan synthetase,Null mutant is v\niable and requires tryptophan\n Cond895:G2MMS\n Cond71:gln3\n Cond54:erg3(haploid)\n COMP.KO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n gala.+gal:Integrated genomic and proteomic analyses of a systematicall\ny perturbed metabolic network. Science. 2001 May 4;292(5518\n):929-34.\n mILV1:threonine deaminase,threonine deaminase,Isoleucine-plus-vali\nne requiring\n Cond171:ste24(haploid)\n Cond26:cka2\n gala.-gal:Integrated genomic and proteomic analyses of a systematicall\ny perturbed metabolic network. Science. 2001 May 4;292(5518\n):929-34.\n mASN1:Asn1p and Asn2p are isozymes,asparagine synthetase,Null muta\nnt is viable; L-asparagine auxotrophy occurs upon mutation o\nf both ASN1 and ASN2\n Cond175:swi4\n Cond69:gcn4\n Cond945:W303_YPD\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mYJR111C:Unknown ,, Unknown\n Cond874:30min\n Cond250:ymr031w-a\n mTMT1:Trans-aconitate Methyltransferase 1,,\n Cond153:sgs1\n Cond27:ckb2\n mPHO86:May collaborate with Pho87p and Pho84p in phosphate uptake,i\nnorganic phosphate transporter (putative),Null mutant is via\nble and expresses repressible acid phosphatase in high phosp\nhate medium; pho86 pho87 double mutant and pho86 pho88 doubl\ne mutant constituvely synthesize repressible acid phosphatas\ne and are arsenate-resistant; pho84 pho86 pho87 triple mutan\nt grows more slowly than pho84 mutant\n Cond73:gyp1\n Cond691:gal5+gal\n mYJR154W:Unknown ,, Unknown\n mMET22:Putative phosphatase gene involved in salt tolerance and met\nhionine biogenesis; halotolerance,3'(2')5'-bisphosphate nucl\neotidase,Methionine requiring; lacks 3'-phosphoadenylylsulfa\nte (PAPS) reductase activity; unable to grow on sulfate as s\nole sulfur source\n Cond475:0.5x/1xAA(MildLeu,HisStarvation)(R176)\n Cond294:Itraconazole\n mGCD1:general control of amino acid biosynthesis and cell cycle in\nitiation,gamma subunit , negative regulator in the general c\nontrol of amino acid biosynthesis , translation initiation f\nactor eIF2B subunit,affect growth rate under nonstarvation c\nonditions\n Cond295:Lovastatin\n Cond299:Tunicamycin\n Chromo.chromo:Genomewide studies of histone deacetylase function in yeast.\n Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13708-13.\n zap1.Series0:Genome-wide characterization of the Zap1p zinc-responsive re\ngulon in yeast. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14)\n:7957-62.\n Cond627:DY1457_(wild_type)_3_mM_vs._76_nM_zinc_y12-122\n COMP.TE:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond938:2h\n mYMR321C:Unknown ,, Unknown\n Cond160:sir4\n Cond477:GCN4/gcn4Din100mM3AT(KNY164/KNY124)\n Cond703:gal10-gal\n mTRP2 mTRP3
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Computational Genomics Lab, Tel-Aviv uniresity