Module number 1088




Database revision : gnsdb28.10
Date : Tue Feb 25 17:43:16 2003
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mHIS4:histidinol dehydrogenase,histidinol dehydrogenase,Null mutan\nt is viable and requires histidine\n Cond397:Nitrogen_Depletion_2_h\n Cond390:aa_starv_0.5_h\n mMET32:Involved in methionine metabolism,highly homologous to Met31\np , transcriptional regulator of sulfur amino acid metabolis\nm , zinc finger protein,the met31 met32 double mutant is a m\nethionine auxotroph\n mDCG1:Product of gene unknown,,\n Cond399:Nitrogen_Depletion_8_h\n mARG1:arginosuccinate synthetase,arginosuccinate synthetase,Argini\nne requiring\n mCTP1:citrate transport protein,citrate tranporter,Null mutant is \nviable\n mYKR033C:Unknown ,, Unknown\n mTFS1:(putative) lipid binding protein; supressor of a cdc25 mutat\nion,lipid binding protein (putative) , supressor of a cdc25 \nmutation,Null mutant is viable.\n mARG3:Sixth step in arginine biosynthesis,ornithine carbamoyltrans\nferase,Arginine requiring\n Cond396:Nitrogen_Depletion_1_h\n mARG4:argininosuccinate lyase,argininosuccinate lyase,Arginine req\nuiring\n RapamycinHap.hap_ram:Rapamycin-modulated transcription defines the subset of nutr\nient-sensitive signaling pathways directly controlled by the\n Tor proteins. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26)\n:14866-70.\n Meiosis.Series0:The core meiotic transcriptome in budding yeasts. Nat Genet\n. 2000 Dec;26(4):415-23.\n mSTR3:Sulfur TRansfer,cystathionine beta-lyase,Null mutant is viab\nle but unable to turn cysteine into homocysteine. No growth \nwhen supplied with cystathionine.\n mDIP5:dicarboxylic amino acid permease,dicarboxylic amino acid per\nmease,Null mutant is viable, exhibits loss of L-aspartate an\nd L-glutamate uptake\n mMSC1:Meiotic Sister-Chromatid recombination,,\n Cond400:Nitrogen_Depletion_12_h\n mHSP12:induced by heat shock, entry into stationary phase, depletio\nn of glucose, and addition of lipids (fatty acids),heat shoc\nk protein 12,Null mutant is viable, but shows induction of h\neat shock response under conditions normally associated with\n low-level HSP12 expression\n mASP3-1:nitrogen catabolite-regulated cell-wall L-asparaginase II,ni\ntrogen catabolite-regulated cell-wall L-asparaginase II,\n mASP3-2:nitrogen catabolite-regulated cell-wall L-asparaginase II,ni\ntrogen catabolite-regulated cell-wall L-asparaginase II,\n Cond971:swi1,_minimal_(d)_\n mASP3-3:nitrogen catabolite-regulated cell-wall L-asparaginase II,ni\ntrogen catabolite-regulated cell-wall L-asparaginase II,\n mYNL276C:Unknown ,, Unknown\n mASP3-4:nitrogen catabolite-regulated cell-wall L-asparaginase II,ni\ntrogen catabolite-regulated cell-wall L-asparaginase II,\n mPBI2:Proteinase inhibitor that inhibits protease Prb1p (yscB),pro\nteinase inhibitor I2B (PBI2),Null mutant is viable but shows\n 50% elevation of protein degradation rate when cells are su\nbject to nutritional stress\n mDAL80:Negative regulator of multiple nitrogen catabolic genes,GATA\n family transcriptional repressor,Null mutant is viable, def\nicient in allantoin degradation\n mYGR154C:Unknown ,, Unknown\n mDLD3:D-lactate dehydrogenase,D-lactate dehydrogenase,\n Cond967:swi1,_YPD_(c)\n mSUL1:Putative sulfate permease,,Null mutant is viable, unable to \ngrow on media containing less than 5 mM sulphate\n mSUL2:Sulfate uptake,high affinity sulfate permease,\n mGPM2:Similar to GPM1 (phosphoglycerate mutase); converts 3-phosph\noglycerate to 2-phosphoglycerate in glycolysis,,Null mutant \nis viable, gpm2 gpm3 double deletion mutants exhibit no synt\nhetic phenotypes\n mECM38:ExtraCellular Mutant; cik1 suppressor,gamma-glutamyltransfer\nase homolog,Null mutant is viable. A Tn3 insertion into this\n gene causes hypersensitivity to the cell surface polymer pe\nrturbing agent calcofluor white.\n Cond391:aa_starv_1_h\n mLEE1:Product of gene unknown,,\n Cond855:pm38-30\n mYGR125W:Unknown ,, Unknown\n Cond393:aa_starv_4_h\n Stress.aa_starv:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mPYC1:converts pyruvate to oxaloacetate,pyruvate carboxylase,Null \nmutant is viable but shows greatly reduced pyruvate decarbox\nylase activity and cannot grow on ethanol in the absence of \naspartate; pyc1 pyc2 double mutant is unable to grow on gluc\nose as sole carbon source unless aspartate is added to the m\nedium\n mYLR053C:Unknown ,, Unknown\n mOPT2:oligopeptide transporter,peptide transporter,Null mutant is \nviable\n mYBR147W:Unknown ,, Unknown\n Cond395:Nitrogen_Depletion_30_min.\n Cond404:Nitrogen_Depletion_5_d\n TorRama.Series0:Partitioning the transcriptional program induced by rapamyci\nn among the effectors of the Tor proteins. Curr Biol. 2000 D\nec 14-28;10(24):1574-81\n mGLN1:glutamine synthetase,glutamine synthetase,Glutamine syntheta\nse non-derepressible\n mYKL202W:Unknown ,, Unknown\n mRMD6:Unknown ,, Unknown\n Cond852:30_min\n mGAP1:general amino acid permease,general amino acid permease,abol\nished activity of the general amino acid transport system\n mYHR029C:Unknown ,, Unknown\n mMET10:subunit of assimilatory sulfite reductase,assimilatory sulfi\nte reductase subunit,Null mutant is viable, and is a methion\nine auxotroph\n Stress.NitroDepl:Genomic expression programs in the response of yeast cells t\no environmental changes. Mol Biol Cell. 2000 Dec;11(12):424\n1-57\n mMET16:3'phosphoadenylylsulfate reductase,3'phosphoadenylylsulfate \nreductase,Null mutant is viable, and is a methionine auxotro\nph\n mGAT1:activator of transcription of nitrogen-regulated genes; inac\ntivated by increases in intracellular glutamate levels,trans\ncriptional activator with GATA-1-type Zn finger DNA-binding \nmotif,Null mutant is viable. Required for expression of nitr\nogen catabolite repression-sensitive genes\n SwiSnf.swisnf:Whole-genome expression analysis of snf/swi mutants of Sacch\naromyces cerevisiae. Proc Natl Acad Sci U S A. 2000 Mar 28;\n97(7):3364-9.\n mYIL165C:Unknown ,, Unknown\n mCIT2:non-mitochondrial citrate synthase,citrate synthase,Null mut\nant is viable; disruption of both CIT1 and CIT2 result in gl\nutamate auxotrophy and poor growth on rich medium containing\n lactate.\n Sporulation.Series0:The transcriptional program of sporulation in budding yeast.\n Science. 1998 Oct 23;282(5389):699-705.\n mGDH1:NADP-specific glutamate dehydrogenase,NADP-specific glutamat\ne dehydrogenase,Null mutant is viable\n Cond403:Nitrogen_Depletion_3_d\n SGD.GO:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n mSER33:catalyzes the first step in serine biosynthesis; isozyme of \nSER3,3-phosphoglycerate dehydrogenase,enzyme activity of 3P-\nglycerate dehydrogenase is decreased in null mutant compared\n to wildtype and abolished in ser3 ser33 double deletion mut\nant\n Cond284:PMA1(tetpromoter)\n Cond402:Nitrogen_Depletion_2_d\n mYLR327C:Unknown ,, Unknown\n Cond394:aa_starv_6_h\n mCPS1:carboxypeptidase yscS,carboxypeptidase yscS,Null mutant is v\niable; leucine auxotroph\n Cond398:Nitrogen_Depletion_4_h\n mECM17:ExtraCellular Mutant,sulfite reductase (putative),loss of fu\nnction mutants are methionine requiring and sensitive to the\n cell wall perturbing agent calcoflour white.\n Cond959:t2_g/r_ratio\n mMEP1:ammonia permease,ammonia permease,\n mMEP2:Ammonia transport protein,ammonia transport protein,Null mut\nant is viable.\n Cond401:Nitrogen_Depletion_1_d\n mPUT1:proline oxidase,proline oxidase,inability to use proline as \na nitrogen source\n Cond969:swi1,_minimal_(a)\n mDAL1:allantoinase,allantoinase,Allantoin degradation deficient\n mRAD59:Involved in mitotic recombination,the RAD59 gene product has\n homology to the Rad52 protein,gamma-ray sensitivity, mitoti\nc recombination defects. rad59 is epistatic to rad52 for its\n repair and recombination defects.\n mMET28:Transcriptional activator of sulfur amino acid metabolism,tr\nanscriptional activator in the Cbf1p-Met4p-Met28p complex,Nu\nll mutant is viable but is a methionine-auxotroph and resist\nant to toxic analogs of sulfate.\n mDAL2:allantoicase,allantoicase,Allantoin degradation deficient\n mMET1:Methionine metabolism,,Null mutant is viable, and is a methi\nonine auxotroph\n mDAL3:ureidoglycolate hydrolase,ureidoglycolate hydrolase,Null mut\nant is viable\n mMET2:homoserine O-trans-acetylase,homoserine O-trans-acetylase,Nu\nll mutant is viable, and is a methionine auxotroph\n mDAL4:allantoin transport,allantoin permease,Null mutant is viable\n, lacks allantoin transport capability\n mMET3:ATP sulfurylase,ATP sulfurylase,Null mutant is viable, and i\ns a methionine auxotroph\n mYGL117W:Unknown ,, Unknown\n mDAL5:allantoate permease,allantoate permease,Null mutant is viabl\ne, unable to transport allontoate or ureidosuccinate\n mYMR088C:Unknown ,, Unknown\n mYLL055W:Unknown ,, Unknown\n mDAL7:allantoin pathway,malate synthase 2,Null mutant is viable\n mAUT7:Forms a protein complex with Aut2p to mediate attachment of \nautophagosomes to microtubules. Defective in maturation of t\nhe vacuolar protein, aminopeptidase I,similar to LC3, a micr\notubule-associated protein from rat,Null mutant is viable bu\nt lacks autophagocytosis and is unable to sporulate. AUT7 is\n a suppressor of mutant phenotypes of aut2-1 cells. Uptake o\nf precursor Aminopeptidase I into the vacuole depends on Aut\n2p and Aut7p.\n mDUR3:Urea active transport protein,,Null mutant is viable; urea d\negradation deficient\n Cond970:swi1,_minimal_(c)\n COMP.TE:Functional classification via a compendium of knockouts. Hug\nes et.al., cell 2000.\n Cond938:2h\n Cond392:aa_starv_2_h\n mYOR289W:Unknown ,, Unknown\n mCPA1:Carbamoyl phosphate synthetase, arginine specific,arginine s\npecific , carbamoyl phosphate synthetase,Null mutant is viab\nle\n mYIR042C:Unknown ,, Unknown\n mMLS1:carbon-catabolite sensitive malate synthase,carbon-catabolit\ne sensitive malate synthase,Null mutant is viable\n mCPA2:carbamyl phosphate synthetase,carbamyl phosphate synthetase,\nNull mutant is viable\n mYSP3:subtilisin-like protease III,subtilisin-like protease III,\n Cond856:pm38-qtop\n Cond958:t0.5_g/r_ratio\n mCPA2 mCPA1
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Computational Genomics Lab, Tel-Aviv uniresity